U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mesenchymal hamartoma

MedGen UID:
83108
•Concept ID:
C0334090
•
Disease or Syndrome
Synonyms: Mesenchymal Hamartoma; mesenchymal hamartoma
SNOMED CT: Mesenchymal hamartoma (80656004)
 
Monarch Initiative: MONDO:0024478

Definition

A hamartoma characterized by the presence of mesenchymal elements. [from NCI]

Professional guidelines

PubMed

Pediatric Hepatic Cystic Lesions: Differential Diagnosis and Multimodality Imaging Approach.
Riedesel EL, Richer EJ, Taylor SD, Tao T, Gagnon MH, Braithwaite KA, Alazraki AL, Khanna G
Radiographics 2022 Sep-Oct;42(5):1514-1531. Epub 2022 Jul 15 doi: 10.1148/rg.220006. PMID: 35839138
Primary mesenchymal liver tumors: radiological spectrum, differential diagnosis, and pathologic correlation.
Harman M, Nart D, Acar T, Elmas N
Abdom Imaging 2015 Jun;40(5):1316-30. doi: 10.1007/s00261-014-0268-9. PMID: 25311993
Pitfalls in the surgical management of undifferentiated sarcoma of the liver and benefits of preoperative chemotherapy.
Merli L, Mussini C, Gabor F, Branchereau S, Martelli H, Pariente D, Guérin F
Eur J Pediatr Surg 2015 Feb;25(1):132-7. Epub 2014 Sep 26 doi: 10.1055/s-0034-1387937. PMID: 25259441

Recent clinical studies

Etiology

Liver Tumors in Pediatric Patients.
Meyers R, Hiyama E, Czauderna P, Tiao GM
Surg Oncol Clin N Am 2021 Apr;30(2):253-274. doi: 10.1016/j.soc.2020.11.006. PMID: 33706899
Benign liver tumors in pediatric patients - Review with emphasis on imaging features.
Chiorean L, Cui XW, Tannapfel A, Franke D, Stenzel M, Kosiak W, Schreiber-Dietrich D, Jüngert J, Chang JM, Dietrich CF
World J Gastroenterol 2015 Jul 28;21(28):8541-61. doi: 10.3748/wjg.v21.i28.8541. PMID: 26229397Free PMC Article
Malignant liver tumors.
Suriawinata AA, Thung SN
Clin Liver Dis 2002 May;6(2):527-54, ix. doi: 10.1016/s1089-3261(02)00005-3. PMID: 12122869
Liver tumors.
Stringer MD
Semin Pediatr Surg 2000 Nov;9(4):196-208. doi: 10.1053/spsu.2000.18844. PMID: 11112837
Liver tumours.
Perilongo G, Shafford EA
Eur J Cancer 1999 Jun;35(6):953-8; discussion 958-9. doi: 10.1016/s0959-8049(99)00049-0. PMID: 10533478

Diagnosis

Mesenchymal Neoplasms of the Liver.
Papke DJ Jr
Surg Pathol Clin 2023 Sep;16(3):609-634. Epub 2023 Jun 11 doi: 10.1016/j.path.2023.04.013. PMID: 37536892
Liver Tumors in Pediatric Patients.
Meyers R, Hiyama E, Czauderna P, Tiao GM
Surg Oncol Clin N Am 2021 Apr;30(2):253-274. doi: 10.1016/j.soc.2020.11.006. PMID: 33706899
Benign liver neoplasms.
Mortele KJ, Ros PR
Clin Liver Dis 2002 Feb;6(1):119-45. doi: 10.1016/s1089-3261(03)00069-2. PMID: 11933585
Liver tumors.
Stringer MD
Semin Pediatr Surg 2000 Nov;9(4):196-208. doi: 10.1053/spsu.2000.18844. PMID: 11112837
Pediatric hepatic surgery.
Guzzetta PC, Randolph JG
Surg Clin North Am 1989 Apr;69(2):251-7. doi: 10.1016/s0039-6109(16)44783-3. PMID: 2538934

Therapy

Liver transplantation for a giant mesenchymal hamartoma of the liver in an adult: Case report and review of the literature.
Li J, Cai JZ, Guo QJ, Li JJ, Sun XY, Hu ZD, Cooper DK, Shen ZY
World J Gastroenterol 2015 May 28;21(20):6409-16. doi: 10.3748/wjg.v21.i20.6409. PMID: 26034379Free PMC Article
Radiological spectrum of hepatic mesenchymal hamartoma in children.
Kim SH, Kim WS, Cheon JE, Yoon HK, Kang GH, Kim IO, Yeon KM
Korean J Radiol 2007 Nov-Dec;8(6):498-505. doi: 10.3348/kjr.2007.8.6.498. PMID: 18071280Free PMC Article
Rhabdomyomatous mesenchymal hamartoma of the eyelid: report of a case and literature review.
Read RW, Burnstine M, Rowland JM, Zamir E, Rao NA
Ophthalmology 2001 Apr;108(4):798-804. doi: 10.1016/s0161-6420(00)00638-2. PMID: 11297501
Liver tumors.
Stringer MD
Semin Pediatr Surg 2000 Nov;9(4):196-208. doi: 10.1053/spsu.2000.18844. PMID: 11112837
Malignant transformation of mesenchymal hamartoma of the liver: case report and review of the literature.
Ramanujam TM, Ramesh JC, Goh DW, Wong KT, Ariffin WA, Kumar G, Taib NA
J Pediatr Surg 1999 Nov;34(11):1684-6. doi: 10.1016/s0022-3468(99)90644-9. PMID: 10591570

