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Mesenchymal hamartoma

MedGen UID:
83108
•Concept ID:
C0334090
•
Disease or Syndrome
Synonyms: Mesenchymal Hamartoma; mesenchymal hamartoma
SNOMED CT: Mesenchymal hamartoma (80656004)
 
Monarch Initiative: MONDO:0024478

Definition

A hamartoma characterized by the presence of mesenchymal elements. [from NCI]

Professional guidelines

PubMed

Pediatric Hepatic Cystic Lesions: Differential Diagnosis and Multimodality Imaging Approach.
Riedesel EL, Richer EJ, Taylor SD, Tao T, Gagnon MH, Braithwaite KA, Alazraki AL, Khanna G
Radiographics 2022 Sep-Oct;42(5):1514-1531. Epub 2022 Jul 15 doi: 10.1148/rg.220006. PMID: 35839138
Primary mesenchymal liver tumors: radiological spectrum, differential diagnosis, and pathologic correlation.
Harman M, Nart D, Acar T, Elmas N
Abdom Imaging 2015 Jun;40(5):1316-30. doi: 10.1007/s00261-014-0268-9. PMID: 25311993
Pitfalls in the surgical management of undifferentiated sarcoma of the liver and benefits of preoperative chemotherapy.
Merli L, Mussini C, Gabor F, Branchereau S, Martelli H, Pariente D, Guérin F
Eur J Pediatr Surg 2015 Feb;25(1):132-7. Epub 2014 Sep 26 doi: 10.1055/s-0034-1387937. PMID: 25259441

Recent clinical studies

Etiology

Liver Tumors in Pediatric Patients.
Meyers R, Hiyama E, Czauderna P, Tiao GM
Surg Oncol Clin N Am 2021 Apr;30(2):253-274. doi: 10.1016/j.soc.2020.11.006. PMID: 33706899
Hamartomas and midline anomalies in association with infantile hemangiomas, PHACE, and LUMBAR syndromes.
Stefanko NS, Davies OMT, Beato MJ, Blei F, Drolet BA, Fairley J, Frieden IJ, Galligan ER, Goddard D, Howard R, Husain S, Lauren CT, Lopez-Gutierrez JC, MacArthur C, Metry DW, Morel KD, Niedt GW, Garzon MC, Sokumbi O, Siegel DH
Pediatr Dermatol 2020 Jan;37(1):78-85. Epub 2019 Oct 20 doi: 10.1111/pde.14006. PMID: 31631401
Malignant liver tumors.
Suriawinata AA, Thung SN
Clin Liver Dis 2002 May;6(2):527-54, ix. doi: 10.1016/s1089-3261(02)00005-3. PMID: 12122869
Liver tumors.
Stringer MD
Semin Pediatr Surg 2000 Nov;9(4):196-208. doi: 10.1053/spsu.2000.18844. PMID: 11112837
Liver tumours.
Perilongo G, Shafford EA
Eur J Cancer 1999 Jun;35(6):953-8; discussion 958-9. doi: 10.1016/s0959-8049(99)00049-0. PMID: 10533478

Diagnosis

Mesenchymal Neoplasms of the Liver.
Papke DJ Jr
Surg Pathol Clin 2023 Sep;16(3):609-634. Epub 2023 Jun 11 doi: 10.1016/j.path.2023.04.013. PMID: 37536892
Liver Tumors in Pediatric Patients.
Meyers R, Hiyama E, Czauderna P, Tiao GM
Surg Oncol Clin N Am 2021 Apr;30(2):253-274. doi: 10.1016/j.soc.2020.11.006. PMID: 33706899
Chest wall lesions.
Watt AJ
Paediatr Respir Rev 2002 Dec;3(4):328-38. PMID: 12457604
Benign liver neoplasms.
Mortele KJ, Ros PR
Clin Liver Dis 2002 Feb;6(1):119-45. doi: 10.1016/s1089-3261(03)00069-2. PMID: 11933585
Liver tumors.
Stringer MD
Semin Pediatr Surg 2000 Nov;9(4):196-208. doi: 10.1053/spsu.2000.18844. PMID: 11112837

Therapy

Liver transplantation for a giant mesenchymal hamartoma of the liver in an adult: Case report and review of the literature.
Li J, Cai JZ, Guo QJ, Li JJ, Sun XY, Hu ZD, Cooper DK, Shen ZY
World J Gastroenterol 2015 May 28;21(20):6409-16. doi: 10.3748/wjg.v21.i20.6409. PMID: 26034379Free PMC Article
Rhabdomyomatous mesenchymal hamartoma of nasal vestibule.
Kang JW, Park HS, Kim JH
J Craniofac Surg 2013;24(5):e481-3. doi: 10.1097/SCS.0b013e3182903357. PMID: 24036822
Rhabdomyomatous mesenchymal hamartoma of the eyelid: report of a case and literature review.
Read RW, Burnstine M, Rowland JM, Zamir E, Rao NA
Ophthalmology 2001 Apr;108(4):798-804. doi: 10.1016/s0161-6420(00)00638-2. PMID: 11297501
Liver tumors.
Stringer MD
Semin Pediatr Surg 2000 Nov;9(4):196-208. doi: 10.1053/spsu.2000.18844. PMID: 11112837
Malignant transformation of mesenchymal hamartoma of the liver: case report and review of the literature.
Ramanujam TM, Ramesh JC, Goh DW, Wong KT, Ariffin WA, Kumar G, Taib NA
J Pediatr Surg 1999 Nov;34(11):1684-6. doi: 10.1016/s0022-3468(99)90644-9. PMID: 10591570

