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Locally Advanced Squamous Cell Carcinoma of Unknown Primary

MedGen UID:
1710496
•Concept ID:
C5237211
•
Neoplastic Process

Definition

A squamous cell carcinoma of unknown primary that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Squamous Cell Carcinoma of Unknown Primary

Professional guidelines

PubMed

Diagnosis, Staging, Radiation Treatment Response Assessment, and Outcome Prognostication of Head and Neck Cancers Using PET Imaging: A Systematic Review.
Hohenstein NA, Chan JW, Wu SY, Tahir P, Yom SS
PET Clin 2020 Jan;15(1):65-75. doi: 10.1016/j.cpet.2019.08.010. PMID: 31735303
Treatment outcomes of unknown primary squamous cell carcinoma of the head and neck.
Hung YH, Liu SA, Wang CC, Wang CP, Jiang RS, Wu SH
PLoS One 2018;13(10):e0205365. Epub 2018 Oct 18 doi: 10.1371/journal.pone.0205365. PMID: 30335795Free PMC Article
The SPECTRUM of findings in treatment options for recurrent/metastatic head and neck cancer.
Misiukiewicz K, Posner M
J Comp Eff Res 2013 Nov;2(6):533-5. doi: 10.2217/cer.13.72. PMID: 24236791

Recent clinical studies

Etiology

Oncological outcomes of standard versus prolonged time to surgery after neoadjuvant chemoradiotherapy for oesophageal cancer in the multicentre, randomised, controlled NeoRes II trial.
Nilsson K, Klevebro F, Sunde B, Rouvelas I, Lindblad M, Szabo E, Halldestam I, Smedh U, Wallner B, Johansson J, Johnsen G, Aahlin EK, Johannessen HO, Alexandersson von Döbeln G, Hjortland GO, Wang N, Shang Y, Borg D, Quaas A, Bartella I, Bruns C, Schröder W, Nilsson M
Ann Oncol 2023 Nov;34(11):1015-1024. Epub 2023 Aug 30 doi: 10.1016/j.annonc.2023.08.010. PMID: 37657554
Sintilimab plus bevacizumab biosimilar IBI305 and chemotherapy for patients with EGFR-mutated non-squamous non-small-cell lung cancer who progressed on EGFR tyrosine-kinase inhibitor therapy (ORIENT-31): first interim results from a randomised, double-blind, multicentre, phase 3 trial.
Lu S, Wu L, Jian H, Chen Y, Wang Q, Fang J, Wang Z, Hu Y, Sun M, Han L, Miao L, Ding C, Cui J, Li B, Pan Y, Li X, Ye F, Liu A, Wang K, Cang S, Zhou H, Sun X, Ferry D, Lin Y, Wang S, Zhang W, Zhang C
Lancet Oncol 2022 Sep;23(9):1167-1179. Epub 2022 Jul 28 doi: 10.1016/S1470-2045(22)00382-5. PMID: 35908558
Weekly Cisplatin Plus Radiation for Postoperative Head and Neck Cancer (JCOG1008): A Multicenter, Noninferiority, Phase II/III Randomized Controlled Trial.
Kiyota N, Tahara M, Mizusawa J, Kodaira T, Fujii H, Yamazaki T, Mitani H, Iwae S, Fujimoto Y, Onozawa Y, Hanai N, Ogawa T, Hara H, Monden N, Shimura E, Minami S, Fujii T, Tanaka K, Homma A, Yoshimoto S, Oridate N, Omori K, Ueda T, Okami K, Ota I, Shiga K, Sugasawa M, Asakage T, Saito Y, Murono S, Nishimura Y, Nakamura K, Hayashi R; Head and Neck Cancer Study Group of the Japan Clinical Oncology Group (JCOG-HNCSG)
J Clin Oncol 2022 Jun 20;40(18):1980-1990. Epub 2022 Mar 1 doi: 10.1200/JCO.21.01293. PMID: 35230884Free PMC Article
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Treatment outcomes of unknown primary squamous cell carcinoma of the head and neck.
Hung YH, Liu SA, Wang CC, Wang CP, Jiang RS, Wu SH
PLoS One 2018;13(10):e0205365. Epub 2018 Oct 18 doi: 10.1371/journal.pone.0205365. PMID: 30335795Free PMC Article

