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Colon Undifferentiated Carcinoma

MedGen UID:
76008
•Concept ID:
C0279643
•
Neoplastic Process
Synonyms: Carcinoma Simplex of the Colon.; Colon Anaplastic Carcinoma; Undifferentiated Carcinoma of Colon; Undifferentiated Carcinoma of the Colon; Undifferentiated Colonic Carcinoma

Definition

An invasive malignant epithelial tumor that arises from the colon. There is no morphologic, immunophenotypic, or molecular biological evidence of glandular or squamous differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon Undifferentiated Carcinoma

Professional guidelines

PubMed

Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Daly MB, Pal T, Berry MP, Buys SS, Dickson P, Domchek SM, Elkhanany A, Friedman S, Goggins M, Hutton ML; CGC, Karlan BY, Khan S, Klein C, Kohlmann W; CGC, Kurian AW, Laronga C, Litton JK, Mak JS; LCGC, Menendez CS, Merajver SD, Norquist BS, Offit K, Pederson HJ, Reiser G; CGC, Senter-Jamieson L; CGC, Shannon KM, Shatsky R, Visvanathan K, Weitzel JN, Wick MJ, Wisinski KB, Yurgelun MB, Darlow SD, Dwyer MA
J Natl Compr Canc Netw 2021 Jan 6;19(1):77-102. doi: 10.6004/jnccn.2021.0001. PMID: 33406487
Mucinous colorectal adenocarcinoma: clinical pathology and treatment options.
Luo C, Cen S, Ding G, Wu W
Cancer Commun (Lond) 2019 Mar 29;39(1):13. doi: 10.1186/s40880-019-0361-0. PMID: 30922401Free PMC Article
Pathophysiology, clinical presentation, and management of colon cancer.
Cappell MS
Gastroenterol Clin North Am 2008 Mar;37(1):1-24, v. doi: 10.1016/j.gtc.2007.12.002. PMID: 18313537

Recent clinical studies

Etiology

Development and Validation of a Deep Learning Algorithm to Differentiate Colon Carcinoma From Acute Diverticulitis in Computed Tomography Images.
Ziegelmayer S, Reischl S, Havrda H, Gawlitza J, Graf M, Lenhart N, Nehls N, Lemke T, Wilhelm D, Lohöfer F, Burian E, Neumann PA, Makowski M, Braren R
JAMA Netw Open 2023 Jan 3;6(1):e2253370. doi: 10.1001/jamanetworkopen.2022.53370. PMID: 36705919
Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer.
Tarazona N, Gimeno-Valiente F, Gambardella V, Zuñiga S, Rentero-Garrido P, Huerta M, Roselló S, Martinez-Ciarpaglini C, Carbonell-Asins JA, Carrasco F, Ferrer-Martínez A, Bruixola G, Fleitas T, Martín J, Tébar-Martínez R, Moro D, Castillo J, Espí A, Roda D, Cervantes A
Ann Oncol 2019 Nov 1;30(11):1804-1812. doi: 10.1093/annonc/mdz390. PMID: 31562764
Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Luo Y, Xie C, Brocker CN, Fan J, Wu X, Feng L, Wang Q, Zhao J, Lu D, Tandon M, Cam M, Krausz KW, Liu W, Gonzalez FJ
Gastroenterology 2019 Sep;157(3):744-759.e4. Epub 2019 May 30 doi: 10.1053/j.gastro.2019.05.057. PMID: 31154022Free PMC Article
Estrogen receptor beta as target for colorectal cancer prevention.
Williams C, DiLeo A, Niv Y, Gustafsson JÅ
Cancer Lett 2016 Mar 1;372(1):48-56. Epub 2015 Dec 18 doi: 10.1016/j.canlet.2015.12.009. PMID: 26708506Free PMC Article

Diagnosis

Colonic mucinous adenocarcinoma in a tufted deer: differential diagnosis and literature review.
Gonzalez-Astudillo V, Navarro MA, Moore J, Uzal FA
J Vet Diagn Invest 2022 Nov;34(6):983-989. Epub 2022 Sep 2 doi: 10.1177/10406387221123007. PMID: 36056527Free PMC Article
Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Segmental Polyposis.
Wu S, Yang J, Turner JR
Gastroenterology 2020 Dec;159(6):e1-e2. Epub 2020 Apr 20 doi: 10.1053/j.gastro.2020.04.022. PMID: 32325087
Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer.
Tarazona N, Gimeno-Valiente F, Gambardella V, Zuñiga S, Rentero-Garrido P, Huerta M, Roselló S, Martinez-Ciarpaglini C, Carbonell-Asins JA, Carrasco F, Ferrer-Martínez A, Bruixola G, Fleitas T, Martín J, Tébar-Martínez R, Moro D, Castillo J, Espí A, Roda D, Cervantes A
Ann Oncol 2019 Nov 1;30(11):1804-1812. doi: 10.1093/annonc/mdz390. PMID: 31562764
Estrogen receptor beta as target for colorectal cancer prevention.
Williams C, DiLeo A, Niv Y, Gustafsson JÅ
Cancer Lett 2016 Mar 1;372(1):48-56. Epub 2015 Dec 18 doi: 10.1016/j.canlet.2015.12.009. PMID: 26708506Free PMC Article

