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Adult Acute Megakaryoblastic Leukemia

MedGen UID:
79016
•Concept ID:
C0279632
•
Neoplastic Process
Synonyms: Adult Acute M7 Leukemia; Adult Acute Megakaryocytic Leukemia; Adult Acute Megakaryocytic Leukemia (M7); M7 Adult Acute Leukemia; M7 Adult Acute Megakaryocytic Leukemia

Definition

An acute megakaryoblastic leukemia occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Acute Megakaryoblastic Leukemia

Professional guidelines

PubMed

CD34+ megakaryoblastic leukaemic cells are CD38-, but CD61+ and glycophorin A+: improved criteria for diagnosis of AML-M7?
Helleberg C, Knudsen H, Hansen PB, Nikolajsen K, Kjaersgaard E, Ralfkiaer E, Johnsen HE
Leukemia 1997 Jun;11(6):830-4. doi: 10.1038/sj.leu.2400648. PMID: 9177436
A prospective trial of the treatment of acute megakaryoblastic leukaemia.
Ruiz-Argüelles GJ, Marín-López A, Ruiz-González DS, Pérez-Romano B
Clin Lab Haematol 1988;10(1):15-23. doi: 10.1111/j.1365-2257.1988.tb01148.x. PMID: 3163299
Acute megakaryoblastic leukaemia: a prospective study of its identification and treatment.
Ruiz-Argüelles GJ, Marín-Lopez A, Lobato-Mendizábal E, Ruiz-Argüelles A, Nichols WL, Katzman JA
Br J Haematol 1986 Jan;62(1):55-63. doi: 10.1111/j.1365-2141.1986.tb02900.x. PMID: 3942696

Recent clinical studies

Etiology

Acute megakaryoblastic leukaemia shows high frequency of chromosome 1q aberrations and dismal outcome.
Pastore F, Gittinger H, Raab S, Tschuri S, Ksienzyk B, Konstandin NP, Schneider S, Rothenberg-Thurley M, Horny HP, Werner M, Sauerland MC, Amler S, Görlich D, Berdel WE, Wörmann B, Braess J, Hiddemann W, Tischer J, Herold T, Metzeler KH, Spiekermann K
Br J Haematol 2023 Sep;202(6):1165-1177. Epub 2023 Jul 16 doi: 10.1111/bjh.18982. PMID: 37455345
Pathologic, cytogenetic, and molecular features of acute myeloid leukemia with megakaryocytic differentiation: A report from the Children's Oncology Group.
Chisholm KM, Smith J, Heerema-McKenney AE, Choi JK, Ries RE, Hirsch BA, Raimondi SC, Wang YC, Dang A, Alonzo TA, Sung L, Aplenc R, Gamis AS, Meshinchi S, Kahwash SB
Pediatr Blood Cancer 2023 May;70(5):e30251. Epub 2023 Feb 15 doi: 10.1002/pbc.30251. PMID: 36789545Free PMC Article
Non-seminomatous mediastinal germ cell tumor and acute megakaryoblastic leukemia.
Mukherjee S, Ibrahimi S, John S, Adnan MM, Scordino T, Khalil MO, Cherry M
Ann Hematol 2017 Sep;96(9):1435-1439. Epub 2017 Jun 3 doi: 10.1007/s00277-017-3037-3. PMID: 28578457
Neonatal and adult megakaryopoiesis.
Liu ZJ, Sola-Visner M
Curr Opin Hematol 2011 Sep;18(5):330-7. doi: 10.1097/MOH.0b013e3283497ed5. PMID: 21738028
Acute megakaryoblastic leukemia.
Gassmann W, Löffler H
Leuk Lymphoma 1995;18 Suppl 1:69-73. doi: 10.3109/10428199509075307. PMID: 7496359

