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Recurrent Malignant Extragonadal Germ Cell Tumor

MedGen UID:
857330
•Concept ID:
C3897736
•
Neoplastic Process

Definition

The reemergence of malignant extragonadal germ cell tumor after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Malignant Extragonadal Germ Cell Tumor

Professional guidelines

PubMed

SEOM-GG clinical guidelines for the management of germ-cell testicular cancer (2023).
Arranz Arija JA, Del Muro XG, Caro RL, Méndez-Vidal MJ, Pérez-Valderrama B, Aparicio J, Climent Durán MÁ, Caballero Díaz C, Durán I, González-Billalabeitia E
Clin Transl Oncol 2024 Nov;26(11):2783-2799. Epub 2024 Jul 3 doi: 10.1007/s12094-024-03532-2. PMID: 38958901Free PMC Article
Management of Germ Cell Tumours of the Testes in Adult Patients: German Clinical Practice Guideline, PART II - Recommendations for the Treatment of Advanced, Recurrent, and Refractory Disease and Extragonadal and Sex Cord/Stromal Tumours and for the Management of Follow-Up, Toxicity, Quality of Life, Palliative Care, and Supportive Therapy.
Kliesch S, Schmidt S, Wilborn D, Aigner C, Albrecht W, Bedke J, Beintker M, Beyersdorff D, Bokemeyer C, Busch J, Classen J, de Wit M, Dieckmann KP, Diemer T, Dieing A, Gockel M, Göckel-Beining B, Hakenberg OW, Heidenreich A, Heinzelbecker J, Herkommer K, Hermanns T, Kaufmann S, Kornmann M, Kotzerke J, Krege S, Kristiansen G, Lorch A, Müller AC, Oechsle K, Ohloff T, Oing C, Otto U, Pfister D, Pichler R, Recken H, Rick O, Rudolph Y, Ruf C, Schirren J, Schmelz H, Schmidberger H, Schrader M, Schweyer S, Seeling S, Souchon R, Winter C, Wittekind C, Zengerling F, Zermann DH, Zillmann R, Albers P
Urol Int 2021;105(3-4):181-191. Epub 2021 Jan 22 doi: 10.1159/000511245. PMID: 33486494Free PMC Article
The treatment of extragonadal seminoma.
Jain KK, Bosl GJ, Bains MS, Whitmore WF, Golbey RB
J Clin Oncol 1984 Jul;2(7):820-7. doi: 10.1200/JCO.1984.2.7.820. PMID: 6204019

Recent clinical studies

Etiology

Sacrococcygeal teratomas: a case-based review from the perspective of individual multidisciplinary experts.
Mosleh MM, Heo TG, Shin HB, Sohn MJ
Childs Nerv Syst 2023 Jan;39(1):57-64. Epub 2022 Nov 24 doi: 10.1007/s00381-022-05768-1. PMID: 36422695
Mature cystic teratoma mimicking meningomyelocele.
Balci M, Yuksel U, Akkaya MA, Akkaya S, Sagsoz N
Childs Nerv Syst 2021 Jul;37(7):2245-2249. Epub 2021 Jan 6 doi: 10.1007/s00381-020-05017-3. PMID: 33404722
Neonatal teratomas.
Lakhoo K
Early Hum Dev 2010 Oct;86(10):643-7. Epub 2010 Sep 29 doi: 10.1016/j.earlhumdev.2010.08.016. PMID: 20884137
Pediatric germ cell tumors.
Rescorla FJ, Breitfeld PP
Curr Probl Cancer 1999 Nov-Dec;23(6):257-303. doi: 10.1016/s0147-0272(99)90009-0. PMID: 10614561
Germ cell tumours.
Talerman A
Ann Pathol 1985;5(3):145-57. PMID: 3000396

Diagnosis

Sacrococcygeal teratomas: a case-based review from the perspective of individual multidisciplinary experts.
Mosleh MM, Heo TG, Shin HB, Sohn MJ
Childs Nerv Syst 2023 Jan;39(1):57-64. Epub 2022 Nov 24 doi: 10.1007/s00381-022-05768-1. PMID: 36422695
Malignant recurrence after mature Sacrococcygeal teratoma: A meta-analysis and review of the literature.
Kops AL, Hulsker CC, Fiocco M, Zsiros J, Mavinkurve-Groothuis AMC, Looijenga LH, van der Steeg AF, Wijnen MH
Crit Rev Oncol Hematol 2020 Dec;156:103140. Epub 2020 Oct 23 doi: 10.1016/j.critrevonc.2020.103140. PMID: 33142194
Neonatal teratomas.
Lakhoo K
Early Hum Dev 2010 Oct;86(10):643-7. Epub 2010 Sep 29 doi: 10.1016/j.earlhumdev.2010.08.016. PMID: 20884137
Pediatric germ cell tumors.
Rescorla FJ, Breitfeld PP
Curr Probl Cancer 1999 Nov-Dec;23(6):257-303. doi: 10.1016/s0147-0272(99)90009-0. PMID: 10614561
Germ cell tumours.
Talerman A
Ann Pathol 1985;5(3):145-57. PMID: 3000396

