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Gallbladder Adenocarcinoma, Gastric Foveolar Type

MedGen UID:
474747
•Concept ID:
C3273114
•
Neoplastic Process

Definition

An unusual, well differentiated adenocarcinoma that arises from the gallbladder. It is characterized by the presence of tall malignant columnar cells with mucin-containing cytoplasm and basally located nuclei. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder Adenocarcinoma, Gastric Foveolar Type

Recent clinical studies

Etiology

Histological phenotype is correlated with the wall-invasion pattern of gallbladder adenocarcinoma.
Toba T, Kijima H, Hakamada K, Igarashi Y
Biomed Res 2014;35(5):295-302. doi: 10.2220/biomedres.35.295. PMID: 25355436

Diagnosis

Pyloric gland adenoma: a histologic, immunohistochemical and molecular genetic study of 23 cases.
Chlumská A, Waloschek T, Mukenšnabl P, Martínek P, Kašpírková J, Zámečník M
Cesk Patol 2015;51(3):137-43. PMID: 26421956
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264
Well-differentiated adenocarcinoma, gastric foveolar type, of the extrahepatic bile ducts: A previously unrecognized and distinctive morphologic variant of bile duct carcinoma.
Albores-Saavedra J, Delgado R, Henson DE
Ann Diagn Pathol 1999 Apr;3(2):75-80. doi: 10.1016/s1092-9134(99)80033-1. PMID: 10196386

Prognosis

Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264

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