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Chondromyxoid fibroma

MedGen UID:
66375
Concept ID:
C0221290
Neoplastic Process
Synonyms: Chondromyxoid Fibroma; chondromyxoid fibroma; CMF - Chondromyxoid fibroma
SNOMED CT: CMF - Chondromyxoid fibroma (39553005); Chondromyxoid fibroma (39553005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018447
Orphanet: ORPHA404507

Definition

A rare bone tumor characterized by a benign lesion composed of lobules of spindle shaped or stellate cells and an abundant myxoid or chondroid matrix. The tumor may occur in almost any osseous location but is most common in long bones, in particular the proximal tibia and the distal femur. Pain is the most common presenting symptom. Prognosis is excellent even in cases with local recurrence. [from ORDO]

Term Hierarchy

Professional guidelines

PubMed

Martin JR, Auran RL, Duran MD, de Comas AM, Jacofsky DJ
J Knee Surg 2022 May;35(6):585-596. Epub 2022 Feb 18 doi: 10.1055/s-0042-1743221. PMID: 35181876
Wu KK
Clin Podiatr Med Surg 1993 Oct;10(4):683-715. PMID: 8221546

Recent clinical studies

Etiology

De La Peña NM, Yekzaman BR, Patra DP, Rath TJ, Lal D, Bendok BR
World Neurosurg 2022 Jun;162:21-28. Epub 2021 Oct 25 doi: 10.1016/j.wneu.2021.10.139. PMID: 34710582
Wangsiricharoen S, Wakely PE Jr, Siddiqui MT, Ali SZ
J Am Soc Cytopathol 2021 Jul-Aug;10(4):366-381. Epub 2021 Apr 7 doi: 10.1016/j.jasc.2021.04.001. PMID: 33958292
Zhong J, Si L, Geng J, Xing Y, Hu Y, Jiao Q, Zhang H, Yao W
BMC Musculoskelet Disord 2020 Jan 29;21(1):53. doi: 10.1186/s12891-020-3063-5. PMID: 31996205Free PMC Article
Kwee TC, de Klerk JMH, Nix M, Heggelman BGF, Dubois SV, Adams HJA
Semin Nucl Med 2017 Jul;47(4):322-351. Epub 2017 Apr 12 doi: 10.1053/j.semnuclmed.2017.02.004. PMID: 28583274
Qasem SA, DeYoung BR
Semin Diagn Pathol 2014 Jan;31(1):10-20. Epub 2014 Jan 23 doi: 10.1053/j.semdp.2014.01.006. PMID: 24680178

Diagnosis

Martin JR, Auran RL, Duran MD, de Comas AM, Jacofsky DJ
J Knee Surg 2022 May;35(6):585-596. Epub 2022 Feb 18 doi: 10.1055/s-0042-1743221. PMID: 35181876
Flaman AN, Wasserman JK, Gravel DH, Purgina BM
Head Neck Pathol 2020 Mar;14(1):83-96. Epub 2020 Jan 16 doi: 10.1007/s12105-019-01091-5. PMID: 31950468Free PMC Article
Qasem SA, DeYoung BR
Semin Diagn Pathol 2014 Jan;31(1):10-20. Epub 2014 Jan 23 doi: 10.1053/j.semdp.2014.01.006. PMID: 24680178
De Mattos CB, Angsanuntsukh C, Arkader A, Dormans JP
J Am Acad Orthop Surg 2013 Apr;21(4):225-33. doi: 10.5435/JAAOS-21-04-225. PMID: 23545728
Giudici MA, Moser RP Jr, Kransdorf MJ
Radiol Clin North Am 1993 Mar;31(2):237-59. PMID: 8446748

Therapy

Bhamra JS, Al-Khateeb H, Dhinsa BS, Gikas PD, Tirabosco R, Pollock RC, Skinner JA, Aston WJ, Saifuddin A, Briggs TW
World J Surg Oncol 2014 Sep 12;12:283. doi: 10.1186/1477-7819-12-283. PMID: 25217119Free PMC Article
Bhatti A, Mahmood A, Minhas MS, Mehboob G
J Coll Physicians Surg Pak 2003 Nov;13(11):644-8. PMID: 14700492
Tallini G, Dorfman H, Brys P, Dal Cin P, De Wever I, Fletcher CD, Jonson K, Mandahl N, Mertens F, Mitelman F, Rosai J, Rydholm A, Samson I, Sciot R, Van den Berghe H, Vanni R, Willén H
J Pathol 2002 Feb;196(2):194-203. doi: 10.1002/path.1023. PMID: 11793371

Prognosis

Gowda PC, Dunlap RH, Ahlawat S, Gross JM, Morris CD, Lyons GR
Skeletal Radiol 2023 Dec;52(12):2497-2501. Epub 2023 Aug 7 doi: 10.1007/s00256-023-04414-4. PMID: 37544967
Dodson V, Majmundar N, Sharer L, Fitzhugh VA, Assina R
Int J Surg Pathol 2020 Oct;28(7):799-803. Epub 2020 May 4 doi: 10.1177/1066896920916784. PMID: 32362154
Zhong J, Si L, Geng J, Xing Y, Hu Y, Jiao Q, Zhang H, Yao W
BMC Musculoskelet Disord 2020 Jan 29;21(1):53. doi: 10.1186/s12891-020-3063-5. PMID: 31996205Free PMC Article
Kilic D, Findikcioglu A, Tepeoglu M, Vural C
Tex Heart Inst J 2015 Aug;42(4):400-2. Epub 2015 Aug 1 doi: 10.14503/THIJ-14-4381. PMID: 26413029Free PMC Article
Bahk WJ, Mirra JM
Skeletal Radiol 2004 Nov;33(11):641-8. Epub 2004 Sep 8 doi: 10.1007/s00256-004-0826-2. PMID: 15365783

Clinical prediction guides

Cleven AHG, Schreuder WH, Groen E, de Lange J, Briaire-de Bruijn IH, Bovée JVMG
Virchows Arch 2022 Oct;481(4):671-675. Epub 2022 May 25 doi: 10.1007/s00428-022-03341-4. PMID: 35612673Free PMC Article
Liu T, Yao J, Li X, Qi X, Zhao P, Tan Z, Wang J, Li Y
Medicine (Baltimore) 2020 Mar;99(11):e19487. doi: 10.1097/MD.0000000000019487. PMID: 32176085Free PMC Article
Kim HS, Jee WH, Ryu KN, Cho KH, Suh JS, Cho JH, Choi YS, Lee SM, Lee JM, Sung MS, Kim JY, Jung ES, Chung YG, Ok IY
Acta Radiol 2011 Oct 1;52(8):875-80. Epub 2011 Aug 11 doi: 10.1258/ar.2011.110180. PMID: 21835889
Bahk WJ, Mirra JM
Skeletal Radiol 2004 Nov;33(11):641-8. Epub 2004 Sep 8 doi: 10.1007/s00256-004-0826-2. PMID: 15365783
Tallini G, Dorfman H, Brys P, Dal Cin P, De Wever I, Fletcher CD, Jonson K, Mandahl N, Mertens F, Mitelman F, Rosai J, Rydholm A, Samson I, Sciot R, Van den Berghe H, Vanni R, Willén H
J Pathol 2002 Feb;196(2):194-203. doi: 10.1002/path.1023. PMID: 11793371

Recent systematic reviews

De La Peña NM, Yekzaman BR, Patra DP, Rath TJ, Lal D, Bendok BR
World Neurosurg 2022 Jun;162:21-28. Epub 2021 Oct 25 doi: 10.1016/j.wneu.2021.10.139. PMID: 34710582

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