Diagnosis

Infant Acute Leukemia.
Wertheim G
Clin Lab Med 2021 Sep;41(3):541-550. doi: 10.1016/j.cll.2021.04.002. PMID: 34304781
Pediatric Acute Megakaryoblastic Leukemia: Multitasking Fusion Proteins and Oncogenic Cooperations.
Lopez CK, Malinge S, Gaudry M, Bernard OA, Mercher T
Trends Cancer 2017 Sep;3(9):631-642. Epub 2017 Aug 18 doi: 10.1016/j.trecan.2017.07.003. PMID: 28867167
Non-seminomatous mediastinal germ cell tumor and acute megakaryoblastic leukemia.
Mukherjee S, Ibrahimi S, John S, Adnan MM, Scordino T, Khalil MO, Cherry M
Ann Hematol 2017 Sep;96(9):1435-1439. Epub 2017 Jun 3 doi: 10.1007/s00277-017-3037-3. PMID: 28578457
Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes.
de Rooij JD, Branstetter C, Ma J, Li Y, Walsh MP, Cheng J, Obulkasim A, Dang J, Easton J, Verboon LJ, Mulder HL, Zimmermann M, Koss C, Gupta P, Edmonson M, Rusch M, Lim JY, Reinhardt K, Pigazzi M, Song G, Yeoh AE, Shih LY, Liang DC, Halene S, Krause DS, Zhang J, Downing JR, Locatelli F, Reinhardt D, van den Heuvel-Eibrink MM, Zwaan CM, Fornerod M, Gruber TA
Nat Genet 2017 Mar;49(3):451-456. Epub 2017 Jan 23 doi: 10.1038/ng.3772. PMID: 28112737Free PMC Article
Acute megakaryoblastic leukemia.
Gassmann W, Löffler H
Leuk Lymphoma 1995;18 Suppl 1:69-73. doi: 10.3109/10428199509075307. PMID: 7496359

Therapy

Acute megakaryoblastic leukaemia shows high frequency of chromosome 1q aberrations and dismal outcome.
Pastore F, Gittinger H, Raab S, Tschuri S, Ksienzyk B, Konstandin NP, Schneider S, Rothenberg-Thurley M, Horny HP, Werner M, Sauerland MC, Amler S, Görlich D, Berdel WE, Wörmann B, Braess J, Hiddemann W, Tischer J, Herold T, Metzeler KH, Spiekermann K
Br J Haematol 2023 Sep;202(6):1165-1177. Epub 2023 Jul 16 doi: 10.1111/bjh.18982. PMID: 37455345
Acute Megakaryoblastic Leukemia Developing as Donor Cell Leukemia after Umbilical Cord Blood Transplantation.
Adachi Y, Yamaguchi Y, Sagou K, Yamaga Y, Fukushima N, Ozeki K, Kohno A
Intern Med 2018 Feb 15;57(4):569-574. Epub 2017 Nov 20 doi: 10.2169/internalmedicine.9005-17. PMID: 29151503Free PMC Article
Myeloid leukemia in Down syndrome.
Khan I, Malinge S, Crispino J
Crit Rev Oncog 2011;16(1-2):25-36. doi: 10.1615/critrevoncog.v16.i1-2.40. PMID: 22150305Free PMC Article
The molecular basis of leukemia.
Gilliland DG, Jordan CT, Felix CA
Hematology Am Soc Hematol Educ Program 2004:80-97. doi: 10.1182/asheducation-2004.1.80. PMID: 15561678
Acute megakaryoblastic leukemia in children and adolescents: a retrospective analysis of 24 cases.
Ribeiro RC, Oliveira MS, Fairclough D, Hurwitz C, Mirro J, Behm FG, Head D, Silva ML, Raimondi SC, Crist WM
Leuk Lymphoma 1993 Jul;10(4-5):299-306. doi: 10.3109/10428199309148552. PMID: 8220128

