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Proneural glioblastoma

MedGen UID:
821212
•Concept ID:
C3828464
•
Neoplastic Process
Synonyms: glioblastoma proneural subtype; Proneural Glioblastoma; proneural glioblastoma
 
Monarch Initiative: MONDO:0000458

Definition

A molecular subtype of glioblastoma that is associated with younger age at presentation and is characterized by p53 mutations and PDGFRa amplifications. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProneural glioblastoma

Professional guidelines

PubMed

Gene regulatory network topology governs resistance and treatment escape in glioma stem-like cells.
Park JH, Hothi P, de Lomana ALG, Pan M, Calder R, Turkarslan S, Wu WJ, Lee H, Patel AP, Cobbs C, Huang S, Baliga NS
Sci Adv 2024 Jun 7;10(23):eadj7706. doi: 10.1126/sciadv.adj7706. PMID: 38848360Free PMC Article
A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression.
Chen Z, Giotti B, Kaluzova M, Vallcorba MP, Rawat K, Price G, Herting CJ, Pinero G, Cristea S, Ross JL, Ackley J, Maximov V, Szulzewsky F, Thomason W, Marquez-Ropero M, Angione A, Nichols N, Tsankova NM, Michor F, Shayakhmetov DM, Gutmann DH, Tsankov AM, Hambardzumyan D
J Clin Invest 2023 Nov 15;133(22) doi: 10.1172/JCI163802. PMID: 37733448Free PMC Article
Using the molecular classification of glioblastoma to inform personalized treatment.
Olar A, Aldape KD
J Pathol 2014 Jan;232(2):165-77. doi: 10.1002/path.4282. PMID: 24114756Free PMC Article

Recent clinical studies

Etiology

Higher vascularity at infiltrated peripheral edema differentiates proneural glioblastoma subtype.
Chelebian E, Fuster-Garcia E, Álvarez-Torres MDM, Juan-Albarracín J, García-Gómez JM
PLoS One 2020;15(10):e0232500. Epub 2020 Oct 14 doi: 10.1371/journal.pone.0232500. PMID: 33052913Free PMC Article
Angiogenin Upregulation Independently Predicts Unfavorable Overall Survival in Proneural Subtype of Glioblastoma.
Hu JL, Luo WJ, Wang H
Technol Cancer Res Treat 2019 Jan 1;18:1533033819846636. doi: 10.1177/1533033819846636. PMID: 31072237Free PMC Article
Patients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio Trial.
Sandmann T, Bourgon R, Garcia J, Li C, Cloughesy T, Chinot OL, Wick W, Nishikawa R, Mason W, Henriksson R, Saran F, Lai A, Moore N, Kharbanda S, Peale F, Hegde P, Abrey LE, Phillips HS, Bais C
J Clin Oncol 2015 Sep 1;33(25):2735-44. Epub 2015 Jun 29 doi: 10.1200/JCO.2015.61.5005. PMID: 26124478Free PMC Article
A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells.
Saito N, Fu J, Zheng S, Yao J, Wang S, Liu DD, Yuan Y, Sulman EP, Lang FF, Colman H, Verhaak RG, Yung WK, Koul D
Stem Cells 2014 Jan;32(1):301-12. doi: 10.1002/stem.1528. PMID: 24038660Free PMC Article

Diagnosis

Angiogenin Upregulation Independently Predicts Unfavorable Overall Survival in Proneural Subtype of Glioblastoma.
Hu JL, Luo WJ, Wang H
Technol Cancer Res Treat 2019 Jan 1;18:1533033819846636. doi: 10.1177/1533033819846636. PMID: 31072237Free PMC Article
Patients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio Trial.
Sandmann T, Bourgon R, Garcia J, Li C, Cloughesy T, Chinot OL, Wick W, Nishikawa R, Mason W, Henriksson R, Saran F, Lai A, Moore N, Kharbanda S, Peale F, Hegde P, Abrey LE, Phillips HS, Bais C
J Clin Oncol 2015 Sep 1;33(25):2735-44. Epub 2015 Jun 29 doi: 10.1200/JCO.2015.61.5005. PMID: 26124478Free PMC Article
A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells.
Saito N, Fu J, Zheng S, Yao J, Wang S, Liu DD, Yuan Y, Sulman EP, Lang FF, Colman H, Verhaak RG, Yung WK, Koul D
Stem Cells 2014 Jan;32(1):301-12. doi: 10.1002/stem.1528. PMID: 24038660Free PMC Article

