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Colon Undifferentiated Carcinoma

MedGen UID:
76008
•Concept ID:
C0279643
•
Neoplastic Process
Synonyms: Carcinoma Simplex of the Colon.; Colon Anaplastic Carcinoma; Undifferentiated Carcinoma of Colon; Undifferentiated Carcinoma of the Colon; Undifferentiated Colonic Carcinoma

Definition

An invasive malignant epithelial tumor that arises from the colon. There is no morphologic, immunophenotypic, or molecular biological evidence of glandular or squamous differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon Undifferentiated Carcinoma

Professional guidelines

PubMed

Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia.
Crockett SD, Nagtegaal ID
Gastroenterology 2019 Oct;157(4):949-966.e4. Epub 2019 Jul 16 doi: 10.1053/j.gastro.2019.06.041. PMID: 31323292
Mucinous colorectal adenocarcinoma: clinical pathology and treatment options.
Luo C, Cen S, Ding G, Wu W
Cancer Commun (Lond) 2019 Mar 29;39(1):13. doi: 10.1186/s40880-019-0361-0. PMID: 30922401Free PMC Article
Pathophysiology, clinical presentation, and management of colon cancer.
Cappell MS
Gastroenterol Clin North Am 2008 Mar;37(1):1-24, v. doi: 10.1016/j.gtc.2007.12.002. PMID: 18313537

Recent clinical studies

Etiology

Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer.
Tarazona N, Gimeno-Valiente F, Gambardella V, Zuñiga S, Rentero-Garrido P, Huerta M, Roselló S, Martinez-Ciarpaglini C, Carbonell-Asins JA, Carrasco F, Ferrer-Martínez A, Bruixola G, Fleitas T, Martín J, Tébar-Martínez R, Moro D, Castillo J, Espí A, Roda D, Cervantes A
Ann Oncol 2019 Nov 1;30(11):1804-1812. doi: 10.1093/annonc/mdz390. PMID: 31562764
Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Luo Y, Xie C, Brocker CN, Fan J, Wu X, Feng L, Wang Q, Zhao J, Lu D, Tandon M, Cam M, Krausz KW, Liu W, Gonzalez FJ
Gastroenterology 2019 Sep;157(3):744-759.e4. Epub 2019 May 30 doi: 10.1053/j.gastro.2019.05.057. PMID: 31154022Free PMC Article
Neoplasia after ureterosigmoidostomy.
Azimuddin K, Khubchandani IT, Stasik JJ, Rosen L, Riether RD
Dis Colon Rectum 1999 Dec;42(12):1632-8. doi: 10.1007/BF02236220. PMID: 10613486

Diagnosis

Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Colon metastasis from hepatocellular carcinoma: a case report and literature review.
Yu YM, Cao YS, Wu Z, Huang R, Shen ZL
World J Surg Oncol 2020 Jul 28;18(1):189. doi: 10.1186/s12957-020-01960-2. PMID: 32723336Free PMC Article
Segmental Polyposis.
Wu S, Yang J, Turner JR
Gastroenterology 2020 Dec;159(6):e1-e2. Epub 2020 Apr 20 doi: 10.1053/j.gastro.2020.04.022. PMID: 32325087
Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer.
Tarazona N, Gimeno-Valiente F, Gambardella V, Zuñiga S, Rentero-Garrido P, Huerta M, Roselló S, Martinez-Ciarpaglini C, Carbonell-Asins JA, Carrasco F, Ferrer-Martínez A, Bruixola G, Fleitas T, Martín J, Tébar-Martínez R, Moro D, Castillo J, Espí A, Roda D, Cervantes A
Ann Oncol 2019 Nov 1;30(11):1804-1812. doi: 10.1093/annonc/mdz390. PMID: 31562764

Therapy

Asymmetric crypt fission in sessile serrated lesions.
Rubio CA, Schmidt PT
J Clin Pathol 2021 Nov;74(11):712-717. Epub 2020 Oct 12 doi: 10.1136/jclinpath-2020-207008. PMID: 33046564
Segmental Polyposis.
Wu S, Yang J, Turner JR
Gastroenterology 2020 Dec;159(6):e1-e2. Epub 2020 Apr 20 doi: 10.1053/j.gastro.2020.04.022. PMID: 32325087
Robot-assisted laparoscopic colorectal surgery.
Alimoglu O, Atak I, Orhun K, Eren T
Minerva Chir 2013 Oct;68(5):471-8. PMID: 24101004
Neoplasia after ureterosigmoidostomy.
Azimuddin K, Khubchandani IT, Stasik JJ, Rosen L, Riether RD
Dis Colon Rectum 1999 Dec;42(12):1632-8. doi: 10.1007/BF02236220. PMID: 10613486
Esophagocoloplasty.
Gregorie HB Jr
Ann Surg 1972 May;175(5):740-51. doi: 10.1097/00000658-197205000-00014. PMID: 5028488Free PMC Article

