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Syringoma

MedGen UID:: 60205
•Concept ID:: C0206673
•: Neoplastic Process

Synonym:	Syringomas
SNOMED CT:	Syringoma (71244007); Syringoma of skin (302828001); Syringoma (302828001)

Monarch Initiative:	MONDO:0002191

Definition

A benign sweat gland neoplasm usually affecting the lower eyelids and upper cheeks. The lesions are papular and are usually numerous. Morphologically, there are nests, cords, and tubules of epithelial cells present, surrounded by a dense stroma in the reticular dermis. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVSyringoma

Neoplasm by Special Category
- Benign neoplasm
  - Benign epithelial neoplasm
    - Benign epithelial skin neoplasm
      - Benign neoplasm of sweat gland
        Benign eccrine neoplasm
        Syringoma
        Vulvar syringoma

Professional guidelines

PubMed

S2k guideline: Laser therapy of the skin.

Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675

Evaluation and management of the patient with multiple syringomas: A systematic review of the literature.

Williams K, Shinkai K
J Am Acad Dermatol 2016 Jun;74(6):1234-1240.e9. Epub 2016 Feb 3 doi: 10.1016/j.jaad.2015.12.006. PMID: 26850654

Syringoma: a clinicopathologic and immunohistologic study and results of treatment.

Lee JH, Chang JY, Lee KH
Yonsei Med J 2007 Feb 28;48(1):35-40. doi: 10.3349/ymj.2007.48.1.35. PMID: 17326243 Free PMC Article

See all (13)

Recent clinical studies

Etiology

Syringomatous dermatitis: a myth or an existing entity?

Hassab-El-Naby HMM, Nouh AH
Arch Dermatol Res 2023 Aug;315(6):1649-1654. Epub 2023 Feb 13 doi: 10.1007/s00403-023-02537-1. PMID: 36781459 Free PMC Article

Generalized eruptive syringomas.

Huang A, Taylor G, Liebman TN
Dermatol Online J 2017 Sep 15;23(9) PMID: 29469728

Chondroid Syringoma.

Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378

Myoepithelial neoplasms of soft tissue: an updated review of the clinicopathologic, immunophenotypic, and genetic features.

Jo VY, Fletcher CD
Head Neck Pathol 2015 Mar;9(1):32-8. Epub 2015 Mar 25 doi: 10.1007/s12105-015-0618-0. PMID: 25804378 Free PMC Article

Syringoid eccrine carcinoma.

Gregurek-Novak T, Talan-Hranilović J, Troskot N, Vucić M, Kruslin B
J Eur Acad Dermatol Venereol 2001 Mar;15(2):143-6. doi: 10.1046/j.1468-3083.2001.00210.x. PMID: 11495522

See all (77)

Diagnosis

Dermoscopy of Adnexal Tumors.

Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149

Generalized eruptive syringomas.

Huang A, Taylor G, Liebman TN
Dermatol Online J 2017 Sep 15;23(9) PMID: 29469728

Microcystic Adnexal Carcinoma: A Review of the Literature.

Gordon S, Fischer C, Martin A, Rosman IS, Council ML
Dermatol Surg 2017 Aug;43(8):1012-1016. doi: 10.1097/DSS.0000000000001142. PMID: 28654578

Chondroid Syringoma.

Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378

Myoepithelial Tumors: An Update.

Jo VY
Surg Pathol Clin 2015 Sep;8(3):445-66. doi: 10.1016/j.path.2015.05.005. PMID: 26297065

See all (343)

Therapy

Er:YAG laser combined with botulinum toxin A for patients with local syringomas: A preliminary report.

Yao B, Chen W, Wu S, Gu Q, Feng W
J Cosmet Dermatol 2023 Oct;22(10):2721-2728. Epub 2023 May 12 doi: 10.1111/jocd.15800. PMID: 37171036

Efficacy and safety of lasers in treating syringomas: a review of the literature.

Alsaidan MS
J Dermatolog Treat 2022 Dec;33(8):3127-3135. Epub 2022 Sep 27 doi: 10.1080/09546634.2022.2127307. PMID: 36125344

Botulinum toxin A as monotherapy for syringoma.

Zaldivar-Fujigaki JL, Achell Nava L
J Cosmet Dermatol 2021 May;20(5):1393-1395. Epub 2020 Dec 31 doi: 10.1111/jocd.13919. PMID: 33355994

Extensive Eruptive Syringoma After Liver Transplantation.

Maeda T, Natsuga K, Nishie W, Yamashita K, Shimizu H
Acta Derm Venereol 2018 Jan 12;98(1):119-120. doi: 10.2340/00015555-2814. PMID: 28971206

Vulvar syringoma: a clinicopathologic and immunohistologic study of 18 patients and results of treatment.

Huang YH, Chuang YH, Kuo TT, Yang LC, Hong HS
J Am Acad Dermatol 2003 May;48(5):735-9. doi: 10.1067/mjd.2003.285. PMID: 12734503

See all (32)

Prognosis

Atypical Chondroid Syringoma of the Toe.

Ge C, Gu J, Deng A, Joshi G, Most M, Tai R
J Am Podiatr Med Assoc 2023 May-Jun;113(3) doi: 10.7547/22-094. PMID: 37463189

Microcystic Adnexal Carcinoma: A Review of the Literature.

Gordon S, Fischer C, Martin A, Rosman IS, Council ML
Dermatol Surg 2017 Aug;43(8):1012-1016. doi: 10.1097/DSS.0000000000001142. PMID: 28654578

Chondroid Syringoma.

Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378

Myoepithelial Tumors: An Update.

Jo VY
Surg Pathol Clin 2015 Sep;8(3):445-66. doi: 10.1016/j.path.2015.05.005. PMID: 26297065

Myoepithelial neoplasms of soft tissue: an updated review of the clinicopathologic, immunophenotypic, and genetic features.

Jo VY, Fletcher CD
Head Neck Pathol 2015 Mar;9(1):32-8. Epub 2015 Mar 25 doi: 10.1007/s12105-015-0618-0. PMID: 25804378 Free PMC Article

See all (68)

Clinical prediction guides

Expression of Hedgehog signalling molecules in microcystic adnexal carcinoma.

Gambichler T, Hartenstein I, Dreißigacker M, Stockfleth E, Stücker M, Schaller J, Schulze HJ, Becker JC, Käfferlein HU, Brüning T, Lang K
Clin Exp Dermatol 2021 Aug;46(6):1052-1057. Epub 2021 May 1 doi: 10.1111/ced.14634. PMID: 33714217

In vivo reflectance confocal microscopy for evaluating seborrheic keratosis, verruca plana, syringoma and lichen nitidus.

Dai H, Jiang HY, Xu AE
Skin Res Technol 2021 Mar;27(2):272-276. Epub 2020 Nov 11 doi: 10.1111/srt.12934. PMID: 33174647

Clinical characteristics and pathological depths of syringomas in 94 Korean patients.

Lim Y, Lee J, Jang D, Abudureyimu G, Lee JH
Skin Res Technol 2021 Jan;27(1):70-73. Epub 2020 Jun 28 doi: 10.1111/srt.12910. PMID: 32596839

Dermoscopy of Adnexal Tumors.

Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149

Syringoma: a clinicopathologic and immunohistologic study and results of treatment.

Lee JH, Chang JY, Lee KH
Yonsei Med J 2007 Feb 28;48(1):35-40. doi: 10.3349/ymj.2007.48.1.35. PMID: 17326243 Free PMC Article

See all (74)