Diagnosis

The impact of squamous cell carcinoma histology on outcomes in nonmetastatic pancreatic cancer.
Gruhl JD, Garrido-Laguna I, Francis SR, Affolter K, Tao R, Lloyd S
Cancer Med 2020 Mar;9(5):1703-1711. Epub 2020 Jan 16 doi: 10.1002/cam4.2851. PMID: 31945808Free PMC Article
Understanding primary parotid squamous cell carcinoma - A systematic review.
Edafe O, Hughes B, Tsirevelou P, Goswamy J, Kumar R
Surgeon 2020 Feb;18(1):44-48. Epub 2019 Apr 28 doi: 10.1016/j.surge.2019.03.006. PMID: 31040083
Setting the stage: Contemporary staging of non-melanomatous skin cancer and implementation of the new American Joint Committee on cancer eighth edition staging manual.
Casswell G, Cavanagh K, Ravi Kumar AS, Giddings C, McDowell L
Oral Oncol 2019 Nov;98:102-108. Epub 2019 Sep 28 doi: 10.1016/j.oraloncology.2019.09.020. PMID: 31574414
Prognostic value of human papillomavirus in anal squamous cell carcinoma.
Ravenda PS, Magni E, Botteri E, Manzotti M, Barberis M, Vacirca D, Trovato CM, Dell'Acqua V, Leonardi MC, Sideri M, Fazio N, Zampino MG
Cancer Chemother Pharmacol 2014 Nov;74(5):1033-8. Epub 2014 Sep 11 doi: 10.1007/s00280-014-2582-x. PMID: 25209946
Role of positron emission tomography--computed tomography in head and neck cancer.
Cashman EC, MacMahon PJ, Shelly MJ, Kavanagh EC
Ann Otol Rhinol Laryngol 2011 Sep;120(9):593-602. doi: 10.1177/000348941112000907. PMID: 22032073

Therapy

Oncological outcomes of standard versus prolonged time to surgery after neoadjuvant chemoradiotherapy for oesophageal cancer in the multicentre, randomised, controlled NeoRes II trial.
Nilsson K, Klevebro F, Sunde B, Rouvelas I, Lindblad M, Szabo E, Halldestam I, Smedh U, Wallner B, Johansson J, Johnsen G, Aahlin EK, Johannessen HO, Alexandersson von Döbeln G, Hjortland GO, Wang N, Shang Y, Borg D, Quaas A, Bartella I, Bruns C, Schröder W, Nilsson M
Ann Oncol 2023 Nov;34(11):1015-1024. Epub 2023 Aug 30 doi: 10.1016/j.annonc.2023.08.010. PMID: 37657554
Sintilimab plus bevacizumab biosimilar IBI305 and chemotherapy for patients with EGFR-mutated non-squamous non-small-cell lung cancer who progressed on EGFR tyrosine-kinase inhibitor therapy (ORIENT-31): first interim results from a randomised, double-blind, multicentre, phase 3 trial.
Lu S, Wu L, Jian H, Chen Y, Wang Q, Fang J, Wang Z, Hu Y, Sun M, Han L, Miao L, Ding C, Cui J, Li B, Pan Y, Li X, Ye F, Liu A, Wang K, Cang S, Zhou H, Sun X, Ferry D, Lin Y, Wang S, Zhang W, Zhang C
Lancet Oncol 2022 Sep;23(9):1167-1179. Epub 2022 Jul 28 doi: 10.1016/S1470-2045(22)00382-5. PMID: 35908558
Weekly Cisplatin Plus Radiation for Postoperative Head and Neck Cancer (JCOG1008): A Multicenter, Noninferiority, Phase II/III Randomized Controlled Trial.
Kiyota N, Tahara M, Mizusawa J, Kodaira T, Fujii H, Yamazaki T, Mitani H, Iwae S, Fujimoto Y, Onozawa Y, Hanai N, Ogawa T, Hara H, Monden N, Shimura E, Minami S, Fujii T, Tanaka K, Homma A, Yoshimoto S, Oridate N, Omori K, Ueda T, Okami K, Ota I, Shiga K, Sugasawa M, Asakage T, Saito Y, Murono S, Nishimura Y, Nakamura K, Hayashi R; Head and Neck Cancer Study Group of the Japan Clinical Oncology Group (JCOG-HNCSG)
J Clin Oncol 2022 Jun 20;40(18):1980-1990. Epub 2022 Mar 1 doi: 10.1200/JCO.21.01293. PMID: 35230884Free PMC Article
Comparison of 3 Paclitaxel-Based Chemoradiotherapy Regimens for Patients With Locally Advanced Esophageal Squamous Cell Cancer: A Randomized Clinical Trial.
Ai D, Ye J, Wei S, Li Y, Luo H, Cao J, Zhu Z, Zhao W, Lin Q, Yang H, Zheng X, Zhou J, Huang G, Li L, Li J, Zhang Z, Zhou G, Gu D, Du M, Mo M, Jia H, Zhang Z, Zhao K
JAMA Netw Open 2022 Feb 1;5(2):e220120. doi: 10.1001/jamanetworkopen.2022.0120. PMID: 35188552Free PMC Article
Feasibility study of nivolumab as neoadjuvant chemotherapy for locally esophageal carcinoma: FRONTiER (JCOG1804E).
Yamamoto S, Kato K, Daiko H, Kojima T, Hara H, Abe T, Tsubosa Y, Nagashima K, Aoki K, Mizoguchi Y, Kitano S, Yachida S, Shiba S, Kitagawa Y
Future Oncol 2020 Jul;16(19):1351-1357. Epub 2020 May 12 doi: 10.2217/fon-2020-0189. PMID: 32396014

