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Malignant dysgerminomatous germ cell tumor of ovary

MedGen UID:
798473
•Concept ID:
CN207439
•
Disease or Syndrome
Synonyms: dysgerminomatous germ cell cancer of ovary; Dysgerminomatous germ cell cancer of the ovary; dysgerminomatous germ cell cancer of the ovary; malignant dysgerminomatous germ cell tumor of ovary; malignant dysgerminomatous germ cell tumor of the ovary; Malignant dysgerminomatous germ cell tumor of the ovary; malignant dysgerminomatous germ cell tumour of the ovary; Malignant ovarian dysgerminoma; malignant ovarian dysgerminoma
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Unknown inheritance (Orphanet)
 
Monarch Initiative: MONDO:0020538
Orphanet: ORPHA99912

Definition

A form of malignant germ cell tumor of ovary, arising from germ cells in the ovary, usually presenting during adolescence with pelvic mass, fever, vaginal bleeding, and acute abdomen and is characterized by bilaterality (around 10% of cases), association with dysgenetic gonads (5 to 10% of cases), elevated serum lactate dehydrogenase (LDH) and human chorionic gonadotrophin (hCG) (in the presence of syncitiotrophoblasts). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant dysgerminomatous germ cell tumor of ovary
Follow this link to review classifications for Malignant dysgerminomatous germ cell tumor of ovary in Orphanet.

Recent clinical studies

Etiology

Malignant germ cell tumors of the ovary. Pregnancy considerations.
Bakri YN, Ezzat A, Akhtar, Dohami, Zahrani
Eur J Obstet Gynecol Reprod Biol 2000 May;90(1):87-91. doi: 10.1016/s0301-2115(99)00213-4. PMID: 10767517
Transformation of ovarian dysgerminoma to yolk sac tumor: evidence for a histogenetic continuum.
Parkash V, Carcangiu ML
Mod Pathol 1995 Oct;8(8):881-7. PMID: 8552580
Malignant germ cell tumors of the ovary: Hacettepe hospital experience.
Ayhan A, Tuncer ZS, Yanik F, Bükülmez O, Yanik A, Küçükali T
Acta Obstet Gynecol Scand 1995 May;74(5):384-90. doi: 10.3109/00016349509024434. PMID: 7778434

Diagnosis

Surgery of germ cell tumours of the ovary.
Schwartz PE
Forum (Genova) 2000 Oct-Dec;10(4):355-65. PMID: 11535985
Malignant germ cell tumors of the ovary: Hacettepe hospital experience.
Ayhan A, Tuncer ZS, Yanik F, Bükülmez O, Yanik A, Küçükali T
Acta Obstet Gynecol Scand 1995 May;74(5):384-90. doi: 10.3109/00016349509024434. PMID: 7778434
Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary.
Pippitt CH Jr, Cain JM, Hakes TB, Pierce VK, Lewis JL Jr
Gynecol Oncol 1988 Oct;31(2):268-75. doi: 10.1016/s0090-8258(88)80004-0. PMID: 2458993
Gonadoblastoma: clinicopathologic correlation in six patients.
Williamson HO, Underwood PB Jr, Kreutner A Jr, Rogers JF, Mathur RS, Pratt-Thomas HR
Am J Obstet Gynecol 1976 Nov 1;126(5):579-85. doi: 10.1016/0002-9378(76)90755-9. PMID: 984129

Therapy

Surgery of germ cell tumours of the ovary.
Schwartz PE
Forum (Genova) 2000 Oct-Dec;10(4):355-65. PMID: 11535985
Long-term results of two VAB-like regimens (vinblastine + actinomycin-D + bleomycin + cyclophosphamide + cisplatin) in malignant germ cell tumours of the ovary.
Culine S, Lhomme C, Kattan J, Duvillard P, Michel G, Droz JP
Eur J Cancer 1994;30A(9):1239-44. doi: 10.1016/0959-8049(94)90165-1. PMID: 7528029
Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary.
Pippitt CH Jr, Cain JM, Hakes TB, Pierce VK, Lewis JL Jr
Gynecol Oncol 1988 Oct;31(2):268-75. doi: 10.1016/s0090-8258(88)80004-0. PMID: 2458993

Prognosis

Surgery of germ cell tumours of the ovary.
Schwartz PE
Forum (Genova) 2000 Oct-Dec;10(4):355-65. PMID: 11535985
Malignant germ cell tumors of the ovary. Pregnancy considerations.
Bakri YN, Ezzat A, Akhtar, Dohami, Zahrani
Eur J Obstet Gynecol Reprod Biol 2000 May;90(1):87-91. doi: 10.1016/s0301-2115(99)00213-4. PMID: 10767517
Malignant germ cell tumors of the ovary: Hacettepe hospital experience.
Ayhan A, Tuncer ZS, Yanik F, Bükülmez O, Yanik A, Küçükali T
Acta Obstet Gynecol Scand 1995 May;74(5):384-90. doi: 10.3109/00016349509024434. PMID: 7778434
Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary.
Pippitt CH Jr, Cain JM, Hakes TB, Pierce VK, Lewis JL Jr
Gynecol Oncol 1988 Oct;31(2):268-75. doi: 10.1016/s0090-8258(88)80004-0. PMID: 2458993

Clinical prediction guides

Malignant germ cell tumors of the ovary: Hacettepe hospital experience.
Ayhan A, Tuncer ZS, Yanik F, Bükülmez O, Yanik A, Küçükali T
Acta Obstet Gynecol Scand 1995 May;74(5):384-90. doi: 10.3109/00016349509024434. PMID: 7778434
Long-term results of two VAB-like regimens (vinblastine + actinomycin-D + bleomycin + cyclophosphamide + cisplatin) in malignant germ cell tumours of the ovary.
Culine S, Lhomme C, Kattan J, Duvillard P, Michel G, Droz JP
Eur J Cancer 1994;30A(9):1239-44. doi: 10.1016/0959-8049(94)90165-1. PMID: 7528029
Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary.
Pippitt CH Jr, Cain JM, Hakes TB, Pierce VK, Lewis JL Jr
Gynecol Oncol 1988 Oct;31(2):268-75. doi: 10.1016/s0090-8258(88)80004-0. PMID: 2458993

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