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Squamous Cell Carcinoma of Unknown Primary

MedGen UID:
76067
Concept ID:
C0280097
Neoplastic Process
Synonyms: Epidermoid Carcinoma of Unknown Primary Origin; Squamous Cell Carcinoma of Occult Primary Site; Squamous Cell Carcinoma of Unknown Primary Origin

Definition

A squamous cell carcinoma which has metastasized to another anatomic site and the original site of growth has not been identified. [from NCI]

Professional guidelines

PubMed

Chen AM
Radiother Oncol 2023 Dec;189:109952. Epub 2023 Oct 14 doi: 10.1016/j.radonc.2023.109952. PMID: 37844736
Maghami E, Ismaila N, Alvarez A, Chernock R, Duvvuri U, Geiger J, Gross N, Haughey B, Paul D, Rodriguez C, Sher D, Stambuk HE, Waldron J, Witek M, Caudell J
J Clin Oncol 2020 Aug 1;38(22):2570-2596. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00275. PMID: 32324430
Martin JM, Galloway TJ
Surg Oncol Clin N Am 2015 Jul;24(3):579-91. Epub 2015 Apr 11 doi: 10.1016/j.soc.2015.03.007. PMID: 25979401

Recent clinical studies

Etiology

Hardman JC, Constable J, Dobbs S, Hogan C, Hulse K, Khosla S, Milinis K, Tudor-Green B, Williamson A, Paleri V; INTEGRATE (The UK ENT Trainee Research Network)
Clin Otolaryngol 2024 Sep;49(5):604-620. Epub 2024 May 20 doi: 10.1111/coa.14167. PMID: 38766691
Hardman JC, Harrington K, O'Leary B, Robinson M, Paleri V
JAMA Otolaryngol Head Neck Surg 2024 Feb 1;150(2):118-126. doi: 10.1001/jamaoto.2023.3993. PMID: 38127339Free PMC Article
Lee MY, Fowler N, Adelstein D, Koyfman S, Prendes B, Burkey BB
Anticancer Res 2020 Aug;40(8):4207-4214. doi: 10.21873/anticanres.14421. PMID: 32727746
Rassy E, Nicolai P, Pavlidis N
Head Neck 2019 Oct;41(10):3700-3711. Epub 2019 Jul 13 doi: 10.1002/hed.25858. PMID: 31301162
Zhou MJ, van Zante A, Lazar AA, Groppo ER, Garsa AA, Ryan WR, El-Sayed IH, Eisele DW, Yom SS
Head Neck 2018 May;40(5):904-916. Epub 2017 Dec 6 doi: 10.1002/hed.25028. PMID: 29210145

Diagnosis

Manoharan M, Kalman NS, Rabinowits G
Oncologist 2024 Mar 4;29(3):192-199. doi: 10.1093/oncolo/oyad311. PMID: 37995312Free PMC Article
Larsen MHH, Channir HI, von Buchwald C
Viruses 2021 Jul 2;13(7) doi: 10.3390/v13071297. PMID: 34372502Free PMC Article
Maghami E, Ismaila N, Alvarez A, Chernock R, Duvvuri U, Geiger J, Gross N, Haughey B, Paul D, Rodriguez C, Sher D, Stambuk HE, Waldron J, Witek M, Caudell J
J Clin Oncol 2020 Aug 1;38(22):2570-2596. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00275. PMID: 32324430
Rassy E, Nicolai P, Pavlidis N
Head Neck 2019 Oct;41(10):3700-3711. Epub 2019 Jul 13 doi: 10.1002/hed.25858. PMID: 31301162
Martin JM, Galloway TJ
Surg Oncol Clin N Am 2015 Jul;24(3):579-91. Epub 2015 Apr 11 doi: 10.1016/j.soc.2015.03.007. PMID: 25979401

Therapy

Thomas R, Kelemen N, Molena E, Lester S
Clin Otolaryngol 2024 Sep;49(5):552-566. Epub 2024 May 22 doi: 10.1111/coa.14168. PMID: 38773941
Bowe CM, Garg M
Clin Otolaryngol 2024 Sep;49(5):531-537. Epub 2024 Apr 25 doi: 10.1111/coa.14157. PMID: 38664927
Fritz C, Ng JJ, Harris J, Romeo DJ, Prasad A, Moreira A, Rajasekaran K
Eur Arch Otorhinolaryngol 2023 Sep;280(9):4195-4204. Epub 2023 Apr 27 doi: 10.1007/s00405-023-07997-9. PMID: 37103581
Maghami E, Ismaila N, Alvarez A, Chernock R, Duvvuri U, Geiger J, Gross N, Haughey B, Paul D, Rodriguez C, Sher D, Stambuk HE, Waldron J, Witek M, Caudell J
J Clin Oncol 2020 Aug 1;38(22):2570-2596. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00275. PMID: 32324430
Galer CE, Kies MS
J Natl Compr Canc Netw 2008 Nov;6(10):1068-75. doi: 10.6004/jnccn.2008.0080. PMID: 19176202

