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Pancreatic Delta Cell Adenoma

MedGen UID:
83548
•Concept ID:
C0279726
•
Neoplastic Process

Definition

An endocrine neoplasm arising from the delta cells of the pancreas which produce somatostatin. It does not show evidence of vascular invasion or metastasis to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic Delta Cell Adenoma

Recent clinical studies

Etiology

Dissociation between plasma adrenal androgens and cortisol in Cushing's disease and ectopic ACTH-producing tumour: relation to adrenarche.
Hauffa BP, Kaplan SL, Grumbach MM
Lancet 1984 Jun 23;1(8391):1373-6. doi: 10.1016/s0140-6736(84)91873-7. PMID: 6145833

Diagnosis

Cavβ3 Regulates Ca(2+) Signaling and Insulin Expression in Pancreatic β-Cells in a Cell-Autonomous Manner.
Becker A, Wardas B, Salah H, Amini M, Fecher-Trost C, Sen Q, Martus D, Beck A, Philipp SE, Flockerzi V, Belkacemi A
Diabetes 2021 Nov;70(11):2532-2544. Epub 2021 Aug 23 doi: 10.2337/db21-0078. PMID: 34426509Free PMC Article
Noninsulinoma pancreatogenous hypoglycemia syndrome: quantitative and immunohistochemical analyses of islet cells for insulin, glucagon, somatostatin, and pancreatic and duodenal homeobox protein.
Sahloul R, Yaqub N, Driscoll HK, Leidy JW Jr, Parkash J, Matthews KA, Chertow BS
Endocr Pract 2007 Mar-Apr;13(2):187-93. doi: 10.4158/EP.13.2.187. PMID: 17490935
Malignant insulinoma presenting with recurrent episodic loss of consciousness.
Misra UK, Pandey BN, Pradhan S, Bal S, Mithal A, Bhatia I
J Assoc Physicians India 1991 Oct;39(10):771-3. PMID: 1816206

Therapy

Protein kinase C: a target for therapy in pancreatic cancer.
El-Rayes BF, Ali S, Philip PA, Sarkar FH
Pancreas 2008 May;36(4):346-52. doi: 10.1097/MPA.0b013e31815ceaf7. PMID: 18437080
RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose.
Zhang G, Hirai H, Cai T, Miura J, Yu P, Huang H, Schiller MR, Swaim WD, Leapman RD, Notkins AL
J Endocrinol 2007 Nov;195(2):313-21. doi: 10.1677/JOE-07-0252. PMID: 17951542
Pancreatic alpha cell tumors: case report and review of the literature.
Lokich J, Anderson N, Rossini A, Hadley W, Federman M, Legg M
Cancer 1980 May 15;45(10):2675-83. doi: 10.1002/1097-0142(19800515)45:10<2675::aid-cncr2820451032>3.0.co;2-3. PMID: 6247056

Prognosis

PGP 9.5 immunocytochemical staining for pancreatic endocrine tumors.
Tomita T
Islets 2013 May-Jun;5(3):122-8. Epub 2013 Jun 27 doi: 10.4161/isl.25351. PMID: 23959334Free PMC Article
miR-197 induces epithelial-mesenchymal transition in pancreatic cancer cells by targeting p120 catenin.
Hamada S, Satoh K, Miura S, Hirota M, Kanno A, Masamune A, Kikuta K, Kume K, Unno J, Egawa S, Motoi F, Unno M, Shimosegawa T
J Cell Physiol 2013 Jun;228(6):1255-63. doi: 10.1002/jcp.24280. PMID: 23139153
The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells.
Moore F, Santin I, Nogueira TC, Gurzov EN, Marselli L, Marchetti P, Eizirik DL
PLoS One 2012;7(2):e31062. Epub 2012 Feb 8 doi: 10.1371/journal.pone.0031062. PMID: 22347430Free PMC Article
Somatostatinoma syndrome: does a clinical entity exist?
Stacpoole PW, Kasselberg AG, Berelowitz M, Chey WY
Acta Endocrinol (Copenh) 1983 Jan;102(1):80-7. doi: 10.1530/acta.0.1020080. PMID: 6297217
Pancreatic alpha cell tumors: case report and review of the literature.
Lokich J, Anderson N, Rossini A, Hadley W, Federman M, Legg M
Cancer 1980 May 15;45(10):2675-83. doi: 10.1002/1097-0142(19800515)45:10<2675::aid-cncr2820451032>3.0.co;2-3. PMID: 6247056

Clinical prediction guides

The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells.
Moore F, Santin I, Nogueira TC, Gurzov EN, Marselli L, Marchetti P, Eizirik DL
PLoS One 2012;7(2):e31062. Epub 2012 Feb 8 doi: 10.1371/journal.pone.0031062. PMID: 22347430Free PMC Article
Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells.
Eitel K, Staiger H, Rieger J, Mischak H, Brandhorst H, Brendel MD, Bretzel RG, Häring HU, Kellerer M
Diabetes 2003 Apr;52(4):991-7. doi: 10.2337/diabetes.52.4.991. PMID: 12663471
T-splenocytes from non-obese diabetic mice binding to xenogeneic pancreatic beta-cells in vitro. Implication of the alpha/beta T-cell receptor and of major histocompatibility complex class II molecules from target cells.
Martignat L, Feve B, Ouary M, Pogu S, Charbonnel B, Saï P
J Autoimmun 1993 Dec;6(6):753-69. doi: 10.1006/jaut.1993.1062. PMID: 8155255
Somatostatinoma syndrome: does a clinical entity exist?
Stacpoole PW, Kasselberg AG, Berelowitz M, Chey WY
Acta Endocrinol (Copenh) 1983 Jan;102(1):80-7. doi: 10.1530/acta.0.1020080. PMID: 6297217
Pancreatic alpha cell tumors: case report and review of the literature.
Lokich J, Anderson N, Rossini A, Hadley W, Federman M, Legg M
Cancer 1980 May 15;45(10):2675-83. doi: 10.1002/1097-0142(19800515)45:10<2675::aid-cncr2820451032>3.0.co;2-3. PMID: 6247056

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