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Proneural glioblastoma

MedGen UID:
821212
Concept ID:
C3828464
Neoplastic Process
Synonyms: glioblastoma proneural subtype; Proneural Glioblastoma; proneural glioblastoma
 
Monarch Initiative: MONDO:0000458

Definition

A molecular subtype of glioblastoma that is associated with younger age at presentation and is characterized by p53 mutations and PDGFRa amplifications. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProneural glioblastoma

Professional guidelines

PubMed

Chen Z, Giotti B, Kaluzova M, Vallcorba MP, Rawat K, Price G, Herting CJ, Pinero G, Cristea S, Ross JL, Ackley J, Maximov V, Szulzewsky F, Thomason W, Marquez-Ropero M, Angione A, Nichols N, Tsankova NM, Michor F, Shayakhmetov DM, Gutmann DH, Tsankov AM, Hambardzumyan D
J Clin Invest 2023 Nov 15;133(22) doi: 10.1172/JCI163802. PMID: 37733448Free PMC Article
Vo VTA, Kim S, Hua TNM, Oh J, Jeong Y
Commun Biol 2022 Jun 16;5(1):593. doi: 10.1038/s42003-022-03538-y. PMID: 35710828Free PMC Article
Olar A, Aldape KD
J Pathol 2014 Jan;232(2):165-77. doi: 10.1002/path.4282. PMID: 24114756Free PMC Article

Recent clinical studies

Etiology

Chelebian E, Fuster-Garcia E, Álvarez-Torres MDM, Juan-Albarracín J, García-Gómez JM
PLoS One 2020;15(10):e0232500. Epub 2020 Oct 14 doi: 10.1371/journal.pone.0232500. PMID: 33052913Free PMC Article
Hu JL, Luo WJ, Wang H
Technol Cancer Res Treat 2019 Jan 1;18:1533033819846636. doi: 10.1177/1533033819846636. PMID: 31072237Free PMC Article
Sandmann T, Bourgon R, Garcia J, Li C, Cloughesy T, Chinot OL, Wick W, Nishikawa R, Mason W, Henriksson R, Saran F, Lai A, Moore N, Kharbanda S, Peale F, Hegde P, Abrey LE, Phillips HS, Bais C
J Clin Oncol 2015 Sep 1;33(25):2735-44. Epub 2015 Jun 29 doi: 10.1200/JCO.2015.61.5005. PMID: 26124478Free PMC Article
Saito N, Fu J, Zheng S, Yao J, Wang S, Liu DD, Yuan Y, Sulman EP, Lang FF, Colman H, Verhaak RG, Yung WK, Koul D
Stem Cells 2014 Jan;32(1):301-12. doi: 10.1002/stem.1528. PMID: 24038660Free PMC Article

Diagnosis

Hu JL, Luo WJ, Wang H
Technol Cancer Res Treat 2019 Jan 1;18:1533033819846636. doi: 10.1177/1533033819846636. PMID: 31072237Free PMC Article
Sandmann T, Bourgon R, Garcia J, Li C, Cloughesy T, Chinot OL, Wick W, Nishikawa R, Mason W, Henriksson R, Saran F, Lai A, Moore N, Kharbanda S, Peale F, Hegde P, Abrey LE, Phillips HS, Bais C
J Clin Oncol 2015 Sep 1;33(25):2735-44. Epub 2015 Jun 29 doi: 10.1200/JCO.2015.61.5005. PMID: 26124478Free PMC Article
Saito N, Fu J, Zheng S, Yao J, Wang S, Liu DD, Yuan Y, Sulman EP, Lang FF, Colman H, Verhaak RG, Yung WK, Koul D
Stem Cells 2014 Jan;32(1):301-12. doi: 10.1002/stem.1528. PMID: 24038660Free PMC Article

