U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pancreatic adenocarcinoma

MedGen UID:
83800
Concept ID:
C0281361
Neoplastic Process
Synonym: Adenocarcinoma of the pancreas
SNOMED CT: Pancreatic adenocarcinoma (700423003); Adenocarcinoma of pancreas (700423003)
 
HPO: HP:0006725
Monarch Initiative: MONDO:0006047

Definition

The presence of an adenocarcinoma of the pancreas. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic adenocarcinoma

Conditions with this feature

Hyperparathyroidism 2 with jaw tumors
MedGen UID:
310065
Concept ID:
C1704981
Neoplastic Process
The spectrum of CDC73-related disorders includes the following phenotypes: Hyperparathyroidism-jaw tumor (HPT-JT) syndrome. Primary hyperparathyroidism, the main finding of HPT-JT syndrome, occurs in up to 95% of affected individuals; onset is typically in late adolescence or early adulthood. HPT-JT-associated primary hyperparathyroidism is usually caused by a single parathyroid adenoma. In approximately 10%-15% of individuals, primary hyperparathyroidism is caused by parathyroid carcinoma. Ossifying fibromas of the mandible or maxilla, also known as cementifying fibromas and cemento-ossifying fibromas, occur in 30%-40% of individuals with HPT-JT syndrome. Although benign, these tumors can be locally aggressive and may continue to enlarge if not treated. Approximately 20% of individuals with HPT-JT syndrome have kidney lesions, most commonly cysts; renal hamartomas and (more rarely) Wilms tumor have also been reported. Benign and malignant uterine tumors appear to be common in women with HPT-JT syndrome. Parathyroid carcinoma. Most parathyroid carcinomas are functional, resulting in hyperparathyroidism and a high serum calcium level; however, nonfunctioning parathyroid carcinomas are also rarely described in individuals with a CDC73-related disorder. A germline CDC73 pathogenic variant has been identified in 20%-29% of individuals with apparently sporadic parathyroid carcinoma. Familial isolated hyperparathyroidism (FIHP). FIHP is characterized by primary hyperparathyroidism without other associated syndromic features. Individuals with CDC73-related FIHP tend to have a more severe clinical presentation and younger age of onset than individuals with FIHP in whom a CDC73 pathogenic variant has not been identified.
Melanoma-pancreatic cancer syndrome
MedGen UID:
325450
Concept ID:
C1838547
Disease or Syndrome
Melanoma-pancreatic cancer syndrome is an inherited cancer predisposition syndrome in which mutation carriers have an increased risk of developing malignant melanoma and/or pancreatic cancer. Mutation carriers within families may develop either or both types of cancer (summary by Harinck et al., 2012). For background and phenotypic information on malignant melanoma and pancreatic cancer, see 155600 and 260350, respectively.
Pancreatic cancer, susceptibility to, 1
MedGen UID:
339739
Concept ID:
C1847351
Finding
Any familial pancreatic carcinoma in which the cause of the disease is a mutation in the PALLD gene.
Familial adenomatous polyposis 3
MedGen UID:
902388
Concept ID:
C4225157
Disease or Syndrome
NTHL1 tumor syndrome is characterized by an increased lifetime risk for colorectal cancer (CRC), breast cancer, and colorectal polyposis. Colorectal polyps can be adenomatous, hyperplastic, and/or sessile serrated. Duodenal polyposis has also been reported. Additional cancers reported in individuals with NTHL1 tumor syndrome include endometrial cancer, cervical cancer, urothelial carcinoma of the bladder, meningiomas, unspecified brain tumors, basal cell carcinomas, head and neck squamous cell carcinomas, and hematologic malignancies. The cumulative lifetime risk of developing extracolonic cancer by age 60 years has been estimated at 35% to 78%.
Pancreatic cancer, susceptibility to, 5
MedGen UID:
1684838
Concept ID:
C5231459
Finding
Susceptibility to pancreatic ductal adenocarcinoma (PDAC) may be conferred by mutation in RABL3. Other cancers, including melanoma, breast cancer, and colon cancer, have been reported in RABL3 mutation-carrying individuals, with or without PDAC (Nissim et al., 2019). For background, phenotypic description, and a discussion of genetic heterogeneity of pancreatic carcinoma, see 260350.

