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Bladder benign neoplasm

MedGen UID:
57811
•Concept ID:
C0154017
•
Neoplastic Process
Synonyms: Benign Bladder Neoplasm; benign bladder neoplasm; Benign bladder tumor; Benign Bladder Tumor; benign bladder tumor; benign bladder tumour; Benign neoplasm of bladder; Benign Neoplasm of Bladder; benign neoplasm of bladder; Benign Neoplasm of the Bladder; benign neoplasm of the bladder; Benign Neoplasm of the Urinary Bladder; benign neoplasm of the urinary bladder; Benign neoplasm of urinary bladder; Benign Neoplasm of Urinary Bladder; benign neoplasm of urinary bladder; Benign Tumor of Bladder; benign tumor of bladder; Benign Tumor of the Bladder; benign tumor of the bladder; Benign Tumor of the Urinary Bladder; benign tumor of the urinary bladder; Benign tumor of urinary bladder; Benign Tumor of Urinary Bladder; benign tumor of urinary bladder; benign tumour of bladder; benign tumour of the bladder; benign tumour of the urinary bladder; benign tumour of urinary bladder; Benign Urinary Bladder Neoplasm; benign urinary bladder neoplasm; Benign Urinary Bladder Tumor; benign urinary bladder tumor; benign urinary bladder tumour; bladder benign neoplasm; urinary bladder benign neoplasm
SNOMED CT: Benign bladder tumor (91992005); Benign tumor of urinary bladder (91992005); Benign neoplasm of bladder (91992005); Benign neoplasm of urinary bladder (91992005)
 
Monarch Initiative: MONDO:0000384

Definition

A neoplasm that arises from the bladder and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Advances in diagnosis and treatment of bladder cancer.
Lopez-Beltran A, Cookson MS, Guercio BJ, Cheng L
BMJ 2024 Feb 12;384:e076743. doi: 10.1136/bmj-2023-076743. PMID: 38346808
Current best practice for bladder cancer: a narrative review of diagnostics and treatments.
Compérat E, Amin MB, Cathomas R, Choudhury A, De Santis M, Kamat A, Stenzl A, Thoeny HC, Witjes JA
Lancet 2022 Nov 12;400(10364):1712-1721. Epub 2022 Sep 26 doi: 10.1016/S0140-6736(22)01188-6. PMID: 36174585
Bladder Cancer: Diagnosis and Treatment.
DeGeorge KC, Holt HR, Hodges SC
Am Fam Physician 2017 Oct 15;96(8):507-514. PMID: 29094888

Recent clinical studies

Etiology

Bladder Epicheck Test: A Novel Tool to Support Urothelial Carcinoma Diagnosis in Urine Samples.
Fiorentino V, Pizzimenti C, Franchina M, Rossi ED, Tralongo P, Carlino A, Larocca LM, Martini M, Fadda G, Pierconti F
Int J Mol Sci 2023 Aug 6;24(15) doi: 10.3390/ijms241512489. PMID: 37569864Free PMC Article
Photodynamic Diagnosis-Assisted Transurethral Resection - Lights Out?
Dahm P, Narayan VM
NEJM Evid 2022 Oct;1(10):EVIDe2200194. Epub 2022 Sep 27 doi: 10.1056/EVIDe2200194. PMID: 38319828
Pediatric urothelial bladder neoplasm.
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Integrated proteogenomic characterization of urothelial carcinoma of the bladder.
Xu N, Yao Z, Shang G, Ye D, Wang H, Zhang H, Qu Y, Xu F, Wang Y, Qin Z, Zhu J, Zhang F, Feng J, Tian S, Liu Y, Zhao J, Hou J, Guo J, Hou Y, Ding C
J Hematol Oncol 2022 Jun 3;15(1):76. doi: 10.1186/s13045-022-01291-7. PMID: 35659036Free PMC Article
Bladder-sparing treatment in MIBC: where do we stand?
Murali-Krishnan S, Pang KH, Greco F, Fiori C, Catto JW, Vavassori VL, Esperto F; EAU-ESRU (European Associations of Urology-European Society of Residents Urologist)
Minerva Urol Nefrol 2019 Apr;71(2):101-112. Epub 2019 Mar 18 doi: 10.23736/S0393-2249.19.03317-4. PMID: 30895765

