U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Locally Advanced Squamous Cell Carcinoma of Unknown Primary

MedGen UID:
1710496
Concept ID:
C5237211
Neoplastic Process

Definition

A squamous cell carcinoma of unknown primary that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Squamous Cell Carcinoma of Unknown Primary

Professional guidelines

PubMed

Fang R, Wang S, Liu Y, Xu J
Adv Ther 2023 Mar;40(3):1019-1030. Epub 2023 Jan 9 doi: 10.1007/s12325-022-02402-z. PMID: 36622553
Hohenstein NA, Chan JW, Wu SY, Tahir P, Yom SS
PET Clin 2020 Jan;15(1):65-75. doi: 10.1016/j.cpet.2019.08.010. PMID: 31735303
Hung YH, Liu SA, Wang CC, Wang CP, Jiang RS, Wu SH
PLoS One 2018;13(10):e0205365. Epub 2018 Oct 18 doi: 10.1371/journal.pone.0205365. PMID: 30335795Free PMC Article

Recent clinical studies

Etiology

Lu S, Wu L, Jian H, Chen Y, Wang Q, Fang J, Wang Z, Hu Y, Sun M, Han L, Miao L, Ding C, Cui J, Li B, Pan Y, Li X, Ye F, Liu A, Wang K, Cang S, Zhou H, Sun X, Ferry D, Lin Y, Wang S, Zhang W, Zhang C
Lancet Oncol 2022 Sep;23(9):1167-1179. Epub 2022 Jul 28 doi: 10.1016/S1470-2045(22)00382-5. PMID: 35908558
Kiyota N, Tahara M, Mizusawa J, Kodaira T, Fujii H, Yamazaki T, Mitani H, Iwae S, Fujimoto Y, Onozawa Y, Hanai N, Ogawa T, Hara H, Monden N, Shimura E, Minami S, Fujii T, Tanaka K, Homma A, Yoshimoto S, Oridate N, Omori K, Ueda T, Okami K, Ota I, Shiga K, Sugasawa M, Asakage T, Saito Y, Murono S, Nishimura Y, Nakamura K, Hayashi R; Head and Neck Cancer Study Group of the Japan Clinical Oncology Group (JCOG-HNCSG)
J Clin Oncol 2022 Jun 20;40(18):1980-1990. Epub 2022 Mar 1 doi: 10.1200/JCO.21.01293. PMID: 35230884Free PMC Article
Gruhl JD, Garrido-Laguna I, Francis SR, Affolter K, Tao R, Lloyd S
Cancer Med 2020 Mar;9(5):1703-1711. Epub 2020 Jan 16 doi: 10.1002/cam4.2851. PMID: 31945808Free PMC Article
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Hung YH, Liu SA, Wang CC, Wang CP, Jiang RS, Wu SH
PLoS One 2018;13(10):e0205365. Epub 2018 Oct 18 doi: 10.1371/journal.pone.0205365. PMID: 30335795Free PMC Article

Diagnosis

Luo J, Sanchez M, Lee E, Hertzler H, Luong N, Mazzola E, Finstein B, Tamen R, Brisbane G, Nguyen T, Paik PK, Chaft JE, Cheng ML, Khalil H, Piha-Paul SA, Sholl LM, Nishino M, Jänne PA, DuBois SG, Hanna GJ, Shapiro GI, French CA
J Thorac Oncol 2024 May;19(5):829-838. Epub 2023 Dec 27 doi: 10.1016/j.jtho.2023.12.022. PMID: 38154515Free PMC Article
Kometani M, Yoneda T, Maeda Y, Ohtsubo K, Yamazaki Y, Ikeda H, Mori S, Aono D, Karashima S, Usukura M, Sasano H, Takeda Y
Endocr J 2021 Oct 28;68(10):1209-1215. Epub 2021 May 18 doi: 10.1507/endocrj.EJ21-0141. PMID: 34011784
Gruhl JD, Garrido-Laguna I, Francis SR, Affolter K, Tao R, Lloyd S
Cancer Med 2020 Mar;9(5):1703-1711. Epub 2020 Jan 16 doi: 10.1002/cam4.2851. PMID: 31945808Free PMC Article
Hohenstein NA, Chan JW, Wu SY, Tahir P, Yom SS
PET Clin 2020 Jan;15(1):65-75. doi: 10.1016/j.cpet.2019.08.010. PMID: 31735303
Edafe O, Hughes B, Tsirevelou P, Goswamy J, Kumar R
Surgeon 2020 Feb;18(1):44-48. Epub 2019 Apr 28 doi: 10.1016/j.surge.2019.03.006. PMID: 31040083

