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Squamous Cell Carcinoma of Unknown Primary

MedGen UID:
76067
Concept ID:
C0280097
Neoplastic Process
Synonyms: Epidermoid Carcinoma of Unknown Primary Origin; Squamous Cell Carcinoma of Occult Primary Site; Squamous Cell Carcinoma of Unknown Primary Origin

Definition

A squamous cell carcinoma which has metastasized to another anatomic site and the original site of growth has not been identified. [from NCI]

Professional guidelines

PubMed

Maghami E, Ismaila N, Alvarez A, Chernock R, Duvvuri U, Geiger J, Gross N, Haughey B, Paul D, Rodriguez C, Sher D, Stambuk HE, Waldron J, Witek M, Caudell J
J Clin Oncol 2020 Aug 1;38(22):2570-2596. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00275. PMID: 32324430
Martin JM, Galloway TJ
Surg Oncol Clin N Am 2015 Jul;24(3):579-91. Epub 2015 Apr 11 doi: 10.1016/j.soc.2015.03.007. PMID: 25979401
Galer CE, Kies MS
J Natl Compr Canc Netw 2008 Nov;6(10):1068-75. doi: 10.6004/jnccn.2008.0080. PMID: 19176202

Recent clinical studies

Etiology

Lee MY, Fowler N, Adelstein D, Koyfman S, Prendes B, Burkey BB
Anticancer Res 2020 Aug;40(8):4207-4214. doi: 10.21873/anticanres.14421. PMID: 32727746
Rassy E, Nicolai P, Pavlidis N
Head Neck 2019 Oct;41(10):3700-3711. Epub 2019 Jul 13 doi: 10.1002/hed.25858. PMID: 31301162
Liu Y
Oral Oncol 2019 May;92:46-51. Epub 2019 Mar 19 doi: 10.1016/j.oraloncology.2019.03.014. PMID: 31010622
Zhou MJ, van Zante A, Lazar AA, Groppo ER, Garsa AA, Ryan WR, El-Sayed IH, Eisele DW, Yom SS
Head Neck 2018 May;40(5):904-916. Epub 2017 Dec 6 doi: 10.1002/hed.25028. PMID: 29210145
Demiroz C, Vainshtein JM, Koukourakis GV, Gutfeld O, Prince ME, Bradford CR, Wolf GT, McLean S, Worden FP, Chepeha DB, Schipper MJ, McHugh JB
Head Neck 2014 Nov;36(11):1589-1595. Epub 2013 Nov 18 doi: 10.1002/hed.23479. PMID: 23996575Free PMC Article

Diagnosis

Fritz C, Ng JJ, Harris J, Romeo DJ, Prasad A, Moreira A, Rajasekaran K
Eur Arch Otorhinolaryngol 2023 Sep;280(9):4195-4204. Epub 2023 Apr 27 doi: 10.1007/s00405-023-07997-9. PMID: 37103581
Larsen MHH, Channir HI, von Buchwald C
Viruses 2021 Jul 2;13(7) doi: 10.3390/v13071297. PMID: 34372502Free PMC Article
Maghami E, Ismaila N, Alvarez A, Chernock R, Duvvuri U, Geiger J, Gross N, Haughey B, Paul D, Rodriguez C, Sher D, Stambuk HE, Waldron J, Witek M, Caudell J
J Clin Oncol 2020 Aug 1;38(22):2570-2596. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00275. PMID: 32324430
Rassy E, Nicolai P, Pavlidis N
Head Neck 2019 Oct;41(10):3700-3711. Epub 2019 Jul 13 doi: 10.1002/hed.25858. PMID: 31301162
Martin JM, Galloway TJ
Surg Oncol Clin N Am 2015 Jul;24(3):579-91. Epub 2015 Apr 11 doi: 10.1016/j.soc.2015.03.007. PMID: 25979401

Therapy

Holm AIS, Elstrøm UV, Nielsen SB, Jensen K
Acta Oncol 2023 Nov;62(11):1412-1417. Epub 2023 Nov 7 doi: 10.1080/0284186X.2023.2263156. PMID: 37815913
Fritz C, Ng JJ, Harris J, Romeo DJ, Prasad A, Moreira A, Rajasekaran K
Eur Arch Otorhinolaryngol 2023 Sep;280(9):4195-4204. Epub 2023 Apr 27 doi: 10.1007/s00405-023-07997-9. PMID: 37103581
Chen B, Zhang H, Liu D, Wang X, Ji B, Gao S
Nucl Med Commun 2021 May 1;42(5):523-527. doi: 10.1097/MNM.0000000000001365. PMID: 33481505
Maghami E, Ismaila N, Alvarez A, Chernock R, Duvvuri U, Geiger J, Gross N, Haughey B, Paul D, Rodriguez C, Sher D, Stambuk HE, Waldron J, Witek M, Caudell J
J Clin Oncol 2020 Aug 1;38(22):2570-2596. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00275. PMID: 32324430
Galer CE, Kies MS
J Natl Compr Canc Netw 2008 Nov;6(10):1068-75. doi: 10.6004/jnccn.2008.0080. PMID: 19176202

