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Neural glioblastoma

MedGen UID:
821580
Concept ID:
C3828832
Neoplastic Process
Synonyms: glioblastoma neural subtype; Neural Glioblastoma; neural glioblastoma
 
Monarch Initiative: MONDO:0000460

Definition

A molecular subtype of glioblastoma characterized by the expression of the neural markers NEFL, GABRA1, SYT1, and SLC12A5. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeural glioblastoma

Professional guidelines

PubMed

Verdugo E, Puerto I, Medina MÁ
Cancer Commun (Lond) 2022 Nov;42(11):1083-1111. Epub 2022 Sep 21 doi: 10.1002/cac2.12361. PMID: 36129048Free PMC Article
Korde LA, Somerfield MR, Carey LA, Crews JR, Denduluri N, Hwang ES, Khan SA, Loibl S, Morris EA, Perez A, Regan MM, Spears PA, Sudheendra PK, Symmans WF, Yung RL, Harvey BE, Hershman DL
J Clin Oncol 2021 May 1;39(13):1485-1505. Epub 2021 Jan 28 doi: 10.1200/JCO.20.03399. PMID: 33507815Free PMC Article
Gholamin S, Mitra SS, Feroze AH, Liu J, Kahn SA, Zhang M, Esparza R, Richard C, Ramaswamy V, Remke M, Volkmer AK, Willingham S, Ponnuswami A, McCarty A, Lovelace P, Storm TA, Schubert S, Hutter G, Narayanan C, Chu P, Raabe EH, Harsh G 4th, Taylor MD, Monje M, Cho YJ, Majeti R, Volkmer JP, Fisher PG, Grant G, Steinberg GK, Vogel H, Edwards M, Weissman IL, Cheshier SH
Sci Transl Med 2017 Mar 15;9(381) doi: 10.1126/scitranslmed.aaf2968. PMID: 28298418

Recent clinical studies

Etiology

Luo C, Song K, Wu S, Hameed NUF, Kudulaiti N, Xu H, Qin ZY, Wu JS
Br J Neurosurg 2021 Oct;35(5):555-561. Epub 2021 Jul 8 doi: 10.1080/02688697.2021.1907306. PMID: 34236262
Korde LA, Somerfield MR, Carey LA, Crews JR, Denduluri N, Hwang ES, Khan SA, Loibl S, Morris EA, Perez A, Regan MM, Spears PA, Sudheendra PK, Symmans WF, Yung RL, Harvey BE, Hershman DL
J Clin Oncol 2021 May 1;39(13):1485-1505. Epub 2021 Jan 28 doi: 10.1200/JCO.20.03399. PMID: 33507815Free PMC Article
Neftel C, Laffy J, Filbin MG, Hara T, Shore ME, Rahme GJ, Richman AR, Silverbush D, Shaw ML, Hebert CM, Dewitt J, Gritsch S, Perez EM, Gonzalez Castro LN, Lan X, Druck N, Rodman C, Dionne D, Kaplan A, Bertalan MS, Small J, Pelton K, Becker S, Bonal D, Nguyen QD, Servis RL, Fung JM, Mylvaganam R, Mayr L, Gojo J, Haberler C, Geyeregger R, Czech T, Slavc I, Nahed BV, Curry WT, Carter BS, Wakimoto H, Brastianos PK, Batchelor TT, Stemmer-Rachamimov A, Martinez-Lage M, Frosch MP, Stamenkovic I, Riggi N, Rheinbay E, Monje M, Rozenblatt-Rosen O, Cahill DP, Patel AP, Hunter T, Verma IM, Ligon KL, Louis DN, Regev A, Bernstein BE, Tirosh I, Suvà ML
Cell 2019 Aug 8;178(4):835-849.e21. Epub 2019 Jul 18 doi: 10.1016/j.cell.2019.06.024. PMID: 31327527Free PMC Article
Venkatesh HS, Tam LT, Woo PJ, Lennon J, Nagaraja S, Gillespie SM, Ni J, Duveau DY, Morris PJ, Zhao JJ, Thomas CJ, Monje M
Nature 2017 Sep 28;549(7673):533-537. Epub 2017 Sep 20 doi: 10.1038/nature24014. PMID: 28959975Free PMC Article
Gholamin S, Mitra SS, Feroze AH, Liu J, Kahn SA, Zhang M, Esparza R, Richard C, Ramaswamy V, Remke M, Volkmer AK, Willingham S, Ponnuswami A, McCarty A, Lovelace P, Storm TA, Schubert S, Hutter G, Narayanan C, Chu P, Raabe EH, Harsh G 4th, Taylor MD, Monje M, Cho YJ, Majeti R, Volkmer JP, Fisher PG, Grant G, Steinberg GK, Vogel H, Edwards M, Weissman IL, Cheshier SH
Sci Transl Med 2017 Mar 15;9(381) doi: 10.1126/scitranslmed.aaf2968. PMID: 28298418

