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Childhood pleomorphic rhabdomyosarcoma

MedGen UID:
76002
Concept ID:
C0279614
Neoplastic Process
Synonyms: childhood anaplastic rhabdomyosarcoma; Childhood Pleomorphic Rhabdomyosarcoma; childhood pleomorphic rhabdomyosarcoma; paediatric pleomorphic rhabdomyosarcoma; Pediatric Pleomorphic Rhabdomyosarcoma; pediatric pleomorphic rhabdomyosarcoma; Pleomorphic Childhood Rhabdomyosarcoma; pleomorphic childhood rhabdomyosarcoma; Pleomorphic rhabdomyosarcoma; pleomorphic rhabdomyosarcoma of childhood
 
Monarch Initiative: MONDO:0004233

Definition

A rare aggressive rhabdomyosarcoma occurring in children. The neoplasm is characterized by the presence of bizarre round, spindle, and polygonal cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood pleomorphic rhabdomyosarcoma

Professional guidelines

PubMed

Parham DM, Giannikopoulos P
Pediatr Dev Pathol 2021 Mar-Apr;24(2):87-95. Epub 2021 Jan 13 doi: 10.1177/1093526620977720. PMID: 33439112
Little DJ, Ballo MT, Zagars GK, Pisters PW, Patel SR, El-Naggar AK, Garden AS, Benjamin RS
Cancer 2002 Jul 15;95(2):377-88. doi: 10.1002/cncr.10669. PMID: 12124838
Downing JR, Khandekar A, Shurtleff SA, Head DR, Parham DM, Webber BL, Pappo AS, Hulshof MG, Conn WP, Shapiro DN
Am J Pathol 1995 Mar;146(3):626-34. PMID: 7887445Free PMC Article

Recent clinical studies

Etiology

Mandong BM, Ngbea JA
Niger J Med 2011 Oct-Dec;20(4):466-9. PMID: 22288325
Parham DM, Ellison DA
Arch Pathol Lab Med 2006 Oct;130(10):1454-65. doi: 10.5858/2006-130-1454-RIAACA. PMID: 17090187
Parham DM
Mod Pathol 2001 May;14(5):506-14. doi: 10.1038/modpathol.3880339. PMID: 11353062
Kodet R, Newton WA Jr, Hamoudi AB, Asmar L, Jacobs DL, Maurer HM
Am J Surg Pathol 1993 May;17(5):443-53. doi: 10.1097/00000478-199305000-00002. PMID: 8470759
Bale PM, Reye RD
Pathology 1975 Apr;7(2):101-11. doi: 10.3109/00313027509092704. PMID: 1153222

Diagnosis

Ahuja M, Tomar R, Thakur S, Mallya V, Mandal S, Khurana N, Sarin YK
Indian J Pathol Microbiol 2022 Oct-Dec;65(4):864-868. doi: 10.4103/ijpm.ijpm_178_21. PMID: 36308195
Kohashi K, Kinoshita I, Oda Y
Head Neck Pathol 2020 Mar;14(1):12-20. Epub 2020 Jan 16 doi: 10.1007/s12105-019-01113-2. PMID: 31950473Free PMC Article
Parham DM, Ellison DA
Arch Pathol Lab Med 2006 Oct;130(10):1454-65. doi: 10.5858/2006-130-1454-RIAACA. PMID: 17090187
Tsokos M
Semin Diagn Pathol 1994 Feb;11(1):26-38. PMID: 8202644
Agamanolis DP, Dasu S, Krill CE Jr
Hum Pathol 1986 Aug;17(8):778-95. doi: 10.1016/s0046-8177(86)80198-8. PMID: 3525381

Therapy

Pondrom M, Bougeard G, Karanian M, Bonneau-Lagacherie J, Boulanger C, Boutroux H, Briandet C, Chevreau C, Corradini N, Coze C, Defachelles AS, Galmiche-Roland L, Orbach D, Piguet C, Scoazec JY, Vérité C, Willems M, Frebourg T, Minard V, Brugières L
Pediatr Blood Cancer 2020 Sep;67(9):e28486. Epub 2020 Jul 13 doi: 10.1002/pbc.28486. PMID: 32658383
Ricker CA, Crawford K, Matlock K, Lathara M, Seguin B, Rudzinski ER, Berlow NE, Keller C
Cold Spring Harb Mol Case Stud 2020 Apr;6(2) Epub 2020 Apr 1 doi: 10.1101/mcs.a005066. PMID: 32238403Free PMC Article
Caruso RA, Napoli P, Villari D, Starrantino M
Arch Gynecol Obstet 2004 Dec;270(4):278-80. Epub 2003 Aug 26 doi: 10.1007/s00404-003-0504-y. PMID: 12942264
Newton WA Jr, Soule EH, Hamoudi AB, Reiman HM, Shimada H, Beltangady M, Maurer H
J Clin Oncol 1988 Jan;6(1):67-75. doi: 10.1200/JCO.1988.6.1.67. PMID: 3275751

Prognosis

Tordecilla C J, Mosso Ch C, Franco S C, Díaz P E, Lobos R G
Andes Pediatr 2021 Jun;92(3):440-445. doi: 10.32641/andespediatr.v92i3.2613. PMID: 34479252
Ricker CA, Crawford K, Matlock K, Lathara M, Seguin B, Rudzinski ER, Berlow NE, Keller C
Cold Spring Harb Mol Case Stud 2020 Apr;6(2) Epub 2020 Apr 1 doi: 10.1101/mcs.a005066. PMID: 32238403Free PMC Article
Parham DM
Mod Pathol 2001 May;14(5):506-14. doi: 10.1038/modpathol.3880339. PMID: 11353062
Tsokos M
Semin Diagn Pathol 1994 Feb;11(1):26-38. PMID: 8202644
Agamanolis DP, Dasu S, Krill CE Jr
Hum Pathol 1986 Aug;17(8):778-95. doi: 10.1016/s0046-8177(86)80198-8. PMID: 3525381

Clinical prediction guides

Ahuja M, Tomar R, Thakur S, Mallya V, Mandal S, Khurana N, Sarin YK
Indian J Pathol Microbiol 2022 Oct-Dec;65(4):864-868. doi: 10.4103/ijpm.ijpm_178_21. PMID: 36308195
Parham DM, Giannikopoulos P
Pediatr Dev Pathol 2021 Mar-Apr;24(2):87-95. Epub 2021 Jan 13 doi: 10.1177/1093526620977720. PMID: 33439112
Kohashi K, Kinoshita I, Oda Y
Head Neck Pathol 2020 Mar;14(1):12-20. Epub 2020 Jan 16 doi: 10.1007/s12105-019-01113-2. PMID: 31950473Free PMC Article
Sultan I, Qaddoumi I, Yaser S, Rodriguez-Galindo C, Ferrari A
J Clin Oncol 2009 Jul 10;27(20):3391-7. Epub 2009 Apr 27 doi: 10.1200/JCO.2008.19.7483. PMID: 19398574
Newton WA Jr, Soule EH, Hamoudi AB, Reiman HM, Shimada H, Beltangady M, Maurer H
J Clin Oncol 1988 Jan;6(1):67-75. doi: 10.1200/JCO.1988.6.1.67. PMID: 3275751

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