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Glottis verrucous carcinoma

MedGen UID:
83631
•Concept ID:
C0280329
•
Neoplastic Process
Synonyms: Glottic Verrucous Carcinoma; glottic verrucous carcinoma; Glottis Verrucous Carcinoma; glottis verrucous carcinoma; Verrucous Carcinoma of Glottis; verrucous carcinoma of glottis; Verrucous Carcinoma of the Glottis; verrucous carcinoma of the glottis
 
Monarch Initiative: MONDO:0004289

Definition

An exophytic, slow growing, well differentiated and non-metastasizing squamous cell carcinoma with pushing margins that arises from the glottic area of the larynx. It usually presents with hoarseness. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlottis verrucous carcinoma

Professional guidelines

PubMed

The role of survivin expression in the differential diagnosis of laryngeal (glottic) verrucous squamous cell carcinoma.
Marioni G, Pillon M, Bertolin A, Staffieri A, Marino F
Eur J Surg Oncol 2007 Mar;33(2):229-33. Epub 2006 Nov 7 doi: 10.1016/j.ejso.2006.09.027. PMID: 17088041
Verrucous carcinoma of the larynx: determining the best treatment option.
Strojan P, Smid L, Cizmarevic B, Zagar T, Auersperg M
Eur J Surg Oncol 2006 Nov;32(9):984-8. Epub 2006 Apr 19 doi: 10.1016/j.ejso.2006.03.025. PMID: 16626921
Endoscopic laser treatment in pre-malignant and malignant vocal fold epithelial lesions.
Remijn EE, Marres HA, van den Hoogen FJ
J Laryngol Otol 2002 Dec;116(12):1019-24. doi: 10.1258/002221502761698766. PMID: 12537615

Recent clinical studies

Etiology

Epidemiological, clinical and oncological outcomes of laryngeal verrucous carcinomas: a systematic review.
Lechien JR, Hans S
J Otolaryngol Head Neck Surg 2023 Dec 13;52(1):81. doi: 10.1186/s40463-023-00666-1. PMID: 38093339Free PMC Article
Laryngeal Verrucous Carcinoma: A Population-Based Analysis.
Dubal PM, Svider PF, Kam D, Dutta R, Baredes S, Eloy JA
Otolaryngol Head Neck Surg 2015 Nov;153(5):799-805. Epub 2015 Jun 29 doi: 10.1177/0194599815591981. PMID: 26124268
Photodynamic therapy and the treatment of neoplastic diseases of the larynx.
Biel MA
Laryngoscope 1994 Apr;104(4):399-403. doi: 10.1288/00005537-199404000-00001. PMID: 8164476
Hemilaryngectomy for verrucous carcinoma of the glottis.
Myers E, Sobol S, Ogura JH
Laryngoscope 1980 Apr;90(4):693-8. doi: 10.1288/00005537-198004000-00019. PMID: 7359990
Horizontal glottectomy.
Calearo CV, Teatini G
Laryngoscope 1978 Sep;88(9 Pt 1):1529-35. doi: 10.1002/lary.1978.88.9.1529. PMID: 682810

Diagnosis

Laryngeal Verrucous Carcinoma: A Population-Based Analysis.
Dubal PM, Svider PF, Kam D, Dutta R, Baredes S, Eloy JA
Otolaryngol Head Neck Surg 2015 Nov;153(5):799-805. Epub 2015 Jun 29 doi: 10.1177/0194599815591981. PMID: 26124268
The role of survivin expression in the differential diagnosis of laryngeal (glottic) verrucous squamous cell carcinoma.
Marioni G, Pillon M, Bertolin A, Staffieri A, Marino F
Eur J Surg Oncol 2007 Mar;33(2):229-33. Epub 2006 Nov 7 doi: 10.1016/j.ejso.2006.09.027. PMID: 17088041
Atypical squamous cell carcinoma of the larynx and hypopharynx: radiologic features and pathologic correlation.
Becker M, Moulin G, Kurt AM, Zbären P, Dulgerov P, Marchal F, Zanaret P, Lehmann W, Rüfenacht DA, Terrier F
Eur Radiol 1998;8(9):1541-51. doi: 10.1007/s003300050584. PMID: 9866759
Photodynamic therapy and the treatment of neoplastic diseases of the larynx.
Biel MA
Laryngoscope 1994 Apr;104(4):399-403. doi: 10.1288/00005537-199404000-00001. PMID: 8164476
Hemilaryngectomy for verrucous carcinoma of the glottis.
Myers E, Sobol S, Ogura JH
Laryngoscope 1980 Apr;90(4):693-8. doi: 10.1288/00005537-198004000-00019. PMID: 7359990

