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Vaginal Transitional Cell Metaplasia

MedGen UID:
925565
•Concept ID:
C4288033
•
Finding

Definition

Vaginal metaplasia in which the vaginal surface squamous epithelium resembles benign transitional urothelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal Transitional Cell Metaplasia

Professional guidelines

PubMed

Laparoscopic management of peritoneal endometriosis, endometriotic cysts, and rectovaginal adenomyosis.
Donnez J, Smets M, Jadoul P, Pirard C, Squifflet J
Ann N Y Acad Sci 2003 Nov;997:274-81. doi: 10.1196/annals.1290.031. PMID: 14644835
ASCUS, mature metaplastic type. Cytologic diagnosis and follow-up.
Gupta D, Kannan V, Komaromy-Hiller G, Kline TS
Acta Cytol 2001 Mar-Apr;45(2):192-6. doi: 10.1159/000327276. PMID: 11284305
ASCUS and AGUS criteria. International Academy of Cytology Task Force summary. Diagnostic Cytology Towards the 21st Century: An International Expert Conference and Tutorial.
Solomon D, Frable WJ, Vooijs GP, Wilbur DC, Amma NS, Collins RJ, Davey DD, Knight BK, Luff RD, Meisels A, Navin J, Rosenthal DL, Sauer T, Stoler M, Suprun HZ, Yamauchi K
Acta Cytol 1998 Jan-Feb;42(1):16-24. doi: 10.1159/000331531. PMID: 9479320

Recent clinical studies

Etiology

Transitional cell metaplasia of the uterine cervix: A histopathological and immunohistochemical analysis suggesting a possible role of androgenic conversion during urothelial-like differentiation in peri/postmenopausal women.
Yoo SH, Kim KR, Park NJ
Ann Diagn Pathol 2022 Feb;56:151839. Epub 2021 Oct 13 doi: 10.1016/j.anndiagpath.2021.151839. PMID: 34784541
Cytological features of transitional cell metaplasia of the lower female genital tract.
Murali R, Loughman NT, Pagliuso J, McKenzie PR, Watson GF, Earls P, Russell P
Pathology 2010 Feb;42(2):113-8. doi: 10.3109/00313020903494110. PMID: 20085511
Laparoscopic management of peritoneal endometriosis, endometriotic cysts, and rectovaginal adenomyosis.
Donnez J, Smets M, Jadoul P, Pirard C, Squifflet J
Ann N Y Acad Sci 2003 Nov;997:274-81. doi: 10.1196/annals.1290.031. PMID: 14644835
Clinical impact of atypical squamous cells of undetermined significance. A cytohistologic comparison.
Lousuebsakul V, Knutsen SM, Gram IT, Akin MR
Acta Cytol 2000 Jan-Feb;44(1):23-30. doi: 10.1159/000326220. PMID: 10667155
The uterine cervix from adolescence to the menopause.
Singer A
Br J Obstet Gynaecol 1975 Feb;82(2):81-99. doi: 10.1111/j.1471-0528.1975.tb02204.x. PMID: 1125147

Diagnosis

Cytologic features of ciliated adenocarcinoma of the cervix: a case report.
O'Connell F, Cibas ES
Acta Cytol 2005 Mar-Apr;49(2):187-90. doi: 10.1159/000326131. PMID: 15839626
Morphologic characteristics of p16INK4a-positive cells in cervical cytology samples.
Trunk MJ, Dallenbach-Hellweg G, Ridder R, Petry KU, Ikenberg H, Schneider V, von Knebel Doeberitz M
Acta Cytol 2004 Nov-Dec;48(6):771-82. doi: 10.1159/000326445. PMID: 15581161
Laparoscopic management of peritoneal endometriosis, endometriotic cysts, and rectovaginal adenomyosis.
Donnez J, Smets M, Jadoul P, Pirard C, Squifflet J
Ann N Y Acad Sci 2003 Nov;997:274-81. doi: 10.1196/annals.1290.031. PMID: 14644835
Intraobserver and interobserver variability in the diagnosis of epithelial abnormalities in cervical smears.
Klinkhamer PJ, Vooijs GP, de Haan AF
Acta Cytol 1988 Nov-Dec;32(6):794-800. PMID: 3201873
Cervical cytology and Chlamydia trachomatis infection.
Boon ME, Hogewoning CJ, Tjiam KH, Meijer CJ, Lindeman J, Ruinaard C, Kievit-Tyson PA
Arch Gynecol 1983;233(2):131-40. doi: 10.1007/BF02114789. PMID: 6349548

