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Vaginal Transitional Cell Metaplasia

MedGen UID:
925565
•Concept ID:
C4288033
•
Finding

Definition

Vaginal metaplasia in which the vaginal surface squamous epithelium resembles benign transitional urothelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal Transitional Cell Metaplasia

Professional guidelines

PubMed

Laparoscopic management of peritoneal endometriosis, endometriotic cysts, and rectovaginal adenomyosis.
Donnez J, Smets M, Jadoul P, Pirard C, Squifflet J
Ann N Y Acad Sci 2003 Nov;997:274-81. doi: 10.1196/annals.1290.031. PMID: 14644835
ASCUS, mature metaplastic type. Cytologic diagnosis and follow-up.
Gupta D, Kannan V, Komaromy-Hiller G, Kline TS
Acta Cytol 2001 Mar-Apr;45(2):192-6. doi: 10.1159/000327276. PMID: 11284305
ASCUS and AGUS criteria. International Academy of Cytology Task Force summary. Diagnostic Cytology Towards the 21st Century: An International Expert Conference and Tutorial.
Solomon D, Frable WJ, Vooijs GP, Wilbur DC, Amma NS, Collins RJ, Davey DD, Knight BK, Luff RD, Meisels A, Navin J, Rosenthal DL, Sauer T, Stoler M, Suprun HZ, Yamauchi K
Acta Cytol 1998 Jan-Feb;42(1):16-24. doi: 10.1159/000331531. PMID: 9479320

Recent clinical studies

Etiology

Transitional cell metaplasia of the uterine cervix: A histopathological and immunohistochemical analysis suggesting a possible role of androgenic conversion during urothelial-like differentiation in peri/postmenopausal women.
Yoo SH, Kim KR, Park NJ
Ann Diagn Pathol 2022 Feb;56:151839. Epub 2021 Oct 13 doi: 10.1016/j.anndiagpath.2021.151839. PMID: 34784541
Histologic Findings in Gynecologic Tissue From Transmasculine Individuals Undergoing Gender-Affirming Surgery.
Lin LH, Hernandez A, Marcus A, Deng FM, Adler E
Arch Pathol Lab Med 2022 Jun 1;146(6):742-748. doi: 10.5858/arpa.2021-0199-OA. PMID: 34591101
Laparoscopic management of peritoneal endometriosis, endometriotic cysts, and rectovaginal adenomyosis.
Donnez J, Smets M, Jadoul P, Pirard C, Squifflet J
Ann N Y Acad Sci 2003 Nov;997:274-81. doi: 10.1196/annals.1290.031. PMID: 14644835
Diethylstilbestrol exposure in utero: review of literature.
Glaze GM
J Am Osteopath Assoc 1984 Feb;83(6):435-8. PMID: 6368486
The uterine cervix from adolescence to the menopause.
Singer A
Br J Obstet Gynaecol 1975 Feb;82(2):81-99. doi: 10.1111/j.1471-0528.1975.tb02204.x. PMID: 1125147

Diagnosis

Never stop wondering: When cells become PAP-art on the slides.
Lombardo V, Cartesio S, Fadda G, Rossi ED
Cancer Cytopathol 2023 Feb;131(2):78-82. Epub 2022 Oct 10 doi: 10.1002/cncy.22650. PMID: 36217282
Ichthyosis uteri with leiomyoma.
Kanno K, Kusakabe T, Takata M, Suzuki K, Oowada M, Suzuki H
J Obstet Gynaecol Res 2016 Nov;42(11):1599-1603. Epub 2016 Aug 16 doi: 10.1111/jog.13108. PMID: 27528500
The expression and diagnostic utility of p63 in the female genital tract.
Houghton O, McCluggage WG
Adv Anat Pathol 2009 Sep;16(5):316-21. doi: 10.1097/PAP.0b013e3181b507c6. PMID: 19700941
Cytologic features of ciliated adenocarcinoma of the cervix: a case report.
O'Connell F, Cibas ES
Acta Cytol 2005 Mar-Apr;49(2):187-90. doi: 10.1159/000326131. PMID: 15839626
Laparoscopic management of peritoneal endometriosis, endometriotic cysts, and rectovaginal adenomyosis.
Donnez J, Smets M, Jadoul P, Pirard C, Squifflet J
Ann N Y Acad Sci 2003 Nov;997:274-81. doi: 10.1196/annals.1290.031. PMID: 14644835