Diagnosis

Molecular classification of urothelial bladder carcinoma.
Schwarzova L, Varchulova Novakova Z, Danisovic L, Ziaran S
Mol Biol Rep 2023 Sep;50(9):7867-7877. Epub 2023 Jul 31 doi: 10.1007/s11033-023-08689-7. PMID: 37525073Free PMC Article
Photodynamic Diagnosis-Assisted Transurethral Resection - Lights Out?
Dahm P, Narayan VM
NEJM Evid 2022 Oct;1(10):EVIDe2200194. Epub 2022 Sep 27 doi: 10.1056/EVIDe2200194. PMID: 38319828
Application of nanotechnology in the diagnosis and treatment of bladder cancer.
Xu Y, Luo C, Wang J, Chen L, Chen J, Chen T, Zeng Q
J Nanobiotechnology 2021 Nov 27;19(1):393. doi: 10.1186/s12951-021-01104-y. PMID: 34838048Free PMC Article
Single-cell RNA sequencing reveals the epithelial cell heterogeneity and invasive subpopulation in human bladder cancer.
Lai H, Cheng X, Liu Q, Luo W, Liu M, Zhang M, Miao J, Ji Z, Lin GN, Song W, Zhang L, Bo J, Yang G, Wang J, Gao WQ
Int J Cancer 2021 Dec 15;149(12):2099-2115. Epub 2021 Sep 16 doi: 10.1002/ijc.33794. PMID: 34480339
Editorial comment.
Kamat AM, Gontero P
Curr Opin Urol 2018 Nov;28(6):555-556. doi: 10.1097/MOU.0000000000000551. PMID: 30256260

Therapy

Application of nanotechnology in the diagnosis and treatment of bladder cancer.
Xu Y, Luo C, Wang J, Chen L, Chen J, Chen T, Zeng Q
J Nanobiotechnology 2021 Nov 27;19(1):393. doi: 10.1186/s12951-021-01104-y. PMID: 34838048Free PMC Article
Defining cisplatin eligibility in patients with muscle-invasive bladder cancer.
Jiang DM, Gupta S, Kitchlu A, Meraz-Munoz A, North SA, Alimohamed NS, Blais N, Sridhar SS
Nat Rev Urol 2021 Feb;18(2):104-114. Epub 2021 Jan 11 doi: 10.1038/s41585-020-00404-6. PMID: 33432181
Role of immunotherapy in bladder cancer.
Rhea LP, Mendez-Marti S, Kim D, Aragon-Ching JB
Cancer Treat Res Commun 2021;26:100296. Epub 2020 Dec 24 doi: 10.1016/j.ctarc.2020.100296. PMID: 33421822
Editorial comment.
Kamat AM, Gontero P
Curr Opin Urol 2018 Nov;28(6):555-556. doi: 10.1097/MOU.0000000000000551. PMID: 30256260
Tissue-engineered urinary conduits.
Kates M, Singh A, Matsui H, Steinberg GD, Smith ND, Schoenberg MP, Bivalacqua TJ
Curr Urol Rep 2015 Mar;16(3):8. doi: 10.1007/s11934-015-0480-3. PMID: 25677229

Prognosis

Myths About Bladder Preservation in Muscle-Invasive Bladder Cancer.
Elumalai T, Joseph N, Choudhury A
Semin Radiat Oncol 2023 Jan;33(1):56-61. doi: 10.1016/j.semradonc.2022.10.007. PMID: 36517194
Pediatric urothelial bladder neoplasm.
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Integrated proteogenomic characterization of urothelial carcinoma of the bladder.
Xu N, Yao Z, Shang G, Ye D, Wang H, Zhang H, Qu Y, Xu F, Wang Y, Qin Z, Zhu J, Zhang F, Feng J, Tian S, Liu Y, Zhao J, Hou J, Guo J, Hou Y, Ding C
J Hematol Oncol 2022 Jun 3;15(1):76. doi: 10.1186/s13045-022-01291-7. PMID: 35659036Free PMC Article
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer.
Lindskrog SV, Prip F, Lamy P, Taber A, Groeneveld CS, Birkenkamp-Demtröder K, Jensen JB, Strandgaard T, Nordentoft I, Christensen E, Sokac M, Birkbak NJ, Maretty L, Hermann GG, Petersen AC, Weyerer V, Grimm MO, Horstmann M, Sjödahl G, Höglund M, Steiniche T, Mogensen K, de Reyniès A, Nawroth R, Jordan B, Lin X, Dragicevic D, Ward DG, Goel A, Hurst CD, Raman JD, Warrick JI, Segersten U, Sikic D, van Kessel KEM, Maurer T, Meeks JJ, DeGraff DJ, Bryan RT, Knowles MA, Simic T, Hartmann A, Zwarthoff EC, Malmström PU, Malats N, Real FX, Dyrskjøt L
Nat Commun 2021 Apr 16;12(1):2301. doi: 10.1038/s41467-021-22465-w. PMID: 33863885Free PMC Article
Editorial comment.
Kamat AM, Gontero P
Curr Opin Urol 2018 Nov;28(6):555-556. doi: 10.1097/MOU.0000000000000551. PMID: 30256260

