Bizarre Parosteal Osteochondromatous Proliferation

MedGen UID:: 755487
•Concept ID:: C2960319
•: Neoplastic Process

Synonyms:	Bizarre parosteal osteochondromatous proliferation; Nora lesion
SNOMED CT:	Bizarre parosteal osteochondromatous proliferation (446593006); Nora lesion (446593006); Bizarre parosteal osteochondromatous proliferation (703696007)

Definition

A benign lesion that usually affects the proximal small bones of the hands or feet. Grossly it consists of a cartilage cap and a bony stalk. Microscopically it is characterized by the presence of spindle cells, cartilage, and bone, usually in a disorganized pattern compared to subungual exostosis. Enlarged (bizarre) chondrocytes are present in the cartilage. Swelling with or without pain is present. Recurrences following resection have been reported in approximately half of cases. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBizarre Parosteal Osteochondromatous Proliferation

Disease
- Neoplasm
  - Neoplasm by Special Category
    - Benign neoplasm
      - Benign connective and soft tissue neoplasm
        Benign chondrogenic neoplasm
        Bizarre Parosteal Osteochondromatous Proliferation

Professional guidelines

PubMed

Bizarre parosteal osteochondromatous proliferation of bone: clinical management of a series of 22 cases.

Berber O, Dawson-Bowling S, Jalgaonkar A, Miles J, Pollock RC, Skinner JA, Aston WJ, Briggs TW
J Bone Joint Surg Br 2011 Aug;93(8):1118-21. doi: 10.1302/0301-620X.93B8.26349. PMID: 21768639

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Recent clinical studies

Prognosis

Identification of COL1A1/2 Mutations and Fusions With Noncoding RNA Genes in Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion).

Kao YC, Yoshida A, Hsieh TH, Nord KH, Saba KH, Ichikawa H, Tsai JW, Huang HY, Chih-Hsueh Chen P, Fletcher CDM, Lee JC
Mod Pathol 2023 Feb;36(2):100011. Epub 2023 Jan 9 doi: 10.1016/j.modpat.2022.100011. PMID: 36853784

Bizarre parosteal osteochondromatous proliferation (Nora's lesion) affecting the distal end of the ulna: a case report.

Matsui Y, Funakoshi T, Kobayashi H, Mitsuhashi T, Kamishima T, Iwasaki N
BMC Musculoskelet Disord 2016 Mar 16;17:130. doi: 10.1186/s12891-016-0981-3. PMID: 26984018 Free PMC Article

Bizarre parosteal osteochondromatous proliferation (Nora's Lesion) of the mandible. a rare bony lesion.

Dashti HM, Reith JD, Schlott BJ, Lewis EL, Cohen DM, Bhattacharyya I
Head Neck Pathol 2012 Jun;6(2):264-9. Epub 2011 Nov 18 doi: 10.1007/s12105-011-0311-x. PMID: 22094873 Free PMC Article

Bizarre parosteal osteochondromatous proliferation (Nora's lesion). Description of six cases and a review of the literature.

Campanacci DA, Guarracino R, Franchi A, Capanna R
Chir Organi Mov 1999 Jan-Mar;84(1):65-71. PMID: 11569017

Bizarre parosteal osteochondromatous proliferation of bone.

Tannenbaum DA, Biermann JS
Orthopedics 1997 Dec;20(12):1186-8. doi: 10.3928/0147-7447-19971201-16. PMID: 9415916

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Clinical prediction guides

Identification of COL1A1/2 Mutations and Fusions With Noncoding RNA Genes in Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion).

Bizarre parosteal osteochondromatous proliferation (Nora's lesion) affecting the distal end of the ulna: a case report.

Matsui Y, Funakoshi T, Kobayashi H, Mitsuhashi T, Kamishima T, Iwasaki N
BMC Musculoskelet Disord 2016 Mar 16;17:130. doi: 10.1186/s12891-016-0981-3. PMID: 26984018 Free PMC Article

Congenital bizarre parosteal osteochondromatous proliferation in unusual location and age: a case report.

Sökücü S, Aycan OE, Arıkan Y, Kabukçuoğlu YS
Acta Orthop Traumatol Turc 2016;50(1):120-4. doi: 10.3944/AOTT.2016.13.0141. PMID: 26854060

Bizarre parosteal osteochondromatous proliferation with an inversion of chromosome 7.

Sakamoto A, Imamura S, Matsumoto Y, Harimaya K, Matsuda S, Takahashi Y, Oda Y, Iwamoto Y
Skeletal Radiol 2011 Nov;40(11):1487-90. Epub 2011 Apr 21 doi: 10.1007/s00256-011-1173-8. PMID: 21509435

Bizarre parosteal osteochondromatous proliferation (Nora's lesion). Description of six cases and a review of the literature.

Campanacci DA, Guarracino R, Franchi A, Capanna R
Chir Organi Mov 1999 Jan-Mar;84(1):65-71. PMID: 11569017

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