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Squamous Metaplasia Without Atypia

MedGen UID:
474885
•Concept ID:
C3273252
•
Finding

Definition

A morphologic finding indicating the transformation of glandular or transitional epithelial cells to squamous epithelial cells that lack atypical features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSquamous Metaplasia Without Atypia

Professional guidelines

PubMed

Atypical squamous epithelium in cytologic specimens from the pancreas: cytological differential diagnosis and clinical implications.
Layfield LJ, Cramer H, Madden J, Gopez EV, Liu K
Diagn Cytopathol 2001 Jul;25(1):38-42. doi: 10.1002/dc.1099. PMID: 11466811
ASCUS, mature metaplastic type. Cytologic diagnosis and follow-up.
Gupta D, Kannan V, Komaromy-Hiller G, Kline TS
Acta Cytol 2001 Mar-Apr;45(2):192-6. doi: 10.1159/000327276. PMID: 11284305
Follow-up of Papanicolaou smears diagnosed as atypical squamous cells of undetermined significance.
Howell LP, Davis RL
Diagn Cytopathol 1996 Feb;14(1):20-4. doi: 10.1002/(SICI)1097-0339(199602)14:1<20::AID-DC5>3.0.CO;2-Z. PMID: 8834072

Recent clinical studies

Etiology

Precursor lesions of the urinary bladder.
McKenney JK
Histopathology 2019 Jan;74(1):68-76. doi: 10.1111/his.13762. PMID: 30565304
Persistence of Bronchial Dysplasia Is Associated with Development of Invasive Squamous Cell Carcinoma.
Merrick DT, Gao D, Miller YE, Keith RL, Baron AE, Feser W, Kennedy TC, Blatchford PJ, Braudrick S, Hirsch FR, Heasley L, Bunn PA Jr, Franklin WA
Cancer Prev Res (Phila) 2016 Jan;9(1):96-104. Epub 2015 Nov 5 doi: 10.1158/1940-6207.CAPR-15-0305. PMID: 26542061Free PMC Article
Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis.
Franklin WA, Gazdar AF, Haney J, Wistuba II, La Rosa FG, Kennedy T, Ritchey DM, Miller YE
J Clin Invest 1997 Oct 15;100(8):2133-7. doi: 10.1172/JCI119748. PMID: 9329980Free PMC Article
The use of urine cytology for diagnosing bladder cancer in spinal cord injured patients.
Stonehill WH, Goldman HB, Dmochowski RR
J Urol 1997 Jun;157(6):2112-4. PMID: 9146593
Chemoprevention of lung cancer.
Benner SE, Lippman SM, Hong WK
Chest 1995 Jun;107(6 Suppl):316S-321S. doi: 10.1378/chest.107.6_supplement.316s. PMID: 7781413

Diagnosis

Epidermoid cyst of the renal pelvis masquerading as malignancy.
Pradhan D, Quiroga-Garza G, Hrebinko R, Dhir R, Parwani AV
Indian J Pathol Microbiol 2017 Oct-Dec;60(4):571-573. doi: 10.4103/IJPM.IJPM_618_16. PMID: 29323077
Uterine Adenosarcoma.
Pinto A, Howitt B
Arch Pathol Lab Med 2016 Mar;140(3):286-90. doi: 10.5858/arpa.2014-0523-RS. PMID: 26927725
Endocervical glandular atypia: a "new" problem for the cytologist.
Wilbur DC
Diagn Cytopathol 1995 Dec;13(5):463-9. doi: 10.1002/dc.2840130515. PMID: 8834321
Necrotizing sialometaplasia.
Samit AM, Mashberg A, Greene GW Jr
J Oral Surg 1979 May;37(5):353-6. PMID: 285245
Irradiation-induced changes in human salivary glands.
Busuttil A
Clin Otolaryngol Allied Sci 1977 Aug;2(3):199-206. doi: 10.1111/j.1365-2273.1977.tb01358.x. PMID: 589840

