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Transitional cell metaplasia

MedGen UID:
569521
•Concept ID:
C0334033
•
Cell or Molecular Dysfunction
Synonym: Transitional Cell Metaplasia
SNOMED CT: Transitional cell metaplasia (44092007)

Definition

A morphologic finding that refers to the replacement of non-transitional epithelium (e.g., squamous epithelium) with transitional epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransitional cell metaplasia

Professional guidelines

PubMed

Treatment of benign prostatic hyperplasia with 5-alpha-reductase inhibitor: morphological changes in patients who fail to respond.
Montironi R, Valli M, Fabris G
J Clin Pathol 1996 Apr;49(4):324-8. doi: 10.1136/jcp.49.4.324. PMID: 8655710Free PMC Article

Recent clinical studies

Etiology

Transitional cell metaplasia of the uterine cervix: A histopathological and immunohistochemical analysis suggesting a possible role of androgenic conversion during urothelial-like differentiation in peri/postmenopausal women.
Yoo SH, Kim KR, Park NJ
Ann Diagn Pathol 2022 Feb;56:151839. Epub 2021 Oct 13 doi: 10.1016/j.anndiagpath.2021.151839. PMID: 34784541
Histologic Findings in Gynecologic Tissue From Transmasculine Individuals Undergoing Gender-Affirming Surgery.
Lin LH, Hernandez A, Marcus A, Deng FM, Adler E
Arch Pathol Lab Med 2022 Jun 1;146(6):742-748. doi: 10.5858/arpa.2021-0199-OA. PMID: 34591101
Cytomorphologic findings of cervical Pap smears from female-to-male transgender patients on testosterone therapy.
Williams MPA, Kukkar V, Stemmer MN, Khurana KK
Cancer Cytopathol 2020 Jul;128(7):491-498. Epub 2020 Mar 3 doi: 10.1002/cncy.22259. PMID: 32125771
Histologic Features of Hysterectomy Specimens From Female-Male Transgender Individuals.
Khalifa MA, Toyama A, Klein ME, Santiago V
Int J Gynecol Pathol 2019 Nov;38(6):520-527. doi: 10.1097/PGP.0000000000000548. PMID: 30252728
Cytological features of transitional cell metaplasia of the lower female genital tract.
Murali R, Loughman NT, Pagliuso J, McKenzie PR, Watson GF, Earls P, Russell P
Pathology 2010 Feb;42(2):113-8. doi: 10.3109/00313020903494110. PMID: 20085511

Diagnosis

Brenner tumour of the ovary--an incidental histological finding.
Tsikouras P, Galazios G, Romanidis K, Pinidis P, Liberis A, Giatromanolaki A, Sivridis E
Eur J Gynaecol Oncol 2016;37(2):267-9. PMID: 27172761
Cytological features of transitional cell metaplasia of the lower female genital tract.
Murali R, Loughman NT, Pagliuso J, McKenzie PR, Watson GF, Earls P, Russell P
Pathology 2010 Feb;42(2):113-8. doi: 10.3109/00313020903494110. PMID: 20085511
Left ovarian Brenner tumor.
Heye S, Bielen D, Vanbeckevoort D
JBR-BTR 2005 Sep-Oct;88(5):245-6. PMID: 16302335
Cytologic and histologic diagnosis and significance of controversial squamous lesions of the uterine cervix.
Duggan MA
Mod Pathol 2000 Mar;13(3):252-60. doi: 10.1038/modpathol.3880046. PMID: 10757336
Transitional cell metaplasia and neoplasia in the female genital tract: an update.
Jones MA
Adv Anat Pathol 1998 Mar;5(2):106-13. doi: 10.1097/00125480-199803000-00005. PMID: 9868518