Therapy

Lescarbeau RS, Lei L, Bakken KK, Sims PA, Sarkaria JN, Canoll P, White FM
Mol Cancer Ther 2016 Jun;15(6):1332-43. Epub 2016 May 17 doi: 10.1158/1535-7163.MCT-15-0692. PMID: 27196784Free PMC Article
Karpel-Massler G, Bâ M, Shu C, Halatsch ME, Westhoff MA, Bruce JN, Canoll P, Siegelin MD
Oncotarget 2015 Nov 3;6(34):36456-71. doi: 10.18632/oncotarget.5505. PMID: 26474387Free PMC Article
Sandmann T, Bourgon R, Garcia J, Li C, Cloughesy T, Chinot OL, Wick W, Nishikawa R, Mason W, Henriksson R, Saran F, Lai A, Moore N, Kharbanda S, Peale F, Hegde P, Abrey LE, Phillips HS, Bais C
J Clin Oncol 2015 Sep 1;33(25):2735-44. Epub 2015 Jun 29 doi: 10.1200/JCO.2015.61.5005. PMID: 26124478Free PMC Article
Sonabend AM, Carminucci AS, Amendolara B, Bansal M, Leung R, Lei L, Realubit R, Li H, Karan C, Yun J, Showers C, Rothcock R, O J, Califano A, Canoll P, Bruce JN
Neuro Oncol 2014 Sep;16(9):1210-9. Epub 2014 Mar 16 doi: 10.1093/neuonc/nou026. PMID: 24637229Free PMC Article

Prognosis

Hu JL, Luo WJ, Wang H
Technol Cancer Res Treat 2019 Jan 1;18:1533033819846636. doi: 10.1177/1533033819846636. PMID: 31072237Free PMC Article
Badri H, Pitter K, Holland EC, Michor F, Leder K
J Math Biol 2016 Apr;72(5):1301-36. Epub 2015 Jun 21 doi: 10.1007/s00285-015-0908-x. PMID: 26094055
Karpel-Massler G, Bâ M, Shu C, Halatsch ME, Westhoff MA, Bruce JN, Canoll P, Siegelin MD
Oncotarget 2015 Nov 3;6(34):36456-71. doi: 10.18632/oncotarget.5505. PMID: 26474387Free PMC Article
Sandmann T, Bourgon R, Garcia J, Li C, Cloughesy T, Chinot OL, Wick W, Nishikawa R, Mason W, Henriksson R, Saran F, Lai A, Moore N, Kharbanda S, Peale F, Hegde P, Abrey LE, Phillips HS, Bais C
J Clin Oncol 2015 Sep 1;33(25):2735-44. Epub 2015 Jun 29 doi: 10.1200/JCO.2015.61.5005. PMID: 26124478Free PMC Article
Kim Y, Kim E, Wu Q, Guryanova O, Hitomi M, Lathia JD, Serwanski D, Sloan AE, Weil RJ, Lee J, Nishiyama A, Bao S, Hjelmeland AB, Rich JN
Genes Dev 2012 Jun 1;26(11):1247-62. doi: 10.1101/gad.193565.112. PMID: 22661233Free PMC Article

Clinical prediction guides

Hu JL, Luo WJ, Wang H
Technol Cancer Res Treat 2019 Jan 1;18:1533033819846636. doi: 10.1177/1533033819846636. PMID: 31072237Free PMC Article
Rahme GJ, Luikart BW, Cheng C, Israel MA
Neuro Oncol 2018 Feb 19;20(3):332-342. doi: 10.1093/neuonc/nox129. PMID: 29016807Free PMC Article
Rahme GJ, Zhang Z, Young AL, Cheng C, Bivona EJ, Fiering SN, Hitoshi Y, Israel MA
Cancer Res 2016 May 15;76(10):2964-76. Epub 2016 Mar 7 doi: 10.1158/0008-5472.CAN-15-2157. PMID: 26951930
Badri H, Pitter K, Holland EC, Michor F, Leder K
J Math Biol 2016 Apr;72(5):1301-36. Epub 2015 Jun 21 doi: 10.1007/s00285-015-0908-x. PMID: 26094055
Sandmann T, Bourgon R, Garcia J, Li C, Cloughesy T, Chinot OL, Wick W, Nishikawa R, Mason W, Henriksson R, Saran F, Lai A, Moore N, Kharbanda S, Peale F, Hegde P, Abrey LE, Phillips HS, Bais C
J Clin Oncol 2015 Sep 1;33(25):2735-44. Epub 2015 Jun 29 doi: 10.1200/JCO.2015.61.5005. PMID: 26124478Free PMC Article

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