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Recurrent Malignant Extragonadal Germ Cell Tumor

MedGen UID:
857330
•Concept ID:
C3897736
•
Neoplastic Process

Definition

The reemergence of malignant extragonadal germ cell tumor after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Malignant Extragonadal Germ Cell Tumor

Professional guidelines

PubMed

Management of Germ Cell Tumours of the Testes in Adult Patients: German Clinical Practice Guideline, PART II - Recommendations for the Treatment of Advanced, Recurrent, and Refractory Disease and Extragonadal and Sex Cord/Stromal Tumours and for the Management of Follow-Up, Toxicity, Quality of Life, Palliative Care, and Supportive Therapy.
Kliesch S, Schmidt S, Wilborn D, Aigner C, Albrecht W, Bedke J, Beintker M, Beyersdorff D, Bokemeyer C, Busch J, Classen J, de Wit M, Dieckmann KP, Diemer T, Dieing A, Gockel M, Göckel-Beining B, Hakenberg OW, Heidenreich A, Heinzelbecker J, Herkommer K, Hermanns T, Kaufmann S, Kornmann M, Kotzerke J, Krege S, Kristiansen G, Lorch A, Müller AC, Oechsle K, Ohloff T, Oing C, Otto U, Pfister D, Pichler R, Recken H, Rick O, Rudolph Y, Ruf C, Schirren J, Schmelz H, Schmidberger H, Schrader M, Schweyer S, Seeling S, Souchon R, Winter C, Wittekind C, Zengerling F, Zermann DH, Zillmann R, Albers P
Urol Int 2021;105(3-4):181-191. Epub 2021 Jan 22 doi: 10.1159/000511245. PMID: 33486494Free PMC Article
Japanese clinical practice guidelines for sacrococcygeal teratoma, 2017.
Fumino S, Tajiri T, Usui N, Tamura M, Sago H, Ono S, Nosaka S, Yoneda A, Souzaki R, Higashi M, Sakai K, Takahashi K, Sugiura T, Taguchi T
Pediatr Int 2019 Jul;61(7):672-678. Epub 2019 Jun 18 doi: 10.1111/ped.13844. PMID: 30903638
Adult primary extragonadal germ cell tumors: Treatment results and long-term follow-up.
Andac A, Mert B, Sevil B, Burak S, Haluk O
Med Pediatr Oncol 2003 Jul;41(1):49-53. doi: 10.1002/mpo.10136. PMID: 12764743

Recent clinical studies

Etiology

Neonatal teratomas.
Lakhoo K
Early Hum Dev 2010 Oct;86(10):643-7. Epub 2010 Sep 29 doi: 10.1016/j.earlhumdev.2010.08.016. PMID: 20884137
Germ-cell tumors in childhood and adolescence. GPOH MAKEI and the MAHO study groups.
Göbel U, Schneider DT, Calaminus G, Haas RJ, Schmidt P, Harms D
Ann Oncol 2000 Mar;11(3):263-71. doi: 10.1023/a:1008360523160. PMID: 10811491
Pediatric germ cell tumors.
Rescorla FJ, Breitfeld PP
Curr Probl Cancer 1999 Nov-Dec;23(6):257-303. doi: 10.1016/s0147-0272(99)90009-0. PMID: 10614561
Germ cell tumors.
Rescorla FJ
Semin Pediatr Surg 1997 Feb;6(1):29-37. PMID: 9117272
Germ cell tumours.
Talerman A
Ann Pathol 1985;5(3):145-57. PMID: 3000396

Diagnosis

Malignant recurrence after mature Sacrococcygeal teratoma: A meta-analysis and review of the literature.
Kops AL, Hulsker CC, Fiocco M, Zsiros J, Mavinkurve-Groothuis AMC, Looijenga LH, van der Steeg AF, Wijnen MH
Crit Rev Oncol Hematol 2020 Dec;156:103140. Epub 2020 Oct 23 doi: 10.1016/j.critrevonc.2020.103140. PMID: 33142194
Neonatal teratomas.
Lakhoo K
Early Hum Dev 2010 Oct;86(10):643-7. Epub 2010 Sep 29 doi: 10.1016/j.earlhumdev.2010.08.016. PMID: 20884137
Germ-cell tumors in childhood and adolescence. GPOH MAKEI and the MAHO study groups.
Göbel U, Schneider DT, Calaminus G, Haas RJ, Schmidt P, Harms D
Ann Oncol 2000 Mar;11(3):263-71. doi: 10.1023/a:1008360523160. PMID: 10811491
Pediatric germ cell tumors.
Rescorla FJ, Breitfeld PP
Curr Probl Cancer 1999 Nov-Dec;23(6):257-303. doi: 10.1016/s0147-0272(99)90009-0. PMID: 10614561
Germ cell tumours.
Talerman A
Ann Pathol 1985;5(3):145-57. PMID: 3000396

