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de novo Myelodysplastic Syndrome

MedGen UID:
79122
•Concept ID:
C0280451
•
Neoplastic Process
Synonym: Untreated Myelodysplastic Syndrome

Definition

A primary myelodysplastic syndrome not associated with prior radiation or chemotherapy treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVde novo Myelodysplastic Syndrome

Professional guidelines

PubMed

Classification, diagnosis and management of myeloproliferative disorders in the JAK2V617F era.
Tefferi A
Hematology Am Soc Hematol Educ Program 2006:240-5. doi: 10.1182/asheducation-2006.1.240. PMID: 17124067

Recent clinical studies

Etiology

Pretransplantation Red Blood Cell and Platelet Transfusion Burden in De Novo Myelodysplastic Syndrome Undergoing Allogeneic Transplantation.
Konuma T, Aoki J, Ozawa Y, Uchida N, Kobayashi T, Onizuka M, Katayama Y, Ohta T, Nakano N, Ota S, Onishi Y, Kobayashi H, Fukuda T, Kanda Y, Atsuta Y; Adult Myelodysplastic Syndrome Working Group of the Japan Society for Hematopoietic Cell Transplantation
Transplant Cell Ther 2021 Aug;27(8):671-678. Epub 2021 May 12 doi: 10.1016/j.jtct.2021.05.003. PMID: 33991723
Comparison of therapy-related myelodysplastic syndrome with ring sideroblasts and de novo myelodysplastic syndrome with ring sideroblasts.
Chen Z, Wang SA, Goswami M, Tang G, Routbort MJ, Patel KP, Luthra R, Medeiros LJ, Ok CY
Leuk Res 2019 Nov;86:106227. Epub 2019 Sep 17 doi: 10.1016/j.leukres.2019.106227. PMID: 31557598
TP53 mutation in allogeneic hematopoietic cell transplantation for de novo myelodysplastic syndrome.
Kim YJ, Jung SH, Hur EH, Choi EJ, Lee KH, Yim SH, Kim HJ, Kwon YR, Jeon YW, Lee SH, Chung YJ, Lee JH
Leuk Res 2018 Nov;74:97-104. Epub 2018 Oct 11 doi: 10.1016/j.leukres.2018.10.004. PMID: 30343213
De Novo Myelodysplastic Syndrome and Subsequent Diagnosis of Primary Solid Tumors: Evidence from the National Cancer Institute 2001-2011.
Victoria K, Freedman IG
Anticancer Res 2018 Oct;38(10):5819-5823. doi: 10.21873/anticanres.12922. PMID: 30275205
Prevalence and clinical characteristics of myelodysplastic syndrome with bone marrow eosinophilia or basophilia.
Matsushima T, Handa H, Yokohama A, Nagasaki J, Koiso H, Kin Y, Tanaka Y, Sakura T, Tsukamoto N, Karasawa M, Itoh K, Hirabayashi H, Sawamura M, Shinonome S, Shimano S, Miyawaki S, Nojima Y, Murakami H
Blood 2003 May 1;101(9):3386-90. Epub 2002 Dec 27 doi: 10.1182/blood-2002-03-0947. PMID: 12506028

Diagnosis

De Novo Myelodysplastic Syndrome and Subsequent Diagnosis of Primary Solid Tumors: Evidence from the National Cancer Institute 2001-2011.
Victoria K, Freedman IG
Anticancer Res 2018 Oct;38(10):5819-5823. doi: 10.21873/anticanres.12922. PMID: 30275205
Spectrum of the WHO Classification De Novo Myelodysplastic Syndrome: Experience from Southern Pakistan.
Sultan S, Irfan SM, Jawed SN
Asian Pac J Cancer Prev 2016;17(3):1049-52. doi: 10.7314/apjcp.2016.17.3.1049. PMID: 27039723
The BCL2L10 Leu21Arg variant and risk of therapy-related myeloid neoplasms and de novo myelodysplastic syndromes.
Fabiani E, Fianchi L, Falconi G, Boncompagni R, Criscuolo M, Guidi F, La Brocca A, Hohaus S, Leone G, Voso MT
Leuk Lymphoma 2014 Jul;55(7):1538-43. Epub 2013 Nov 1 doi: 10.3109/10428194.2013.845885. PMID: 24047476
Classification, diagnosis and management of myeloproliferative disorders in the JAK2V617F era.
Tefferi A
Hematology Am Soc Hematol Educ Program 2006:240-5. doi: 10.1182/asheducation-2006.1.240. PMID: 17124067
Acute panmyelosis with myelofibrosis.
Thiele J, Kvasnicka HM, Schmitt-Graeff A
Leuk Lymphoma 2004 Apr;45(4):681-7. doi: 10.1080/10428190310001625692. PMID: 15160939

