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Tubulovillous adenoma

MedGen UID:
83125
Concept ID:
C0334307
Neoplastic Process
Synonyms: Gastrointestinal Tract Tubulovillous Adenoma; GI Tract Tubulovillous Adenoma; Papillotubular adenoma; Tubulo-papillary adenoma; Tubulovillous Adenoma; tubulovillous adenoma; Villoglandular adenoma
SNOMED CT: Tubulovillous adenoma (61722000); Villoglandular adenoma (61722000); Papillotubular adenoma (61722000); Tubulo-papillary adenoma (61722000)
 
Monarch Initiative: MONDO:0024661

Definition

An adenoma arising from the glandular epithelium of the gastrointestinal tract. It is characterized by the presence of a tubular and a villous architectural pattern. Most often it occurs in the large intestine, small intestine, and the stomach. The neoplastic epithelial cells show dysplastic features. [from NCI]

Professional guidelines

PubMed

Cansiz Ersöz C, Kiremitci S, Savas B, Ensari A
Acta Gastroenterol Belg 2020 Oct-Dec;83(4):549-556. PMID: 33321010
Tamer F, Yuksel ME
Dermatol Ther 2020 Jul;33(4):e13720. Epub 2020 Jun 29 doi: 10.1111/dth.13720. PMID: 32506694
Rea JD, Lockhart ME, Yarbrough DE, Leeth RR, Bledsoe SE, Clements RH
Am Surg 2007 Nov;73(11):1098-105. PMID: 18092641

Recent clinical studies

Etiology

Li LC, Zheng LR, Han N
Clin Imaging 2022 Feb;82:135-138. Epub 2021 Nov 18 doi: 10.1016/j.clinimag.2021.11.015. PMID: 34813992
Zhang Y, Pan M, Li CY, Li JY, Ge W, Xu L, Xiao Y
Bioengineered 2021 Dec;12(1):6831-6843. doi: 10.1080/21655979.2021.1971036. PMID: 34585630Free PMC Article
Bateman AC
Histopathology 2021 May;78(6):780-790. Epub 2021 Jan 31 doi: 10.1111/his.14305. PMID: 33332664
Cansiz Ersöz C, Kiremitci S, Savas B, Ensari A
Acta Gastroenterol Belg 2020 Oct-Dec;83(4):549-556. PMID: 33321010
Ackroyd FW, Hedberg SE
Annu Rev Med 1985;36:619-25. doi: 10.1146/annurev.me.36.020185.003155. PMID: 3994327

Diagnosis

Li LC, Zheng LR, Han N
Clin Imaging 2022 Feb;82:135-138. Epub 2021 Nov 18 doi: 10.1016/j.clinimag.2021.11.015. PMID: 34813992
Bateman AC
Histopathology 2021 May;78(6):780-790. Epub 2021 Jan 31 doi: 10.1111/his.14305. PMID: 33332664
Cansiz Ersöz C, Kiremitci S, Savas B, Ensari A
Acta Gastroenterol Belg 2020 Oct-Dec;83(4):549-556. PMID: 33321010
Singhal M, Kang M, Narayanan S, Gupta R, Wig JD, Bal A
J Gastrointest Surg 2009 Feb;13(2):386-8. Epub 2008 Apr 4 doi: 10.1007/s11605-008-0509-8. PMID: 18389325
Ackroyd FW, Hedberg SE
Annu Rev Med 1985;36:619-25. doi: 10.1146/annurev.me.36.020185.003155. PMID: 3994327