Therapy

Spontaneous infarction of pleomorphic adenoma: report of a case simulating malignancy on fine-needle cytology sample.
Fulciniti F, Losito NS, Botti G, Manola M, Ionna F
Diagn Cytopathol 2010 Jun;38(6):430-4. doi: 10.1002/dc.21229. PMID: 19894261
Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis.
Franklin WA, Gazdar AF, Haney J, Wistuba II, La Rosa FG, Kennedy T, Ritchey DM, Miller YE
J Clin Invest 1997 Oct 15;100(8):2133-7. doi: 10.1172/JCI119748. PMID: 9329980Free PMC Article
Chemoprevention of lung cancer.
Benner SE, Lippman SM, Hong WK
Chest 1995 Jun;107(6 Suppl):316S-321S. doi: 10.1378/chest.107.6_supplement.316s. PMID: 7781413
Cytologic and histologic findings in women using an IUD.
Risse EK, Beerthuizen RJ, Vooijs GP
Obstet Gynecol 1981 Nov;58(5):569-73. PMID: 7301231
Irradiation-induced changes in human salivary glands.
Busuttil A
Clin Otolaryngol Allied Sci 1977 Aug;2(3):199-206. doi: 10.1111/j.1365-2273.1977.tb01358.x. PMID: 589840

Prognosis

Pitfalls in Salivary Gland Cytology.
Saoud C, Bailey GE, Graham A, Bonilla LM, Sanchez SI, Maleki Z
Acta Cytol 2024;68(3):194-205. Epub 2024 Feb 28 doi: 10.1159/000538069. PMID: 38417405
Uterine Adenosarcoma.
Pinto A, Howitt B
Arch Pathol Lab Med 2016 Mar;140(3):286-90. doi: 10.5858/arpa.2014-0523-RS. PMID: 26927725
How to approach the many faces of endometrioid carcinoma.
Malpica A
Mod Pathol 2016 Jan;29 Suppl 1:S29-44. doi: 10.1038/modpathol.2015.142. PMID: 26715172
Persistence of Bronchial Dysplasia Is Associated with Development of Invasive Squamous Cell Carcinoma.
Merrick DT, Gao D, Miller YE, Keith RL, Baron AE, Feser W, Kennedy TC, Blatchford PJ, Braudrick S, Hirsch FR, Heasley L, Bunn PA Jr, Franklin WA
Cancer Prev Res (Phila) 2016 Jan;9(1):96-104. Epub 2015 Nov 5 doi: 10.1158/1940-6207.CAPR-15-0305. PMID: 26542061Free PMC Article
Cytological changes due to urinary calculi: a consideration of the relationship between calculi and the development of urothelial carcinoma.
Beyer-Boon ME, Cuypers LH, de Voogt HJ, Brussee JA
Br J Urol 1978 Apr;50(2):81-9. doi: 10.1111/j.1464-410x.1978.tb03031.x. PMID: 89882

Clinical prediction guides

Pitfalls in Salivary Gland Cytology.
Saoud C, Bailey GE, Graham A, Bonilla LM, Sanchez SI, Maleki Z
Acta Cytol 2024;68(3):194-205. Epub 2024 Feb 28 doi: 10.1159/000538069. PMID: 38417405
Epithelial Squamous Metaplasia and Dysplasia in Inflammatory Nasal Polyps: An Observational Study.
Perić A, Stoiljkov M, Đokić D, Đurđević BV
Ear Nose Throat J 2021 Feb;100(2):NP120-NP124. Epub 2019 Jul 16 doi: 10.1177/0145561319862207. PMID: 31309847
Endocervical columnar cell atypia coincident with cervical neoplasia characterized by digital image analysis.
Rosenthal DL, McLatchie C, Stern E, White BS, Castleman KR
Acta Cytol 1982 Mar-Apr;26(2):115-20. PMID: 7044016
Cytological changes due to urinary calculi: a consideration of the relationship between calculi and the development of urothelial carcinoma.
Beyer-Boon ME, Cuypers LH, de Voogt HJ, Brussee JA
Br J Urol 1978 Apr;50(2):81-9. doi: 10.1111/j.1464-410x.1978.tb03031.x. PMID: 89882
Irradiation-induced changes in human salivary glands.
Busuttil A
Clin Otolaryngol Allied Sci 1977 Aug;2(3):199-206. doi: 10.1111/j.1365-2273.1977.tb01358.x. PMID: 589840

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