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Sinonasal Small Cell Neuroendocrine Carcinoma

MedGen UID:
857751
•Concept ID:
C3898157
•
Neoplastic Process
Synonyms: Nasal Cavity and Paranasal Sinus Small Cell Carcinoma; Nasal Cavity and Paranasal Sinus Small Cell Neuroendocrine Carcinoma; Sinonasal Small Cell Carcinoma

Definition

A very rare small cell neuroendocrine carcinoma that arises from the nose and paranasal sinuses. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSinonasal Small Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Challenging differential diagnoses in small biopsies from the sinonasal tract.
Israel AK, Cracolici V, Griffith CC
Semin Diagn Pathol 2023 Sep;40(5):321-332. Epub 2023 Apr 14 doi: 10.1053/j.semdp.2023.04.011. PMID: 37085435
Management of olfactory neuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma involving the skullbase.
Mehta GU, Raza SM, Su SY, Hanna EY, DeMonte F
J Neurooncol 2020 Dec;150(3):367-375. Epub 2020 May 18 doi: 10.1007/s11060-020-03537-1. PMID: 32424573
Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article

Recent clinical studies

Etiology

68Ga DOTANOC PET/CT for accurate delineation of disease extent in a case of sinonasal small cell neuroendocrine carcinoma.
Singhal A, Singla S, Sharma P, Dhull VS, Khangembam BC, Kumar R
Clin Nucl Med 2013 Oct;38(10):e395-6. doi: 10.1097/RLU.0b013e318279b976. PMID: 23603589

Diagnosis

Improved survival for stage IV sinonasal small cell neuroendocrine carcinoma treated with chemotherapy and anti-PD-L1 therapy.
Selesky M, Elghawy O, Kaur V
BMJ Case Rep 2023 Nov 17;16(11) doi: 10.1136/bcr-2023-255313. PMID: 37977842Free PMC Article
Sinonasal Small Cell Carcinoma-Case Series of a Rare Malignancy.
Chapurin N, Totten DJ, Louis PC, Lewis JS Jr, Chowdhury NI, Turner J, Chandra RK
Ear Nose Throat J 2022 Jul;101(6):392-395. Epub 2020 Oct 22 doi: 10.1177/0145561320964640. PMID: 33090899
The value of (68) Gallium-DOTATATE PET/CT in sinonasal neuroendocrine tumor management: A case series.
Liu KY, Goldrich DY, Ninan SJ, Filimonov A, Lam H, Govindaraj S, Iloreta AM
Head Neck 2021 Jun;43(6):E30-E40. Epub 2021 Mar 31 doi: 10.1002/hed.26695. PMID: 33786927
Clinical value of (99m)Tc-HYNIC-TOC SPECT/CT for the diagnosis primary small cell neuroendocrine carcinomas of the nasal cavity and paranasal sinuses.
Chen H, Li Y, Gao X, Shen X
Clin Imaging 2018 Nov-Dec;52:365-369. Epub 2018 Sep 20 doi: 10.1016/j.clinimag.2018.09.010. PMID: 30248495
Blindness: a sequela of sinonasal small cell neuroendocrine carcinoma.
Avitia S, Osborne RF
Ear Nose Throat J 2004 Aug;83(8):530, 532. PMID: 15487631

Therapy

Improved survival for stage IV sinonasal small cell neuroendocrine carcinoma treated with chemotherapy and anti-PD-L1 therapy.
Selesky M, Elghawy O, Kaur V
BMJ Case Rep 2023 Nov 17;16(11) doi: 10.1136/bcr-2023-255313. PMID: 37977842Free PMC Article

Prognosis

Sinonasal Small Cell Carcinoma-Case Series of a Rare Malignancy.
Chapurin N, Totten DJ, Louis PC, Lewis JS Jr, Chowdhury NI, Turner J, Chandra RK
Ear Nose Throat J 2022 Jul;101(6):392-395. Epub 2020 Oct 22 doi: 10.1177/0145561320964640. PMID: 33090899
Rare sinonasal small cell neuroendocrine carcinoma evaluated by F-18-FDG PET/MRI.
Treglia G, Bongiovanni M, Giovanella L
Endocrine 2014 Nov;47(2):654-5. Epub 2014 Feb 8 doi: 10.1007/s12020-014-0190-5. PMID: 24510632

Recent systematic reviews

Sinonasal small cell neuroendocrine carcinoma: a systematic review of 80 patients.
Rivero A, Liang J
Int Forum Allergy Rhinol 2016 Jul;6(7):744-51. Epub 2016 Feb 16 doi: 10.1002/alr.21734. PMID: 26880574

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