Diagnosis

Verdugo E, Puerto I, Medina MÁ
Cancer Commun (Lond) 2022 Nov;42(11):1083-1111. Epub 2022 Sep 21 doi: 10.1002/cac2.12361. PMID: 36129048Free PMC Article
Luo C, Song K, Wu S, Hameed NUF, Kudulaiti N, Xu H, Qin ZY, Wu JS
Br J Neurosurg 2021 Oct;35(5):555-561. Epub 2021 Jul 8 doi: 10.1080/02688697.2021.1907306. PMID: 34236262
Osuka S, Zhu D, Zhang Z, Li C, Stackhouse CT, Sampetrean O, Olson JJ, Gillespie GY, Saya H, Willey CD, Van Meir EG
J Clin Invest 2021 Mar 15;131(6) doi: 10.1172/JCI136098. PMID: 33720050Free PMC Article
Frattini V, Trifonov V, Chan JM, Castano A, Lia M, Abate F, Keir ST, Ji AX, Zoppoli P, Niola F, Danussi C, Dolgalev I, Porrati P, Pellegatta S, Heguy A, Gupta G, Pisapia DJ, Canoll P, Bruce JN, McLendon RE, Yan H, Aldape K, Finocchiaro G, Mikkelsen T, Privé GG, Bigner DD, Lasorella A, Rabadan R, Iavarone A
Nat Genet 2013 Oct;45(10):1141-9. Epub 2013 Aug 5 doi: 10.1038/ng.2734. PMID: 23917401Free PMC Article
Ohgaki H, Kleihues P
Clin Cancer Res 2013 Feb 15;19(4):764-72. Epub 2012 Dec 3 doi: 10.1158/1078-0432.CCR-12-3002. PMID: 23209033

