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Recurrent Ovarian Germ Cell Tumor

MedGen UID:
79058
•Concept ID:
C0279975
•
Neoplastic Process
Synonyms: Recurrent Germ Cell Neoplasm of Ovary; Recurrent Germ Cell Neoplasm of the Ovary; Recurrent Germ Cell Tumor of Ovary; Recurrent Germ Cell Tumor of the Ovary; Recurrent Ovarian Germ Cell Neoplasm; Relapsed Germ Cell Neoplasm of Ovary; Relapsed Germ Cell Neoplasm of the Ovary; Relapsed Germ Cell Tumor of Ovary; Relapsed Germ Cell Tumor of the Ovary; Relapsed Ovarian Germ Cell Neoplasm; Relapsed Ovarian Germ Cell Tumor

Definition

The reemergence of ovarian germ cell tumor after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Ovarian Germ Cell Tumor

Professional guidelines

PubMed

Tumor treating fields: narrative review of a promising treatment modality for cancer.
Kutuk T, Atak E, La Rosa A, Kotecha R, Mehta MP, Chuong MD
Chin Clin Oncol 2023 Dec;12(6):64. Epub 2023 Nov 2 doi: 10.21037/cco-23-82. PMID: 37953242
Contemporary management of ovarian germ cell tumors and remaining controversies.
Veneris JT, Mahajan P, Frazier AL
Gynecol Oncol 2020 Aug;158(2):467-475. Epub 2020 Jun 5 doi: 10.1016/j.ygyno.2020.05.007. PMID: 32507650
The use of serum tumor markers in the management of patients with malignancy.
Markman M
J Cancer Res Clin Oncol 1993;119(11):635-6. doi: 10.1007/BF01215980. PMID: 7688748

Recent clinical studies

Etiology

Recurrent Loss of Heterozygosity in Pancreatic Neuroendocrine Tumors.
Parilla M, Chapel D, Hechtman JF, Wanjari P, El Jabbour T, Sharma A, Ritterhouse L, Segal J, Vanderbilt C, Klimstra DS, Setia N, Tang L
Am J Surg Pathol 2022 Jun 1;46(6):823-831. Epub 2022 Feb 4 doi: 10.1097/PAS.0000000000001860. PMID: 35125451Free PMC Article
Prevalence of metachronous contralateral mature ovarian teratoma: A systematic review.
Kiely D, Lewis C, Gray J, Hall N
Pediatr Blood Cancer 2021 Nov;68(11):e29237. Epub 2021 Jul 31 doi: 10.1002/pbc.29237. PMID: 34331503
Ovarian Dysgerminoma: A Tertiary Center Experience.
Kilic C, Cakir C, Yuksel D, Kilic F, Kayikcioglu F, Koc S, Korkmaz V, Kimyon Comert G, Turkmen O, Boran N, Turan T
J Adolesc Young Adult Oncol 2021 Jun;10(3):303-308. Epub 2020 Aug 5 doi: 10.1089/jayao.2020.0087. PMID: 32762565
Dermoid cysts in adolescents.
Multani J, Kives S
Curr Opin Obstet Gynecol 2015 Oct;27(5):315-9. doi: 10.1097/GCO.0000000000000206. PMID: 26308203
Neonatal teratomas.
Lakhoo K
Early Hum Dev 2010 Oct;86(10):643-7. Epub 2010 Sep 29 doi: 10.1016/j.earlhumdev.2010.08.016. PMID: 20884137

Diagnosis

A curious case of ovarian cysts.
Hodges R, Watkins E
JAAPA 2022 Dec 1;35(12):61-63. doi: 10.1097/01.JAA.0000892764.53306.c4. PMID: 36412944
Ovarian dysgerminoma.
Mohamed A, Ali A, Younis FM
Int J Gynecol Cancer 2022 Nov 7;32(11):1490-1491. doi: 10.1136/ijgc-2022-003978. PMID: 36343973
Ovarian Dysgerminoma: A Tertiary Center Experience.
Kilic C, Cakir C, Yuksel D, Kilic F, Kayikcioglu F, Koc S, Korkmaz V, Kimyon Comert G, Turkmen O, Boran N, Turan T
J Adolesc Young Adult Oncol 2021 Jun;10(3):303-308. Epub 2020 Aug 5 doi: 10.1089/jayao.2020.0087. PMID: 32762565
Dermoid cysts in adolescents.
Multani J, Kives S
Curr Opin Obstet Gynecol 2015 Oct;27(5):315-9. doi: 10.1097/GCO.0000000000000206. PMID: 26308203
Rare gynecologic malignancies.
Schink JC, Lurain JR
Curr Opin Obstet Gynecol 1991 Feb;3(1):78-90. PMID: 1652301