Therapy

Wang ZK, Liu F, Wang Y, Wang XD, Tang P, Li W
World J Gastroenterol 2020 Oct 7;26(37):5673-5681. doi: 10.3748/wjg.v26.i37.5673. PMID: 33088160Free PMC Article
Pezhouh MK, Burgart LJ, Chiu K, Cohen DA, Hutchings DA, Sanderson SO, Shirazi M, Stanich PP, VandenBussche CJ, Voltaggio L, Willhoit ED, Xue Y, Arnold CA
Am J Surg Pathol 2020 Jun;44(6):793-798. doi: 10.1097/PAS.0000000000001435. PMID: 31934919
Song M, Lee IM, Manson JE, Buring JE, Dushkes R, Gordon D, Walter J, Wu K, Chan AT, Ogino S, Fuchs CS, Meyerhardt JA, Giovannucci EL; VITAL Research Group
JAMA Oncol 2020 Jan 1;6(1):108-115. doi: 10.1001/jamaoncol.2019.4587. PMID: 31750855Free PMC Article
Koritala T, Zolotarevsky E, Bartley AN, Ellis CD, Krolikowski JA, Burton J, Gunaratnam NT
Gastrointest Endosc 2015 Apr;81(4):985-8. Epub 2014 Nov 22 doi: 10.1016/j.gie.2014.09.043. PMID: 25440288
Scozzari G, Trapani R, Toppino M, Morino M
Surg Obes Relat Dis 2013 Jan-Feb;9(1):133-42. Epub 2012 Oct 12 doi: 10.1016/j.soard.2012.10.002. PMID: 23265766

Prognosis

Li LC, Zheng LR, Han N
Clin Imaging 2022 Feb;82:135-138. Epub 2021 Nov 18 doi: 10.1016/j.clinimag.2021.11.015. PMID: 34813992
Laish I, Seregeev I, Naftali T, Konikoff FM
Dig Liver Dis 2017 Oct;49(10):1115-1120. Epub 2017 May 16 doi: 10.1016/j.dld.2017.05.005. PMID: 28641945
Bodin R, Peycru T, Schwartz A, Jarry J, Pommier N, Durand-Dastes F
Gastroenterol Clin Biol 2010 Nov;34(11):633-5. Epub 2010 Aug 23 doi: 10.1016/j.gcb.2010.07.006. PMID: 20739133
Beger HG, Staib L, Schoenberg MH
Langenbecks Arch Surg 1998 Apr;383(2):190-3. doi: 10.1007/s004230050117. PMID: 9641898
Ackroyd FW, Hedberg SE
Annu Rev Med 1985;36:619-25. doi: 10.1146/annurev.me.36.020185.003155. PMID: 3994327

Clinical prediction guides

Gomez Cifuentes JD, Berger S, Caskey K, Jove A, Sealock R, Hair C, Velez M, Jarbrink-Sehgal M, Thrift AP, da Costa WL Jr, Gyanprakash K
Dig Dis Sci 2023 Oct;68(10):3935-3942. Epub 2023 Aug 7 doi: 10.1007/s10620-023-08054-5. PMID: 37548897
Jiang AC, Buckingham L, Bishehsari F, Sutherland S, Ma K, Melson JE
Clin Transl Gastroenterol 2021 Jun 1;12(6):e00369. doi: 10.14309/ctg.0000000000000369. PMID: 34060495Free PMC Article
Laish I, Seregeev I, Naftali T, Konikoff FM
Dig Liver Dis 2017 Oct;49(10):1115-1120. Epub 2017 May 16 doi: 10.1016/j.dld.2017.05.005. PMID: 28641945
Binmoeller KF, Hamerski CM, Shah JN, Bhat YM, Kane SD
Gastrointest Endosc 2016 Mar;83(3):638-42. Epub 2015 Sep 14 doi: 10.1016/j.gie.2015.08.079. PMID: 26375437
Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Glickman JN, Chan AT, Kirkner GJ, Mino-Kenudson M, Fuchs CS, Ogino S
BMC Cancer 2008 Jan 29;8:33. doi: 10.1186/1471-2407-8-33. PMID: 18230181Free PMC Article

Recent systematic reviews

Scozzari G, Trapani R, Toppino M, Morino M
Surg Obes Relat Dis 2013 Jan-Feb;9(1):133-42. Epub 2012 Oct 12 doi: 10.1016/j.soard.2012.10.002. PMID: 23265766

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