Prognosis

Hardman JC, Constable J, Dobbs S, Hogan C, Hulse K, Khosla S, Milinis K, Tudor-Green B, Williamson A, Paleri V; INTEGRATE (The UK ENT Trainee Research Network)
Clin Otolaryngol 2024 Sep;49(5):604-620. Epub 2024 May 20 doi: 10.1111/coa.14167. PMID: 38766691
Meng W, Gao Y, Pan L, Zhao G, Chen Q, Bai L, Zheng R
Medicine (Baltimore) 2024 Jan 26;103(4):e37057. doi: 10.1097/MD.0000000000037057. PMID: 38277516Free PMC Article
Maghami E, Ismaila N, Alvarez A, Chernock R, Duvvuri U, Geiger J, Gross N, Haughey B, Paul D, Rodriguez C, Sher D, Stambuk HE, Waldron J, Witek M, Caudell J
J Clin Oncol 2020 Aug 1;38(22):2570-2596. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00275. PMID: 32324430
Rassy E, Nicolai P, Pavlidis N
Head Neck 2019 Oct;41(10):3700-3711. Epub 2019 Jul 13 doi: 10.1002/hed.25858. PMID: 31301162
Martin JM, Galloway TJ
Surg Oncol Clin N Am 2015 Jul;24(3):579-91. Epub 2015 Apr 11 doi: 10.1016/j.soc.2015.03.007. PMID: 25979401

Clinical prediction guides

Hardman JC, Constable J, Dobbs S, Hogan C, Hulse K, Khosla S, Milinis K, Tudor-Green B, Williamson A, Paleri V; INTEGRATE (The UK ENT Trainee Research Network)
Clin Otolaryngol 2024 Sep;49(5):604-620. Epub 2024 May 20 doi: 10.1111/coa.14167. PMID: 38766691
Fritz C, Ng JJ, Harris J, Romeo DJ, Prasad A, Moreira A, Rajasekaran K
Eur Arch Otorhinolaryngol 2023 Sep;280(9):4195-4204. Epub 2023 Apr 27 doi: 10.1007/s00405-023-07997-9. PMID: 37103581
Maghami E, Ismaila N, Alvarez A, Chernock R, Duvvuri U, Geiger J, Gross N, Haughey B, Paul D, Rodriguez C, Sher D, Stambuk HE, Waldron J, Witek M, Caudell J
J Clin Oncol 2020 Aug 1;38(22):2570-2596. Epub 2020 Apr 23 doi: 10.1200/JCO.20.00275. PMID: 32324430
Strojan P, Kokalj M, Zadnik V, Aničin A, Plavc G, Didanović V, Šifrer R, Lanišnik B
Eur Arch Otorhinolaryngol 2016 Dec;273(12):4561-4569. Epub 2016 Jun 30 doi: 10.1007/s00405-016-4172-5. PMID: 27363402
Krane JF
Acta Cytol 2013;57(2):117-26. Epub 2013 Feb 28 doi: 10.1159/000346715. PMID: 23406782

Recent systematic reviews

Thomas R, Kelemen N, Molena E, Lester S
Clin Otolaryngol 2024 Sep;49(5):552-566. Epub 2024 May 22 doi: 10.1111/coa.14168. PMID: 38773941
Bowe CM, Garg M
Clin Otolaryngol 2024 Sep;49(5):531-537. Epub 2024 Apr 25 doi: 10.1111/coa.14157. PMID: 38664927
Chen AM
Radiother Oncol 2023 Dec;189:109952. Epub 2023 Oct 14 doi: 10.1016/j.radonc.2023.109952. PMID: 37844736
Fu TS, Foreman A, Goldstein DP, de Almeida JR
J Otolaryngol Head Neck Surg 2016 May 4;45(1):28. doi: 10.1186/s40463-016-0142-6. PMID: 27142355Free PMC Article
Boscolo-Rizzo P, Schroeder L, Romeo S, Pawlita M
Clin Exp Metastasis 2015 Dec;32(8):835-45. Epub 2015 Sep 10 doi: 10.1007/s10585-015-9744-z. PMID: 26358913

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