Prognosis

Undifferentiated embryonal sarcoma of the liver: a concise review.
Putra J, Ornvold K
Arch Pathol Lab Med 2015 Feb;139(2):269-73. doi: 10.5858/arpa.2013-0463-RS. PMID: 25611111
Neonatal liver tumours.
von Schweinitz D
Semin Neonatol 2003 Oct;8(5):403-10. doi: 10.1016/S1084-2756(03)00092-7. PMID: 15001128
Hepatic mesenchymal hamartoma.
Yen JB, Kong MS, Lin JN
J Paediatr Child Health 2003 Nov;39(8):632-4. doi: 10.1046/j.1440-1754.2003.00250.x. PMID: 14629534
Malignant liver tumors.
Suriawinata AA, Thung SN
Clin Liver Dis 2002 May;6(2):527-54, ix. doi: 10.1016/s1089-3261(02)00005-3. PMID: 12122869
Liver tumours.
Perilongo G, Shafford EA
Eur J Cancer 1999 Jun;35(6):953-8; discussion 958-9. doi: 10.1016/s0959-8049(99)00049-0. PMID: 10533478

Clinical prediction guides

Benign liver tumors in pediatric patients - Review with emphasis on imaging features.
Chiorean L, Cui XW, Tannapfel A, Franke D, Stenzel M, Kosiak W, Schreiber-Dietrich D, Jüngert J, Chang JM, Dietrich CF
World J Gastroenterol 2015 Jul 28;21(28):8541-61. doi: 10.3748/wjg.v21.i28.8541. PMID: 26229397Free PMC Article
Biopsy-proven spontaneous regression of a rhabdomyomatous mesenchymal hamartoma.
Mazza JM, Linnell E, Votava HJ, Wisoff JH, Silverberg NB
Pediatr Dermatol 2015 Mar-Apr;32(2):256-62. Epub 2014 Mar 24 doi: 10.1111/pde.12331. PMID: 24661237
Mesenchymal Hamartoma of the Liver in Older Children: An Adult Variant or a Different Entity? Report of a Case With Review of the Literature.
Virgone C, Cecchetto G, Dall'Igna P, Zanon GF, Cillo U, Alaggio R
Appl Immunohistochem Mol Morphol 2015 Oct;23(9):667-73. doi: 10.1097/PAI.0b013e31826b56ae. PMID: 22935827
Occult androgenetic-biparental mosaicism and sporadic hepatic mesenchymal hamartoma.
Lin J, Cole BL, Qin X, Zhang M, Kapur RP
Pediatr Dev Pathol 2011 Sep-Oct;14(5):360-9. Epub 2011 May 19 doi: 10.2350/11-03-0999-OA.1. PMID: 21585278
Mesenchymal hamartoma of the liver in adulthood: immunohistochemical profiles, clinical and histopathological features in two patients.
Yesim G, Gupse T, Zafer U, Ahmet A
J Hepatobiliary Pancreat Surg 2005;12(6):502-7. doi: 10.1007/s00534-005-1025-9. PMID: 16365828

Recent systematic reviews

Outcomes of Primary Tumor Excision do not Differ from Non-Resection Methods in Pediatric Mesenchymal Hamartoma of the Liver: A Rapid Systematic Review.
Bauzon J, Froehlich M, Dadon N, Morris D, Chang S
J Pediatr Surg 2023 Dec;58(12):2356-2361. Epub 2023 Aug 22 doi: 10.1016/j.jpedsurg.2023.08.012. PMID: 37775408
Liver Transplant for Adult Recurrent Hepatic Mesenchymal Hamartoma and a Feasible Treatment Modality: A Case Report and Literature Review.
Idrees M, Chung K, Philipoff A, Jeffrey G, Garas G, Jaques B, Delriviere L, De Boer B, Bhandari M, Mou L
Transplant Proc 2022 Jul-Aug;54(6):1636-1639. Epub 2022 Jul 14 doi: 10.1016/j.transproceed.2022.04.020. PMID: 35842317
En bloc resection for treatment of tumor-induced osteomalacia: a case presentation and a systematic review.
Meng T, Zhou W, Li B, Yin H, Li Z, Zhou L, Kong J, Yan W, Yang X, Liu T, Song D, Xiao J
World J Surg Oncol 2015 May 8;13:176. doi: 10.1186/s12957-015-0589-3. PMID: 25951872Free PMC Article
Mesenchymal hamartoma of the liver: a systematic review.
Stringer MD, Alizai NK
J Pediatr Surg 2005 Nov;40(11):1681-90. doi: 10.1016/j.jpedsurg.2005.07.052. PMID: 16291152

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...