Therapy

Segmental Polyposis.
Wu S, Yang J, Turner JR
Gastroenterology 2020 Dec;159(6):e1-e2. Epub 2020 Apr 20 doi: 10.1053/j.gastro.2020.04.022. PMID: 32325087
Novel insight into the role of microbiota in colorectal surgery.
Bachmann R, Leonard D, Delzenne N, Kartheuser A, Cani PD
Gut 2017 Apr;66(4):738-749. Epub 2017 Feb 2 doi: 10.1136/gutjnl-2016-312569. PMID: 28153961
Estrogen receptor beta as target for colorectal cancer prevention.
Williams C, DiLeo A, Niv Y, Gustafsson JÅ
Cancer Lett 2016 Mar 1;372(1):48-56. Epub 2015 Dec 18 doi: 10.1016/j.canlet.2015.12.009. PMID: 26708506Free PMC Article
Robot-assisted laparoscopic colorectal surgery.
Alimoglu O, Atak I, Orhun K, Eren T
Minerva Chir 2013 Oct;68(5):471-8. PMID: 24101004
Esophagocoloplasty.
Gregorie HB Jr
Ann Surg 1972 May;175(5):740-51. doi: 10.1097/00000658-197205000-00014. PMID: 5028488Free PMC Article

Prognosis

hsa‑miR‑15a‑5p inhibits colon cell carcinoma via targeting CCND1.
Li Z, Zhu Z, Wang Y, Wang Y, Li W, Wang Z, Zhou X, Bao Y
Mol Med Rep 2021 Oct;24(4) Epub 2021 Aug 20 doi: 10.3892/mmr.2021.12375. PMID: 34414457Free PMC Article
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Histotype influences emergency presentation and prognosis in colon cancer surgery.
Sibio S, Di Giorgio A, D'Ugo S, Palmieri G, Cinelli L, Formica V, Sensi B, Bagaglini G, Di Carlo S, Bellato V, Sica GS
Langenbecks Arch Surg 2019 Nov;404(7):841-851. Epub 2019 Nov 23 doi: 10.1007/s00423-019-01826-6. PMID: 31760472
Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer.
Tarazona N, Gimeno-Valiente F, Gambardella V, Zuñiga S, Rentero-Garrido P, Huerta M, Roselló S, Martinez-Ciarpaglini C, Carbonell-Asins JA, Carrasco F, Ferrer-Martínez A, Bruixola G, Fleitas T, Martín J, Tébar-Martínez R, Moro D, Castillo J, Espí A, Roda D, Cervantes A
Ann Oncol 2019 Nov 1;30(11):1804-1812. doi: 10.1093/annonc/mdz390. PMID: 31562764
Colon cancer.
Labianca R, Beretta GD, Kildani B, Milesi L, Merlin F, Mosconi S, Pessi MA, Prochilo T, Quadri A, Gatta G, de Braud F, Wils J
Crit Rev Oncol Hematol 2010 May;74(2):106-33. doi: 10.1016/j.critrevonc.2010.01.010. PMID: 20138539

Clinical prediction guides

hsa‑miR‑15a‑5p inhibits colon cell carcinoma via targeting CCND1.
Li Z, Zhu Z, Wang Y, Wang Y, Li W, Wang Z, Zhou X, Bao Y
Mol Med Rep 2021 Oct;24(4) Epub 2021 Aug 20 doi: 10.3892/mmr.2021.12375. PMID: 34414457Free PMC Article
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer.
Tarazona N, Gimeno-Valiente F, Gambardella V, Zuñiga S, Rentero-Garrido P, Huerta M, Roselló S, Martinez-Ciarpaglini C, Carbonell-Asins JA, Carrasco F, Ferrer-Martínez A, Bruixola G, Fleitas T, Martín J, Tébar-Martínez R, Moro D, Castillo J, Espí A, Roda D, Cervantes A
Ann Oncol 2019 Nov 1;30(11):1804-1812. doi: 10.1093/annonc/mdz390. PMID: 31562764
Medullary carcinoma of the colon: can the undifferentiated be differentiated?
Fiehn AM, Grauslund M, Glenthøj A, Melchior LC, Vainer B, Willemoe GL
Virchows Arch 2015 Jan;466(1):13-20. Epub 2014 Oct 23 doi: 10.1007/s00428-014-1675-6. PMID: 25339302
Robot-assisted laparoscopic colorectal surgery.
Alimoglu O, Atak I, Orhun K, Eren T
Minerva Chir 2013 Oct;68(5):471-8. PMID: 24101004

Recent systematic reviews

The role of mir-151a-5p in tumorigenesis; A systematic review.
Ebrahimi A, Derakhshan SM, Ghavi D, Foruzandeh Z, Hashemi S
Pathol Res Pract 2023 Sep;249:154576. Epub 2023 Jun 1 doi: 10.1016/j.prp.2023.154576. PMID: 37562284
Effects and duration of exercise-based prehabilitation in surgical therapy of colon and rectal cancer: a systematic review and meta-analysis.
Falz R, Bischoff C, Thieme R, Lässing J, Mehdorn M, Stelzner S, Busse M, Gockel I
J Cancer Res Clin Oncol 2022 Sep;148(9):2187-2213. Epub 2022 Jun 13 doi: 10.1007/s00432-022-04088-w. PMID: 35695931Free PMC Article
Consumption of red meat and processed meat and cancer incidence: a systematic review and meta-analysis of prospective studies.
Farvid MS, Sidahmed E, Spence ND, Mante Angua K, Rosner BA, Barnett JB
Eur J Epidemiol 2021 Sep;36(9):937-951. Epub 2021 Aug 29 doi: 10.1007/s10654-021-00741-9. PMID: 34455534
Medullary carcinoma in the colorectum: a systematic review and meta-analysis.
Pyo JS, Sohn JH, Kang G
Hum Pathol 2016 Jul;53:91-6. Epub 2016 Mar 19 doi: 10.1016/j.humpath.2016.02.018. PMID: 27001432
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

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