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Central nervous system tuberculosis

MedGen UID:
82907
Concept ID:
C0275904
Disease or Syndrome
Synonyms: Central Nervous System Tuberculosis; Tuberculosis, Central Nervous System
SNOMED CT: Tuberculosis of central nervous system (10706006)
 
Monarch Initiative: MONDO:0005696

Definition

A well-circumscribed mass composed of tuberculous granulation tissue that may occur in the cerebral hemispheres, cerebellum, brain stem, or perimeningeal spaces. Multiple lesions are quite common. Management of intracranial manifestations vary with lesion site. Intracranial tuberculomas may be associated with seizures, focal neurologic deficits, and intracranial hypertension. Spinal cord tuberculomas may be associated with localized or radicular pain, weakness, sensory loss, and incontinence. Tuberculomas may arise as opportunistic infections, but also occur in immunocompetent individuals. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral nervous system tuberculosis

Professional guidelines

PubMed

van der Harst JJ, Luijckx GJ
Curr Pharm Des 2011;17(27):2940-7. doi: 10.2174/138161211797470237. PMID: 21834764
Buonsenso D, Serranti D, Valentini P
Eur Rev Med Pharmacol Sci 2010 Oct;14(10):845-53. PMID: 21222370
Thwaites G, Fisher M, Hemingway C, Scott G, Solomon T, Innes J; British Infection Society
J Infect 2009 Sep;59(3):167-87. Epub 2009 Jul 4 doi: 10.1016/j.jinf.2009.06.011. PMID: 19643501

Recent clinical studies

Etiology

Navarro-Flores A, Fernandez-Chinguel JE, Pacheco-Barrios N, Soriano-Moreno DR, Pacheco-Barrios K
J Neurol 2022 Jul;269(7):3482-3494. Epub 2022 Mar 15 doi: 10.1007/s00415-022-11052-8. PMID: 35288778Free PMC Article
Rodriguez-Takeuchi SY, Renjifo ME, Medina FJ
Radiographics 2019 Nov-Dec;39(7):2023-2037. doi: 10.1148/rg.2019190109. PMID: 31697616
Chamie G, Marquez C, Luetkemeyer A
Semin Neurol 2014 Feb;34(1):103-15. Epub 2014 Apr 8 doi: 10.1055/s-0034-1372347. PMID: 24715493
Garcia-Monco JC
Handb Clin Neurol 2014;121:1485-99. doi: 10.1016/B978-0-7020-4088-7.00100-0. PMID: 24365432
Cherian A, Thomas SV
Afr Health Sci 2011 Mar;11(1):116-27. PMID: 21572867Free PMC Article

Diagnosis

Shahan B, Choi EY, Nieves G
Am Fam Physician 2021 Apr 1;103(7):422-428. PMID: 33788511
Dian S, Ganiem AR, van Laarhoven A
Curr Opin Neurol 2021 Jun 1;34(3):396-402. doi: 10.1097/WCO.0000000000000920. PMID: 33661159Free PMC Article
Rodriguez-Takeuchi SY, Renjifo ME, Medina FJ
Radiographics 2019 Nov-Dec;39(7):2023-2037. doi: 10.1148/rg.2019190109. PMID: 31697616
Giovane RA, Lavender PD
Prim Care 2018 Sep;45(3):505-518. Epub 2018 Jul 9 doi: 10.1016/j.pop.2018.05.007. PMID: 30115337
Leonard JM
Microbiol Spectr 2017 Mar;5(2) doi: 10.1128/microbiolspec.TNMI7-0044-2017. PMID: 28281443

Therapy

Navarro-Flores A, Fernandez-Chinguel JE, Pacheco-Barrios N, Soriano-Moreno DR, Pacheco-Barrios K
J Neurol 2022 Jul;269(7):3482-3494. Epub 2022 Mar 15 doi: 10.1007/s00415-022-11052-8. PMID: 35288778Free PMC Article
Dian S, Ganiem AR, van Laarhoven A
Curr Opin Neurol 2021 Jun 1;34(3):396-402. doi: 10.1097/WCO.0000000000000920. PMID: 33661159Free PMC Article
Schaller MA, Wicke F, Foerch C, Weidauer S
Clin Neuroradiol 2019 Mar;29(1):3-18. Epub 2018 Sep 17 doi: 10.1007/s00062-018-0726-9. PMID: 30225516
Giovane RA, Lavender PD
Prim Care 2018 Sep;45(3):505-518. Epub 2018 Jul 9 doi: 10.1016/j.pop.2018.05.007. PMID: 30115337
Leonard JM
Microbiol Spectr 2017 Mar;5(2) doi: 10.1128/microbiolspec.TNMI7-0044-2017. PMID: 28281443

Prognosis

Shahan B, Choi EY, Nieves G
Am Fam Physician 2021 Apr 1;103(7):422-428. PMID: 33788511
Dian S, Ganiem AR, van Laarhoven A
Curr Opin Neurol 2021 Jun 1;34(3):396-402. doi: 10.1097/WCO.0000000000000920. PMID: 33661159Free PMC Article
Schaller MA, Wicke F, Foerch C, Weidauer S
Clin Neuroradiol 2019 Mar;29(1):3-18. Epub 2018 Sep 17 doi: 10.1007/s00062-018-0726-9. PMID: 30225516
Giovane RA, Lavender PD
Prim Care 2018 Sep;45(3):505-518. Epub 2018 Jul 9 doi: 10.1016/j.pop.2018.05.007. PMID: 30115337
Leonard JM
Microbiol Spectr 2017 Mar;5(2) doi: 10.1128/microbiolspec.TNMI7-0044-2017. PMID: 28281443

Clinical prediction guides

Navarro-Flores A, Fernandez-Chinguel JE, Pacheco-Barrios N, Soriano-Moreno DR, Pacheco-Barrios K
J Neurol 2022 Jul;269(7):3482-3494. Epub 2022 Mar 15 doi: 10.1007/s00415-022-11052-8. PMID: 35288778Free PMC Article
Dhiman R, Lakra S, Panda PK, Hemachandran N, Sharma S, Saxena R
Eye (Lond) 2022 Jan;36(1):15-28. Epub 2021 Jun 14 doi: 10.1038/s41433-021-01619-6. PMID: 34127839Free PMC Article
Popoca-Rodríguez I, Cárdenas G
Gac Med Mex 2021;157(4):371-376. doi: 10.24875/GMM.M21000577. PMID: 35133328
Salvador GLO, Basso ACN, Barbieri PP, Leitao CA, Teixeira BCA, Neto AC
Clin Imaging 2021 Jan;69:158-168. Epub 2020 Jul 29 doi: 10.1016/j.clinimag.2020.07.020. PMID: 32853843
Be NA, Kim KS, Bishai WR, Jain SK
Curr Mol Med 2009 Mar;9(2):94-9. doi: 10.2174/156652409787581655. PMID: 19275620Free PMC Article

Recent systematic reviews

Kruthika P
Int J Mycobacteriol 2022 Jul-Sep;11(3):229-235. doi: 10.4103/ijmy.ijmy_101_22. PMID: 36260439
Navarro-Flores A, Fernandez-Chinguel JE, Pacheco-Barrios N, Soriano-Moreno DR, Pacheco-Barrios K
J Neurol 2022 Jul;269(7):3482-3494. Epub 2022 Mar 15 doi: 10.1007/s00415-022-11052-8. PMID: 35288778Free PMC Article

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