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Plasmablastic lymphoma

MedGen UID:
483338
Concept ID:
C3472614
Neoplastic Process
Synonyms: Lymphoma, Plasmablastic; Lymphomas, Plasmablastic; Plasmablastic Diffuse Large B cell Lymphoma; Plasmablastic Diffuse Large B-cell Lymphoma; Plasmablastic Lymphoma; Plasmablastic Lymphomas; Plasmablasts Diffuse Large B cell Lymphoma; Plasmablasts Diffuse Large B-cell Lymphoma
SNOMED CT: Plasmablastic lymphoma (450909005); Plasmablastic lymphoma (724648008)
 
Monarch Initiative: MONDO:0017347
Orphanet: ORPHA289666

Definition

A rare aggressive B-cell non-Hodgkin lymphoma characterized by neoplastic cells resembling B immunoblasts or plasmablasts with a CD20-negative plasmacytic phenotype. The tumor may occur in the oral cavity, the gastrointestinal tract, or other, predominantly extranodal, sites and is typically associated with immunodeficiency or -suppression. The tumor cells are EBV-positive in most cases. Patients often present with disseminated bone involvement. Paraproteinemia may also be detected. Prognosis is generally poor. [from ORDO]

Professional guidelines

PubMed

Ramirez-Gamero A, Martínez-Cordero H, Beltrán BE, Florindez J, Malpica L, Castillo JJ
Am J Hematol 2024 Aug;99(8):1586-1594. Epub 2024 May 20 doi: 10.1002/ajh.27376. PMID: 38767403
Frontzek F, Hailfinger S, Lenz G
Leuk Lymphoma 2023 Apr;64(4):799-807. Epub 2022 Dec 28 doi: 10.1080/10428194.2022.2162341. PMID: 36577021
Malpica L, Marques-Piubelli ML, Beltran BE, Chavez JC, Miranda RN, Castillo JJ
Am J Hematol 2022 Jul;97(7):951-965. Epub 2022 May 3 doi: 10.1002/ajh.26579. PMID: 35472248

Recent clinical studies

Etiology

Ramirez-Gamero A, Martínez-Cordero H, Beltrán BE, Florindez J, Malpica L, Castillo JJ
Am J Hematol 2024 Aug;99(8):1586-1594. Epub 2024 May 20 doi: 10.1002/ajh.27376. PMID: 38767403
Di Ciaccio PR, Polizzotto MN, Cwynarski K, Gerrie AS, Burton C, Bower M, Kuruvilla J, Montoto S, McKay P, Fox CP, Milliken S, Jiamsakul A, Osborne W, Collins GP, Manos K, Linton KM, Iyengar S, Kassam S, Limei MP, Kliman D, Wong Doo N, Watson AM, Fedele P, Yannakou CK, Hunt S, Ku M, Sehn LH, Smith A, Renshaw H, Maxwell A, Liu Q, Dhairyawan R, Ferguson G, Pickard K, Painter D, Thakrar N, Song KW, Hamad N
Blood 2024 Jan 11;143(2):152-165. doi: 10.1182/blood.2023021348. PMID: 37832030
Malpica L, Marques-Piubelli ML, Beltran BE, Chavez JC, Miranda RN, Castillo JJ
Am J Hematol 2022 Jul;97(7):951-965. Epub 2022 May 3 doi: 10.1002/ajh.26579. PMID: 35472248
Carbone A, Vaccher E, Gloghini A
Blood 2022 Feb 17;139(7):995-1012. doi: 10.1182/blood.2020005469. PMID: 34469512
Dittus C, Grover N, Ellsworth S, Tan X, Park SI
Leuk Lymphoma 2018 Sep;59(9):2121-2127. Epub 2018 Jan 5 doi: 10.1080/10428194.2017.1416365. PMID: 29303024

Diagnosis

Ramirez-Gamero A, Martínez-Cordero H, Beltrán BE, Florindez J, Malpica L, Castillo JJ
Am J Hematol 2024 Aug;99(8):1586-1594. Epub 2024 May 20 doi: 10.1002/ajh.27376. PMID: 38767403
Kaur S, Kollimuttathuillam S
Clin Lymphoma Myeloma Leuk 2023 Sep;23(9):e253-e259. Epub 2023 Jun 14 doi: 10.1016/j.clml.2023.05.014. PMID: 37453866
Bailly J, Jenkins N, Chetty D, Mohamed Z, Verburgh ER, Opie JJ
Int J Lab Hematol 2022 Sep;44 Suppl 1(Suppl 1):54-63. doi: 10.1111/ijlh.13863. PMID: 36074710Free PMC Article
Malpica L, Marques-Piubelli ML, Beltran BE, Chavez JC, Miranda RN, Castillo JJ
Am J Hematol 2022 Jul;97(7):951-965. Epub 2022 May 3 doi: 10.1002/ajh.26579. PMID: 35472248
Sukswai N, Lyapichev K, Khoury JD, Medeiros LJ
Pathology 2020 Jan;52(1):53-67. Epub 2019 Nov 15 doi: 10.1016/j.pathol.2019.08.013. PMID: 31735345

