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Invasive Breast Lobular Carcinoma, Solid Variant

MedGen UID:
474850
•Concept ID:
C3273217
•
Neoplastic Process
Synonym: Invasive Lobular Breast Carcinoma, Solid Variant

Definition

A grade I invasive lobular carcinoma of the breast, characterized by the presence of neoplastic cells that form trabeculae and groups infiltrating collagen bundles. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive Breast Lobular Carcinoma, Solid Variant

Professional guidelines

PubMed

Comparison of Treatment Outcome Between Invasive Lobular and Ductal Carcinomas in Patients Receiving Partial Breast Irradiation With Intraoperative Electrons.
Leonardi MC, Maisonneuve P, Mastropasqua MG, Cattani F, Fanetti G, Morra A, Lazzari R, Bazzani F, Caputo M, Rotmensz N, Gerardi MA, Ricotti R, Enrica Galimberti V, Veronesi P, Dicuonzo S, Viale G, Jereczek-Fossa BA, Orecchia R
Int J Radiat Oncol Biol Phys 2017 Sep 1;99(1):173-181. Epub 2017 May 4 doi: 10.1016/j.ijrobp.2017.04.033. PMID: 28816144

Recent clinical studies

Etiology

Biomarker profile of invasive lobular carcinoma: pleomorphic versus classic subtypes, clinicopathological characteristics and prognosis analyses.
Zhang Y, Luo X, Chen M, Yang L, Lei T, Pu T, Wei B, Bu H, Zhang Z
Breast Cancer Res Treat 2022 Jul;194(2):279-295. Epub 2022 Jun 6 doi: 10.1007/s10549-022-06627-y. PMID: 35666367
Invasive lobular carcinoma of the breast: clinicopathological features and patient outcomes.
Bozkurt E, Kaya C, Ucak R, Demircioglu MK, Guven O, Mihmanli M
Ann Ital Chir 2021;92:494-499. PMID: 34795114
Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions.
Yu BH, Tang SX, Xu XL, Cheng YF, Bi R, Shui RH, Tu XY, Lu HF, Zhou XY, Yang WT
J Clin Pathol 2018 Jun;71(6):546-553. Epub 2018 Feb 7 doi: 10.1136/jclinpath-2017-204751. PMID: 29436376
ERBB2 mutations associated with solid variant of high-grade invasive lobular breast carcinomas.
Deniziaut G, Tille JC, Bidard FC, Vacher S, Schnitzler A, Chemlali W, Trémoulet L, Fuhrmann L, Cottu P, Rouzier R, Bièche I, Vincent-Salomon A
Oncotarget 2016 Nov 8;7(45):73337-73346. doi: 10.18632/oncotarget.11819. PMID: 27602491Free PMC Article
Lobular carcinoma, not only a classic.
Brogi E, Murray MP, Corben AD
Breast J 2010 Sep-Oct;16 Suppl 1:S10-4. doi: 10.1111/j.1524-4741.2010.00994.x. PMID: 21050299

Diagnosis

Uncommon invasive lobular carcinoma with papillary architecture-clinicopathologic and molecular characterization with review of the literature.
Gessain G, Joyon N, Petit T, Cotteret S, Lacroix-Triki M
Virchows Arch 2023 Nov;483(5):723-729. Epub 2023 Mar 16 doi: 10.1007/s00428-023-03526-5. PMID: 36928170
Invasive Lobular Carcinoma Mimicking Encapsulated Papillary Carcinoma with a Literature Review: A Rare Variant Detected Serendipitously.
Zheng L, Saluja K, Guo T
Int J Surg Pathol 2022 Dec;30(8):912-920. Epub 2022 Jun 3 doi: 10.1177/10668969221088878. PMID: 35656761
New variant of breast-invasive lobular carcinoma with solid and encapsulated papillary carcinoma growth pattern.
Li X, Lin M, Xu J, Pang Y, Chen H, Sun P, Hou G
Breast Cancer 2021 Nov;28(6):1383-1388. Epub 2021 Aug 7 doi: 10.1007/s12282-021-01285-2. PMID: 34363596
Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions.
Yu BH, Tang SX, Xu XL, Cheng YF, Bi R, Shui RH, Tu XY, Lu HF, Zhou XY, Yang WT
J Clin Pathol 2018 Jun;71(6):546-553. Epub 2018 Feb 7 doi: 10.1136/jclinpath-2017-204751. PMID: 29436376
Histology and immunophenotype of invasive lobular breast cancer. daily practice and pitfalls.
Varga Z, Mallon E
Breast Dis 2008-2009;30:15-9. doi: 10.3233/BD-2009-0278. PMID: 19850991

