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Glioblastoma by Gene Expression Profile

MedGen UID:
819942
•Concept ID:
C3827194
•
Neoplastic Process

Definition

Classification of glioblastoma into molecular subtypes as defined by gene expression profiling. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlioblastoma by Gene Expression Profile

Professional guidelines

PubMed

Exploring the Mechanism of Adjuvant Treatment of Glioblastoma Using Temozolomide and Metformin.
Feng SW, Chang PC, Chen HY, Hueng DY, Li YF, Huang SM
Int J Mol Sci 2022 Jul 25;23(15) doi: 10.3390/ijms23158171. PMID: 35897747Free PMC Article
Gene expression-based biomarkers designating glioblastomas resistant to multiple treatment strategies.
Menyhárt O, Fekete JT, Győrffy B
Carcinogenesis 2021 Jun 21;42(6):804-813. doi: 10.1093/carcin/bgab024. PMID: 33754151Free PMC Article
The Effect of Molecular Diagnostics on the Treatment of Glioma.
Bush NA, Butowski N
Curr Oncol Rep 2017 Apr;19(4):26. doi: 10.1007/s11912-017-0585-6. PMID: 28303493

Recent clinical studies

Etiology

Combining single-cell sequencing and spatial transcriptome sequencing to identify exosome-related features of glioblastoma and constructing a prognostic model to identify BARD1 as a potential therapeutic target for GBM patients.
Zhao S, Wang Q, Ni K, Zhang P, Liu Y, Xie J, Ji W, Cheng C, Zhou Q
Front Immunol 2023;14:1263329. Epub 2023 Aug 31 doi: 10.3389/fimmu.2023.1263329. PMID: 37727789Free PMC Article
Construction and validation of a cuproptosis-related prognostic model for glioblastoma.
Zhang B, Xie L, Liu J, Liu A, He M
Front Immunol 2023;14:1082974. Epub 2023 Feb 6 doi: 10.3389/fimmu.2023.1082974. PMID: 36814929Free PMC Article
EREG is the core onco-immunological biomarker of cuproptosis and mediates the cross-talk between VEGF and CD99 signaling in glioblastoma.
Zhou Y, Xiao D, Jiang X, Nie C
J Transl Med 2023 Jan 16;21(1):28. doi: 10.1186/s12967-023-03883-4. PMID: 36647156Free PMC Article
Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium.
Shern JF, Selfe J, Izquierdo E, Patidar R, Chou HC, Song YK, Yohe ME, Sindiri S, Wei J, Wen X, Rudzinski ER, Barkauskas DA, Lo T, Hall D, Linardic CM, Hughes D, Jamal S, Jenney M, Chisholm J, Brown R, Jones K, Hicks B, Angelini P, George S, Chesler L, Hubank M, Kelsey A, Gatz SA, Skapek SX, Hawkins DS, Shipley JM, Khan J
J Clin Oncol 2021 Sep 10;39(26):2859-2871. Epub 2021 Jun 24 doi: 10.1200/JCO.20.03060. PMID: 34166060Free PMC Article
Identification of targetable FGFR gene fusions in diverse cancers.
Wu YM, Su F, Kalyana-Sundaram S, Khazanov N, Ateeq B, Cao X, Lonigro RJ, Vats P, Wang R, Lin SF, Cheng AJ, Kunju LP, Siddiqui J, Tomlins SA, Wyngaard P, Sadis S, Roychowdhury S, Hussain MH, Feng FY, Zalupski MM, Talpaz M, Pienta KJ, Rhodes DR, Robinson DR, Chinnaiyan AM
Cancer Discov 2013 Jun;3(6):636-47. Epub 2013 Apr 4 doi: 10.1158/2159-8290.CD-13-0050. PMID: 23558953Free PMC Article

