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Acute biphenotypic leukemia

MedGen UID:
7318
Concept ID:
C0023464
Neoplastic Process
Synonyms: Acute leukemia of undetermined lineage; ALL with myeloid markers; AML with lymphoid markers; Hybrid acute leukemia
SNOMED CT: Acute biphenotypic leukemia (128818009); Acute biphenotypic leukemia (278453007)
 
HPO: HP:0005531
Monarch Initiative: MONDO:0020322

Definition

A type of actue leukemia with features characteristic of both the myeloid and lymphoid lineages. These leukemias are for this reason are designated mixed-lineage, hybrid or biphenotypic acute leukemias. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute biphenotypic leukemia
Follow this link to review classifications for Acute biphenotypic leukemia in Orphanet.

Professional guidelines

PubMed

Weinberg OK, Seetharam M, Ren L, Alizadeh A, Arber DA
Am J Clin Pathol 2014 Dec;142(6):803-8. doi: 10.1309/AJCPPVUPOTUVOIB5. PMID: 25389334
Zheng C, Wu J, Liu X, Ding K, Cai X, Zhu W
Haematologica 2009 Dec;94(12):1778-80; author reply 1780. doi: 10.3324/haematol.2009.014829. PMID: 19996120Free PMC Article
Park JA, Ghim TT, Bae Kw, Im HJ, Jang SS, Park CJ, Chi HS, Seo JJ
Pediatr Blood Cancer 2009 Sep;53(3):444-52. doi: 10.1002/pbc.22105. PMID: 19489056

Recent clinical studies

Etiology

Orgel E, Alexander TB, Wood BL, Kahwash SB, Devidas M, Dai Y, Alonzo TA, Mullighan CG, Inaba H, Hunger SP, Raetz EA, Gamis AS, Rabin KR, Carroll AJ 3rd, Heerema NA, Berman JN, Woods WG, Loh ML, Zweidler-McKay PA, Horan JT; Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force
Cancer 2020 Feb 1;126(3):593-601. Epub 2019 Oct 29 doi: 10.1002/cncr.32552. PMID: 31661160Free PMC Article
Alexander TB, Gu Z, Iacobucci I, Dickerson K, Choi JK, Xu B, Payne-Turner D, Yoshihara H, Loh ML, Horan J, Buldini B, Basso G, Elitzur S, de Haas V, Zwaan CM, Yeoh A, Reinhardt D, Tomizawa D, Kiyokawa N, Lammens T, De Moerloose B, Catchpoole D, Hori H, Moorman A, Moore AS, Hrusak O, Meshinchi S, Orgel E, Devidas M, Borowitz M, Wood B, Heerema NA, Carrol A, Yang YL, Smith MA, Davidsen TM, Hermida LC, Gesuwan P, Marra MA, Ma Y, Mungall AJ, Moore RA, Jones SJM, Valentine M, Janke LJ, Rubnitz JE, Pui CH, Ding L, Liu Y, Zhang J, Nichols KE, Downing JR, Cao X, Shi L, Pounds S, Newman S, Pei D, Guidry Auvil JM, Gerhard DS, Hunger SP, Inaba H, Mullighan CG
Nature 2018 Oct;562(7727):373-379. Epub 2018 Sep 12 doi: 10.1038/s41586-018-0436-0. PMID: 30209392Free PMC Article
Maruffi M, Sposto R, Oberley MJ, Kysh L, Orgel E
Leukemia 2018 Jul;32(7):1515-1528. Epub 2018 Feb 27 doi: 10.1038/s41375-018-0058-4. PMID: 29550836Free PMC Article
Cernan M, Szotkowski T, Pikalova Z
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2017 Sep;161(3):234-241. Epub 2017 Apr 18 doi: 10.5507/bp.2017.013. PMID: 28422191
Ye Z, Wang S
Chin Med J (Engl) 2014;127(16):2999-3003. PMID: 25131241

Diagnosis

Weinberg OK, Arber DA
Am J Clin Pathol 2022 Jul 1;158(1):27-34. doi: 10.1093/ajcp/aqac070. PMID: 35775438
Harris MH, Czuchlewski DR, Arber DA, Czader M
Am J Clin Pathol 2019 Aug 1;152(3):322-346. doi: 10.1093/ajcp/aqz093. PMID: 31367767
Porwit A, Béné MC
Cytometry B Clin Cytom 2019 May;96(3):183-194. Epub 2019 Apr 29 doi: 10.1002/cyto.b.21783. PMID: 31033213
Charles NJ, Boyer DF
Arch Pathol Lab Med 2017 Nov;141(11):1462-1468. doi: 10.5858/arpa.2017-0218-RA. PMID: 29072953
Cernan M, Szotkowski T, Pikalova Z
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2017 Sep;161(3):234-241. Epub 2017 Apr 18 doi: 10.5507/bp.2017.013. PMID: 28422191

