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Classical glioblastoma

MedGen UID:
820001
•Concept ID:
C3827253
•
Neoplastic Process
Synonyms: Classical Glioblastoma; classical glioblastoma; glioblastoma classical subtype
 
Monarch Initiative: MONDO:0000457

Definition

A molecular subtype of glioblastoma characterized by lack of p53 mutations, chromosome 7 amplifications or deletions, and high levels of EGFR amplification. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClassical glioblastoma

Professional guidelines

PubMed

A contemporary perspective on the diagnosis and treatment of diffuse gliomas in adults.
Roth P, Hottinger AF, Hundsberger T, Läubli H, Schucht P, Reinert M, Mamot C, Roelcke U, Pesce G, Hofer S, Weller M
Swiss Med Wkly 2020 Jun 1;150:w20256. Epub 2020 Jun 18 doi: 10.4414/smw.2020.20256. PMID: 32557428

Recent clinical studies

Etiology

PHIP drives glioblastoma motility and invasion by regulating the focal adhesion complex.
de Semir D, Bezrookove V, Nosrati M, Scanlon KR, Singer E, Judkins J, Rieken C, Wu C, Shen J, Schmudermayer C, Dar AA, Miller JR 3rd, Cobbs C, Yount G, Desprez PY, Debs RJ, Salomonis N, McAllister S, Cleaver JE, Soroceanu L, Kashani-Sabet M
Proc Natl Acad Sci U S A 2020 Apr 21;117(16):9064-9073. Epub 2020 Apr 9 doi: 10.1073/pnas.1914505117. PMID: 32273388Free PMC Article
Glioblastomas with oligodendroglial component have the same clinical phenotype as classical glioblastomas.
Elmahdi A, Frary AJ, Scotton WJ, O'Donovan DG, Price SJ
Br J Neurosurg 2013 Aug;27(4):419-24. Epub 2013 Feb 18 doi: 10.3109/02688697.2013.767315. PMID: 23418780
Gliomas of the brain among Nigerians.
Odeku EL, Adeloye A
Afr J Med Med Sci 1976 Mar;5(1):31-3. PMID: 829703

Diagnosis

Small cell glioblastoma multiforme: a case series and clinicopathological update.
Yadav AK, Madan R, Chatterjee D, Dhiman S, Goyal S, Kumar N, Sahoo SK
CNS Oncol 2020 Dec 1;9(4):CNS63. Epub 2020 Dec 7 doi: 10.2217/cns-2020-0016. PMID: 33283529Free PMC Article
A contemporary perspective on the diagnosis and treatment of diffuse gliomas in adults.
Roth P, Hottinger AF, Hundsberger T, Läubli H, Schucht P, Reinert M, Mamot C, Roelcke U, Pesce G, Hofer S, Weller M
Swiss Med Wkly 2020 Jun 1;150:w20256. Epub 2020 Jun 18 doi: 10.4414/smw.2020.20256. PMID: 32557428
Regulatory T cells are not a strong predictor of survival for patients with glioblastoma.
Thomas AA, Fisher JL, Rahme GJ, Hampton TH, Baron U, Olek S, Schwachula T, Rhodes CH, Gui J, Tafe LJ, Tsongalis GJ, Lefferts JA, Wishart H, Kleen J, Miller M, Whipple CA, de Abreu FB, Ernstoff MS, Fadul CE
Neuro Oncol 2015 Jun;17(6):801-9. Epub 2015 Jan 24 doi: 10.1093/neuonc/nou363. PMID: 25618892Free PMC Article
Rhabdoid glioblastoma is distinguishable from classical glioblastoma by cytogenetics and molecular genetics.
Byeon SJ, Cho HJ, Baek HW, Park CK, Choi SH, Kim SH, Kim HK, Park SH
Hum Pathol 2014 Mar;45(3):611-20. Epub 2013 Nov 7 doi: 10.1016/j.humpath.2013.08.024. PMID: 24457079
Glioblastomas with oligodendroglial component have the same clinical phenotype as classical glioblastomas.
Elmahdi A, Frary AJ, Scotton WJ, O'Donovan DG, Price SJ
Br J Neurosurg 2013 Aug;27(4):419-24. Epub 2013 Feb 18 doi: 10.3109/02688697.2013.767315. PMID: 23418780