Diagnosis

Construction and validation of a cuproptosis-related prognostic model for glioblastoma.
Zhang B, Xie L, Liu J, Liu A, He M
Front Immunol 2023;14:1082974. Epub 2023 Feb 6 doi: 10.3389/fimmu.2023.1082974. PMID: 36814929Free PMC Article
SLIT2/ROBO signaling in tumor-associated microglia and macrophages drives glioblastoma immunosuppression and vascular dysmorphia.
Geraldo LH, Xu Y, Jacob L, Pibouin-Fragner L, Rao R, Maissa N, Verreault M, Lemaire N, Knosp C, Lesaffre C, Daubon T, Dejaegher J, Solie L, Rudewicz J, Viel T, Tavitian B, De Vleeschouwer S, Sanson M, Bikfalvi A, Idbaih A, Lu QR, Lima FR, Thomas JL, Eichmann A, Mathivet T
J Clin Invest 2021 Aug 16;131(16) doi: 10.1172/JCI141083. PMID: 34181595Free PMC Article
Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium.
Shern JF, Selfe J, Izquierdo E, Patidar R, Chou HC, Song YK, Yohe ME, Sindiri S, Wei J, Wen X, Rudzinski ER, Barkauskas DA, Lo T, Hall D, Linardic CM, Hughes D, Jamal S, Jenney M, Chisholm J, Brown R, Jones K, Hicks B, Angelini P, George S, Chesler L, Hubank M, Kelsey A, Gatz SA, Skapek SX, Hawkins DS, Shipley JM, Khan J
J Clin Oncol 2021 Sep 10;39(26):2859-2871. Epub 2021 Jun 24 doi: 10.1200/JCO.20.03060. PMID: 34166060Free PMC Article
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.
Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Sauvé CG, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, Verhaak RGW
Cancer Cell 2017 Jul 10;32(1):42-56.e6. doi: 10.1016/j.ccell.2017.06.003. PMID: 28697342Free PMC Article
FGF receptors: cancer biology and therapeutics.
Katoh M, Nakagama H
Med Res Rev 2014 Mar;34(2):280-300. Epub 2013 May 21 doi: 10.1002/med.21288. PMID: 23696246

Therapy

Single-cell RNA sequencing reveals changes in glioma-associated macrophage polarization and cellular states of malignant gliomas with high AQP4 expression.
Wang R, Peng L, Xiao Y, Zhou Q, Wang Z, Tang L, Xiao H, Yang K, Liu H, Li L
Cancer Gene Ther 2023 May;30(5):716-726. Epub 2023 Jan 4 doi: 10.1038/s41417-022-00582-y. PMID: 36599974Free PMC Article
Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma.
Xuan W, Hsu WH, Khan F, Dunterman M, Pang L, Wainwright DA, Ahmed AU, Heimberger AB, Lesniak MS, Chen P
Cancer Immunol Res 2022 Jun 3;10(6):770-784. doi: 10.1158/2326-6066.CIR-21-0559. PMID: 35413115Free PMC Article
Anti-invasive efficacy and survival benefit of the YAP-TEAD inhibitor verteporfin in preclinical glioblastoma models.
Barrette AM, Ronk H, Joshi T, Mussa Z, Mehrotra M, Bouras A, Nudelman G, Jesu Raj JG, Bozec D, Lam W, Houldsworth J, Yong R, Zaslavsky E, Hadjipanayis CG, Birtwistle MR, Tsankova NM
Neuro Oncol 2022 May 4;24(5):694-707. doi: 10.1093/neuonc/noab244. PMID: 34657158Free PMC Article
Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.
Huang T, Xu T, Wang Y, Zhou Y, Yu D, Wang Z, He L, Chen Z, Zhang Y, Davidson D, Dai Y, Hang C, Liu X, Yan C
Autophagy 2021 Nov;17(11):3592-3606. Epub 2021 Feb 25 doi: 10.1080/15548627.2021.1885203. PMID: 33629929Free PMC Article
FGF receptors: cancer biology and therapeutics.
Katoh M, Nakagama H
Med Res Rev 2014 Mar;34(2):280-300. Epub 2013 May 21 doi: 10.1002/med.21288. PMID: 23696246

Prognosis

Construction and validation of a cuproptosis-related prognostic model for glioblastoma.
Zhang B, Xie L, Liu J, Liu A, He M
Front Immunol 2023;14:1082974. Epub 2023 Feb 6 doi: 10.3389/fimmu.2023.1082974. PMID: 36814929Free PMC Article
Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma.
Xuan W, Hsu WH, Khan F, Dunterman M, Pang L, Wainwright DA, Ahmed AU, Heimberger AB, Lesniak MS, Chen P
Cancer Immunol Res 2022 Jun 3;10(6):770-784. doi: 10.1158/2326-6066.CIR-21-0559. PMID: 35413115Free PMC Article
Clinical characterization and immunosuppressive regulation of CD161 (KLRB1) in glioma through 916 samples.
Di W, Fan W, Wu F, Shi Z, Wang Z, Yu M, Zhai Y, Chang Y, Pan C, Li G, Kahlert UD, Zhang W
Cancer Sci 2022 Feb;113(2):756-769. Epub 2021 Dec 24 doi: 10.1111/cas.15236. PMID: 34881489Free PMC Article
The landscape and therapeutic relevance of cancer-associated transcript fusions.
Yoshihara K, Wang Q, Torres-Garcia W, Zheng S, Vegesna R, Kim H, Verhaak RG
Oncogene 2015 Sep 10;34(37):4845-54. Epub 2014 Dec 15 doi: 10.1038/onc.2014.406. PMID: 25500544Free PMC Article
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.
Patel AP, Tirosh I, Trombetta JJ, Shalek AK, Gillespie SM, Wakimoto H, Cahill DP, Nahed BV, Curry WT, Martuza RL, Louis DN, Rozenblatt-Rosen O, Suvà ML, Regev A, Bernstein BE
Science 2014 Jun 20;344(6190):1396-401. Epub 2014 Jun 12 doi: 10.1126/science.1254257. PMID: 24925914Free PMC Article