Therapy

Effect and timing of operative treatment for teratoma associated N-Methyl-d-Aspartate receptor-antibody encephalitis: A systematic review with meta-analysis.
Erlebach R, Brandi G
J Neuroimmunol 2023 Sep 15;382:578153. Epub 2023 Jul 22 doi: 10.1016/j.jneuroim.2023.578153. PMID: 37499300
Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article
Pathophysiology of cisplatin-induced acute kidney injury.
Ozkok A, Edelstein CL
Biomed Res Int 2014;2014:967826. Epub 2014 Aug 6 doi: 10.1155/2014/967826. PMID: 25165721Free PMC Article
Gestational trophoblastic disease.
Tse KY, Ngan HY
Best Pract Res Clin Obstet Gynaecol 2012 Jun;26(3):357-70. Epub 2012 Jan 28 doi: 10.1016/j.bpobgyn.2011.11.009. PMID: 22285526
Autologous stem-cell transplantation for solid tumors in adults.
Nieto Y, Shpall EJ
Hematol Oncol Clin North Am 1999 Oct;13(5):939-68, vi. doi: 10.1016/s0889-8588(05)70104-0. PMID: 10553256

Prognosis

Recurrent Loss of Heterozygosity in Pancreatic Neuroendocrine Tumors.
Parilla M, Chapel D, Hechtman JF, Wanjari P, El Jabbour T, Sharma A, Ritterhouse L, Segal J, Vanderbilt C, Klimstra DS, Setia N, Tang L
Am J Surg Pathol 2022 Jun 1;46(6):823-831. Epub 2022 Feb 4 doi: 10.1097/PAS.0000000000001860. PMID: 35125451Free PMC Article
Gynecologic cancer in pregnancy.
Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951Free PMC Article
Genetic Syndromes with Pancreatic Manifestations.
Pittman ME, Brosens LA, Wood LD
Surg Pathol Clin 2016 Dec;9(4):705-715. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.012. PMID: 27926368
Immature teratomas in children.
Kooijman CD
Histopathology 1988 May;12(5):491-502. doi: 10.1111/j.1365-2559.1988.tb01969.x. PMID: 3397045
Intrapericardial teratoma in the newborn.
Agozzino L, Vosa C, Arciprete P, de Leva F, Cotrufo M
Int J Cardiol 1984 Jan;5(1):21-8. doi: 10.1016/0167-5273(84)90054-8. PMID: 6693207

Clinical prediction guides

Mature cystic teratoma of the ovary with a grossly visible, completely developed intestinal loop: A case report and review of the literature.
Cao Y, Wang B, Jia AR, Li X, Yang L, Jia Z
Medicine (Baltimore) 2023 Jun 30;102(26):e34081. doi: 10.1097/MD.0000000000034081. PMID: 37390246Free PMC Article
Utility of polygenic risk scores in UK cancer screening: a modelling analysis.
Huntley C, Torr B, Sud A, Rowlands CF, Way R, Snape K, Hanson H, Swanton C, Broggio J, Lucassen A, McCartney M, Houlston RS, Hingorani AD, Jones ME, Turnbull C
Lancet Oncol 2023 Jun;24(6):658-668. Epub 2023 May 10 doi: 10.1016/S1470-2045(23)00156-0. PMID: 37178708
A rare case of highly differentiated follicular carcinoma in ovary with FGFR4 Gly388Arg polymorphism: a case report and literature review.
Bao YT, Wang C, Huang W, Yao LQ, Yuan L
J Ovarian Res 2022 Jun 14;15(1):71. doi: 10.1186/s13048-022-01007-y. PMID: 35701820Free PMC Article
Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article
Analysis of the factors determining the type of surgical procedure in mature cystic teratomas.
Özer A, Kıran H
Ginekol Pol 2017;88(3):134-137. doi: 10.5603/GP.a2017.0025. PMID: 28397201

Recent systematic reviews

Clinical Utility of Anti-Mullerian Hormone in Pediatrics.
Kanakatti Shankar R, Dowlut-McElroy T, Dauber A, Gomez-Lobo V
J Clin Endocrinol Metab 2022 Jan 18;107(2):309-323. doi: 10.1210/clinem/dgab687. PMID: 34537849Free PMC Article
Prevalence of metachronous contralateral mature ovarian teratoma: A systematic review.
Kiely D, Lewis C, Gray J, Hall N
Pediatr Blood Cancer 2021 Nov;68(11):e29237. Epub 2021 Jul 31 doi: 10.1002/pbc.29237. PMID: 34331503
Short- and Long-Term Complications of Intraoperative Benign Ovarian Cyst Spillage: A Systematic Review and Meta-analysis.
Eisenberg N, Volodarsky-Perel A, Brochu I, Tremblay C, Gorak E, Hudon E, Fortin S, Kogan L, Rivard C
J Minim Invasive Gynecol 2021 May;28(5):957-970. Epub 2020 Dec 3 doi: 10.1016/j.jmig.2020.11.025. PMID: 33279627
Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article
Chemotherapy in ovarian germ cell tumors: A systematic review.
Simone CG, Markham MJ, Dizon DS
Gynecol Oncol 2016 Jun;141(3):602-607. Epub 2016 Feb 9 doi: 10.1016/j.ygyno.2016.02.007. PMID: 26873864

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