Therapy

Cytomorphologic findings of cervical Pap smears from female-to-male transgender patients on testosterone therapy.
Williams MPA, Kukkar V, Stemmer MN, Khurana KK
Cancer Cytopathol 2020 Jul;128(7):491-498. Epub 2020 Mar 3 doi: 10.1002/cncy.22259. PMID: 32125771
Histologic Features of Hysterectomy Specimens From Female-Male Transgender Individuals.
Khalifa MA, Toyama A, Klein ME, Santiago V
Int J Gynecol Pathol 2019 Nov;38(6):520-527. doi: 10.1097/PGP.0000000000000548. PMID: 30252728
Histopathological effects of androgen deprivation in prostatic cancer.
Civantos F, Soloway MS, Pinto JE
Semin Urol Oncol 1996 May;14(2 Suppl 2):22-31. PMID: 8725888
Treatment of benign prostatic hyperplasia with 5-alpha-reductase inhibitor: morphological changes in patients who fail to respond.
Montironi R, Valli M, Fabris G
J Clin Pathol 1996 Apr;49(4):324-8. doi: 10.1136/jcp.49.4.324. PMID: 8655710Free PMC Article
Pathology of androgen deprivation therapy in prostate carcinoma. A comparative study of 173 patients.
Civantos F, Marcial MA, Banks ER, Ho CK, Speights VO, Drew PA, Murphy WM, Soloway MS
Cancer 1995 Apr 1;75(7):1634-41. doi: 10.1002/1097-0142(19950401)75:7<1634::aid-cncr2820750713>3.0.co;2-#. PMID: 8826921

Prognosis

Benign and Malignant Brenner Tumors Show an Absence of TERT Promoter Mutations That Are Commonly Present in Urothelial Carcinoma.
Khani F, Diolombi ML, Khattar P, Huang W, Fallon JT, Epstein JI, Zhong M
Am J Surg Pathol 2016 Sep;40(9):1291-5. doi: 10.1097/PAS.0000000000000680. PMID: 27299795
p63 expression in ovarian tumours: a marker for Brenner tumours but not transitional cell carcinomas.
Liao XY, Xue WC, Shen DH, Ngan HY, Siu MK, Cheung AN
Histopathology 2007 Oct;51(4):477-83. doi: 10.1111/j.1365-2559.2007.02804.x. PMID: 17880529
Transitional cell metaplasia of the uterine cervix is related to human papillomavirus: molecular analysis in seven patients with cytohistologic correlation.
Ng WK, Cheung LK, Li AS, Cheung FM, Chow JC
Cancer 2002 Aug 25;96(4):250-8. doi: 10.1002/cncr.10722. PMID: 12209668
Transitional cell neoplasms (carcinomas and inverted papillomas) of the uterine cervix. A report of five cases.
Albores-Saavedra J, Young RH
Am J Surg Pathol 1995 Oct;19(10):1138-45. PMID: 7573672

Clinical prediction guides

Transitional cell metaplasia of the uterine cervix: A histopathological and immunohistochemical analysis suggesting a possible role of androgenic conversion during urothelial-like differentiation in peri/postmenopausal women.
Yoo SH, Kim KR, Park NJ
Ann Diagn Pathol 2022 Feb;56:151839. Epub 2021 Oct 13 doi: 10.1016/j.anndiagpath.2021.151839. PMID: 34784541
Histologic Features of Hysterectomy Specimens From Female-Male Transgender Individuals.
Khalifa MA, Toyama A, Klein ME, Santiago V
Int J Gynecol Pathol 2019 Nov;38(6):520-527. doi: 10.1097/PGP.0000000000000548. PMID: 30252728
Histopathological effects of androgen deprivation in prostatic cancer.
Civantos F, Soloway MS, Pinto JE
Semin Urol Oncol 1996 May;14(2 Suppl 2):22-31. PMID: 8725888
Pathology of androgen deprivation therapy in prostate carcinoma. A comparative study of 173 patients.
Civantos F, Marcial MA, Banks ER, Ho CK, Speights VO, Drew PA, Murphy WM, Soloway MS
Cancer 1995 Apr 1;75(7):1634-41. doi: 10.1002/1097-0142(19950401)75:7<1634::aid-cncr2820750713>3.0.co;2-#. PMID: 8826921
Mucinous metaplasia in the prostate gland.
Grignon DJ, O'Malley FP
Am J Surg Pathol 1993 Mar;17(3):287-90. doi: 10.1097/00000478-199303000-00009. PMID: 7679558

Recent systematic reviews

Histologic Findings in Surgical Pathology Specimens From Individuals Taking Masculinizing Hormone Therapy for the Purpose of Gender Transition.
Andrews AR, Kakadekar A, Greene DN, Khalifa MA, Santiago V, Schmidt RL
Arch Pathol Lab Med 2022 Jun 1;146(6):766-779. doi: 10.5858/arpa.2020-0774-RA. PMID: 34559874

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