Professional guidelines

PubMed

Li K, Tandurella JA, Gai J, Zhu Q, Lim SJ, Thomas DL 2nd, Xia T, Mo G, Mitchell JT, Montagne J, Lyman M, Danilova LV, Zimmerman JW, Kinny-Köster B, Zhang T, Chen L, Blair AB, Heumann T, Parkinson R, Durham JN, Narang AK, Anders RA, Wolfgang CL, Laheru DA, He J, Osipov A, Thompson ED, Wang H, Fertig EJ, Jaffee EM, Zheng L
Cancer Cell 2022 Nov 14;40(11):1374-1391.e7. Epub 2022 Oct 27 doi: 10.1016/j.ccell.2022.10.001. PMID: 36306792Free PMC Article
Tempero MA, Malafa MP, Al-Hawary M, Behrman SW, Benson AB, Cardin DB, Chiorean EG, Chung V, Czito B, Del Chiaro M, Dillhoff M, Donahue TR, Dotan E, Ferrone CR, Fountzilas C, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Moravek C, Nakakura EK, Narang AK, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Vollmer C, Wolff RA, Wolpin BM, Lynn B, George GV
J Natl Compr Canc Netw 2021 Apr 1;19(4):439-457. doi: 10.6004/jnccn.2021.0017. PMID: 33845462
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article

Recent clinical studies

Etiology

Yan C, Niu Y, Li F, Zhao W, Ma L
J Transl Med 2022 Oct 5;20(1):455. doi: 10.1186/s12967-022-03632-z. PMID: 36199146Free PMC Article
Wu Z, Huang X, Cai M, Huang P, Guan Z
Aging (Albany NY) 2022 Jan 24;14(2):869-891. doi: 10.18632/aging.203846. PMID: 35077391Free PMC Article
Moore A, Donahue T
JAMA 2019 Oct 8;322(14):1426. doi: 10.1001/jama.2019.14699. PMID: 31593274Free PMC Article
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Lindquist CM, Miller FH, Hammond NA, Nikolaidis P
Abdom Radiol (NY) 2018 Feb;43(2):264-272. doi: 10.1007/s00261-017-1308-z. PMID: 28840303

Diagnosis

Chapa-Azuela Ó, Corona-Torres MJ, Ayala-Moreno EA, Arroyo-Paredes PS, Pérez-Torres E, Rodríguez-Báez A, Montalvo-Javé EE
Cir Cir 2023;91(2):262-267. doi: 10.24875/CIRU.22000364. PMID: 37084317
La Salvia A, Persano I, Parlagreco E, Audisio A, Cani M, Brizzi MP
Med Oncol 2022 Aug 16;39(11):168. doi: 10.1007/s12032-022-01764-2. PMID: 35972607
Wang H, Lu L, Liang X, Chen Y
Cancer Immunol Immunother 2022 Jul;71(7):1757-1769. Epub 2021 Dec 2 doi: 10.1007/s00262-021-03110-3. PMID: 34854950
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Brand RE, Tempero MA
Curr Opin Oncol 1998 Jul;10(4):362-6. doi: 10.1097/00001622-199807000-00014. PMID: 9702405

Therapy

Wainberg ZA, Bekaii-Saab T, Boland PM, Dayyani F, Macarulla T, Mody K, Belanger B, Maxwell F, Moore Y, Thiagalingam A, Wang T, Zhang B, Dean A
Eur J Cancer 2021 Jul;151:14-24. Epub 2021 May 4 doi: 10.1016/j.ejca.2021.03.028. PMID: 33957442
Schizas D, Charalampakis N, Kole C, Economopoulou P, Koustas E, Gkotsis E, Ziogas D, Psyrri A, Karamouzis MV
Cancer Treat Rev 2020 Jun;86:102016. Epub 2020 Mar 25 doi: 10.1016/j.ctrv.2020.102016. PMID: 32247999
Wang-Gillam A, Hubner RA, Siveke JT, Von Hoff DD, Belanger B, de Jong FA, Mirakhur B, Chen LT
Eur J Cancer 2019 Feb;108:78-87. Epub 2019 Jan 14 doi: 10.1016/j.ejca.2018.12.007. PMID: 30654298
Gilliland TM, Villafane-Ferriol N, Shah KP, Shah RM, Tran Cao HS, Massarweh NN, Silberfein EJ, Choi EA, Hsu C, McElhany AL, Barakat O, Fisher W, Van Buren G
Nutrients 2017 Mar 7;9(3) doi: 10.3390/nu9030243. PMID: 28272344Free PMC Article
Morello A, Sadelain M, Adusumilli PS
Cancer Discov 2016 Feb;6(2):133-46. Epub 2015 Oct 26 doi: 10.1158/2159-8290.CD-15-0583. PMID: 26503962Free PMC Article