Therapy

The clinical outcomes of haploidentical stem cell transplantation (haplo-HSCT) for patients with therapy-related myelodysplastic syndrome: comparable to de novo myelodysplastic syndrome.
Tang F, Wang Y, Wang Y, Jin J, Han W, Chen Y, Yan C, Xu L, Zhang X, Huang X
Clin Exp Med 2024 Feb 8;24(1):33. doi: 10.1007/s10238-023-01287-8. PMID: 38329593Free PMC Article
TP53 mutation in allogeneic hematopoietic cell transplantation for de novo myelodysplastic syndrome.
Kim YJ, Jung SH, Hur EH, Choi EJ, Lee KH, Yim SH, Kim HJ, Kwon YR, Jeon YW, Lee SH, Chung YJ, Lee JH
Leuk Res 2018 Nov;74:97-104. Epub 2018 Oct 11 doi: 10.1016/j.leukres.2018.10.004. PMID: 30343213
Myelodysplastic syndrome evolving from aplastic anemia treated with immunosuppressive therapy: efficacy of hematopoietic stem cell transplantation.
Kim SY, Le Rademacher J, Antin JH, Anderlini P, Ayas M, Battiwalla M, Carreras J, Kurtzberg J, Nakamura R, Eapen M, Deeg HJ
Haematologica 2014 Dec;99(12):1868-75. Epub 2014 Aug 8 doi: 10.3324/haematol.2014.108977. PMID: 25107891Free PMC Article
Therapy-related myeloid neoplasms with isolated del(20q): comparison with cases of de novo myelodysplastic syndrome with del(20q).
Kanagal-Shamanna R, Yin CC, Miranda RN, Bueso-Ramos CE, Wang XI, Muddasani R, Medeiros LJ, Lu G
Cancer Genet 2013 Jan-Feb;206(1-2):42-6. Epub 2013 Jan 26 doi: 10.1016/j.cancergen.2012.12.005. PMID: 23357231
Aberration of p73 promoter methylation in de novo myelodysplastic syndrome.
Zhao Y, Gu S, Guo J, Zhang Z, Zhang X, Li X, Chang C
Hematology 2012 Sep;17(5):275-82. doi: 10.1179/1607845412Y.0000000018. PMID: 22971533

Prognosis

TP53 mutation in allogeneic hematopoietic cell transplantation for de novo myelodysplastic syndrome.
Kim YJ, Jung SH, Hur EH, Choi EJ, Lee KH, Yim SH, Kim HJ, Kwon YR, Jeon YW, Lee SH, Chung YJ, Lee JH
Leuk Res 2018 Nov;74:97-104. Epub 2018 Oct 11 doi: 10.1016/j.leukres.2018.10.004. PMID: 30343213
De Novo Myelodysplastic Syndrome and Subsequent Diagnosis of Primary Solid Tumors: Evidence from the National Cancer Institute 2001-2011.
Victoria K, Freedman IG
Anticancer Res 2018 Oct;38(10):5819-5823. doi: 10.21873/anticanres.12922. PMID: 30275205
Acute panmyelosis with myelofibrosis.
Thiele J, Kvasnicka HM, Schmitt-Graeff A
Leuk Lymphoma 2004 Apr;45(4):681-7. doi: 10.1080/10428190310001625692. PMID: 15160939
Prevalence and clinical characteristics of myelodysplastic syndrome with bone marrow eosinophilia or basophilia.
Matsushima T, Handa H, Yokohama A, Nagasaki J, Koiso H, Kin Y, Tanaka Y, Sakura T, Tsukamoto N, Karasawa M, Itoh K, Hirabayashi H, Sawamura M, Shinonome S, Shimano S, Miyawaki S, Nojima Y, Murakami H
Blood 2003 May 1;101(9):3386-90. Epub 2002 Dec 27 doi: 10.1182/blood-2002-03-0947. PMID: 12506028
De novo myelodysplastic syndrome (MDS) with deletion of the long arm of chromosome 20: a subtype of MDS with distinct hematological and prognostic features?
Wattel E, Laï JL, Hebbar M, Preudhomme C, Grahek D, Morel P, Bauters F, Fenaux P
Leuk Res 1993 Nov;17(11):921-6. doi: 10.1016/0145-2126(93)90038-m. PMID: 8231232

Clinical prediction guides

De Novo Myelodysplastic Syndrome and Subsequent Diagnosis of Primary Solid Tumors: Evidence from the National Cancer Institute 2001-2011.
Victoria K, Freedman IG
Anticancer Res 2018 Oct;38(10):5819-5823. doi: 10.21873/anticanres.12922. PMID: 30275205
Therapy-related myeloid neoplasms with isolated del(20q): comparison with cases of de novo myelodysplastic syndrome with del(20q).
Kanagal-Shamanna R, Yin CC, Miranda RN, Bueso-Ramos CE, Wang XI, Muddasani R, Medeiros LJ, Lu G
Cancer Genet 2013 Jan-Feb;206(1-2):42-6. Epub 2013 Jan 26 doi: 10.1016/j.cancergen.2012.12.005. PMID: 23357231
Trisomy 8 is the most frequent cytogenetic abnormality in de novo myelodysplastic syndrome in China.
Xiao Y, Wei J, Chen Y, Zhang K, Zhou J, Zhang Y
Onkologie 2012;35(3):100-6. Epub 2012 Feb 20 doi: 10.1159/000336815. PMID: 22414973
Cytogenetic characteristics and prognosis analysis in 231 myelodysplastic syndrome patients from a single institution.
Jung SW, Lee SY, Jekarl DW, Kim M, Lim J, Kim Y, Han K, Kim YJ, Cho SG, Song J
Leuk Res 2011 Jun;35(6):735-40. Epub 2010 Dec 13 doi: 10.1016/j.leukres.2010.11.009. PMID: 21146871
Prevalence and clinical characteristics of myelodysplastic syndrome with bone marrow eosinophilia or basophilia.
Matsushima T, Handa H, Yokohama A, Nagasaki J, Koiso H, Kin Y, Tanaka Y, Sakura T, Tsukamoto N, Karasawa M, Itoh K, Hirabayashi H, Sawamura M, Shinonome S, Shimano S, Miyawaki S, Nojima Y, Murakami H
Blood 2003 May 1;101(9):3386-90. Epub 2002 Dec 27 doi: 10.1182/blood-2002-03-0947. PMID: 12506028

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