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Neurothekeoma

MedGen UID:: 64641
•Concept ID:: C0206730
•: Neoplastic Process

Synonyms:	Myxoma, Nerve Sheath; Myxomas, Nerve Sheath; Nerve Sheath Myxoma; Nerve Sheath Myxomas; Neurotheceoma; Neurotheceomas; Neurothecoma; Neurothecomas; Neurothekeomas
SNOMED CT:	Neurothekeoma (51836001); Nerve sheath myxoma (51836001)

Monarch Initiative:	MONDO:0006317

Definition

A benign neoplasm arising from nerve sheaths. It is characterized by the presence of a myxoid stroma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNeurothekeoma

Neoplasm by Special Category
- Benign neoplasm
  - Benign connective and soft tissue neoplasm
    - Benign soft tissue neoplasm
      - Benign Soft Tissue Neoplasm of Uncertain Differentiation
        Myxoma
        Neurothekeoma
        Cellular Nerve Sheath Myxoma
        Dermal Nerve Sheath Myxoma

Recent clinical studies

Etiology

Pediatric cellular neurothekeoma: Seven cases and systematic review of the literature.

Murphrey M, Huy Nguyen A, White KP, Krol A, Bernert R, Yarbrough K
Pediatr Dermatol 2020 Mar;37(2):320-325. Epub 2020 Jan 12 doi: 10.1111/pde.14043. PMID: 31930561

Neurothekeoma of the toe.

Wiemeyer S, Hafer G
Foot Ankle Spec 2013 Dec;6(6):479-81. Epub 2013 Oct 9 doi: 10.1177/1938640013507106. PMID: 24107319

Neurothekeoma.

Ward JL, Prieto VG, Joseph A, Chevray P, Kronowitz S, Sturgis EM
Otolaryngol Head Neck Surg 2005 Jan;132(1):86-9. doi: 10.1016/j.otohns.2004.05.031. PMID: 15632914

Myxoid tumours of soft tissue.

Graadt van Roggen JF, Hogendoorn PC, Fletcher CD
Histopathology 1999 Oct;35(4):291-312. doi: 10.1046/j.1365-2559.1999.00835.x. PMID: 10564384

Prominent myofibroblastic differentiation. A pitfall in the diagnosis of dermatofibroma.

Zelger BW, Zelger BG, Rappersberger K
Am J Dermatopathol 1997 Apr;19(2):138-46. doi: 10.1097/00000372-199704000-00007. PMID: 9129698

See all (23)

Diagnosis

Positive MITF and NKI/C3 Expression in Cellular Neurothekeoma and Dermatofibroma.

Abdaljaleel M, North JP
Appl Immunohistochem Mol Morphol 2021 Jul 1;29(6):440-445. doi: 10.1097/PAI.0000000000000889. PMID: 33264109

Classic neurothekeoma (nerve sheath myxoma) and cellular neurothekeoma of the oral mucosa: immunohistochemical profiles.

Vered M, Fridman E, Carpenter WM, Buchner A
J Oral Pathol Med 2011 Feb;40(2):174-80. Epub 2010 Oct 4 doi: 10.1111/j.1600-0714.2010.00952.x. PMID: 20923450

Neurothekeoma.

Ward JL, Prieto VG, Joseph A, Chevray P, Kronowitz S, Sturgis EM
Otolaryngol Head Neck Surg 2005 Jan;132(1):86-9. doi: 10.1016/j.otohns.2004.05.031. PMID: 15632914

Myxoid tumours of soft tissue.

Graadt van Roggen JF, Hogendoorn PC, Fletcher CD
Histopathology 1999 Oct;35(4):291-312. doi: 10.1046/j.1365-2559.1999.00835.x. PMID: 10564384

Cellular neurothekeoma.

Tomasini C, Aloi F, Pippione M
Dermatology 1996;192(2):160-3. doi: 10.1159/000246348. PMID: 8829503

See all (139)

Therapy

Fibrous and fibrohistiocytic neoplasms: an update.

Clarke LE
Dermatol Clin 2012 Oct;30(4):643-56, vi. Epub 2012 Aug 11 doi: 10.1016/j.det.2012.06.005. PMID: 23021051

Atypical cellular neurothekeoma--a diagnosis to be aware of.

