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Subungual Exostosis

MedGen UID:
52542
Concept ID:
C0038604
Neoplastic Process
Synonym: Subungual exostoses
SNOMED CT: Subungual exostosis (703697003); Subungual exostosis (26904005)

Definition

A benign tumor that affects the distal phalanx, most often the great toe. Grossly it consists of a cartilage cap and a bony stalk. Microscopically it is characterized by an osteochondromatous proliferation with a gradual transition of a peripheral spindle-cell proliferation to hyaline cartilage to trabecular bone. Pain and swelling are present. Simple resection is usually curative. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubungual Exostosis

Professional guidelines

PubMed

Malkoc M, Korkmaz O, Keskinbora M, Seker A, Oltulu I, Bulbul AM, Say F, Cakir A
Singapore Med J 2016 Nov;57(11):630-633. Epub 2015 Dec 14 doi: 10.11622/smedj.2015180. PMID: 26778465Free PMC Article
Richert B, André J
Am J Clin Dermatol 2011 Apr 1;12(2):101-12. doi: 10.2165/11537110-000000000-00000. PMID: 21348541
Cohen PR, Scher RK
J Am Acad Dermatol 1992 Apr;26(4):521-31. doi: 10.1016/0190-9622(92)70075-q. PMID: 1597537

Recent clinical studies

Etiology

Mundada P, Becker M, Lenoir V, Stefanelli S, Rougemont AL, Beaulieu JY, Boudabbous S
Eur J Radiol 2019 Mar;112:93-105. Epub 2019 Jan 6 doi: 10.1016/j.ejrad.2019.01.004. PMID: 30777226
Göktay F, Atış G, Güneş P, Macit B, Çelik NS, Gürdal Kösem E
Int J Dermatol 2018 Jul;57(7):872-881. Epub 2018 Apr 27 doi: 10.1111/ijd.14003. PMID: 29704255
Bryant A, Knox A
Aust Fam Physician 2015 Mar;44(3):102-5. PMID: 25770573
Valero J, Gallart J, Gonzalez D, Deus J, Lahoz M
J Eur Acad Dermatol Venereol 2014 Oct;28(10):1292-7. Epub 2013 Oct 3 doi: 10.1111/jdv.12271. PMID: 24118406
Caprioli R, Bilotti MA
Clin Podiatr Med Surg 1989 Apr;6(2):431-51. PMID: 2650852

Diagnosis

Yousefian F, Davis B, Browning JC
Cutis 2021 Nov;108(5):256-257. doi: 10.12788/cutis.0380. PMID: 35100532
Shah SN
Indian J Pathol Microbiol 2021 Jul-Sep;64(3):598-599. doi: 10.4103/IJPM.IJPM_656_20. PMID: 34341284
Vaccaro M, Bartolomeo LD, Cannavo SP
Indian Pediatr 2021 Feb 15;58(2):201. PMID: 33632969
Russell JD, Nance K, Nunley JR, Maher IA
Cutis 2016 Aug;98(2):128-9. PMID: 27622256
Calligaris L, Berti I
J Pediatr 2014 Aug;165(2):412. Epub 2014 Apr 27 doi: 10.1016/j.jpeds.2014.03.046. PMID: 24787537

Therapy

Pascoal D, Balacó I, Alves C, Cardoso PS, Ling TP, Matos G
J Pediatr Orthop B 2020 Jul;29(4):382-386. doi: 10.1097/BPB.0000000000000723. PMID: 32195759
DaCambra MP, Gupta SK, Ferri-de-Barros F
Clin Orthop Relat Res 2014 Apr;472(4):1251-9. Epub 2013 Oct 22 doi: 10.1007/s11999-013-3345-4. PMID: 24146360Free PMC Article
Delivanis DA, Bhargava A, Luthra P
Endocr Pract 2013 Sep-Oct;19(5):e115-7. doi: 10.4158/EP13040.CR. PMID: 23757619
Khunger N, Kandhari R
Indian J Dermatol Venereol Leprol 2012 May-Jun;78(3):279-89. doi: 10.4103/0378-6323.95442. PMID: 22565427
Singh G, Haneef NS, Uday A
Indian J Dermatol Venereol Leprol 2005 Nov-Dec;71(6):386-92. doi: 10.4103/0378-6323.18941. PMID: 16394478

Prognosis

Memon RA, Wei S, Siegal GP
Arch Pathol Lab Med 2022 Jan 1;146(1):60-69. doi: 10.5858/arpa.2020-0817-RA. PMID: 33946096
Goez JC, Kilfoil RL, Wang CA, Sax Z, Arif F
J Am Podiatr Med Assoc 2020 Jul 1;110(4) doi: 10.7547/17-207. PMID: 32997760
Valero J, Gallart J, Gonzalez D, Deus J, Lahoz M
J Eur Acad Dermatol Venereol 2014 Oct;28(10):1292-7. Epub 2013 Oct 3 doi: 10.1111/jdv.12271. PMID: 24118406
Kim SW, Moon SE, Kim JA
J Dermatol 1998 Jan;25(1):60-2. doi: 10.1111/j.1346-8138.1998.tb02349.x. PMID: 9519614
Mikhail GR
J Am Acad Dermatol 1984 Aug;11(2 Pt 1):291-8. doi: 10.1016/s0190-9622(84)70165-4. PMID: 6480930

Clinical prediction guides

Sławińska M, Żółkiewicz J, Ribereau-Gayon E, Maińska U, Sobjanek M, Thomas L
J Eur Acad Dermatol Venereol 2024 Oct;38(10):1988-1996. Epub 2024 May 8 doi: 10.1111/jdv.20078. PMID: 38717320
Pascoal D, Balacó I, Alves C, Cardoso PS, Ling TP, Matos G
J Pediatr Orthop B 2020 Jul;29(4):382-386. doi: 10.1097/BPB.0000000000000723. PMID: 32195759
Malkoc M, Korkmaz O, Keskinbora M, Seker A, Oltulu I, Bulbul AM, Say F, Cakir A
Singapore Med J 2016 Nov;57(11):630-633. Epub 2015 Dec 14 doi: 10.11622/smedj.2015180. PMID: 26778465Free PMC Article
Singh R, Jain M, Goel R, Siwach R, Kalra R, Kaur K
Foot Ankle Spec 2011 Dec;4(6):376-8. Epub 2011 Sep 16 doi: 10.1177/1938640011418495. PMID: 21926360
Cohen PR, Scher RK
J Am Acad Dermatol 1992 Apr;26(4):521-31. doi: 10.1016/0190-9622(92)70075-q. PMID: 1597537

Recent systematic reviews

Sławińska M, Żółkiewicz J, Ribereau-Gayon E, Maińska U, Sobjanek M, Thomas L
J Eur Acad Dermatol Venereol 2024 Oct;38(10):1988-1996. Epub 2024 May 8 doi: 10.1111/jdv.20078. PMID: 38717320
Pérez-Palma L, Manzanares-Céspedes MC, de Veciana EG
J Am Podiatr Med Assoc 2018 Jul;108(4):320-333. doi: 10.7547/17-102. PMID: 30156888
DaCambra MP, Gupta SK, Ferri-de-Barros F
Clin Orthop Relat Res 2014 Apr;472(4):1251-9. Epub 2013 Oct 22 doi: 10.1007/s11999-013-3345-4. PMID: 24146360Free PMC Article

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