Therapy

Malignant recurrence after mature Sacrococcygeal teratoma: A meta-analysis and review of the literature.
Kops AL, Hulsker CC, Fiocco M, Zsiros J, Mavinkurve-Groothuis AMC, Looijenga LH, van der Steeg AF, Wijnen MH
Crit Rev Oncol Hematol 2020 Dec;156:103140. Epub 2020 Oct 23 doi: 10.1016/j.critrevonc.2020.103140. PMID: 33142194
Primary mediastinal and retroperitoneal malignant germ cell tumors in children and adolescents: Results of the TGM95 trial, a study of the French Society of Pediatric Oncology (Société Française des Cancers de l'Enfant).
Sudour-Bonnange H, Faure-Conter C, Martelli H, Hameury F, Fresneau B, Orbach D, Vérité C
Pediatr Blood Cancer 2017 Sep;64(9) Epub 2017 Mar 17 doi: 10.1002/pbc.26494. PMID: 28306215
Adult primary extragonadal germ cell tumors: Treatment results and long-term follow-up.
Andac A, Mert B, Sevil B, Burak S, Haluk O
Med Pediatr Oncol 2003 Jul;41(1):49-53. doi: 10.1002/mpo.10136. PMID: 12764743
High-dose chemotherapy with autologous stem-cell support for germ cell tumors: a critical review.
Sobecks RM, Vogelzang NJ
Semin Oncol 1999 Feb;26(1):106-18. PMID: 10073567
Salvage therapy in recurrent germ cell cancer: ifosfamide and cisplatin plus either vinblastine or etoposide.
Loehrer PJ Sr, Lauer R, Roth BJ, Williams SD, Kalasinski LA, Einhorn LH
Ann Intern Med 1988 Oct 1;109(7):540-6. doi: 10.7326/0003-4819-109-7-540. PMID: 2844110

Prognosis

Malignant recurrence after mature Sacrococcygeal teratoma: A meta-analysis and review of the literature.
Kops AL, Hulsker CC, Fiocco M, Zsiros J, Mavinkurve-Groothuis AMC, Looijenga LH, van der Steeg AF, Wijnen MH
Crit Rev Oncol Hematol 2020 Dec;156:103140. Epub 2020 Oct 23 doi: 10.1016/j.critrevonc.2020.103140. PMID: 33142194
Japanese clinical practice guidelines for sacrococcygeal teratoma, 2017.
Fumino S, Tajiri T, Usui N, Tamura M, Sago H, Ono S, Nosaka S, Yoneda A, Souzaki R, Higashi M, Sakai K, Takahashi K, Sugiura T, Taguchi T
Pediatr Int 2019 Jul;61(7):672-678. Epub 2019 Jun 18 doi: 10.1111/ped.13844. PMID: 30903638
Late relapse of nonseminomatous germ cell tumours.
Oldenburg J, Fosså SD
BJU Int 2009 Nov;104(9 Pt B):1413-7. doi: 10.1111/j.1464-410X.2009.08868.x. PMID: 19840022
Laboratory markers and germ cell tumors.
von Eyben FE
Crit Rev Clin Lab Sci 2003 Aug;40(4):377-427. doi: 10.1080/10408360390247814. PMID: 14582602
Germ-cell tumors in childhood and adolescence. GPOH MAKEI and the MAHO study groups.
Göbel U, Schneider DT, Calaminus G, Haas RJ, Schmidt P, Harms D
Ann Oncol 2000 Mar;11(3):263-71. doi: 10.1023/a:1008360523160. PMID: 10811491

Clinical prediction guides

Mature cystic teratoma mimicking meningomyelocele.
Balci M, Yuksel U, Akkaya MA, Akkaya S, Sagsoz N
Childs Nerv Syst 2021 Jul;37(7):2245-2249. Epub 2021 Jan 6 doi: 10.1007/s00381-020-05017-3. PMID: 33404722
Unusual presentation of sacrococcygeal teratomas and associated malformations in children: clinical experience and review of the literature.
Paradies G, Zullino F, Orofino A, Leggio S
Ann Ital Chir 2013 May-Jun;84(3):333-46. PMID: 23160138
Laboratory markers and germ cell tumors.
von Eyben FE
Crit Rev Clin Lab Sci 2003 Aug;40(4):377-427. doi: 10.1080/10408360390247814. PMID: 14582602
Germ cell tumors.
Rescorla FJ
Semin Pediatr Surg 1997 Feb;6(1):29-37. PMID: 9117272
Germ cell tumours.
Talerman A
Ann Pathol 1985;5(3):145-57. PMID: 3000396

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