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Tubulovillous adenoma

MedGen UID:
83125
•Concept ID:
C0334307
•
Neoplastic Process
Synonyms: Gastrointestinal Tract Tubulovillous Adenoma; GI Tract Tubulovillous Adenoma; Papillotubular adenoma; Tubulo-papillary adenoma; Tubulovillous Adenoma; tubulovillous adenoma; Villoglandular adenoma
SNOMED CT: Tubulovillous adenoma (61722000); Villoglandular adenoma (61722000); Papillotubular adenoma (61722000); Tubulo-papillary adenoma (61722000)
 
Monarch Initiative: MONDO:0024661

Definition

An adenoma arising from the glandular epithelium of the gastrointestinal tract. It is characterized by the presence of a tubular and a villous architectural pattern. Most often it occurs in the large intestine, small intestine, and the stomach. The neoplastic epithelial cells show dysplastic features. [from NCI]

Professional guidelines

PubMed

Differential diagnosis of traditional serrated adenomas and tubulovillous adenomas: a compartmental morphologic and immunohistochemical analysis.
Cansiz Ersöz C, Kiremitci S, Savas B, Ensari A
Acta Gastroenterol Belg 2020 Oct-Dec;83(4):549-556. PMID: 33321010
Colonoscopy in patients with psoriasis before the initiation of treatment with biological agents.
Tamer F, Yuksel ME
Dermatol Ther 2020 Jul;33(4):e13720. Epub 2020 Jun 29 doi: 10.1111/dth.13720. PMID: 32506694
Surgical management of benign duodenal tumours.
Yan JQ, Peng CH, Yang WP, Ding JZ, Zhou GW, Ma D, Li HW
ANZ J Surg 2010 Jul-Aug;80(7-8):526-30. doi: 10.1111/j.1445-2197.2010.05378.x. PMID: 20795967

Recent clinical studies

Etiology

Multi-slice spiral CT findings of tubulovillous adenoma of the duodenum.
Li LC, Zheng LR, Han N
Clin Imaging 2022 Feb;82:135-138. Epub 2021 Nov 18 doi: 10.1016/j.clinimag.2021.11.015. PMID: 34813992
Exploration of the typical features of tubulovillous adenoma using in-depth quantitative proteomics analysis.
Zhang Y, Pan M, Li CY, Li JY, Ge W, Xu L, Xiao Y
Bioengineered 2021 Dec;12(1):6831-6843. doi: 10.1080/21655979.2021.1971036. PMID: 34585630Free PMC Article
The spectrum of serrated colorectal lesions-new entities and unanswered questions.
Bateman AC
Histopathology 2021 May;78(6):780-790. Epub 2021 Jan 31 doi: 10.1111/his.14305. PMID: 33332664
Clonality of combined tumors.
Huang J, Behrens C, Wistuba II, Gazdar AF, Jagirdar J
Arch Pathol Lab Med 2002 Apr;126(4):437-41. doi: 10.5858/2002-126-0437-COCT. PMID: 11900568
Colonic polyps.
Ackroyd FW, Hedberg SE
Annu Rev Med 1985;36:619-25. doi: 10.1146/annurev.me.36.020185.003155. PMID: 3994327

Diagnosis

McKittrick-Wheelock Syndrome: A Case Report.
Marcinkevičiūtė K, Kryžauskas M, Poškus T
Medicina (Kaunas) 2023 Mar 22;59(3) doi: 10.3390/medicina59030633. PMID: 36984634Free PMC Article
Multi-slice spiral CT findings of tubulovillous adenoma of the duodenum.
Li LC, Zheng LR, Han N
Clin Imaging 2022 Feb;82:135-138. Epub 2021 Nov 18 doi: 10.1016/j.clinimag.2021.11.015. PMID: 34813992
Duodenoduodenal intussusception.
Singhal M, Kang M, Narayanan S, Gupta R, Wig JD, Bal A
J Gastrointest Surg 2009 Feb;13(2):386-8. Epub 2008 Apr 4 doi: 10.1007/s11605-008-0509-8. PMID: 18389325
Tubulovillous adenoma of the vulva.
Vitrey D, Frachon S, Balme B, Golfier F
Obstet Gynecol 2003 Nov;102(5 Pt 2):1160-3. doi: 10.1016/s0029-7844(03)00626-4. PMID: 14607042
Colonic polyps.
Ackroyd FW, Hedberg SE
Annu Rev Med 1985;36:619-25. doi: 10.1146/annurev.me.36.020185.003155. PMID: 3994327