Prognosis

Acute megakaryoblastic leukaemia shows high frequency of chromosome 1q aberrations and dismal outcome.
Pastore F, Gittinger H, Raab S, Tschuri S, Ksienzyk B, Konstandin NP, Schneider S, Rothenberg-Thurley M, Horny HP, Werner M, Sauerland MC, Amler S, Görlich D, Berdel WE, Wörmann B, Braess J, Hiddemann W, Tischer J, Herold T, Metzeler KH, Spiekermann K
Br J Haematol 2023 Sep;202(6):1165-1177. Epub 2023 Jul 16 doi: 10.1111/bjh.18982. PMID: 37455345
CBFA2T3-GLIS2-positive acute myeloid leukaemia. A peculiar paediatric entity.
Masetti R, Bertuccio SN, Pession A, Locatelli F
Br J Haematol 2019 Feb;184(3):337-347. Epub 2018 Dec 28 doi: 10.1111/bjh.15725. PMID: 30592296Free PMC Article
Pediatric Acute Megakaryoblastic Leukemia: Multitasking Fusion Proteins and Oncogenic Cooperations.
Lopez CK, Malinge S, Gaudry M, Bernard OA, Mercher T
Trends Cancer 2017 Sep;3(9):631-642. Epub 2017 Aug 18 doi: 10.1016/j.trecan.2017.07.003. PMID: 28867167
Non-seminomatous mediastinal germ cell tumor and acute megakaryoblastic leukemia.
Mukherjee S, Ibrahimi S, John S, Adnan MM, Scordino T, Khalil MO, Cherry M
Ann Hematol 2017 Sep;96(9):1435-1439. Epub 2017 Jun 3 doi: 10.1007/s00277-017-3037-3. PMID: 28578457
Acute megakaryoblastic leukemia, unlike acute erythroid leukemia, predicts an unfavorable outcome after allogeneic HSCT.
Ishiyama K, Yamaguchi T, Eto T, Ohashi K, Uchida N, Kanamori H, Fukuda T, Miyamura K, Inoue Y, Taguchi J, Mori T, Iwato K, Morishima Y, Nagamura-Inoue T, Atsuta Y, Sakamaki H, Takami A
Leuk Res 2016 Aug;47:47-53. Epub 2016 May 12 doi: 10.1016/j.leukres.2016.04.017. PMID: 27244257

Clinical prediction guides

Pathologic, cytogenetic, and molecular features of acute myeloid leukemia with megakaryocytic differentiation: A report from the Children's Oncology Group.
Chisholm KM, Smith J, Heerema-McKenney AE, Choi JK, Ries RE, Hirsch BA, Raimondi SC, Wang YC, Dang A, Alonzo TA, Sung L, Aplenc R, Gamis AS, Meshinchi S, Kahwash SB
Pediatr Blood Cancer 2023 May;70(5):e30251. Epub 2023 Feb 15 doi: 10.1002/pbc.30251. PMID: 36789545Free PMC Article
Acute megakaryoblastic leukemia, unlike acute erythroid leukemia, predicts an unfavorable outcome after allogeneic HSCT.
Ishiyama K, Yamaguchi T, Eto T, Ohashi K, Uchida N, Kanamori H, Fukuda T, Miyamura K, Inoue Y, Taguchi J, Mori T, Iwato K, Morishima Y, Nagamura-Inoue T, Atsuta Y, Sakamaki H, Takami A
Leuk Res 2016 Aug;47:47-53. Epub 2016 May 12 doi: 10.1016/j.leukres.2016.04.017. PMID: 27244257
The molecular basis of leukemia.
Gilliland DG, Jordan CT, Felix CA
Hematology Am Soc Hematol Educ Program 2004:80-97. doi: 10.1182/asheducation-2004.1.80. PMID: 15561678
Acute leukemia after a primary myelodysplastic syndrome: immunophenotypic, genotypic, and clinical characteristics.
San Miguel JF, Hernández JM, González-Sarmiento R, González M, Sánchez I, Orfao A, Cañizo MC, López Borrasca A
Blood 1991 Aug 1;78(3):768-74. PMID: 1859889
Hematologic neoplasia associated with primary mediastinal germ-cell tumors.
Nichols CR, Roth BJ, Heerema N, Griep J, Tricot G
N Engl J Med 1990 May 17;322(20):1425-9. doi: 10.1056/NEJM199005173222004. PMID: 2158625

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