Prognosis

Undifferentiated embryonal sarcoma of the liver: a concise review.
Putra J, Ornvold K
Arch Pathol Lab Med 2015 Feb;139(2):269-73. doi: 10.5858/arpa.2013-0463-RS. PMID: 25611111
Neonatal liver tumours.
von Schweinitz D
Semin Neonatol 2003 Oct;8(5):403-10. doi: 10.1016/S1084-2756(03)00092-7. PMID: 15001128
Hepatic mesenchymal hamartoma.
Yen JB, Kong MS, Lin JN
J Paediatr Child Health 2003 Nov;39(8):632-4. doi: 10.1046/j.1440-1754.2003.00250.x. PMID: 14629534
Hepatic tumors in children.
Stocker JT
Clin Liver Dis 2001 Feb;5(1):259-81, viii-ix. doi: 10.1016/s1089-3261(05)70163-x. PMID: 11218918
Liver tumours.
Perilongo G, Shafford EA
Eur J Cancer 1999 Jun;35(6):953-8; discussion 958-9. doi: 10.1016/s0959-8049(99)00049-0. PMID: 10533478

Clinical prediction guides

Benign liver tumors in pediatric patients - Review with emphasis on imaging features.
Chiorean L, Cui XW, Tannapfel A, Franke D, Stenzel M, Kosiak W, Schreiber-Dietrich D, Jüngert J, Chang JM, Dietrich CF
World J Gastroenterol 2015 Jul 28;21(28):8541-61. doi: 10.3748/wjg.v21.i28.8541. PMID: 26229397Free PMC Article
Biopsy-proven spontaneous regression of a rhabdomyomatous mesenchymal hamartoma.
Mazza JM, Linnell E, Votava HJ, Wisoff JH, Silverberg NB
Pediatr Dermatol 2015 Mar-Apr;32(2):256-62. Epub 2014 Mar 24 doi: 10.1111/pde.12331. PMID: 24661237
Expression of glypican-3 in undifferentiated embryonal sarcoma and mesenchymal hamartoma of the liver.
Levy M, Trivedi A, Zhang J, Miles L, Mattis AN, Kim GE, Lassman C, Anders RA, Misdraji J, Yerian LM, Xu H, Dhall D, Wang HL
Hum Pathol 2012 May;43(5):695-701. Epub 2011 Sep 19 doi: 10.1016/j.humpath.2011.06.016. PMID: 21937079Free PMC Article
Occult androgenetic-biparental mosaicism and sporadic hepatic mesenchymal hamartoma.
Lin J, Cole BL, Qin X, Zhang M, Kapur RP
Pediatr Dev Pathol 2011 Sep-Oct;14(5):360-9. Epub 2011 May 19 doi: 10.2350/11-03-0999-OA.1. PMID: 21585278
Mesenchymal hamartoma of the liver in adulthood: immunohistochemical profiles, clinical and histopathological features in two patients.
Yesim G, Gupse T, Zafer U, Ahmet A
J Hepatobiliary Pancreat Surg 2005;12(6):502-7. doi: 10.1007/s00534-005-1025-9. PMID: 16365828

Recent systematic reviews

Outcomes of Primary Tumor Excision do not Differ from Non-Resection Methods in Pediatric Mesenchymal Hamartoma of the Liver: A Rapid Systematic Review.
Bauzon J, Froehlich M, Dadon N, Morris D, Chang S
J Pediatr Surg 2023 Dec;58(12):2356-2361. Epub 2023 Aug 22 doi: 10.1016/j.jpedsurg.2023.08.012. PMID: 37775408
Liver Transplant for Adult Recurrent Hepatic Mesenchymal Hamartoma and a Feasible Treatment Modality: A Case Report and Literature Review.
Idrees M, Chung K, Philipoff A, Jeffrey G, Garas G, Jaques B, Delriviere L, De Boer B, Bhandari M, Mou L
Transplant Proc 2022 Jul-Aug;54(6):1636-1639. Epub 2022 Jul 14 doi: 10.1016/j.transproceed.2022.04.020. PMID: 35842317
En bloc resection for treatment of tumor-induced osteomalacia: a case presentation and a systematic review.
Meng T, Zhou W, Li B, Yin H, Li Z, Zhou L, Kong J, Yan W, Yang X, Liu T, Song D, Xiao J
World J Surg Oncol 2015 May 8;13:176. doi: 10.1186/s12957-015-0589-3. PMID: 25951872Free PMC Article
Mesenchymal hamartoma of the liver: a systematic review.
Stringer MD, Alizai NK
J Pediatr Surg 2005 Nov;40(11):1681-90. doi: 10.1016/j.jpedsurg.2005.07.052. PMID: 16291152

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