Clinical prediction guides

Selective multimodal bladder-sparing therapy for muscle-invasive bladder cancer: the present and the future.
Koga F
Expert Rev Anticancer Ther 2023 Jul-Dec;23(11):1127-1139. Epub 2023 Oct 27 doi: 10.1080/14737140.2023.2257389. PMID: 37753554
Bladder Epicheck Test: A Novel Tool to Support Urothelial Carcinoma Diagnosis in Urine Samples.
Fiorentino V, Pizzimenti C, Franchina M, Rossi ED, Tralongo P, Carlino A, Larocca LM, Martini M, Fadda G, Pierconti F
Int J Mol Sci 2023 Aug 6;24(15) doi: 10.3390/ijms241512489. PMID: 37569864Free PMC Article
Myths About Bladder Preservation in Muscle-Invasive Bladder Cancer.
Elumalai T, Joseph N, Choudhury A
Semin Radiat Oncol 2023 Jan;33(1):56-61. doi: 10.1016/j.semradonc.2022.10.007. PMID: 36517194
The past, present, and future of pT0 in bladder cancer clinical trials.
Schober JP, Plimack E, Geynisman DM, Zibelman M
Curr Opin Urol 2022 Sep 1;32(5):495-499. Epub 2022 Jul 18 doi: 10.1097/MOU.0000000000001022. PMID: 35855573
The role of STAG2 in bladder cancer.
Aquila L, Ohm J, Woloszynska-Read A
Pharmacol Res 2018 May;131:143-149. Epub 2018 Mar 1 doi: 10.1016/j.phrs.2018.02.025. PMID: 29501732

Recent systematic reviews

Epidemiology of Bladder Cancer in 2023: A Systematic Review of Risk Factors.
Jubber I, Ong S, Bukavina L, Black PC, Compérat E, Kamat AM, Kiemeney L, Lawrentschuk N, Lerner SP, Meeks JJ, Moch H, Necchi A, Panebianco V, Sridhar SS, Znaor A, Catto JWF, Cumberbatch MG
Eur Urol 2023 Aug;84(2):176-190. Epub 2023 May 16 doi: 10.1016/j.eururo.2023.03.029. PMID: 37198015
Air pollution exposure and bladder, kidney and urinary tract cancer risk: A systematic review.
Zare Sakhvidi MJ, Lequy E, Goldberg M, Jacquemin B
Environ Pollut 2020 Dec;267:115328. Epub 2020 Aug 20 doi: 10.1016/j.envpol.2020.115328. PMID: 32871482
Epidemiology of Bladder Cancer: A Systematic Review and Contemporary Update of Risk Factors in 2018.
Cumberbatch MGK, Jubber I, Black PC, Esperto F, Figueroa JD, Kamat AM, Kiemeney L, Lotan Y, Pang K, Silverman DT, Znaor A, Catto JWF
Eur Urol 2018 Dec;74(6):784-795. Epub 2018 Sep 26 doi: 10.1016/j.eururo.2018.09.001. PMID: 30268659
Diagnosis and Treatment of Non-Muscle Invasive Bladder Cancer: AUA/SUO Guideline.
Chang SS, Boorjian SA, Chou R, Clark PE, Daneshmand S, Konety BR, Pruthi R, Quale DZ, Ritch CR, Seigne JD, Skinner EC, Smith ND, McKiernan JM
J Urol 2016 Oct;196(4):1021-9. Epub 2016 Jun 16 doi: 10.1016/j.juro.2016.06.049. PMID: 27317986
Neoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer: A Systematic Review and Two-Step Meta-Analysis.
Yin M, Joshi M, Meijer RP, Glantz M, Holder S, Harvey HA, Kaag M, Fransen van de Putte EE, Horenblas S, Drabick JJ
Oncologist 2016 Jun;21(6):708-15. Epub 2016 Apr 6 doi: 10.1634/theoncologist.2015-0440. PMID: 27053504Free PMC Article

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