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DS Stage III Plasma Cell Myeloma

MedGen UID:
82969
Concept ID:
C0278724
Neoplastic Process
Synonyms: DS Stage III Multiple Myeloma; Durie/Salmon Stage III Multiple Myeloma; Durie/Salmon Stage III Plasma Cell Myeloma; Multiple Myeloma Stage III; Stage III Multiple Myeloma; Stage III Plasma Cell Myeloma

Definition

Plasma cell myeloma with one or more of the following: 1. Hemoglobin less than 8.5 g/dL. 2. Serum calcium greater than 12.0 mg/dL. 3. More than three lytic bone lesions. 4. High M protein production as shown by: a. IgG greater than 7.0 g/dL. b. IgA greater than 5.0 g/dL. c. Urinary kappa or lamda greater than 12.0 g/24 hours. Estimated myeloma cell mass: greater than 1.2 trillion (1012)/m2 (high burden). The following subclassification of stages is used: a. Creatinine less than 2.0 mg/dL. b. Creatinine greater than or equal to 2.0 mg/dL. Serum beta-2-microglobulin has been shown to be a reliable marker for prognosis. Since the great majority of symptomatic myeloma patients are classified as stage III by the Durie/Salmon criteria, this staging system has not proven to be very useful for identifying the patients with intermediate and poor prognosis. Note that the newer International Staging System defines stage III quite differently: Beta-2-microglobulin greater than or equal to 5.5 (median survival of 29 months). (PDQ) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDS Stage III Plasma Cell Myeloma

Professional guidelines

PubMed

Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345Free PMC Article

Recent clinical studies

Etiology

Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345Free PMC Article
Szudy-Szczyrek A, Mlak R, Mielnik M, Mazurek M, Chocholska S, Podgajna M, Szczyrek M, Homa-Mlak I, Małecka-Massalska T, Hus M
Cells 2022 Feb 21;11(4) doi: 10.3390/cells11040752. PMID: 35203396Free PMC Article
Usmani SZ, Quach H, Mateos MV, Landgren O, Leleu X, Siegel D, Weisel K, Gavriatopoulou M, Oriol A, Rabin N, Nooka A, Qi M, Beksac M, Jakubowiak A, Ding B, Zahlten-Kumeli A, Yusuf A, Dimopoulos M
Lancet Oncol 2022 Jan;23(1):65-76. Epub 2021 Dec 3 doi: 10.1016/S1470-2045(21)00579-9. PMID: 34871550
Lu SY, Ma MC, Wang MC, Hsue SS
J Formos Med Assoc 2021 Nov;120(11):1967-1976. Epub 2021 Feb 4 doi: 10.1016/j.jfma.2021.01.015. PMID: 33551311
Rodon P, Linassier C, Gauvain JB, Benboubker L, Goupille P, Maigre M, Luthier F, Dugay J, Lucas V, Colombat P
Eur J Haematol 2001 Jan;66(1):11-7. doi: 10.1034/j.1600-0609.2001.00301.x. PMID: 11168502

Diagnosis

Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345Free PMC Article
Szudy-Szczyrek A, Mlak R, Mielnik M, Mazurek M, Chocholska S, Podgajna M, Szczyrek M, Homa-Mlak I, Małecka-Massalska T, Hus M
Cells 2022 Feb 21;11(4) doi: 10.3390/cells11040752. PMID: 35203396Free PMC Article
Lu SY, Ma MC, Wang MC, Hsue SS
J Formos Med Assoc 2021 Nov;120(11):1967-1976. Epub 2021 Feb 4 doi: 10.1016/j.jfma.2021.01.015. PMID: 33551311
Xu J, Liu B, Ma S, Zhang J, Ji Y, Xu L, Zhu M, Chen S, Wu X, Wu D
Cell Physiol Biochem 2018;45(4):1631-1640. Epub 2018 Feb 21 doi: 10.1159/000487730. PMID: 29486474
Rodon P, Linassier C, Gauvain JB, Benboubker L, Goupille P, Maigre M, Luthier F, Dugay J, Lucas V, Colombat P
Eur J Haematol 2001 Jan;66(1):11-7. doi: 10.1034/j.1600-0609.2001.00301.x. PMID: 11168502