Therapy

Preliminary experience of hybrid endoscopic submucosal dissection by duodenoscope for recurrent laterally spreading papillary lesions.
Wang ZK, Liu F, Wang Y, Wang XD, Tang P, Li W
World J Gastroenterol 2020 Oct 7;26(37):5673-5681. doi: 10.3748/wjg.v26.i37.5673. PMID: 33088160Free PMC Article
Evaluation of recurrence and surgical complementation rates after endoscopic resection of large colorectal non-pedunculated lesions.
Azevedo AAS, Ribeiro MCDPN, Mota FL, Correa PAFP, Loureiro JFM
Rev Esp Enferm Dig 2020 Dec;112(12):898-902. doi: 10.17235/reed.2020.6695/2019. PMID: 33054283
Efficacy and safety of the band and slough technique for endoscopic therapy of nonampullary duodenal adenomas: a case series.
Koritala T, Zolotarevsky E, Bartley AN, Ellis CD, Krolikowski JA, Burton J, Gunaratnam NT
Gastrointest Endosc 2015 Apr;81(4):985-8. Epub 2014 Nov 22 doi: 10.1016/j.gie.2014.09.043. PMID: 25440288
Transanal single-port microsurgery for rectal tumors: minimal invasive surgery under spinal anesthesia.
Lee TG, Lee SJ
Surg Endosc 2014 Jan;28(1):271-80. Epub 2013 Sep 6 doi: 10.1007/s00464-013-3184-0. PMID: 24061623
Esophagogastric cancer after bariatric surgery: systematic review of the literature.
Scozzari G, Trapani R, Toppino M, Morino M
Surg Obes Relat Dis 2013 Jan-Feb;9(1):133-42. Epub 2012 Oct 12 doi: 10.1016/j.soard.2012.10.002. PMID: 23265766

Prognosis

Multi-slice spiral CT findings of tubulovillous adenoma of the duodenum.
Li LC, Zheng LR, Han N
Clin Imaging 2022 Feb;82:135-138. Epub 2021 Nov 18 doi: 10.1016/j.clinimag.2021.11.015. PMID: 34813992
Prognostic role and biologic features of Musashi-2 expression in colon polyps and during colorectal cancer progression.
Kharin L, Bychkov I, Karnaukhov N, Voloshin M, Fazliyeva R, Deneka A, Frantsiyants E, Kit O, Golemis E, Boumber Y
PLoS One 2021;16(7):e0252132. Epub 2021 Jul 8 doi: 10.1371/journal.pone.0252132. PMID: 34237057Free PMC Article
Surveillance after positive colonoscopy based on adenoma characteristics.
Laish I, Seregeev I, Naftali T, Konikoff FM
Dig Liver Dis 2017 Oct;49(10):1115-1120. Epub 2017 May 16 doi: 10.1016/j.dld.2017.05.005. PMID: 28641945
Tubulovillous adenoma of the appendix: a case report and review of the literature.
Bodin R, Peycru T, Schwartz A, Jarry J, Pommier N, Durand-Dastes F
Gastroenterol Clin Biol 2010 Nov;34(11):633-5. Epub 2010 Aug 23 doi: 10.1016/j.gcb.2010.07.006. PMID: 20739133
Colonic polyps.
Ackroyd FW, Hedberg SE
Annu Rev Med 1985;36:619-25. doi: 10.1146/annurev.me.36.020185.003155. PMID: 3994327

Clinical prediction guides

Pseudoinvasion and squamous metaplasia/morules in colorectal adenomatous polyp: a case report and literature review.
Shi L, Li H, Li S, Lin S, Wu Y
Diagn Pathol 2024 Sep 17;19(1):126. doi: 10.1186/s13000-024-01535-9. PMID: 39289686Free PMC Article
Correlation of LINE-1 Hypomethylation With Size and Pathologic Extent of Dysplasia in Colorectal Tubular Adenomas.
Jiang AC, Buckingham L, Bishehsari F, Sutherland S, Ma K, Melson JE
Clin Transl Gastroenterol 2021 Jun 1;12(6):e00369. doi: 10.14309/ctg.0000000000000369. PMID: 34060495Free PMC Article
Serum miR-20a and miR-486 are potential biomarkers for discriminating colorectal neoplasia: A pilot study.
Yang Q, Wang S, Huang J, Xia C, Jin H, Fan Y
J Cancer Res Ther 2018;14(7):1572-1577. doi: 10.4103/jcrt.JCRT_1198_16. PMID: 30589041
Surveillance after positive colonoscopy based on adenoma characteristics.
Laish I, Seregeev I, Naftali T, Konikoff FM
Dig Liver Dis 2017 Oct;49(10):1115-1120. Epub 2017 May 16 doi: 10.1016/j.dld.2017.05.005. PMID: 28641945
Underwater EMR of adenomas of the appendiceal orifice (with video).
Binmoeller KF, Hamerski CM, Shah JN, Bhat YM, Kane SD
Gastrointest Endosc 2016 Mar;83(3):638-42. Epub 2015 Sep 14 doi: 10.1016/j.gie.2015.08.079. PMID: 26375437

Recent systematic reviews

Esophagogastric cancer after bariatric surgery: systematic review of the literature.
Scozzari G, Trapani R, Toppino M, Morino M
Surg Obes Relat Dis 2013 Jan-Feb;9(1):133-42. Epub 2012 Oct 12 doi: 10.1016/j.soard.2012.10.002. PMID: 23265766

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