Therapy

Comparison of Treatment Outcome Between Invasive Lobular and Ductal Carcinomas in Patients Receiving Partial Breast Irradiation With Intraoperative Electrons.
Leonardi MC, Maisonneuve P, Mastropasqua MG, Cattani F, Fanetti G, Morra A, Lazzari R, Bazzani F, Caputo M, Rotmensz N, Gerardi MA, Ricotti R, Enrica Galimberti V, Veronesi P, Dicuonzo S, Viale G, Jereczek-Fossa BA, Orecchia R
Int J Radiat Oncol Biol Phys 2017 Sep 1;99(1):173-181. Epub 2017 May 4 doi: 10.1016/j.ijrobp.2017.04.033. PMID: 28816144

Prognosis

Biomarker profile of invasive lobular carcinoma: pleomorphic versus classic subtypes, clinicopathological characteristics and prognosis analyses.
Zhang Y, Luo X, Chen M, Yang L, Lei T, Pu T, Wei B, Bu H, Zhang Z
Breast Cancer Res Treat 2022 Jul;194(2):279-295. Epub 2022 Jun 6 doi: 10.1007/s10549-022-06627-y. PMID: 35666367
Invasive lobular carcinoma with extracellular mucin (ILCEM): clinicopathologic and molecular characterization of a rare entity.
Soong TR, Dillon DA, Rice-Stitt TL, Wieczorek TJ, Baker GM, Darvishian F, Collins LC, Lester SC, Schnitt SJ, Harrison BT
Mod Pathol 2022 Oct;35(10):1370-1382. Epub 2022 Apr 27 doi: 10.1038/s41379-022-01084-w. PMID: 35477749
Invasive lobular carcinoma of the breast: clinicopathological features and patient outcomes.
Bozkurt E, Kaya C, Ucak R, Demircioglu MK, Guven O, Mihmanli M
Ann Ital Chir 2021;92:494-499. PMID: 34795114
ERBB2 mutations associated with solid variant of high-grade invasive lobular breast carcinomas.
Deniziaut G, Tille JC, Bidard FC, Vacher S, Schnitzler A, Chemlali W, Trémoulet L, Fuhrmann L, Cottu P, Rouzier R, Bièche I, Vincent-Salomon A
Oncotarget 2016 Nov 8;7(45):73337-73346. doi: 10.18632/oncotarget.11819. PMID: 27602491Free PMC Article
Histology and immunophenotype of invasive lobular breast cancer. daily practice and pitfalls.
Varga Z, Mallon E
Breast Dis 2008-2009;30:15-9. doi: 10.3233/BD-2009-0278. PMID: 19850991

Clinical prediction guides

Ovarian Mucinous Tumor Presenting Atypical Lobular Endocervical Glandular Hyperplasia-Like Appearance in a Patient With Germline STK11 p.F354L Variant: A Case Report.
Yoshida H, Hiranuma K, Nakahara M, Kobayashi-Kato M, Tanase Y, Uno M, Shiraishi K, Ishikawa M, Kato T
Int J Surg Pathol 2024 Apr;32(2):394-400. Epub 2023 May 24 doi: 10.1177/10668969231177256. PMID: 37226494
Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions.
Yu BH, Tang SX, Xu XL, Cheng YF, Bi R, Shui RH, Tu XY, Lu HF, Zhou XY, Yang WT
J Clin Pathol 2018 Jun;71(6):546-553. Epub 2018 Feb 7 doi: 10.1136/jclinpath-2017-204751. PMID: 29436376
Comparison of Treatment Outcome Between Invasive Lobular and Ductal Carcinomas in Patients Receiving Partial Breast Irradiation With Intraoperative Electrons.
Leonardi MC, Maisonneuve P, Mastropasqua MG, Cattani F, Fanetti G, Morra A, Lazzari R, Bazzani F, Caputo M, Rotmensz N, Gerardi MA, Ricotti R, Enrica Galimberti V, Veronesi P, Dicuonzo S, Viale G, Jereczek-Fossa BA, Orecchia R
Int J Radiat Oncol Biol Phys 2017 Sep 1;99(1):173-181. Epub 2017 May 4 doi: 10.1016/j.ijrobp.2017.04.033. PMID: 28816144
Solid papillary carcinoma of the nipple: an in situ carcinoma or an expansive growth tumor?
Tacchini D, Vassallo L, Butorano MA, Mancini V, Megha T
Pathologica 2016 Sep;108(3):136-139. PMID: 28195265
Histiocytoid breast carcinoma: solid variant of invasive lobular carcinoma with decreased expression of both E-cadherin and CD44 epithelial variant.
Fujiwara M, Horiguchi M, Mori S, Yokoyama K, Horiguchi H, Fukazawa M, Fujiwara H, Yano Y, Satoh H, Kamma H
Pathol Int 2005 Jun;55(6):353-9. doi: 10.1111/j.1440-1827.2005.01836.x. PMID: 15943793

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