Prognosis

Afghani E, Klein AP
Hematol Oncol Clin North Am 2022 Oct;36(5):879-895. Epub 2022 Sep 23 doi: 10.1016/j.hoc.2022.07.002. PMID: 36154788Free PMC Article
Khalaf N, El-Serag HB, Abrams HR, Thrift AP
Clin Gastroenterol Hepatol 2021 May;19(5):876-884. Epub 2020 Mar 6 doi: 10.1016/j.cgh.2020.02.054. PMID: 32147593Free PMC Article
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Maroni L, Ravaioli M, Pinna AD
Expert Rev Anticancer Ther 2016 Oct;16(10):1003-4. Epub 2016 Aug 31 doi: 10.1080/14737140.2016.1224972. PMID: 27552648
Cohen SJ, Pinover WH, Watson JC, Meropol NJ
Curr Treat Options Oncol 2000 Dec;1(5):375-86. doi: 10.1007/s11864-000-0065-2. PMID: 12057145

Clinical prediction guides

Yan C, Niu Y, Li F, Zhao W, Ma L
J Transl Med 2022 Oct 5;20(1):455. doi: 10.1186/s12967-022-03632-z. PMID: 36199146Free PMC Article
Wu Z, Huang X, Cai M, Huang P, Guan Z
Aging (Albany NY) 2022 Jan 24;14(2):869-891. doi: 10.18632/aging.203846. PMID: 35077391Free PMC Article
Wang H, Lu L, Liang X, Chen Y
Cancer Immunol Immunother 2022 Jul;71(7):1757-1769. Epub 2021 Dec 2 doi: 10.1007/s00262-021-03110-3. PMID: 34854950
Ai D, Yao J, Yang F, Huo L, Chen H, Lu W, Soto LMS, Jiang M, Raso MG, Wang S, Bell D, Liu J, Wang H, Tan D, Torres-Cabala C, Gan Q, Wu Y, Albarracin C, Hung MC, Meric-Bernstam F, Wistuba II, Prieto VG, Sahin AA, Ding Q
Mod Pathol 2021 Apr;34(4):710-719. Epub 2020 Oct 3 doi: 10.1038/s41379-020-00692-8. PMID: 33011748
Lee ES, Lee JM
World J Gastroenterol 2014 Jun 28;20(24):7864-77. doi: 10.3748/wjg.v20.i24.7864. PMID: 24976723Free PMC Article

Recent systematic reviews

Chandana SR, Woods LM, Maxwell F, Gandolfo R, Bekaii-Saab T
Eur J Cancer 2024 Feb;198:113471. Epub 2023 Dec 12 doi: 10.1016/j.ejca.2023.113471. PMID: 38154392
Frassini S, Calabretto F, Granieri S, Fugazzola P, Viganò J, Fazzini N, Ansaloni L, Cobianchi L
Eur J Surg Oncol 2022 Sep;48(9):1911-1921. Epub 2022 Jun 2 doi: 10.1016/j.ejso.2022.05.030. PMID: 35688711
Yoon SB, Jeon TY, Moon SH, Lee SM, Kim MH
Eur Radiol 2022 Oct;32(10):6691-6701. Epub 2022 Apr 29 doi: 10.1007/s00330-022-08816-1. PMID: 35486167
Meneses-Medina MI, Gervaso L, Cella CA, Pellicori S, Gandini S, Sousa MJ, Fazio N
Cancer Treat Rev 2022 Mar;104:102338. Epub 2022 Jan 22 doi: 10.1016/j.ctrv.2022.102338. PMID: 35114498
Dhir M, Malhotra GK, Sohal DPS, Hein NA, Smith LM, O'Reilly EM, Bahary N, Are C
World J Surg Oncol 2017 Oct 10;15(1):183. doi: 10.1186/s12957-017-1240-2. PMID: 29017581Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...