Therapy

Quantitative Phosphoproteomics Reveals Wee1 Kinase as a Therapeutic Target in a Model of Proneural Glioblastoma.
Lescarbeau RS, Lei L, Bakken KK, Sims PA, Sarkaria JN, Canoll P, White FM
Mol Cancer Ther 2016 Jun;15(6):1332-43. Epub 2016 May 17 doi: 10.1158/1535-7163.MCT-15-0692. PMID: 27196784Free PMC Article
TIC10/ONC201 synergizes with Bcl-2/Bcl-xL inhibition in glioblastoma by suppression of Mcl-1 and its binding partners in vitro and in vivo.
Karpel-Massler G, Bâ M, Shu C, Halatsch ME, Westhoff MA, Bruce JN, Canoll P, Siegelin MD
Oncotarget 2015 Nov 3;6(34):36456-71. doi: 10.18632/oncotarget.5505. PMID: 26474387Free PMC Article
Patients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio Trial.
Sandmann T, Bourgon R, Garcia J, Li C, Cloughesy T, Chinot OL, Wick W, Nishikawa R, Mason W, Henriksson R, Saran F, Lai A, Moore N, Kharbanda S, Peale F, Hegde P, Abrey LE, Phillips HS, Bais C
J Clin Oncol 2015 Sep 1;33(25):2735-44. Epub 2015 Jun 29 doi: 10.1200/JCO.2015.61.5005. PMID: 26124478Free PMC Article
Convection-enhanced delivery of etoposide is effective against murine proneural glioblastoma.
Sonabend AM, Carminucci AS, Amendolara B, Bansal M, Leung R, Lei L, Realubit R, Li H, Karan C, Yun J, Showers C, Rothcock R, O J, Califano A, Canoll P, Bruce JN
Neuro Oncol 2014 Sep;16(9):1210-9. Epub 2014 Mar 16 doi: 10.1093/neuonc/nou026. PMID: 24637229Free PMC Article

Prognosis

Angiogenin Upregulation Independently Predicts Unfavorable Overall Survival in Proneural Subtype of Glioblastoma.
Hu JL, Luo WJ, Wang H
Technol Cancer Res Treat 2019 Jan 1;18:1533033819846636. doi: 10.1177/1533033819846636. PMID: 31072237Free PMC Article
Optimization of radiation dosing schedules for proneural glioblastoma.
Badri H, Pitter K, Holland EC, Michor F, Leder K
J Math Biol 2016 Apr;72(5):1301-36. Epub 2015 Jun 21 doi: 10.1007/s00285-015-0908-x. PMID: 26094055
TIC10/ONC201 synergizes with Bcl-2/Bcl-xL inhibition in glioblastoma by suppression of Mcl-1 and its binding partners in vitro and in vivo.
Karpel-Massler G, Bâ M, Shu C, Halatsch ME, Westhoff MA, Bruce JN, Canoll P, Siegelin MD
Oncotarget 2015 Nov 3;6(34):36456-71. doi: 10.18632/oncotarget.5505. PMID: 26474387Free PMC Article
Patients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio Trial.
Sandmann T, Bourgon R, Garcia J, Li C, Cloughesy T, Chinot OL, Wick W, Nishikawa R, Mason W, Henriksson R, Saran F, Lai A, Moore N, Kharbanda S, Peale F, Hegde P, Abrey LE, Phillips HS, Bais C
J Clin Oncol 2015 Sep 1;33(25):2735-44. Epub 2015 Jun 29 doi: 10.1200/JCO.2015.61.5005. PMID: 26124478Free PMC Article
Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity.
Kim Y, Kim E, Wu Q, Guryanova O, Hitomi M, Lathia JD, Serwanski D, Sloan AE, Weil RJ, Lee J, Nishiyama A, Bao S, Hjelmeland AB, Rich JN
Genes Dev 2012 Jun 1;26(11):1247-62. doi: 10.1101/gad.193565.112. PMID: 22661233Free PMC Article

Clinical prediction guides

Angiogenin Upregulation Independently Predicts Unfavorable Overall Survival in Proneural Subtype of Glioblastoma.
Hu JL, Luo WJ, Wang H
Technol Cancer Res Treat 2019 Jan 1;18:1533033819846636. doi: 10.1177/1533033819846636. PMID: 31072237Free PMC Article
A recombinant lentiviral PDGF-driven mouse model of proneural glioblastoma.
Rahme GJ, Luikart BW, Cheng C, Israel MA
Neuro Oncol 2018 Feb 19;20(3):332-342. doi: 10.1093/neuonc/nox129. PMID: 29016807Free PMC Article
PDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-Mediated Survival of Proneural Glioma Cells.
Rahme GJ, Zhang Z, Young AL, Cheng C, Bivona EJ, Fiering SN, Hitoshi Y, Israel MA
Cancer Res 2016 May 15;76(10):2964-76. Epub 2016 Mar 7 doi: 10.1158/0008-5472.CAN-15-2157. PMID: 26951930
Optimization of radiation dosing schedules for proneural glioblastoma.
Badri H, Pitter K, Holland EC, Michor F, Leder K
J Math Biol 2016 Apr;72(5):1301-36. Epub 2015 Jun 21 doi: 10.1007/s00285-015-0908-x. PMID: 26094055
Patients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio Trial.
Sandmann T, Bourgon R, Garcia J, Li C, Cloughesy T, Chinot OL, Wick W, Nishikawa R, Mason W, Henriksson R, Saran F, Lai A, Moore N, Kharbanda S, Peale F, Hegde P, Abrey LE, Phillips HS, Bais C
J Clin Oncol 2015 Sep 1;33(25):2735-44. Epub 2015 Jun 29 doi: 10.1200/JCO.2015.61.5005. PMID: 26124478Free PMC Article

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