Therapy

Luo J, Sanchez M, Lee E, Hertzler H, Luong N, Mazzola E, Finstein B, Tamen R, Brisbane G, Nguyen T, Paik PK, Chaft JE, Cheng ML, Khalil H, Piha-Paul SA, Sholl LM, Nishino M, Jänne PA, DuBois SG, Hanna GJ, Shapiro GI, French CA
J Thorac Oncol 2024 May;19(5):829-838. Epub 2023 Dec 27 doi: 10.1016/j.jtho.2023.12.022. PMID: 38154515Free PMC Article
Lu S, Wu L, Jian H, Chen Y, Wang Q, Fang J, Wang Z, Hu Y, Sun M, Han L, Miao L, Ding C, Cui J, Li B, Pan Y, Li X, Ye F, Liu A, Wang K, Cang S, Zhou H, Sun X, Ferry D, Lin Y, Wang S, Zhang W, Zhang C
Lancet Oncol 2022 Sep;23(9):1167-1179. Epub 2022 Jul 28 doi: 10.1016/S1470-2045(22)00382-5. PMID: 35908558
Kiyota N, Tahara M, Mizusawa J, Kodaira T, Fujii H, Yamazaki T, Mitani H, Iwae S, Fujimoto Y, Onozawa Y, Hanai N, Ogawa T, Hara H, Monden N, Shimura E, Minami S, Fujii T, Tanaka K, Homma A, Yoshimoto S, Oridate N, Omori K, Ueda T, Okami K, Ota I, Shiga K, Sugasawa M, Asakage T, Saito Y, Murono S, Nishimura Y, Nakamura K, Hayashi R; Head and Neck Cancer Study Group of the Japan Clinical Oncology Group (JCOG-HNCSG)
J Clin Oncol 2022 Jun 20;40(18):1980-1990. Epub 2022 Mar 1 doi: 10.1200/JCO.21.01293. PMID: 35230884Free PMC Article
Ai D, Ye J, Wei S, Li Y, Luo H, Cao J, Zhu Z, Zhao W, Lin Q, Yang H, Zheng X, Zhou J, Huang G, Li L, Li J, Zhang Z, Zhou G, Gu D, Du M, Mo M, Jia H, Zhang Z, Zhao K
JAMA Netw Open 2022 Feb 1;5(2):e220120. doi: 10.1001/jamanetworkopen.2022.0120. PMID: 35188552Free PMC Article
Yamamoto S, Kato K, Daiko H, Kojima T, Hara H, Abe T, Tsubosa Y, Nagashima K, Aoki K, Mizoguchi Y, Kitano S, Yachida S, Shiba S, Kitagawa Y
Future Oncol 2020 Jul;16(19):1351-1357. Epub 2020 May 12 doi: 10.2217/fon-2020-0189. PMID: 32396014

Prognosis

Luo J, Sanchez M, Lee E, Hertzler H, Luong N, Mazzola E, Finstein B, Tamen R, Brisbane G, Nguyen T, Paik PK, Chaft JE, Cheng ML, Khalil H, Piha-Paul SA, Sholl LM, Nishino M, Jänne PA, DuBois SG, Hanna GJ, Shapiro GI, French CA
J Thorac Oncol 2024 May;19(5):829-838. Epub 2023 Dec 27 doi: 10.1016/j.jtho.2023.12.022. PMID: 38154515Free PMC Article
Gruhl JD, Garrido-Laguna I, Francis SR, Affolter K, Tao R, Lloyd S
Cancer Med 2020 Mar;9(5):1703-1711. Epub 2020 Jan 16 doi: 10.1002/cam4.2851. PMID: 31945808Free PMC Article
Edafe O, Hughes B, Tsirevelou P, Goswamy J, Kumar R
Surgeon 2020 Feb;18(1):44-48. Epub 2019 Apr 28 doi: 10.1016/j.surge.2019.03.006. PMID: 31040083
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Hung YH, Liu SA, Wang CC, Wang CP, Jiang RS, Wu SH
PLoS One 2018;13(10):e0205365. Epub 2018 Oct 18 doi: 10.1371/journal.pone.0205365. PMID: 30335795Free PMC Article

Clinical prediction guides

Nilsson K, Klevebro F, Sunde B, Rouvelas I, Lindblad M, Szabo E, Halldestam I, Smedh U, Wallner B, Johansson J, Johnsen G, Aahlin EK, Johannessen HO, Alexandersson von Döbeln G, Hjortland GO, Wang N, Shang Y, Borg D, Quaas A, Bartella I, Bruns C, Schröder W, Nilsson M
Ann Oncol 2023 Nov;34(11):1015-1024. Epub 2023 Aug 30 doi: 10.1016/j.annonc.2023.08.010. PMID: 37657554
Cho WK, Roh JL, Cho KJ, Choi SH, Nam SY, Kim SY
J Cancer Res Clin Oncol 2020 Apr;146(4):925-933. Epub 2019 Dec 19 doi: 10.1007/s00432-019-03111-x. PMID: 31858242
Edafe O, Hughes B, Tsirevelou P, Goswamy J, Kumar R
Surgeon 2020 Feb;18(1):44-48. Epub 2019 Apr 28 doi: 10.1016/j.surge.2019.03.006. PMID: 31040083
Alsidawi S, Price KA, Chintakuntlawar AV, Westin GF, Garcia JJ, Ma DJ, Okuno SH
Oral Oncol 2017 Sep;72:104-109. Epub 2017 Jul 17 doi: 10.1016/j.oraloncology.2017.07.010. PMID: 28797445
Ravenda PS, Magni E, Botteri E, Manzotti M, Barberis M, Vacirca D, Trovato CM, Dell'Acqua V, Leonardi MC, Sideri M, Fazio N, Zampino MG
Cancer Chemother Pharmacol 2014 Nov;74(5):1033-8. Epub 2014 Sep 11 doi: 10.1007/s00280-014-2582-x. PMID: 25209946

Recent systematic reviews

Hohenstein NA, Chan JW, Wu SY, Tahir P, Yom SS
PET Clin 2020 Jan;15(1):65-75. doi: 10.1016/j.cpet.2019.08.010. PMID: 31735303
Edafe O, Hughes B, Tsirevelou P, Goswamy J, Kumar R
Surgeon 2020 Feb;18(1):44-48. Epub 2019 Apr 28 doi: 10.1016/j.surge.2019.03.006. PMID: 31040083

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...