Therapy

Krishna S, Choudhury A, Keough MB, Seo K, Ni L, Kakaizada S, Lee A, Aabedi A, Popova G, Lipkin B, Cao C, Nava Gonzales C, Sudharshan R, Egladyous A, Almeida N, Zhang Y, Molinaro AM, Venkatesh HS, Daniel AGS, Shamardani K, Hyer J, Chang EF, Findlay A, Phillips JJ, Nagarajan S, Raleigh DR, Brang D, Monje M, Hervey-Jumper SL
Nature 2023 May;617(7961):599-607. Epub 2023 May 3 doi: 10.1038/s41586-023-06036-1. PMID: 37138086Free PMC Article
Verdugo E, Puerto I, Medina MÁ
Cancer Commun (Lond) 2022 Nov;42(11):1083-1111. Epub 2022 Sep 21 doi: 10.1002/cac2.12361. PMID: 36129048Free PMC Article
Shepherd JH, Ballman K, Polley MC, Campbell JD, Fan C, Selitsky S, Fernandez-Martinez A, Parker JS, Hoadley KA, Hu Z, Li Y, Soloway MG, Spears PA, Singh B, Tolaney SM, Somlo G, Port ER, Ma C, Kuzma C, Mamounas E, Golshan M, Bellon JR, Collyar D, Hahn OM, Hudis CA, Winer EP, Partridge A, Hyslop T, Carey LA, Perou CM, Sikov WM
J Clin Oncol 2022 Apr 20;40(12):1323-1334. Epub 2022 Jan 19 doi: 10.1200/JCO.21.01506. PMID: 35044810Free PMC Article
Fares J, Ahmed AU, Ulasov IV, Sonabend AM, Miska J, Lee-Chang C, Balyasnikova IV, Chandler JP, Portnow J, Tate MC, Kumthekar P, Lukas RV, Grimm SA, Adams AK, Hébert CD, Strong TV, Amidei C, Arrieta VA, Zannikou M, Horbinski C, Zhang H, Burdett KB, Curiel DT, Sachdev S, Aboody KS, Stupp R, Lesniak MS
Lancet Oncol 2021 Aug;22(8):1103-1114. Epub 2021 Jun 29 doi: 10.1016/S1470-2045(21)00245-X. PMID: 34214495Free PMC Article
Korde LA, Somerfield MR, Carey LA, Crews JR, Denduluri N, Hwang ES, Khan SA, Loibl S, Morris EA, Perez A, Regan MM, Spears PA, Sudheendra PK, Symmans WF, Yung RL, Harvey BE, Hershman DL
J Clin Oncol 2021 May 1;39(13):1485-1505. Epub 2021 Jan 28 doi: 10.1200/JCO.20.03399. PMID: 33507815Free PMC Article

Prognosis

Krishna S, Choudhury A, Keough MB, Seo K, Ni L, Kakaizada S, Lee A, Aabedi A, Popova G, Lipkin B, Cao C, Nava Gonzales C, Sudharshan R, Egladyous A, Almeida N, Zhang Y, Molinaro AM, Venkatesh HS, Daniel AGS, Shamardani K, Hyer J, Chang EF, Findlay A, Phillips JJ, Nagarajan S, Raleigh DR, Brang D, Monje M, Hervey-Jumper SL
Nature 2023 May;617(7961):599-607. Epub 2023 May 3 doi: 10.1038/s41586-023-06036-1. PMID: 37138086Free PMC Article
Verdugo E, Puerto I, Medina MÁ
Cancer Commun (Lond) 2022 Nov;42(11):1083-1111. Epub 2022 Sep 21 doi: 10.1002/cac2.12361. PMID: 36129048Free PMC Article
Luo C, Song K, Wu S, Hameed NUF, Kudulaiti N, Xu H, Qin ZY, Wu JS
Br J Neurosurg 2021 Oct;35(5):555-561. Epub 2021 Jul 8 doi: 10.1080/02688697.2021.1907306. PMID: 34236262
Ohgaki H, Kleihues P
Clin Cancer Res 2013 Feb 15;19(4):764-72. Epub 2012 Dec 3 doi: 10.1158/1078-0432.CCR-12-3002. PMID: 23209033
Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, Miller CR, Ding L, Golub T, Mesirov JP, Alexe G, Lawrence M, O'Kelly M, Tamayo P, Weir BA, Gabriel S, Winckler W, Gupta S, Jakkula L, Feiler HS, Hodgson JG, James CD, Sarkaria JN, Brennan C, Kahn A, Spellman PT, Wilson RK, Speed TP, Gray JW, Meyerson M, Getz G, Perou CM, Hayes DN; Cancer Genome Atlas Research Network
Cancer Cell 2010 Jan 19;17(1):98-110. doi: 10.1016/j.ccr.2009.12.020. PMID: 20129251Free PMC Article

