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Syringoma

MedGen UID:
60205
Concept ID:
C0206673
Neoplastic Process
Synonym: Syringomas
SNOMED CT: Syringoma (71244007); Syringoma of skin (302828001); Syringoma (302828001)
 
Monarch Initiative: MONDO:0002191

Definition

A benign sweat gland neoplasm usually affecting the lower eyelids and upper cheeks. The lesions are papular and are usually numerous. Morphologically, there are nests, cords, and tubules of epithelial cells present, surrounded by a dense stroma in the reticular dermis. [from NCI]

Professional guidelines

PubMed

Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675
Williams K, Shinkai K
J Am Acad Dermatol 2016 Jun;74(6):1234-1240.e9. Epub 2016 Feb 3 doi: 10.1016/j.jaad.2015.12.006. PMID: 26850654
Lee JH, Chang JY, Lee KH
Yonsei Med J 2007 Feb 28;48(1):35-40. doi: 10.3349/ymj.2007.48.1.35. PMID: 17326243Free PMC Article

Recent clinical studies

Etiology

Plaza JA, Brenn T, Chung C, Salim S, Linos KD, Jour G, Duran Rincon J, Wick M, Sangueza M, Gru AA
J Cutan Pathol 2021 Jul;48(7):847-855. Epub 2021 Jan 7 doi: 10.1111/cup.13942. PMID: 33340147
Huang A, Taylor G, Liebman TN
Dermatol Online J 2017 Sep 15;23(9) PMID: 29469728
Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378
Jo VY, Fletcher CD
Head Neck Pathol 2015 Mar;9(1):32-8. Epub 2015 Mar 25 doi: 10.1007/s12105-015-0618-0. PMID: 25804378Free PMC Article
Hughes PS, Apisarnthanarax P
Arch Dermatol 1977 Oct;113(10):1435-6. PMID: 911173

Diagnosis

Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Huang A, Taylor G, Liebman TN
Dermatol Online J 2017 Sep 15;23(9) PMID: 29469728
Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378
Jo VY
Surg Pathol Clin 2015 Sep;8(3):445-66. doi: 10.1016/j.path.2015.05.005. PMID: 26297065
Gropper CA
Clin Cornerstone 2001;4(1):1-14. doi: 10.1016/s1098-3597(01)90002-x. PMID: 12739317

Therapy

Alsaidan MS
J Dermatolog Treat 2022 Dec;33(8):3127-3135. Epub 2022 Sep 27 doi: 10.1080/09546634.2022.2127307. PMID: 36125344
Zaldivar-Fujigaki JL, Achell Nava L
J Cosmet Dermatol 2021 May;20(5):1393-1395. Epub 2020 Dec 31 doi: 10.1111/jocd.13919. PMID: 33355994
Ahn GR, Jeong GJ, Kim JM, Hong JY, Li K, Lee CK, Kim BJ
Aesthet Surg J 2021 Mar 12;41(4):490-498. doi: 10.1093/asj/sjz288. PMID: 31630165
Kitano Y
J Cosmet Laser Ther 2016 Oct;18(5):280-5. Epub 2016 May 12 doi: 10.3109/14764172.2016.1157361. PMID: 26963492
Huang YH, Chuang YH, Kuo TT, Yang LC, Hong HS
J Am Acad Dermatol 2003 May;48(5):735-9. doi: 10.1067/mjd.2003.285. PMID: 12734503

Prognosis

Ge C, Gu J, Deng A, Joshi G, Most M, Tai R
J Am Podiatr Med Assoc 2023 May-Jun;113(3) doi: 10.7547/22-094. PMID: 37463189
Gordon S, Fischer C, Martin A, Rosman IS, Council ML
Dermatol Surg 2017 Aug;43(8):1012-1016. doi: 10.1097/DSS.0000000000001142. PMID: 28654578
Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378
Jo VY
Surg Pathol Clin 2015 Sep;8(3):445-66. doi: 10.1016/j.path.2015.05.005. PMID: 26297065
Gropper CA
Clin Cornerstone 2001;4(1):1-14. doi: 10.1016/s1098-3597(01)90002-x. PMID: 12739317

Clinical prediction guides

Gambichler T, Hartenstein I, Dreißigacker M, Stockfleth E, Stücker M, Schaller J, Schulze HJ, Becker JC, Käfferlein HU, Brüning T, Lang K
Clin Exp Dermatol 2021 Aug;46(6):1052-1057. Epub 2021 May 1 doi: 10.1111/ced.14634. PMID: 33714217
Dai H, Jiang HY, Xu AE
Skin Res Technol 2021 Mar;27(2):272-276. Epub 2020 Nov 11 doi: 10.1111/srt.12934. PMID: 33174647
Lim Y, Lee J, Jang D, Abudureyimu G, Lee JH
Skin Res Technol 2021 Jan;27(1):70-73. Epub 2020 Jun 28 doi: 10.1111/srt.12910. PMID: 32596839
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Lau J, Haber RM
J Cutan Med Surg 2013 Mar-Apr;17(2):84-8. doi: 10.2310/7750.2012.12027. PMID: 23582162

Recent systematic reviews

Williams K, Shinkai K
J Am Acad Dermatol 2016 Jun;74(6):1234-1240.e9. Epub 2016 Feb 3 doi: 10.1016/j.jaad.2015.12.006. PMID: 26850654

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