Clinical prediction guides

Transcriptome analysis reveals tumor microenvironment changes in glioblastoma.
Hoogstrate Y, Draaisma K, Ghisai SA, van Hijfte L, Barin N, de Heer I, Coppieters W, van den Bosch TPP, Bolleboom A, Gao Z, Vincent AJPE, Karim L, Deckers M, Taphoorn MJB, Kerkhof M, Weyerbrock A, Sanson M, Hoeben A, Lukacova S, Lombardi G, Leenstra S, Hanse M, Fleischeuer REM, Watts C, Angelopoulos N, Gorlia T, Golfinopoulos V, Bours V, van den Bent MJ, Robe PA, French PJ
Cancer Cell 2023 Apr 10;41(4):678-692.e7. Epub 2023 Mar 9 doi: 10.1016/j.ccell.2023.02.019. PMID: 36898379
Single-cell RNA sequencing and spatial transcriptomics reveal cancer-associated fibroblasts in glioblastoma with protumoral effects.
Jain S, Rick JW, Joshi RS, Beniwal A, Spatz J, Gill S, Chang AC, Choudhary N, Nguyen AT, Sudhir S, Chalif EJ, Chen JS, Chandra A, Haddad AF, Wadhwa H, Shah SS, Choi S, Hayes JL, Wang L, Yagnik G, Costello JF, Diaz A, Heiland DH, Aghi MK
J Clin Invest 2023 Mar 1;133(5) doi: 10.1172/JCI147087. PMID: 36856115Free PMC Article
Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium.
Shern JF, Selfe J, Izquierdo E, Patidar R, Chou HC, Song YK, Yohe ME, Sindiri S, Wei J, Wen X, Rudzinski ER, Barkauskas DA, Lo T, Hall D, Linardic CM, Hughes D, Jamal S, Jenney M, Chisholm J, Brown R, Jones K, Hicks B, Angelini P, George S, Chesler L, Hubank M, Kelsey A, Gatz SA, Skapek SX, Hawkins DS, Shipley JM, Khan J
J Clin Oncol 2021 Sep 10;39(26):2859-2871. Epub 2021 Jun 24 doi: 10.1200/JCO.20.03060. PMID: 34166060Free PMC Article
The landscape and therapeutic relevance of cancer-associated transcript fusions.
Yoshihara K, Wang Q, Torres-Garcia W, Zheng S, Vegesna R, Kim H, Verhaak RG
Oncogene 2015 Sep 10;34(37):4845-54. Epub 2014 Dec 15 doi: 10.1038/onc.2014.406. PMID: 25500544Free PMC Article
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.
Patel AP, Tirosh I, Trombetta JJ, Shalek AK, Gillespie SM, Wakimoto H, Cahill DP, Nahed BV, Curry WT, Martuza RL, Louis DN, Rozenblatt-Rosen O, Suvà ML, Regev A, Bernstein BE
Science 2014 Jun 20;344(6190):1396-401. Epub 2014 Jun 12 doi: 10.1126/science.1254257. PMID: 24925914Free PMC Article

Recent systematic reviews

Transitioning pre-clinical glioblastoma models to clinical settings with biomarkers identified in 3D cell-based models: A systematic scoping review.
Phon BWS, Kamarudin MNA, Bhuvanendran S, Radhakrishnan AK
Biomed Pharmacother 2022 Jan;145:112396. Epub 2021 Nov 11 doi: 10.1016/j.biopha.2021.112396. PMID: 34775238
A meta-analysis of microRNA networks regulated by melatonin in cancer: Portrait of potential candidates for breast cancer treatment.
Chuffa LGA, Carvalho RF, Justulin LA, Cury SS, Seiva FRF, Jardim-Perassi BV, Zuccari DAPC, Reiter RJ
J Pineal Res 2020 Nov;69(4):e12693. Epub 2020 Sep 19 doi: 10.1111/jpi.12693. PMID: 32910542
The Epithelial-to-Mesenchymal Transition-Like Process in Glioblastoma: An Updated Systematic Review and In Silico Investigation.
Iser IC, Pereira MB, Lenz G, Wink MR
Med Res Rev 2017 Mar;37(2):271-313. Epub 2016 Sep 12 doi: 10.1002/med.21408. PMID: 27617697

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