Therapy

Ramirez-Gamero A, Martínez-Cordero H, Beltrán BE, Florindez J, Malpica L, Castillo JJ
Am J Hematol 2024 Aug;99(8):1586-1594. Epub 2024 May 20 doi: 10.1002/ajh.27376. PMID: 38767403
Jessa R, Chien N, Villa D, Freeman CL, Slack GW, Savage KJ, Scott DW, Sehn LH, Song KW, Gerrie AS
Br J Haematol 2022 Oct;199(2):230-238. Epub 2022 Aug 12 doi: 10.1111/bjh.18399. PMID: 35961783
Lilly AJ, Fedoriw Y
Surg Pathol Clin 2019 Sep;12(3):771-782. Epub 2019 May 17 doi: 10.1016/j.path.2019.03.005. PMID: 31352987
Dittus C, Grover N, Ellsworth S, Tan X, Park SI
Leuk Lymphoma 2018 Sep;59(9):2121-2127. Epub 2018 Jan 5 doi: 10.1080/10428194.2017.1416365. PMID: 29303024
Castillo JJ, Bibas M, Miranda RN
Blood 2015 Apr 9;125(15):2323-30. Epub 2015 Jan 30 doi: 10.1182/blood-2014-10-567479. PMID: 25636338

Prognosis

Ramirez-Gamero A, Martínez-Cordero H, Beltrán BE, Florindez J, Malpica L, Castillo JJ
Am J Hematol 2024 Aug;99(8):1586-1594. Epub 2024 May 20 doi: 10.1002/ajh.27376. PMID: 38767403
Di Ciaccio PR, Polizzotto MN, Cwynarski K, Gerrie AS, Burton C, Bower M, Kuruvilla J, Montoto S, McKay P, Fox CP, Milliken S, Jiamsakul A, Osborne W, Collins GP, Manos K, Linton KM, Iyengar S, Kassam S, Limei MP, Kliman D, Wong Doo N, Watson AM, Fedele P, Yannakou CK, Hunt S, Ku M, Sehn LH, Smith A, Renshaw H, Maxwell A, Liu Q, Dhairyawan R, Ferguson G, Pickard K, Painter D, Thakrar N, Song KW, Hamad N
Blood 2024 Jan 11;143(2):152-165. doi: 10.1182/blood.2023021348. PMID: 37832030
Kaur S, Kollimuttathuillam S
Clin Lymphoma Myeloma Leuk 2023 Sep;23(9):e253-e259. Epub 2023 Jun 14 doi: 10.1016/j.clml.2023.05.014. PMID: 37453866
Jessa R, Chien N, Villa D, Freeman CL, Slack GW, Savage KJ, Scott DW, Sehn LH, Song KW, Gerrie AS
Br J Haematol 2022 Oct;199(2):230-238. Epub 2022 Aug 12 doi: 10.1111/bjh.18399. PMID: 35961783
Malpica L, Marques-Piubelli ML, Beltran BE, Chavez JC, Miranda RN, Castillo JJ
Am J Hematol 2022 Jul;97(7):951-965. Epub 2022 May 3 doi: 10.1002/ajh.26579. PMID: 35472248

Clinical prediction guides

Ramirez-Gamero A, Martínez-Cordero H, Beltrán BE, Florindez J, Malpica L, Castillo JJ
Am J Hematol 2024 Aug;99(8):1586-1594. Epub 2024 May 20 doi: 10.1002/ajh.27376. PMID: 38767403
Malpica L, Marques-Piubelli ML, Beltran BE, Chavez JC, Miranda RN, Castillo JJ
Am J Hematol 2022 Jul;97(7):951-965. Epub 2022 May 3 doi: 10.1002/ajh.26579. PMID: 35472248
Leeman-Neill RJ, Soderquist CR, Montanari F, Raciti P, Park D, Radeski D, Mansukhani MM, Murty VV, Hsiao S, Alobeid B, Bhagat G
Haematologica 2022 Jan 1;107(1):201-210. doi: 10.3324/haematol.2020.267294. [Epub ahead of print] PMID: 33297669Free PMC Article
Jaffe ES
Mod Pathol 2020 Jan;33(Suppl 1):96-106. Epub 2019 Oct 25 doi: 10.1038/s41379-019-0385-7. PMID: 31653979
Castillo JJ, Winer ES, Stachurski D, Perez K, Jabbour M, Milani C, Colvin GA, Butera JN
Clin Lymphoma Myeloma Leuk 2011 Apr;11(2):185-9. Epub 2011 Apr 8 doi: 10.1016/j.clml.2011.03.008. PMID: 21575922

Recent systematic reviews

Gomes NR, Lima LA, Morais-Perdigão AL, de Caceres CVBL, Sant'Ana MSP, Pontes HAR, Pontes FSC, Smit C, van Heerden WFP, Robinson L, Brasileiro CB, Brennan PA, Fonseca FP
J Oral Pathol Med 2023 Apr;52(4):315-323. Epub 2023 Mar 7 doi: 10.1111/jop.13422. PMID: 36852531
Rodrigues-Fernandes CI, de Souza LL, Santos-Costa SFD, Silva AMB, Pontes HAR, Lopes MA, de Almeida OP, Brennan PA, Fonseca FP
J Oral Pathol Med 2018 Nov;47(10):915-922. Epub 2018 Jul 5 doi: 10.1111/jop.12753. PMID: 29917262
Guerrero-Garcia TA, Mogollon RJ, Castillo JJ
Leuk Res 2017 Nov;62:12-16. Epub 2017 Sep 27 doi: 10.1016/j.leukres.2017.09.020. PMID: 28963907
Li J, Zhao S, Wang J, Chen J, Wen W, Zhang Q
Tumour Biol 2016 Mar;37(3):3619-37. Epub 2015 Oct 12 doi: 10.1007/s13277-015-4205-5. PMID: 26459310
Castillo JJ, Reagan JL
ScientificWorldJournal 2011 Mar 22;11:687-96. doi: 10.1100/tsw.2011.59. PMID: 21442146Free PMC Article

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