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Classical glioblastoma

MedGen UID:
820001
Concept ID:
C3827253
Neoplastic Process
Synonyms: Classical Glioblastoma; classical glioblastoma; glioblastoma classical subtype
 
Monarch Initiative: MONDO:0000457

Definition

A molecular subtype of glioblastoma characterized by lack of p53 mutations, chromosome 7 amplifications or deletions, and high levels of EGFR amplification. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClassical glioblastoma

Professional guidelines

PubMed

Roth P, Hottinger AF, Hundsberger T, Läubli H, Schucht P, Reinert M, Mamot C, Roelcke U, Pesce G, Hofer S, Weller M
Swiss Med Wkly 2020 Jun 1;150:w20256. Epub 2020 Jun 18 doi: 10.4414/smw.2020.20256. PMID: 32557428

Recent clinical studies

Etiology

de Semir D, Bezrookove V, Nosrati M, Scanlon KR, Singer E, Judkins J, Rieken C, Wu C, Shen J, Schmudermayer C, Dar AA, Miller JR 3rd, Cobbs C, Yount G, Desprez PY, Debs RJ, Salomonis N, McAllister S, Cleaver JE, Soroceanu L, Kashani-Sabet M
Proc Natl Acad Sci U S A 2020 Apr 21;117(16):9064-9073. Epub 2020 Apr 9 doi: 10.1073/pnas.1914505117. PMID: 32273388Free PMC Article
Elmahdi A, Frary AJ, Scotton WJ, O'Donovan DG, Price SJ
Br J Neurosurg 2013 Aug;27(4):419-24. Epub 2013 Feb 18 doi: 10.3109/02688697.2013.767315. PMID: 23418780
Odeku EL, Adeloye A
Afr J Med Med Sci 1976 Mar;5(1):31-3. PMID: 829703

Diagnosis

Yadav AK, Madan R, Chatterjee D, Dhiman S, Goyal S, Kumar N, Sahoo SK
CNS Oncol 2020 Dec 1;9(4):CNS63. Epub 2020 Dec 7 doi: 10.2217/cns-2020-0016. PMID: 33283529Free PMC Article
Roth P, Hottinger AF, Hundsberger T, Läubli H, Schucht P, Reinert M, Mamot C, Roelcke U, Pesce G, Hofer S, Weller M
Swiss Med Wkly 2020 Jun 1;150:w20256. Epub 2020 Jun 18 doi: 10.4414/smw.2020.20256. PMID: 32557428
Thomas AA, Fisher JL, Rahme GJ, Hampton TH, Baron U, Olek S, Schwachula T, Rhodes CH, Gui J, Tafe LJ, Tsongalis GJ, Lefferts JA, Wishart H, Kleen J, Miller M, Whipple CA, de Abreu FB, Ernstoff MS, Fadul CE
Neuro Oncol 2015 Jun;17(6):801-9. Epub 2015 Jan 24 doi: 10.1093/neuonc/nou363. PMID: 25618892Free PMC Article
Byeon SJ, Cho HJ, Baek HW, Park CK, Choi SH, Kim SH, Kim HK, Park SH
Hum Pathol 2014 Mar;45(3):611-20. Epub 2013 Nov 7 doi: 10.1016/j.humpath.2013.08.024. PMID: 24457079
Elmahdi A, Frary AJ, Scotton WJ, O'Donovan DG, Price SJ
Br J Neurosurg 2013 Aug;27(4):419-24. Epub 2013 Feb 18 doi: 10.3109/02688697.2013.767315. PMID: 23418780