Prognosis

Comparison of 3 Paclitaxel-Based Chemoradiotherapy Regimens for Patients With Locally Advanced Esophageal Squamous Cell Cancer: A Randomized Clinical Trial.
Ai D, Ye J, Wei S, Li Y, Luo H, Cao J, Zhu Z, Zhao W, Lin Q, Yang H, Zheng X, Zhou J, Huang G, Li L, Li J, Zhang Z, Zhou G, Gu D, Du M, Mo M, Jia H, Zhang Z, Zhao K
JAMA Netw Open 2022 Feb 1;5(2):e220120. doi: 10.1001/jamanetworkopen.2022.0120. PMID: 35188552Free PMC Article
The impact of squamous cell carcinoma histology on outcomes in nonmetastatic pancreatic cancer.
Gruhl JD, Garrido-Laguna I, Francis SR, Affolter K, Tao R, Lloyd S
Cancer Med 2020 Mar;9(5):1703-1711. Epub 2020 Jan 16 doi: 10.1002/cam4.2851. PMID: 31945808Free PMC Article
Understanding primary parotid squamous cell carcinoma - A systematic review.
Edafe O, Hughes B, Tsirevelou P, Goswamy J, Kumar R
Surgeon 2020 Feb;18(1):44-48. Epub 2019 Apr 28 doi: 10.1016/j.surge.2019.03.006. PMID: 31040083
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Treatment outcomes of unknown primary squamous cell carcinoma of the head and neck.
Hung YH, Liu SA, Wang CC, Wang CP, Jiang RS, Wu SH
PLoS One 2018;13(10):e0205365. Epub 2018 Oct 18 doi: 10.1371/journal.pone.0205365. PMID: 30335795Free PMC Article

Clinical prediction guides

Oncological outcomes of standard versus prolonged time to surgery after neoadjuvant chemoradiotherapy for oesophageal cancer in the multicentre, randomised, controlled NeoRes II trial.
Nilsson K, Klevebro F, Sunde B, Rouvelas I, Lindblad M, Szabo E, Halldestam I, Smedh U, Wallner B, Johansson J, Johnsen G, Aahlin EK, Johannessen HO, Alexandersson von Döbeln G, Hjortland GO, Wang N, Shang Y, Borg D, Quaas A, Bartella I, Bruns C, Schröder W, Nilsson M
Ann Oncol 2023 Nov;34(11):1015-1024. Epub 2023 Aug 30 doi: 10.1016/j.annonc.2023.08.010. PMID: 37657554
Predictors of survival and recurrence after primary surgery for cervical metastasis of unknown primary.
Cho WK, Roh JL, Cho KJ, Choi SH, Nam SY, Kim SY
J Cancer Res Clin Oncol 2020 Apr;146(4):925-933. Epub 2019 Dec 19 doi: 10.1007/s00432-019-03111-x. PMID: 31858242
Understanding primary parotid squamous cell carcinoma - A systematic review.
Edafe O, Hughes B, Tsirevelou P, Goswamy J, Kumar R
Surgeon 2020 Feb;18(1):44-48. Epub 2019 Apr 28 doi: 10.1016/j.surge.2019.03.006. PMID: 31040083
Characteristics and long-term outcomes of head and neck squamous cell carcinoma after solid organ transplantation.
Alsidawi S, Price KA, Chintakuntlawar AV, Westin GF, Garcia JJ, Ma DJ, Okuno SH
Oral Oncol 2017 Sep;72:104-109. Epub 2017 Jul 17 doi: 10.1016/j.oraloncology.2017.07.010. PMID: 28797445
Prognostic value of human papillomavirus in anal squamous cell carcinoma.
Ravenda PS, Magni E, Botteri E, Manzotti M, Barberis M, Vacirca D, Trovato CM, Dell'Acqua V, Leonardi MC, Sideri M, Fazio N, Zampino MG
Cancer Chemother Pharmacol 2014 Nov;74(5):1033-8. Epub 2014 Sep 11 doi: 10.1007/s00280-014-2582-x. PMID: 25209946

Recent systematic reviews

Diagnosis, Staging, Radiation Treatment Response Assessment, and Outcome Prognostication of Head and Neck Cancers Using PET Imaging: A Systematic Review.
Hohenstein NA, Chan JW, Wu SY, Tahir P, Yom SS
PET Clin 2020 Jan;15(1):65-75. doi: 10.1016/j.cpet.2019.08.010. PMID: 31735303
Understanding primary parotid squamous cell carcinoma - A systematic review.
Edafe O, Hughes B, Tsirevelou P, Goswamy J, Kumar R
Surgeon 2020 Feb;18(1):44-48. Epub 2019 Apr 28 doi: 10.1016/j.surge.2019.03.006. PMID: 31040083

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