Therapy

Orgel E, Alexander TB, Wood BL, Kahwash SB, Devidas M, Dai Y, Alonzo TA, Mullighan CG, Inaba H, Hunger SP, Raetz EA, Gamis AS, Rabin KR, Carroll AJ 3rd, Heerema NA, Berman JN, Woods WG, Loh ML, Zweidler-McKay PA, Horan JT; Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force
Cancer 2020 Feb 1;126(3):593-601. Epub 2019 Oct 29 doi: 10.1002/cncr.32552. PMID: 31661160Free PMC Article
Khan M, Siddiqi R, Naqvi K
Ann Hematol 2018 Jun;97(6):945-953. Epub 2018 Mar 15 doi: 10.1007/s00277-018-3297-6. PMID: 29546454
Tong H, Liu Z, Lu C, Wang Q
Asia Pac J Clin Oncol 2013 Jun;9(2):146-54. Epub 2012 Jul 9 doi: 10.1111/j.1743-7563.2012.01571.x. PMID: 22898323
Béné MC, Porwit A
Semin Diagn Pathol 2012 Feb;29(1):12-8. doi: 10.1053/j.semdp.2011.08.004. PMID: 22372202
Al-Seraihy AS, Owaidah TM, Ayas M, El-Solh H, Al-Mahr M, Al-Ahmari A, Belgaumi AF
Haematologica 2009 Dec;94(12):1682-90. Epub 2009 Aug 27 doi: 10.3324/haematol.2009.009282. PMID: 19713227Free PMC Article

Prognosis

Harris MH, Czuchlewski DR, Arber DA, Czader M
Am J Clin Pathol 2019 Aug 1;152(3):322-346. doi: 10.1093/ajcp/aqz093. PMID: 31367767
Porwit A, Béné MC
Cytometry B Clin Cytom 2019 May;96(3):183-194. Epub 2019 Apr 29 doi: 10.1002/cyto.b.21783. PMID: 31033213
Khan M, Siddiqi R, Naqvi K
Ann Hematol 2018 Jun;97(6):945-953. Epub 2018 Mar 15 doi: 10.1007/s00277-018-3297-6. PMID: 29546454
Charles NJ, Boyer DF
Arch Pathol Lab Med 2017 Nov;141(11):1462-1468. doi: 10.5858/arpa.2017-0218-RA. PMID: 29072953
Cernan M, Szotkowski T, Pikalova Z
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2017 Sep;161(3):234-241. Epub 2017 Apr 18 doi: 10.5507/bp.2017.013. PMID: 28422191

Clinical prediction guides

Kabra A, Bushweller J
J Mol Biol 2022 Jan 15;434(1):167117. Epub 2021 Jun 23 doi: 10.1016/j.jmb.2021.167117. PMID: 34174329Free PMC Article
Granja JM, Klemm S, McGinnis LM, Kathiria AS, Mezger A, Corces MR, Parks B, Gars E, Liedtke M, Zheng GXY, Chang HY, Majeti R, Greenleaf WJ
Nat Biotechnol 2019 Dec;37(12):1458-1465. Epub 2019 Dec 2 doi: 10.1038/s41587-019-0332-7. PMID: 31792411Free PMC Article
Maruffi M, Sposto R, Oberley MJ, Kysh L, Orgel E
Leukemia 2018 Jul;32(7):1515-1528. Epub 2018 Feb 27 doi: 10.1038/s41375-018-0058-4. PMID: 29550836Free PMC Article
Al-Seraihy AS, Owaidah TM, Ayas M, El-Solh H, Al-Mahr M, Al-Ahmari A, Belgaumi AF
Haematologica 2009 Dec;94(12):1682-90. Epub 2009 Aug 27 doi: 10.3324/haematol.2009.009282. PMID: 19713227Free PMC Article
Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, Catovsky D
Haematologica 1997 Jan-Feb;82(1):64-6. PMID: 9107085

Recent systematic reviews

Maruffi M, Sposto R, Oberley MJ, Kysh L, Orgel E
Leukemia 2018 Jul;32(7):1515-1528. Epub 2018 Feb 27 doi: 10.1038/s41375-018-0058-4. PMID: 29550836Free PMC Article

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