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Pancreatic Mixed Acinar-Ductal Carcinoma

MedGen UID:
758636
•Concept ID:
C3472609
•
Neoplastic Process
Synonyms: Mixed acinar-ductal carcinoma; Mixed Acinar-Ductal Carcinoma of the Pancreas
SNOMED CT: Mixed acinar-ductal carcinoma (450897002)

Definition

A carcinoma that arises from the pancreas showing either extensive mucin accumulation and acinar neoplastic cells or a mixture of columnar or signet-ring cells and acinar neoplastic cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic Mixed Acinar-Ductal Carcinoma

Recent clinical studies

Etiology

Clinical outcomes of patients with resectable pancreatic acinar cell carcinoma.
Seo S, Yoo C, Kim KP, Ryoo BY, Chang HM, Hong SM, Lee JH, Song KB, Hwang DW, Kim KH, Hwang S, Kim SC
J Dig Dis 2017 Aug;18(8):480-486. doi: 10.1111/1751-2980.12505. PMID: 28671770
Simultaneous occurrence of pancreatic mixed acinar-ductal adenocarcinoma and primary follicular lymphoma of the duodenum, accompanied by increased number of IgG4 plasma cells in tumor-free parenchyma as concomitant IgG4-related disease or reaction to tumor? A case report.
Ranković B, Limbaeck-Stokin C, Đokić M, Stanisavljević D, Volavšek M
Pol J Pathol 2017;68(1):86-91. doi: 10.5114/pjp.2017.67622. PMID: 28547986
Acinar neoplasms of the pancreas-A summary of 25 years of research.
Klimstra DS, Adsay V
Semin Diagn Pathol 2016 Sep;33(5):307-18. Epub 2016 May 13 doi: 10.1053/j.semdp.2016.05.009. PMID: 27320062

Diagnosis

Cytomorphologic, immunophenotypical and molecular features of pancreatic acinar cell carcinoma.
Sun T, Gilani S, Jain D, Cai G
Diagn Cytopathol 2023 Nov;51(11):674-683. Epub 2023 Jul 19 doi: 10.1002/dc.25196. PMID: 37469257
Pancreatic acinar cell carcinoma with a ductal adenocarcinoma component: a case report and analysis of the histogenesis of the tumor.
Kimura T, Tabata S, Togawa T, Onchi H, Iida A, Sato Y, Goi T
World J Surg Oncol 2020 Sep 5;18(1):238. doi: 10.1186/s12957-020-02014-3. PMID: 32891173Free PMC Article
Simultaneous occurrence of pancreatic mixed acinar-ductal adenocarcinoma and primary follicular lymphoma of the duodenum, accompanied by increased number of IgG4 plasma cells in tumor-free parenchyma as concomitant IgG4-related disease or reaction to tumor? A case report.
Ranković B, Limbaeck-Stokin C, Đokić M, Stanisavljević D, Volavšek M
Pol J Pathol 2017;68(1):86-91. doi: 10.5114/pjp.2017.67622. PMID: 28547986
Acinar neoplasms of the pancreas-A summary of 25 years of research.
Klimstra DS, Adsay V
Semin Diagn Pathol 2016 Sep;33(5):307-18. Epub 2016 May 13 doi: 10.1053/j.semdp.2016.05.009. PMID: 27320062
Total pancreatectomy for metachronous mixed acinar-ductal carcinoma in a remnant pancreas.
Shonaka T, Inagaki M, Akabane H, Yanagida N, Shomura H, Yanagawa N, Oikawa K, Nakano S
World J Gastroenterol 2014 Sep 7;20(33):11904-9. doi: 10.3748/wjg.v20.i33.11904. PMID: 25206298Free PMC Article

Therapy

Clinical outcomes of patients with resectable pancreatic acinar cell carcinoma.
Seo S, Yoo C, Kim KP, Ryoo BY, Chang HM, Hong SM, Lee JH, Song KB, Hwang DW, Kim KH, Hwang S, Kim SC
J Dig Dis 2017 Aug;18(8):480-486. doi: 10.1111/1751-2980.12505. PMID: 28671770
Total pancreatectomy for metachronous mixed acinar-ductal carcinoma in a remnant pancreas.
Shonaka T, Inagaki M, Akabane H, Yanagida N, Shomura H, Yanagawa N, Oikawa K, Nakano S
World J Gastroenterol 2014 Sep 7;20(33):11904-9. doi: 10.3748/wjg.v20.i33.11904. PMID: 25206298Free PMC Article

Prognosis

Pancreatic acinar cell carcinoma with a ductal adenocarcinoma component: a case report and analysis of the histogenesis of the tumor.
Kimura T, Tabata S, Togawa T, Onchi H, Iida A, Sato Y, Goi T
World J Surg Oncol 2020 Sep 5;18(1):238. doi: 10.1186/s12957-020-02014-3. PMID: 32891173Free PMC Article
Clinical outcomes of patients with resectable pancreatic acinar cell carcinoma.
Seo S, Yoo C, Kim KP, Ryoo BY, Chang HM, Hong SM, Lee JH, Song KB, Hwang DW, Kim KH, Hwang S, Kim SC
J Dig Dis 2017 Aug;18(8):480-486. doi: 10.1111/1751-2980.12505. PMID: 28671770
Total pancreatectomy for metachronous mixed acinar-ductal carcinoma in a remnant pancreas.
Shonaka T, Inagaki M, Akabane H, Yanagida N, Shomura H, Yanagawa N, Oikawa K, Nakano S
World J Gastroenterol 2014 Sep 7;20(33):11904-9. doi: 10.3748/wjg.v20.i33.11904. PMID: 25206298Free PMC Article
Pancreatic acinar cell carcinomas with prominent ductal differentiation: Mixed acinar ductal carcinoma and mixed acinar endocrine ductal carcinoma.
Stelow EB, Shaco-Levy R, Bao F, Garcia J, Klimstra DS
Am J Surg Pathol 2010 Apr;34(4):510-8. doi: 10.1097/PAS.0b013e3181cfcac7. PMID: 20182344

Clinical prediction guides

Cytomorphologic, immunophenotypical and molecular features of pancreatic acinar cell carcinoma.
Sun T, Gilani S, Jain D, Cai G
Diagn Cytopathol 2023 Nov;51(11):674-683. Epub 2023 Jul 19 doi: 10.1002/dc.25196. PMID: 37469257
Pancreatic acinar cell carcinoma with a ductal adenocarcinoma component: a case report and analysis of the histogenesis of the tumor.
Kimura T, Tabata S, Togawa T, Onchi H, Iida A, Sato Y, Goi T
World J Surg Oncol 2020 Sep 5;18(1):238. doi: 10.1186/s12957-020-02014-3. PMID: 32891173Free PMC Article
A novel experimental model for human mixed acinar-ductal pancreatic cancer.
Doiron B, DeFronzo RA
Carcinogenesis 2018 Feb 9;39(2):180-190. doi: 10.1093/carcin/bgx119. PMID: 29106450Free PMC Article
Total pancreatectomy for metachronous mixed acinar-ductal carcinoma in a remnant pancreas.
Shonaka T, Inagaki M, Akabane H, Yanagida N, Shomura H, Yanagawa N, Oikawa K, Nakano S
World J Gastroenterol 2014 Sep 7;20(33):11904-9. doi: 10.3748/wjg.v20.i33.11904. PMID: 25206298Free PMC Article

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