Clinical prediction guides

Song Q, Ruiz J, Xing F, Lo HW, Craddock L, Pullikuth AK, Miller LD, Soike MH, O'Neill SS, Watabe K, Chan MD, Su J
Commun Biol 2023 Jul 21;6(1):760. doi: 10.1038/s42003-023-05124-2. PMID: 37479733Free PMC Article
Krishna S, Choudhury A, Keough MB, Seo K, Ni L, Kakaizada S, Lee A, Aabedi A, Popova G, Lipkin B, Cao C, Nava Gonzales C, Sudharshan R, Egladyous A, Almeida N, Zhang Y, Molinaro AM, Venkatesh HS, Daniel AGS, Shamardani K, Hyer J, Chang EF, Findlay A, Phillips JJ, Nagarajan S, Raleigh DR, Brang D, Monje M, Hervey-Jumper SL
Nature 2023 May;617(7961):599-607. Epub 2023 May 3 doi: 10.1038/s41586-023-06036-1. PMID: 37138086Free PMC Article
Shepherd JH, Ballman K, Polley MC, Campbell JD, Fan C, Selitsky S, Fernandez-Martinez A, Parker JS, Hoadley KA, Hu Z, Li Y, Soloway MG, Spears PA, Singh B, Tolaney SM, Somlo G, Port ER, Ma C, Kuzma C, Mamounas E, Golshan M, Bellon JR, Collyar D, Hahn OM, Hudis CA, Winer EP, Partridge A, Hyslop T, Carey LA, Perou CM, Sikov WM
J Clin Oncol 2022 Apr 20;40(12):1323-1334. Epub 2022 Jan 19 doi: 10.1200/JCO.21.01506. PMID: 35044810Free PMC Article
Luo C, Song K, Wu S, Hameed NUF, Kudulaiti N, Xu H, Qin ZY, Wu JS
Br J Neurosurg 2021 Oct;35(5):555-561. Epub 2021 Jul 8 doi: 10.1080/02688697.2021.1907306. PMID: 34236262
Tang M, Xie Q, Gimple RC, Zhong Z, Tam T, Tian J, Kidwell RL, Wu Q, Prager BC, Qiu Z, Yu A, Zhu Z, Mesci P, Jing H, Schimelman J, Wang P, Lee D, Lorenzini MH, Dixit D, Zhao L, Bhargava S, Miller TE, Wan X, Tang J, Sun B, Cravatt BF, Muotri AR, Chen S, Rich JN
Cell Res 2020 Oct;30(10):833-853. Epub 2020 Jun 4 doi: 10.1038/s41422-020-0338-1. PMID: 32499560Free PMC Article

Recent systematic reviews

Ji H, Wang F, Liu Z, Li Y, Sun H, Xiao A, Zhang H, You C, Hu S, Liu Y
J Transl Med 2023 Aug 8;21(1):533. doi: 10.1186/s12967-023-04382-2. PMID: 37553713Free PMC Article
Shafi O, Siddiqui G
World J Surg Oncol 2022 May 10;20(1):146. doi: 10.1186/s12957-022-02602-5. PMID: 35538578Free PMC Article
Cozzi S, Najafi M, Gomar M, Ciammella P, Iotti C, Iaccarino C, Dominici M, Pavesi G, Chiavelli C, Kazemian A, Jahanbakhshi A
Curr Oncol 2022 Feb 4;29(2):881-891. doi: 10.3390/curroncol29020075. PMID: 35200574Free PMC Article
Xu K, Khine KT, Ooi YC, Quinsey CS
Clin Neurol Neurosurg 2018 Nov;174:239-243. Epub 2018 Sep 27 doi: 10.1016/j.clineuro.2018.09.038. PMID: 30292900
Deighton RF, McGregor R, Kemp J, McCulloch J, Whittle IR
Brain Pathol 2010 Jul;20(4):691-703. Epub 2010 Jan 13 doi: 10.1111/j.1750-3639.2010.00376.x. PMID: 20175778Free PMC Article

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