Therapy

Outcomes of relapsed/refractory extracranial germ cell tumors treated on conventional salvage chemotherapy without stem cell rescue: Experience from a tertiary cancer center.
Ramanathan S, Prasad M, Vora T, Badira CP, Kembhavi S, Ramadwar M, Khanna N, Laskar S, Muckaden MA, Qureshi S, Banavali S, Chinnaswamy G
Pediatr Blood Cancer 2023 Apr;70(4):e30179. Epub 2023 Jan 16 doi: 10.1002/pbc.30179. PMID: 36645132
Malignant recurrence after mature Sacrococcygeal teratoma: A meta-analysis and review of the literature.
Kops AL, Hulsker CC, Fiocco M, Zsiros J, Mavinkurve-Groothuis AMC, Looijenga LH, van der Steeg AF, Wijnen MH
Crit Rev Oncol Hematol 2020 Dec;156:103140. Epub 2020 Oct 23 doi: 10.1016/j.critrevonc.2020.103140. PMID: 33142194
Primary mediastinal and retroperitoneal malignant germ cell tumors in children and adolescents: Results of the TGM95 trial, a study of the French Society of Pediatric Oncology (Société Française des Cancers de l'Enfant).
Sudour-Bonnange H, Faure-Conter C, Martelli H, Hameury F, Fresneau B, Orbach D, Vérité C
Pediatr Blood Cancer 2017 Sep;64(9) Epub 2017 Mar 17 doi: 10.1002/pbc.26494. PMID: 28306215
Adult primary extragonadal germ cell tumors: Treatment results and long-term follow-up.
Andac A, Mert B, Sevil B, Burak S, Haluk O
Med Pediatr Oncol 2003 Jul;41(1):49-53. doi: 10.1002/mpo.10136. PMID: 12764743
The treatment of extragonadal seminoma.
Jain KK, Bosl GJ, Bains MS, Whitmore WF, Golbey RB
J Clin Oncol 1984 Jul;2(7):820-7. doi: 10.1200/JCO.1984.2.7.820. PMID: 6204019

Prognosis

Extragonadal germ cell tumors: A clinicopathologic study with emphasis on molecular features, clinical outcomes and associated secondary malignancies.
Abdulfatah E, Brown NA, Davenport MS, Reichert ZR, Camelo-Piragua S, Heider A, Huang T, Vaishampayan UN, Skala SL, Montgomery JS, Chinnaiyan AM, Kaffenberger SD, Bawa P, Shao L, Mehra R
Hum Pathol 2024 Jun;148:41-50. Epub 2024 Apr 30 doi: 10.1016/j.humpath.2024.04.015. PMID: 38697270
Malignant recurrence after mature Sacrococcygeal teratoma: A meta-analysis and review of the literature.
Kops AL, Hulsker CC, Fiocco M, Zsiros J, Mavinkurve-Groothuis AMC, Looijenga LH, van der Steeg AF, Wijnen MH
Crit Rev Oncol Hematol 2020 Dec;156:103140. Epub 2020 Oct 23 doi: 10.1016/j.critrevonc.2020.103140. PMID: 33142194
Japanese clinical practice guidelines for sacrococcygeal teratoma, 2017.
Fumino S, Tajiri T, Usui N, Tamura M, Sago H, Ono S, Nosaka S, Yoneda A, Souzaki R, Higashi M, Sakai K, Takahashi K, Sugiura T, Taguchi T
Pediatr Int 2019 Jul;61(7):672-678. Epub 2019 Jun 18 doi: 10.1111/ped.13844. PMID: 30903638
Laboratory markers and germ cell tumors.
von Eyben FE
Crit Rev Clin Lab Sci 2003 Aug;40(4):377-427. doi: 10.1080/10408360390247814. PMID: 14582602
Germ-cell tumors in childhood and adolescence. GPOH MAKEI and the MAHO study groups.
Göbel U, Schneider DT, Calaminus G, Haas RJ, Schmidt P, Harms D
Ann Oncol 2000 Mar;11(3):263-71. doi: 10.1023/a:1008360523160. PMID: 10811491

Clinical prediction guides

Postoperative recurrence of mixed extragonadal germ cell tumor in the right shoulder: a case report.
Li Y, Huang X, Meng X, Luo Y, Luo S, Wang J
Diagn Pathol 2023 Feb 20;18(1):26. doi: 10.1186/s13000-023-01312-0. PMID: 36805679Free PMC Article
Mature cystic teratoma mimicking meningomyelocele.
Balci M, Yuksel U, Akkaya MA, Akkaya S, Sagsoz N
Childs Nerv Syst 2021 Jul;37(7):2245-2249. Epub 2021 Jan 6 doi: 10.1007/s00381-020-05017-3. PMID: 33404722
Unusual presentation of sacrococcygeal teratomas and associated malformations in children: clinical experience and review of the literature.
Paradies G, Zullino F, Orofino A, Leggio S
Ann Ital Chir 2013 May-Jun;84(3):333-46. PMID: 23160138
Laboratory markers and germ cell tumors.
von Eyben FE
Crit Rev Clin Lab Sci 2003 Aug;40(4):377-427. doi: 10.1080/10408360390247814. PMID: 14582602
Germ cell tumours.
Talerman A
Ann Pathol 1985;5(3):145-57. PMID: 3000396

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