Wilson AD, Rigby H, Orlando A
J Plast Reconstr Aesthet Surg 2008;61(2):186-8. Epub 2007 Aug 20 doi: 10.1016/j.bjps.2007.01.078. PMID: 17709307

Right ventricular nerve sheath tumour and patent foramen ovale presenting with transient ischemic attack.

Sharif MN, Schwarz D, Cujec B, Radhi J, Thomson D
Can J Cardiol 1996 Sep;12(9):789-91. PMID: 8842130

See all (3)

Prognosis

Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification.

Abdel Razek AAK, Gamaleldin OA, Elsebaie NA
J Comput Assist Tomogr 2020 Nov/Dec;44(6):928-940. doi: 10.1097/RCT.0000000000001109. PMID: 33196600

Neurothekeoma of the toe.

Wiemeyer S, Hafer G
Foot Ankle Spec 2013 Dec;6(6):479-81. Epub 2013 Oct 9 doi: 10.1177/1938640013507106. PMID: 24107319

Fibrous and fibrohistiocytic neoplasms: an update.

Clarke LE
Dermatol Clin 2012 Oct;30(4):643-56, vi. Epub 2012 Aug 11 doi: 10.1016/j.det.2012.06.005. PMID: 23021051

A rare case of atypical cellular neurothekeoma in a 68-year-old woman.

Mertz KD, Mentzel T, Grob M, Pfaltz M, Kempf W
J Cutan Pathol 2009 Nov;36(11):1210-4. doi: 10.1111/j.1600-0560.2009.01261.x. PMID: 19469878

Atypical neurothekeoma: a new case and review of the literature.

Campanati A, Brandozzi G, Sisti S, Bernardini ML, Offidani AM
J Cutan Pathol 2007 May;34(5):435-7. doi: 10.1111/j.1600-0560.2006.00637.x. PMID: 17448203

See all (20)

Clinical prediction guides

Cellular neurothekeoma occurring at the site of radiation therapy in a child with medulloblastoma.

Zhao Z, Koh MJA
Pediatr Dermatol 2022 May;39(3):488-490. Epub 2022 Feb 17 doi: 10.1111/pde.14941. PMID: 35178793

Multiple myxoid cellular neurothekeomas in a patient with systemic lupus erythematosus.

Lau SK, Cassarino DS, Koh SS
J Cutan Pathol 2021 Jul;48(7):980-985. Epub 2021 May 9 doi: 10.1111/cup.14025. PMID: 33844324

Peripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification.

Abdel Razek AAK, Gamaleldin OA, Elsebaie NA
J Comput Assist Tomogr 2020 Nov/Dec;44(6):928-940. doi: 10.1097/RCT.0000000000001109. PMID: 33196600

Neurothekeoma of the toe.

Wiemeyer S, Hafer G
Foot Ankle Spec 2013 Dec;6(6):479-81. Epub 2013 Oct 9 doi: 10.1177/1938640013507106. PMID: 24107319

Studies on the cellular origin of neurothekeoma: clinical, light microscopic, immunohistochemical, and ultrastructural observations.

Barnhill RL, Dickersin GR, Nickeleit V, Bhan AK, Muhlbauer JE, Phillips ME, Mihm MC Jr
J Am Acad Dermatol 1991 Jul;25(1 Pt 1):80-8. doi: 10.1016/0190-9622(91)70177-4. PMID: 1880258

See all (22)

Recent systematic reviews

Pediatric cellular neurothekeoma: Seven cases and systematic review of the literature.

Murphrey M, Huy Nguyen A, White KP, Krol A, Bernert R, Yarbrough K
Pediatr Dermatol 2020 Mar;37(2):320-325. Epub 2020 Jan 12 doi: 10.1111/pde.14043. PMID: 31930561

Intraoral nerve sheath myxoma: case report and systematic review of the literature.

Rozza-de-Menezes RE, Andrade RM, Israel MS, Gonçalves Cunha KS
Head Neck 2013 Dec;35(12):E397-404. Epub 2013 Jul 30 doi: 10.1002/hed.23361. PMID: 23616426

See all (2)

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Neurothekeoma

Definition

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

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