Prognosis

Lee MY, Fowler N, Adelstein D, Koyfman S, Prendes B, Burkey BB
Anticancer Res 2020 Aug;40(8):4207-4214. doi: 10.21873/anticanres.14421. PMID: 32727746
Maghami E, Ismaila N, Alvarez A, Chernock R, Duvvuri U, Geiger J, Gross N, Haughey B, Paul D, Rodriguez C, Sher D, Stambuk HE, Waldron J, Witek M, Caudell J
J Clin Oncol 2020 Aug 1;38(22):2570-2596. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00275. PMID: 32324430
Rassy E, Nicolai P, Pavlidis N
Head Neck 2019 Oct;41(10):3700-3711. Epub 2019 Jul 13 doi: 10.1002/hed.25858. PMID: 31301162
Zhou MJ, van Zante A, Lazar AA, Groppo ER, Garsa AA, Ryan WR, El-Sayed IH, Eisele DW, Yom SS
Head Neck 2018 May;40(5):904-916. Epub 2017 Dec 6 doi: 10.1002/hed.25028. PMID: 29210145
Martin JM, Galloway TJ
Surg Oncol Clin N Am 2015 Jul;24(3):579-91. Epub 2015 Apr 11 doi: 10.1016/j.soc.2015.03.007. PMID: 25979401

Clinical prediction guides

Fritz C, Ng JJ, Harris J, Romeo DJ, Prasad A, Moreira A, Rajasekaran K
Eur Arch Otorhinolaryngol 2023 Sep;280(9):4195-4204. Epub 2023 Apr 27 doi: 10.1007/s00405-023-07997-9. PMID: 37103581
Maghami E, Ismaila N, Alvarez A, Chernock R, Duvvuri U, Geiger J, Gross N, Haughey B, Paul D, Rodriguez C, Sher D, Stambuk HE, Waldron J, Witek M, Caudell J
J Clin Oncol 2020 Aug 1;38(22):2570-2596. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00275. PMID: 32324430
Molony P, Werner R, Martin C, Callanan D, Sheahan P, Heffron C, Feeley L
Head Neck Pathol 2020 Sep;14(3):606-615. Epub 2019 Sep 24 doi: 10.1007/s12105-019-01081-7. PMID: 31552619Free PMC Article
Strojan P, Kokalj M, Zadnik V, Aničin A, Plavc G, Didanović V, Šifrer R, Lanišnik B
Eur Arch Otorhinolaryngol 2016 Dec;273(12):4561-4569. Epub 2016 Jun 30 doi: 10.1007/s00405-016-4172-5. PMID: 27363402
Krane JF
Acta Cytol 2013;57(2):117-26. Epub 2013 Feb 28 doi: 10.1159/000346715. PMID: 23406782

Recent systematic reviews

Chen AM
Radiother Oncol 2023 Dec;189:109952. Epub 2023 Oct 14 doi: 10.1016/j.radonc.2023.109952. PMID: 37844736
Di Maio P, Iocca O, De Virgilio A, Giudice M, Pellini R, D'Ascanio L, Golusiński P, Ricci G, Spriano G
Laryngoscope 2020 Jul;130(7):1692-1700. Epub 2019 Nov 12 doi: 10.1002/lary.28350. PMID: 31714611
Di Maio P, Iocca O, De Virgilio A, Ferreli F, Cristalli G, Pellini R, Golusinski P, Ricci G, Spriano G
Head Neck 2019 Apr;41(4):1112-1121. Epub 2018 Dec 21 doi: 10.1002/hed.25522. PMID: 30575162
Fu TS, Foreman A, Goldstein DP, de Almeida JR
J Otolaryngol Head Neck Surg 2016 May 4;45(1):28. doi: 10.1186/s40463-016-0142-6. PMID: 27142355Free PMC Article
Boscolo-Rizzo P, Schroeder L, Romeo S, Pawlita M
Clin Exp Metastasis 2015 Dec;32(8):835-45. Epub 2015 Sep 10 doi: 10.1007/s10585-015-9744-z. PMID: 26358913

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