Therapy

Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival.
Hoffman HT, Porter K, Karnell LH, Cooper JS, Weber RS, Langer CJ, Ang KK, Gay G, Stewart A, Robinson RA
Laryngoscope 2006 Sep;116(9 Pt 2 Suppl 111):1-13. doi: 10.1097/01.mlg.0000236095.97947.26. PMID: 16946667
CO(2) laser surgery in the treatment of glottic cancer.
Motta G, Esposito E, Motta S, Tartaro G, Testa D
Head Neck 2005 Jul;27(7):566-73; discussion 573-4. doi: 10.1002/hed.20135. PMID: 15898101
Laryngeal verrucous carcinoma: effective treatment with tegafur.
Kitano H, Kitajima K
Auris Nasus Larynx 1994;21(1):64-8. doi: 10.1016/s0385-8146(12)80012-5. PMID: 7980196
Radiation therapy for stage I and II laryngeal cancer using 10 MV X-rays or cobalt-60 gamma-rays.
Hayakawa K, Mitsuhashi N, Tamaki Y, Takahashi M, Honjo J, Kamei T, Koyama I, Niibe H
Radiat Med 1992 Sep-Oct;10(5):199-205. PMID: 1438927
Excisional biopsy in the selective management of T1 glottic cancer: a three-year follow-up study.
Blakeslee D, Vaughan CW, Shapshay SM, Simpson GT, Strong MS
Laryngoscope 1984 Apr;94(4):488-94. doi: 10.1288/00005537-198404000-00012. PMID: 6708692

Prognosis

Early-stage glottic cancer of rare squamous cell carcinoma variants: a population-based study.
Takenaka Y, Uno A, Tanaka H, Takemoto N, Inohara H
Acta Otolaryngol 2023 Jan;143(1):70-76. Epub 2023 Jan 3 doi: 10.1080/00016489.2022.2161626. PMID: 36595382
Laryngeal Verrucous Carcinoma.
Echanique KA, Desai SV, Marchiano E, Spinazzi EF, Strojan P, Baredes S, Eloy JA
Otolaryngol Head Neck Surg 2017 Jan;156(1):38-45. Epub 2016 Aug 9 doi: 10.1177/0194599816662631. PMID: 27484231
Laryngeal Verrucous Carcinoma: A Population-Based Analysis.
Dubal PM, Svider PF, Kam D, Dutta R, Baredes S, Eloy JA
Otolaryngol Head Neck Surg 2015 Nov;153(5):799-805. Epub 2015 Jun 29 doi: 10.1177/0194599815591981. PMID: 26124268
Photodynamic therapy and the treatment of neoplastic diseases of the larynx.
Biel MA
Laryngoscope 1994 Apr;104(4):399-403. doi: 10.1288/00005537-199404000-00001. PMID: 8164476
Horizontal glottectomy.
Calearo CV, Teatini G
Laryngoscope 1978 Sep;88(9 Pt 1):1529-35. doi: 10.1002/lary.1978.88.9.1529. PMID: 682810

Clinical prediction guides

Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival.
Hoffman HT, Porter K, Karnell LH, Cooper JS, Weber RS, Langer CJ, Ang KK, Gay G, Stewart A, Robinson RA
Laryngoscope 2006 Sep;116(9 Pt 2 Suppl 111):1-13. doi: 10.1097/01.mlg.0000236095.97947.26. PMID: 16946667
Atypical squamous cell carcinoma of the larynx and hypopharynx: radiologic features and pathologic correlation.
Becker M, Moulin G, Kurt AM, Zbären P, Dulgerov P, Marchal F, Zanaret P, Lehmann W, Rüfenacht DA, Terrier F
Eur Radiol 1998;8(9):1541-51. doi: 10.1007/s003300050584. PMID: 9866759

Recent systematic reviews

Epidemiological, clinical and oncological outcomes of laryngeal verrucous carcinomas: a systematic review.
Lechien JR, Hans S
J Otolaryngol Head Neck Surg 2023 Dec 13;52(1):81. doi: 10.1186/s40463-023-00666-1. PMID: 38093339Free PMC Article
Laryngeal Verrucous Carcinoma.
Echanique KA, Desai SV, Marchiano E, Spinazzi EF, Strojan P, Baredes S, Eloy JA
Otolaryngol Head Neck Surg 2017 Jan;156(1):38-45. Epub 2016 Aug 9 doi: 10.1177/0194599816662631. PMID: 27484231

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