Therapy

E-cadherin expression in cervical epithelial cells of postmenopausal women: association with hormone therapy, tibolone, and raloxifene.
Sioulas V, Christodoulakos G, Lambrinoudaki I, Politi E, Sergentanis TN, Creatsas G
Fertil Steril 2008 Apr;89(4):1018-20. Epub 2007 Aug 8 doi: 10.1016/j.fertnstert.2007.04.033. PMID: 17689538
Cytologic features of ciliated adenocarcinoma of the cervix: a case report.
O'Connell F, Cibas ES
Acta Cytol 2005 Mar-Apr;49(2):187-90. doi: 10.1159/000326131. PMID: 15839626
Cytologic and histologic findings in women using an IUD.
Risse EK, Beerthuizen RJ, Vooijs GP
Obstet Gynecol 1981 Nov;58(5):569-73. PMID: 7301231
Accretion of biopsy specimens of vaginal adenosis from patients exposed in utero to diethylstilbestrol, when transplanted to athymic nude mice.
Pienkowski MM, Mann LC, Rosloniec EF Jr, Welsch CW
J Natl Cancer Inst 1979 Mar;62(3):521-3. doi: 10.1093/jnci/62.3.521. PMID: 283281
Natural history of vaginal adenosis in women exposed to diethylstilbestrol in utero.
Ng AB, Reagan JW, Nadji M, Greening S
J Reprod Med 1977 Jan;18(1):1-13. PMID: 833795

Prognosis

Nuclear alterations of cells and atypical metaplastic cells in cervical smears are predictive criteria of high-grade cervical intraepithelial neoplasia.
Dufloth RM, Messias-Silva SM, Andrade LA, di Loreto C, Munhoz DM, Zeferino LC
Eur J Gynaecol Oncol 2005;26(2):186-90. PMID: 15858905
Morphologic characteristics of p16INK4a-positive cells in cervical cytology samples.
Trunk MJ, Dallenbach-Hellweg G, Ridder R, Petry KU, Ikenberg H, Schneider V, von Knebel Doeberitz M
Acta Cytol 2004 Nov-Dec;48(6):771-82. doi: 10.1159/000326445. PMID: 15581161
Laparoscopic management of peritoneal endometriosis, endometriotic cysts, and rectovaginal adenomyosis.
Donnez J, Smets M, Jadoul P, Pirard C, Squifflet J
Ann N Y Acad Sci 2003 Nov;997:274-81. doi: 10.1196/annals.1290.031. PMID: 14644835
Papillary immature metaplasia of the uterine cervix: a report of 5 cases with an emphasis on the differential diagnosis from reactive squamous metaplasia, high-grade squamous intraepithelial lesion and papillary squamous cell carcinoma.
Kang GH, Min K, Shim YH, Kim KR
J Korean Med Sci 2001 Dec;16(6):762-8. doi: 10.3346/jkms.2001.16.6.762. PMID: 11748359Free PMC Article
Transitional cell neoplasms (carcinomas and inverted papillomas) of the uterine cervix. A report of five cases.
Albores-Saavedra J, Young RH
Am J Surg Pathol 1995 Oct;19(10):1138-45. PMID: 7573672

Clinical prediction guides

Morphologic characteristics of p16INK4a-positive cells in cervical cytology samples.
Trunk MJ, Dallenbach-Hellweg G, Ridder R, Petry KU, Ikenberg H, Schneider V, von Knebel Doeberitz M
Acta Cytol 2004 Nov-Dec;48(6):771-82. doi: 10.1159/000326445. PMID: 15581161
Clinical impact of atypical squamous cells of undetermined significance. A cytohistologic comparison.
Lousuebsakul V, Knutsen SM, Gram IT, Akin MR
Acta Cytol 2000 Jan-Feb;44(1):23-30. doi: 10.1159/000326220. PMID: 10667155
Intraobserver and interobserver variability in the diagnosis of epithelial abnormalities in cervical smears.
Klinkhamer PJ, Vooijs GP, de Haan AF
Acta Cytol 1988 Nov-Dec;32(6):794-800. PMID: 3201873
Healing of cervical epithelium after laser ablation of cervical intraepithelial neoplasia.
Sharp GL, Cordiner JW, Murray EL, More IA
J Clin Pathol 1984 Jun;37(6):611-5. doi: 10.1136/jcp.37.6.611. PMID: 6725609Free PMC Article
The effects of local progesterone on stilbestrol-associated vaginal adenosis.
Herbst AL, Robboy SJ, Macdonald GJ, Scully E
Am J Obstet Gynecol 1974 Mar 1;118(5):607-15. doi: 10.1016/s0002-9378(16)33736-x. PMID: 4130676

Recent systematic reviews

Histologic Findings in Surgical Pathology Specimens From Individuals Taking Masculinizing Hormone Therapy for the Purpose of Gender Transition.
Andrews AR, Kakadekar A, Greene DN, Khalifa MA, Santiago V, Schmidt RL
Arch Pathol Lab Med 2022 Jun 1;146(6):766-779. doi: 10.5858/arpa.2020-0774-RA. PMID: 34559874

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