Prognosis

Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Histotype influences emergency presentation and prognosis in colon cancer surgery.
Sibio S, Di Giorgio A, D'Ugo S, Palmieri G, Cinelli L, Formica V, Sensi B, Bagaglini G, Di Carlo S, Bellato V, Sica GS
Langenbecks Arch Surg 2019 Nov;404(7):841-851. Epub 2019 Nov 23 doi: 10.1007/s00423-019-01826-6. PMID: 31760472
Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer.
Tarazona N, Gimeno-Valiente F, Gambardella V, Zuñiga S, Rentero-Garrido P, Huerta M, Roselló S, Martinez-Ciarpaglini C, Carbonell-Asins JA, Carrasco F, Ferrer-Martínez A, Bruixola G, Fleitas T, Martín J, Tébar-Martínez R, Moro D, Castillo J, Espí A, Roda D, Cervantes A
Ann Oncol 2019 Nov 1;30(11):1804-1812. doi: 10.1093/annonc/mdz390. PMID: 31562764
Colon cancer.
Labianca R, Beretta GD, Kildani B, Milesi L, Merlin F, Mosconi S, Pessi MA, Prochilo T, Quadri A, Gatta G, de Braud F, Wils J
Crit Rev Oncol Hematol 2010 May;74(2):106-33. doi: 10.1016/j.critrevonc.2010.01.010. PMID: 20138539
Neoplasia after ureterosigmoidostomy.
Azimuddin K, Khubchandani IT, Stasik JJ, Rosen L, Riether RD
Dis Colon Rectum 1999 Dec;42(12):1632-8. doi: 10.1007/BF02236220. PMID: 10613486

Clinical prediction guides

Colonic mucinous adenocarcinoma in a tufted deer: differential diagnosis and literature review.
Gonzalez-Astudillo V, Navarro MA, Moore J, Uzal FA
J Vet Diagn Invest 2022 Nov;34(6):983-989. Epub 2022 Sep 2 doi: 10.1177/10406387221123007. PMID: 36056527Free PMC Article
Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors.
Johncilla M, Yantiss RK
Surg Pathol Clin 2020 Sep;13(3):503-520. Epub 2020 Jul 9 doi: 10.1016/j.path.2020.05.008. PMID: 32773197
Targeted next-generation sequencing of circulating-tumor DNA for tracking minimal residual disease in localized colon cancer.
Tarazona N, Gimeno-Valiente F, Gambardella V, Zuñiga S, Rentero-Garrido P, Huerta M, Roselló S, Martinez-Ciarpaglini C, Carbonell-Asins JA, Carrasco F, Ferrer-Martínez A, Bruixola G, Fleitas T, Martín J, Tébar-Martínez R, Moro D, Castillo J, Espí A, Roda D, Cervantes A
Ann Oncol 2019 Nov 1;30(11):1804-1812. doi: 10.1093/annonc/mdz390. PMID: 31562764
Mini-probe ultrasonography for the staging of colon cancer: a systematic review and meta-analysis.
Gall TM, Markar SR, Jackson D, Haji A, Faiz O
Colorectal Dis 2014 Jan;16(1):O1-8. doi: 10.1111/codi.12445. PMID: 24119196
Robot-assisted laparoscopic colorectal surgery.
Alimoglu O, Atak I, Orhun K, Eren T
Minerva Chir 2013 Oct;68(5):471-8. PMID: 24101004

Recent systematic reviews

Effects and duration of exercise-based prehabilitation in surgical therapy of colon and rectal cancer: a systematic review and meta-analysis.
Falz R, Bischoff C, Thieme R, Lässing J, Mehdorn M, Stelzner S, Busse M, Gockel I
J Cancer Res Clin Oncol 2022 Sep;148(9):2187-2213. Epub 2022 Jun 13 doi: 10.1007/s00432-022-04088-w. PMID: 35695931Free PMC Article
Consumption of red meat and processed meat and cancer incidence: a systematic review and meta-analysis of prospective studies.
Farvid MS, Sidahmed E, Spence ND, Mante Angua K, Rosner BA, Barnett JB
Eur J Epidemiol 2021 Sep;36(9):937-951. Epub 2021 Aug 29 doi: 10.1007/s10654-021-00741-9. PMID: 34455534
Cryotherapy for liver metastases.
Bala MM, Riemsma RP, Wolff R, Pedziwiatr M, Mitus JW, Storman D, Swierz MJ, Kleijnen J
Cochrane Database Syst Rev 2019 Jul 10;7(7):CD009058. doi: 10.1002/14651858.CD009058.pub3. PMID: 31291464Free PMC Article
Vitamin D receptor polymorphisms and cancer.
Gandini S, Gnagnarella P, Serrano D, Pasquali E, Raimondi S
Adv Exp Med Biol 2014;810:69-105. doi: 10.1007/978-1-4939-0437-2_5. PMID: 25207361
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E
J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

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