Therapy

Dramatic clinical response in the treatment of small cell glioblastoma multiforme.
Zaman FY, McLean C, Ameratunga M
J Clin Pharm Ther 2022 Jun;47(6):832-834. Epub 2022 Jan 11 doi: 10.1111/jcpt.13608. PMID: 35018664Free PMC Article
A contemporary perspective on the diagnosis and treatment of diffuse gliomas in adults.
Roth P, Hottinger AF, Hundsberger T, Läubli H, Schucht P, Reinert M, Mamot C, Roelcke U, Pesce G, Hofer S, Weller M
Swiss Med Wkly 2020 Jun 1;150:w20256. Epub 2020 Jun 18 doi: 10.4414/smw.2020.20256. PMID: 32557428
Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.
Kang YJ, Balter B, Csizmadia E, Haas B, Sharma H, Bronson R, Yan CT
Nat Commun 2017 Jan 17;8:14013. doi: 10.1038/ncomms14013. PMID: 28094268Free PMC Article
Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma.
Zheng Y, McFarland BC, Drygin D, Yu H, Bellis SL, Kim H, Bredel M, Benveniste EN
Clin Cancer Res 2013 Dec 1;19(23):6484-94. Epub 2013 Sep 13 doi: 10.1158/1078-0432.CCR-13-0265. PMID: 24036851Free PMC Article

Prognosis

Dramatic clinical response in the treatment of small cell glioblastoma multiforme.
Zaman FY, McLean C, Ameratunga M
J Clin Pharm Ther 2022 Jun;47(6):832-834. Epub 2022 Jan 11 doi: 10.1111/jcpt.13608. PMID: 35018664Free PMC Article
A contemporary perspective on the diagnosis and treatment of diffuse gliomas in adults.
Roth P, Hottinger AF, Hundsberger T, Läubli H, Schucht P, Reinert M, Mamot C, Roelcke U, Pesce G, Hofer S, Weller M
Swiss Med Wkly 2020 Jun 1;150:w20256. Epub 2020 Jun 18 doi: 10.4414/smw.2020.20256. PMID: 32557428
Wnt5a Drives an Invasive Phenotype in Human Glioblastoma Stem-like Cells.
Binda E, Visioli A, Giani F, Trivieri N, Palumbo O, Restelli S, Dezi F, Mazza T, Fusilli C, Legnani F, Carella M, Di Meco F, Duggal R, Vescovi AL
Cancer Res 2017 Feb 15;77(4):996-1007. Epub 2016 Dec 23 doi: 10.1158/0008-5472.CAN-16-1693. PMID: 28011620
The transcription factor PPARα is overexpressed and is associated with a favourable prognosis in IDH-wildtype primary glioblastoma.
Haynes HR, White P, Hares KM, Redondo J, Kemp KC, Singleton WGB, Killick-Cole CL, Stevens JR, Garadi K, Guglani S, Wilkins A, Kurian KM
Histopathology 2017 Jun;70(7):1030-1043. Epub 2017 Mar 23 doi: 10.1111/his.13142. PMID: 27926792
Regulatory T cells are not a strong predictor of survival for patients with glioblastoma.
Thomas AA, Fisher JL, Rahme GJ, Hampton TH, Baron U, Olek S, Schwachula T, Rhodes CH, Gui J, Tafe LJ, Tsongalis GJ, Lefferts JA, Wishart H, Kleen J, Miller M, Whipple CA, de Abreu FB, Ernstoff MS, Fadul CE
Neuro Oncol 2015 Jun;17(6):801-9. Epub 2015 Jan 24 doi: 10.1093/neuonc/nou363. PMID: 25618892Free PMC Article

Clinical prediction guides

Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.
Kang YJ, Balter B, Csizmadia E, Haas B, Sharma H, Bronson R, Yan CT
Nat Commun 2017 Jan 17;8:14013. doi: 10.1038/ncomms14013. PMID: 28094268Free PMC Article
The transcription factor PPARα is overexpressed and is associated with a favourable prognosis in IDH-wildtype primary glioblastoma.
Haynes HR, White P, Hares KM, Redondo J, Kemp KC, Singleton WGB, Killick-Cole CL, Stevens JR, Garadi K, Guglani S, Wilkins A, Kurian KM
Histopathology 2017 Jun;70(7):1030-1043. Epub 2017 Mar 23 doi: 10.1111/his.13142. PMID: 27926792
Regulatory T cells are not a strong predictor of survival for patients with glioblastoma.
Thomas AA, Fisher JL, Rahme GJ, Hampton TH, Baron U, Olek S, Schwachula T, Rhodes CH, Gui J, Tafe LJ, Tsongalis GJ, Lefferts JA, Wishart H, Kleen J, Miller M, Whipple CA, de Abreu FB, Ernstoff MS, Fadul CE
Neuro Oncol 2015 Jun;17(6):801-9. Epub 2015 Jan 24 doi: 10.1093/neuonc/nou363. PMID: 25618892Free PMC Article
Rhabdoid glioblastoma is distinguishable from classical glioblastoma by cytogenetics and molecular genetics.
Byeon SJ, Cho HJ, Baek HW, Park CK, Choi SH, Kim SH, Kim HK, Park SH
Hum Pathol 2014 Mar;45(3):611-20. Epub 2013 Nov 7 doi: 10.1016/j.humpath.2013.08.024. PMID: 24457079

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