Therapy

Cytomorphologic findings of cervical Pap smears from female-to-male transgender patients on testosterone therapy.
Williams MPA, Kukkar V, Stemmer MN, Khurana KK
Cancer Cytopathol 2020 Jul;128(7):491-498. Epub 2020 Mar 3 doi: 10.1002/cncy.22259. PMID: 32125771
Normal and abnormal epithelial differentiation in the female reproductive tract.
Kurita T
Differentiation 2011 Oct;82(3):117-26. Epub 2011 May 25 doi: 10.1016/j.diff.2011.04.008. PMID: 21612855Free PMC Article
Cytologic features of ciliated adenocarcinoma of the cervix: a case report.
O'Connell F, Cibas ES
Acta Cytol 2005 Mar-Apr;49(2):187-90. doi: 10.1159/000326131. PMID: 15839626
Diethylstilbestrol exposure in utero: review of literature.
Glaze GM
J Am Osteopath Assoc 1984 Feb;83(6):435-8. PMID: 6368486
Cytologic and histologic findings in women using an IUD.
Risse EK, Beerthuizen RJ, Vooijs GP
Obstet Gynecol 1981 Nov;58(5):569-73. PMID: 7301231

Prognosis

Nuclear alterations of cells and atypical metaplastic cells in cervical smears are predictive criteria of high-grade cervical intraepithelial neoplasia.
Dufloth RM, Messias-Silva SM, Andrade LA, di Loreto C, Munhoz DM, Zeferino LC
Eur J Gynaecol Oncol 2005;26(2):186-90. PMID: 15858905
Laparoscopic management of peritoneal endometriosis, endometriotic cysts, and rectovaginal adenomyosis.
Donnez J, Smets M, Jadoul P, Pirard C, Squifflet J
Ann N Y Acad Sci 2003 Nov;997:274-81. doi: 10.1196/annals.1290.031. PMID: 14644835
Transitional cell metaplasia of the uterine cervix is related to human papillomavirus: molecular analysis in seven patients with cytohistologic correlation.
Ng WK, Cheung LK, Li AS, Cheung FM, Chow JC
Cancer 2002 Aug 25;96(4):250-8. doi: 10.1002/cncr.10722. PMID: 12209668
Papillary immature metaplasia of the uterine cervix: a report of 5 cases with an emphasis on the differential diagnosis from reactive squamous metaplasia, high-grade squamous intraepithelial lesion and papillary squamous cell carcinoma.
Kang GH, Min K, Shim YH, Kim KR
J Korean Med Sci 2001 Dec;16(6):762-8. doi: 10.3346/jkms.2001.16.6.762. PMID: 11748359Free PMC Article
Transitional cell neoplasms (carcinomas and inverted papillomas) of the uterine cervix. A report of five cases.
Albores-Saavedra J, Young RH
Am J Surg Pathol 1995 Oct;19(10):1138-45. PMID: 7573672

Clinical prediction guides

Transitional cell metaplasia of the uterine cervix: A histopathological and immunohistochemical analysis suggesting a possible role of androgenic conversion during urothelial-like differentiation in peri/postmenopausal women.
Yoo SH, Kim KR, Park NJ
Ann Diagn Pathol 2022 Feb;56:151839. Epub 2021 Oct 13 doi: 10.1016/j.anndiagpath.2021.151839. PMID: 34784541
Nuclear alterations of cells and atypical metaplastic cells in cervical smears are predictive criteria of high-grade cervical intraepithelial neoplasia.
Dufloth RM, Messias-Silva SM, Andrade LA, di Loreto C, Munhoz DM, Zeferino LC
Eur J Gynaecol Oncol 2005;26(2):186-90. PMID: 15858905
Intraobserver and interobserver variability in the diagnosis of epithelial abnormalities in cervical smears.
Klinkhamer PJ, Vooijs GP, de Haan AF
Acta Cytol 1988 Nov-Dec;32(6):794-800. PMID: 3201873
Healing of cervical epithelium after laser ablation of cervical intraepithelial neoplasia.
Sharp GL, Cordiner JW, Murray EL, More IA
J Clin Pathol 1984 Jun;37(6):611-5. doi: 10.1136/jcp.37.6.611. PMID: 6725609Free PMC Article
Diethylstilbestrol exposure in utero: review of literature.
Glaze GM
J Am Osteopath Assoc 1984 Feb;83(6):435-8. PMID: 6368486

Recent systematic reviews

Histologic Findings in Surgical Pathology Specimens From Individuals Taking Masculinizing Hormone Therapy for the Purpose of Gender Transition.
Andrews AR, Kakadekar A, Greene DN, Khalifa MA, Santiago V, Schmidt RL
Arch Pathol Lab Med 2022 Jun 1;146(6):766-779. doi: 10.5858/arpa.2020-0774-RA. PMID: 34559874

Supplemental Content

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