Therapy

Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345Free PMC Article
Szudy-Szczyrek A, Mlak R, Mielnik M, Mazurek M, Chocholska S, Podgajna M, Szczyrek M, Homa-Mlak I, Małecka-Massalska T, Hus M
Cells 2022 Feb 21;11(4) doi: 10.3390/cells11040752. PMID: 35203396Free PMC Article
Usmani SZ, Quach H, Mateos MV, Landgren O, Leleu X, Siegel D, Weisel K, Gavriatopoulou M, Oriol A, Rabin N, Nooka A, Qi M, Beksac M, Jakubowiak A, Ding B, Zahlten-Kumeli A, Yusuf A, Dimopoulos M
Lancet Oncol 2022 Jan;23(1):65-76. Epub 2021 Dec 3 doi: 10.1016/S1470-2045(21)00579-9. PMID: 34871550
Nanni C, Versari A, Chauvie S, Bertone E, Bianchi A, Rensi M, Bellò M, Gallamini A, Patriarca F, Gay F, Gamberi B, Ghedini P, Cavo M, Fanti S, Zamagni E
Eur J Nucl Med Mol Imaging 2018 May;45(5):712-719. Epub 2017 Dec 21 doi: 10.1007/s00259-017-3909-8. PMID: 29270787
Rodon P, Linassier C, Gauvain JB, Benboubker L, Goupille P, Maigre M, Luthier F, Dugay J, Lucas V, Colombat P
Eur J Haematol 2001 Jan;66(1):11-7. doi: 10.1034/j.1600-0609.2001.00301.x. PMID: 11168502

Prognosis

Liu F, Cheng Q, Song K, Yu H, Li J, Zhang H, Hu G, Zhou M, Wang J, Ding Z, Luo Z, Peng T, Ding L, Zhao L, Liu J, He Y, Peng H
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Apr 28;47(4):497-504. doi: 10.11817/j.issn.1672-7347.2022.210555. PMID: 35545345Free PMC Article
Szudy-Szczyrek A, Mlak R, Mielnik M, Mazurek M, Chocholska S, Podgajna M, Szczyrek M, Homa-Mlak I, Małecka-Massalska T, Hus M
Cells 2022 Feb 21;11(4) doi: 10.3390/cells11040752. PMID: 35203396Free PMC Article
Lu SY, Ma MC, Wang MC, Hsue SS
J Formos Med Assoc 2021 Nov;120(11):1967-1976. Epub 2021 Feb 4 doi: 10.1016/j.jfma.2021.01.015. PMID: 33551311
Qian J, Jin J, Luo H, Jin C, Wang L, Qian W, Meng H
Hematology 2017 Sep;22(8):472-476. Epub 2017 May 2 doi: 10.1080/10245332.2017.1309493. PMID: 28463078
Rodon P, Linassier C, Gauvain JB, Benboubker L, Goupille P, Maigre M, Luthier F, Dugay J, Lucas V, Colombat P
Eur J Haematol 2001 Jan;66(1):11-7. doi: 10.1034/j.1600-0609.2001.00301.x. PMID: 11168502

Clinical prediction guides

Szudy-Szczyrek A, Mlak R, Mielnik M, Mazurek M, Chocholska S, Podgajna M, Szczyrek M, Homa-Mlak I, Małecka-Massalska T, Hus M
Cells 2022 Feb 21;11(4) doi: 10.3390/cells11040752. PMID: 35203396Free PMC Article
Lu SY, Ma MC, Wang MC, Hsue SS
J Formos Med Assoc 2021 Nov;120(11):1967-1976. Epub 2021 Feb 4 doi: 10.1016/j.jfma.2021.01.015. PMID: 33551311
Deng S, Zhang B, Zhou Y, Xu X, Li J, Sang S, Zhang W
Contrast Media Mol Imaging 2018;2018:4198673. Epub 2018 Jul 30 doi: 10.1155/2018/4198673. PMID: 30154686Free PMC Article
Nanni C, Versari A, Chauvie S, Bertone E, Bianchi A, Rensi M, Bellò M, Gallamini A, Patriarca F, Gay F, Gamberi B, Ghedini P, Cavo M, Fanti S, Zamagni E
Eur J Nucl Med Mol Imaging 2018 May;45(5):712-719. Epub 2017 Dec 21 doi: 10.1007/s00259-017-3909-8. PMID: 29270787
Rodon P, Linassier C, Gauvain JB, Benboubker L, Goupille P, Maigre M, Luthier F, Dugay J, Lucas V, Colombat P
Eur J Haematol 2001 Jan;66(1):11-7. doi: 10.1034/j.1600-0609.2001.00301.x. PMID: 11168502

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