Therapy

Zaman FY, McLean C, Ameratunga M
J Clin Pharm Ther 2022 Jun;47(6):832-834. Epub 2022 Jan 11 doi: 10.1111/jcpt.13608. PMID: 35018664Free PMC Article
Roth P, Hottinger AF, Hundsberger T, Läubli H, Schucht P, Reinert M, Mamot C, Roelcke U, Pesce G, Hofer S, Weller M
Swiss Med Wkly 2020 Jun 1;150:w20256. Epub 2020 Jun 18 doi: 10.4414/smw.2020.20256. PMID: 32557428
Kang YJ, Balter B, Csizmadia E, Haas B, Sharma H, Bronson R, Yan CT
Nat Commun 2017 Jan 17;8:14013. doi: 10.1038/ncomms14013. PMID: 28094268Free PMC Article
Zheng Y, McFarland BC, Drygin D, Yu H, Bellis SL, Kim H, Bredel M, Benveniste EN
Clin Cancer Res 2013 Dec 1;19(23):6484-94. Epub 2013 Sep 13 doi: 10.1158/1078-0432.CCR-13-0265. PMID: 24036851Free PMC Article

Prognosis

Yadav AK, Madan R, Chatterjee D, Dhiman S, Goyal S, Kumar N, Sahoo SK
CNS Oncol 2020 Dec 1;9(4):CNS63. Epub 2020 Dec 7 doi: 10.2217/cns-2020-0016. PMID: 33283529Free PMC Article
Roth P, Hottinger AF, Hundsberger T, Läubli H, Schucht P, Reinert M, Mamot C, Roelcke U, Pesce G, Hofer S, Weller M
Swiss Med Wkly 2020 Jun 1;150:w20256. Epub 2020 Jun 18 doi: 10.4414/smw.2020.20256. PMID: 32557428
Binda E, Visioli A, Giani F, Trivieri N, Palumbo O, Restelli S, Dezi F, Mazza T, Fusilli C, Legnani F, Carella M, Di Meco F, Duggal R, Vescovi AL
Cancer Res 2017 Feb 15;77(4):996-1007. Epub 2016 Dec 23 doi: 10.1158/0008-5472.CAN-16-1693. PMID: 28011620
Haynes HR, White P, Hares KM, Redondo J, Kemp KC, Singleton WGB, Killick-Cole CL, Stevens JR, Garadi K, Guglani S, Wilkins A, Kurian KM
Histopathology 2017 Jun;70(7):1030-1043. Epub 2017 Mar 23 doi: 10.1111/his.13142. PMID: 27926792
Thomas AA, Fisher JL, Rahme GJ, Hampton TH, Baron U, Olek S, Schwachula T, Rhodes CH, Gui J, Tafe LJ, Tsongalis GJ, Lefferts JA, Wishart H, Kleen J, Miller M, Whipple CA, de Abreu FB, Ernstoff MS, Fadul CE
Neuro Oncol 2015 Jun;17(6):801-9. Epub 2015 Jan 24 doi: 10.1093/neuonc/nou363. PMID: 25618892Free PMC Article

Clinical prediction guides

Kang YJ, Balter B, Csizmadia E, Haas B, Sharma H, Bronson R, Yan CT
Nat Commun 2017 Jan 17;8:14013. doi: 10.1038/ncomms14013. PMID: 28094268Free PMC Article
Haynes HR, White P, Hares KM, Redondo J, Kemp KC, Singleton WGB, Killick-Cole CL, Stevens JR, Garadi K, Guglani S, Wilkins A, Kurian KM
Histopathology 2017 Jun;70(7):1030-1043. Epub 2017 Mar 23 doi: 10.1111/his.13142. PMID: 27926792
Thomas AA, Fisher JL, Rahme GJ, Hampton TH, Baron U, Olek S, Schwachula T, Rhodes CH, Gui J, Tafe LJ, Tsongalis GJ, Lefferts JA, Wishart H, Kleen J, Miller M, Whipple CA, de Abreu FB, Ernstoff MS, Fadul CE
Neuro Oncol 2015 Jun;17(6):801-9. Epub 2015 Jan 24 doi: 10.1093/neuonc/nou363. PMID: 25618892Free PMC Article
Byeon SJ, Cho HJ, Baek HW, Park CK, Choi SH, Kim SH, Kim HK, Park SH
Hum Pathol 2014 Mar;45(3):611-20. Epub 2013 Nov 7 doi: 10.1016/j.humpath.2013.08.024. PMID: 24457079

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