U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Spindle cell lipoma

MedGen UID:
83153
•Concept ID:
C0334474
•
Neoplastic Process
Synonyms: Spindle Cell Lipoma; spindle cell lipoma; spindle cell lipoma (morphologic abnormality)
SNOMED CT: Spindle cell lipoma (404058008); Spindle cell lipoma (27313007)
 
Monarch Initiative: MONDO:0000962

Definition

A benign circumscribed tumor composed of spindled cells, adipocytes, and collagen bundles. There is no evidence of nuclear hyperchromasia or mitotic activity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpindle cell lipoma

Professional guidelines

PubMed

The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
From head and neck lipoma to liposarcoma: a wide spectrum of differential diagnoses and their therapeutic implications.
Barisella M, Giannini L, Piazza C
Curr Opin Otolaryngol Head Neck Surg 2020 Apr;28(2):136-143. doi: 10.1097/MOO.0000000000000608. PMID: 32011399
Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661

Recent clinical studies

Etiology

Hypopharyngeal spindle cell lipoma: A case report and review of literature.
Liang Z, Zang Y, Jing Z, Zhang Y, Cao H, Zhou H
Medicine (Baltimore) 2021 May 7;100(18):e25782. doi: 10.1097/MD.0000000000025782. PMID: 33950973Free PMC Article
Combined classical spindle cell/pleomorphic lipoma spectrum imaging and clinical data.
Younan Y, Martinez A, Reimer N, Edgar M, Gonzalez F, Umpierrez M, Subhawong T, Singer AD
Skeletal Radiol 2018 Jan;47(1):51-59. Epub 2017 Aug 19 doi: 10.1007/s00256-017-2751-1. PMID: 28823067
Spindle cell lipoma.
Pardhe N, Singh N, Bharadwaj G, Nayak PA
BMJ Case Rep 2013 Aug 13;2013 doi: 10.1136/bcr-2013-010438. PMID: 23946512Free PMC Article
Spindle cell lipoma.
Comunoglu N, Comunoglu C, Ekici AI, Ozkan F, Dervişoglu S
Pol J Pathol 2007;58(1):7-11. PMID: 17585537
Spindle cell lipoma.
Enzinger FM, Harvey DA
Cancer 1975 Nov;36(5):1852-9. doi: 10.1002/1097-0142(197511)36:5<1852::aid-cncr2820360542>3.0.co;2-u. PMID: 1192370

Diagnosis

Hypopharyngeal spindle cell lipoma: A case report and review of literature.
Liang Z, Zang Y, Jing Z, Zhang Y, Cao H, Zhou H
Medicine (Baltimore) 2021 May 7;100(18):e25782. doi: 10.1097/MD.0000000000025782. PMID: 33950973Free PMC Article
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Spindle Cell Lipoma Arising from the Supraglottis: A Case Report and Review of the Literature.
Azar SS, Buen F, Chia JJ, Ma Y, Caron J, Dry S, Bhuta S, Abemayor E
Head Neck Pathol 2021 Dec;15(4):1299-1302. Epub 2021 Jan 4 doi: 10.1007/s12105-020-01259-4. PMID: 33394369Free PMC Article
Updates in spindle cell/pleomorphic lipomas.
Van Treeck BJ, Fritchie KJ
Semin Diagn Pathol 2019 Mar;36(2):105-111. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.005. PMID: 30850230
Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661

Therapy

Cutaneous side effects in a cohort of patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors: General description and further characterization, correlation with photoexposition and study of hypopigmentation as treatment's prognostic factor.
Llamas-Velasco M, Ovejero-Merino E, García-Diez A, Requena L, Daudén E, Steegmann JL
Dermatol Ther 2020 Nov;33(6):e14428. Epub 2020 Nov 3 doi: 10.1111/dth.14428. PMID: 33073453
Loss of retinoblastoma in pleomorphic fibroma: An immunohistochemical and genomic analysis.
Hinds B, Agulló Pérez AD, LeBoit PE, McCalmont TH, North JP
J Cutan Pathol 2017 Aug;44(8):665-671. Epub 2017 Jun 13 doi: 10.1111/cup.12965. PMID: 28543636
Selected case from the Arkadi M. Rywlin International Pathology Slide Seminar: sclerotic (fibroma-like) lipoma, dorsum of right hand.
Allen PW
Adv Anat Pathol 2013 Jan;20(1):68-72. doi: 10.1097/PAP.0b013e31827b65e3. PMID: 23232574
Sinonasal and nasopharyngeal applications of the hand-held CO2 laser fiber.
Agarwal G, Kupferman ME, Holsinger FC, Hanna EY
Int Forum Allergy Rhinol 2011 Mar-Apr;1(2):109-12. doi: 10.1002/alr.20017. PMID: 22287328

Prognosis

The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Practical approach to diagnosis of bland-looking spindle cell lesions of the breast.
Magro G, Salvatorelli L, Puzzo L, Piombino E, Bartoloni G, Broggi G, Vecchio GM
Pathologica 2019 Dec;111(4):344-360. doi: 10.32074/1591-951X-31-19. PMID: 31965112Free PMC Article
Spindle cell lipoma of the hypopharynx.
Evcimik MF, Ozkurt FE, Sapci T, Bozkurt Z
Int J Med Sci 2011;8(6):479-81. Epub 2011 Aug 6 doi: 10.7150/ijms.8.479. PMID: 21850199Free PMC Article
Spindle cell lipoma.
Angervall L, Dahl I, Kindblom LG, Säve-Söderbergh
Acta Pathol Microbiol Scand A 1976 Nov;84(6):477-87. doi: 10.1111/j.1699-0463.1976.tb00145.x. PMID: 998247
Spindle cell lipoma.
Enzinger FM, Harvey DA
Cancer 1975 Nov;36(5):1852-9. doi: 10.1002/1097-0142(197511)36:5<1852::aid-cncr2820360542>3.0.co;2-u. PMID: 1192370

Clinical prediction guides

Pseudoangiomatous Spindle Cell Lipoma: A Rare and Distinct Pattern of Lipomatous Tumors.
Shaker N, Blankenship H, Shaker N, Alhalaseh Y, Niu S, Mansoor I, Shakra RA, Sangueza OP
Int J Surg Pathol 2024 Aug;32(5):1046-1050. Epub 2023 Oct 31 doi: 10.1177/10668969231211337. PMID: 37908107
Histopathologic and genetic findings in atypical spindle cell/pleomorphic lipomatous tumors and atypical pleomorphic fibromas.
Kouhsari LM, LeBoit PE, McCalmont TH, Hinds B, North JP
J Cutan Pathol 2022 Jul;49(7):623-631. Epub 2022 Apr 5 doi: 10.1111/cup.14230. PMID: 35332938
Spindle Cell Lipoma with Ossification Mimicking Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma: A Case Report.
Ichikawa J, Kawasaki T, Imada H, Enomoto A, Taniguchi N, Tatsuno R, Kanno S, Haro H
Int J Surg Pathol 2022 Jun;30(4):413-418. Epub 2021 Nov 23 doi: 10.1177/10668969211055798. PMID: 34812072
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Spindle cell lipoma.
Angervall L, Dahl I, Kindblom LG, Säve-Söderbergh
Acta Pathol Microbiol Scand A 1976 Nov;84(6):477-87. doi: 10.1111/j.1699-0463.1976.tb00145.x. PMID: 998247

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...