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Spindle Cell/Pleomorphic Lipoma

MedGen UID:
234807
•Concept ID:
C1336053
•
Neoplastic Process

Definition

A benign lipomatous neoplasm characterized by the presence of an admixture of mature adipose tissue and bland spindle cells. The pleomorphic variant contains in addition multinucleated giant cells. It usually arises in the neck and upper trunk in older males. [from NCI]

Professional guidelines

PubMed

From head and neck lipoma to liposarcoma: a wide spectrum of differential diagnoses and their therapeutic implications.
Barisella M, Giannini L, Piazza C
Curr Opin Otolaryngol Head Neck Surg 2020 Apr;28(2):136-143. doi: 10.1097/MOO.0000000000000608. PMID: 32011399
Cytogenetic and molecular genetic analyses of liposarcoma and its soft tissue simulators: recognition of new variants and differential diagnosis.
Meis-Kindblom JM, Sjögren H, Kindblom LG, Peydró-Mellquist A, Röijer E, Aman P, Stenman G
Virchows Arch 2001 Aug;439(2):141-51. doi: 10.1007/s004280100423. PMID: 11561754

Recent clinical studies

Etiology

What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
A contemporary review of myxoid adipocytic tumors.
Creytens D
Semin Diagn Pathol 2019 Mar;36(2):129-141. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.008. PMID: 30853315
Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update.
Schaefer IM, Hornick JL
Adv Anat Pathol 2018 Nov;25(6):400-412. doi: 10.1097/PAP.0000000000000204. PMID: 30134255Free PMC Article
Combined classical spindle cell/pleomorphic lipoma spectrum imaging and clinical data.
Younan Y, Martinez A, Reimer N, Edgar M, Gonzalez F, Umpierrez M, Subhawong T, Singer AD
Skeletal Radiol 2018 Jan;47(1):51-59. Epub 2017 Aug 19 doi: 10.1007/s00256-017-2751-1. PMID: 28823067
Lipomatous tumors.
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Diagnosis

What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Molecular updates in adipocytic neoplasms(✰).
Demicco EG
Semin Diagn Pathol 2019 Mar;36(2):85-94. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.003. PMID: 30857767
A contemporary review of myxoid adipocytic tumors.
Creytens D
Semin Diagn Pathol 2019 Mar;36(2):129-141. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.008. PMID: 30853315
Updates in spindle cell/pleomorphic lipomas.
Van Treeck BJ, Fritchie KJ
Semin Diagn Pathol 2019 Mar;36(2):105-111. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.005. PMID: 30850230
Lipomatous tumors.
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Therapy

CD34-positive superficial myxofibrosarcoma: a potential diagnostic pitfall.
Smith SC, Poznanski AA, Fullen DR, Ma L, McHugh JB, Lucas DR, Patel RM
J Cutan Pathol 2013 Jul;40(7):639-45. Epub 2013 Apr 19 doi: 10.1111/cup.12158. PMID: 23600956
Selected case from the Arkadi M. Rywlin International Pathology Slide Seminar: sclerotic (fibroma-like) lipoma, dorsum of right hand.
Allen PW
Adv Anat Pathol 2013 Jan;20(1):68-72. doi: 10.1097/PAP.0b013e31827b65e3. PMID: 23232574
Infantile fibrosarcoma successfully treated with chemotherapy, with occurrence of calcifying aponeurotic fibroma and pleomorphic/spindled celled lipoma at the site 12 years later.
DeComas AM, Heinrich SD, Craver R
J Pediatr Hematol Oncol 2009 Jun;31(6):448-52. doi: 10.1097/MPH.0b013e3181a1c0c4. PMID: 19648795
Sclerotic (fibroma-like) lipoma: a distinctive lipoma variant with a predilection for the distal extremities.
Laskin WB, Fetsch JF, Michal M, Miettinen M
Am J Dermatopathol 2006 Aug;28(4):308-16. doi: 10.1097/00000372-200608000-00003. PMID: 16871033

Prognosis

Atypical lipomatous tumor/well differentiated liposarcoma and related mimics with updates. When is molecular testing most cost-effective, necessary, and indicated?
Kilpatrick SE
Hum Pathol 2024 May;147:82-91. Epub 2023 Dec 21 doi: 10.1016/j.humpath.2023.12.005. PMID: 38135062
What's new in adipocytic neoplasia?
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Molecular updates in adipocytic neoplasms(✰).
Demicco EG
Semin Diagn Pathol 2019 Mar;36(2):85-94. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.003. PMID: 30857767
Uncommon Tumor, Uncommon Location: A Dermal-Based Spindle Cell/Pleomorphic Lipoma.
Lincoln M, Royer M
Am J Dermatopathol 2016 Aug;38(8):e122-4. doi: 10.1097/DAD.0000000000000546. PMID: 26913848
Lipomatous tumors.
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Clinical prediction guides

Atypical lipomatous tumor/well differentiated liposarcoma and related mimics with updates. When is molecular testing most cost-effective, necessary, and indicated?
Kilpatrick SE
Hum Pathol 2024 May;147:82-91. Epub 2023 Dec 21 doi: 10.1016/j.humpath.2023.12.005. PMID: 38135062
Atypical spindle cell/pleomorphic lipomatous tumour (ASPLT): A report of three FNA cases and comparison with spindle cell/pleomorphic lipoma cytopathology.
Wakely PE Jr
Cytopathology 2023 Jul;34(4):346-352. Epub 2023 Mar 17 doi: 10.1111/cyt.13227. PMID: 36856555
Intraoral lipomas: A clinicopathological study of 43 cases, including four cases of spindle cell/pleomorphic subtype.
Linares MF, Leonel AC, Carvalho EJ, de Castro JF, de Almeida OP, Perez DE
Med Oral Patol Oral Cir Bucal 2019 May 1;24(3):e373-e378. doi: 10.4317/medoral.22931. PMID: 31041916Free PMC Article
Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update.
Schaefer IM, Hornick JL
Adv Anat Pathol 2018 Nov;25(6):400-412. doi: 10.1097/PAP.0000000000000204. PMID: 30134255Free PMC Article
Uncommon Tumor, Uncommon Location: A Dermal-Based Spindle Cell/Pleomorphic Lipoma.
Lincoln M, Royer M
Am J Dermatopathol 2016 Aug;38(8):e122-4. doi: 10.1097/DAD.0000000000000546. PMID: 26913848

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