U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Direct Extension

MedGen UID:
858963
Concept ID:
C3899369
Neoplastic Process
Synonyms: Contiguous Spread; Direct Tumor Extension

Definition

The spread or migration of cancer cells through the wall of an organ into surrounding organs and/or adjacent tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDirect Extension

Professional guidelines

PubMed

Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Conen A, Raabe A, Schaller K, Fux CA, Vajkoczy P, Trampuz A
Swiss Med Wkly 2020 Apr 20;150:w20208. Epub 2020 Apr 24 doi: 10.4414/smw.2020.20208. PMID: 32329803
Jubran RF, Erdreich-Epstein A, Butturini A, Murphree AL, Villablanca JG
J Pediatr Hematol Oncol 2004 Jan;26(1):31-4. doi: 10.1097/00043426-200401000-00011. PMID: 14707710

Recent clinical studies

Etiology

Mirian C, Jensen LR, Juratli TA, Maier AD, Torp SH, Shih HA, Morshed RA, Young JS, Magill ST, Bertero L, Stummer W, Spille DC, Brokinkel B, Oya S, Miyawaki S, Saito N, Proescholdt M, Kuroi Y, Gousias K, Simon M, Moliterno J, Prat-Acin R, Goutagny S, Prabhu VC, Tsiang JT, Wach J, Güresir E, Yamamoto J, Kim YZ, Lee JH, Koshy M, Perumal K, Baskaya MK, Cannon DM, Shrieve DC, Suh CO, Chang JH, Kamenova M, Straumann S, Soleman J, Eyüpoglu IY, Catalan T, Lui A, Theodosopoulos PV, McDermott MW, Wang F, Guo F, Góes P, de Paiva Neto MA, Jamshidi A, Komotar R, Ivan M, Luther E, Souhami L, Guiot MC, Csonka T, Endo T, Barrett OC, Jensen R, Gupta T, Patel AJ, Klisch TJ, Kim JW, Maiuri F, Barresi V, Tabernero MD, Skyrman S, Broechner A, Bach MJ, Law I, Scheie D, Kristensen BW, Munch TN, Meling T, Fugleholm K, Blanche P, Mathiesen T
J Neurooncol 2024 Feb;166(3):503-511. Epub 2024 Feb 10 doi: 10.1007/s11060-024-04572-y. PMID: 38336917Free PMC Article
Gilcrease-Garcia BM, Deshmukh SD, Parsons MS
Radiographics 2020 Oct;40(6):1686-1714. doi: 10.1148/rg.2020200012. PMID: 33001787
Li SX, Polacco MA, Gosselin BJ, Harrington LX, Titus AJ, Paydarfar JA
J Laryngol Otol 2017 Aug;131(8):740-744. Epub 2017 Jun 8 doi: 10.1017/S0022215117001244. PMID: 28592347Free PMC Article
Siefker-Radtke A
Semin Oncol 2012 Oct;39(5):619-24. doi: 10.1053/j.seminoncol.2012.08.011. PMID: 23040259
Novelli G
Intern Emerg Med 2010 Oct;5 Suppl 1:S81-90. doi: 10.1007/s11739-010-0455-9. PMID: 20865479

Diagnosis

Gardini G, Zanotti P, Pucci A, Tomasoni L, Caligaris S, Paro B, Gavazzi E, Albano D, Bonardelli S, Maroldi R, Giubbini R, Castelli F
Infection 2019 Dec;47(6):1059-1063. Epub 2019 Jul 18 doi: 10.1007/s15010-019-01344-z. PMID: 31321641
Jiménez-Pérez JC, Yoon MK
Semin Ophthalmol 2017;32(1):116-124. Epub 2016 Oct 14 doi: 10.1080/08820538.2016.1228405. PMID: 27740876
McKinney TJ, Patel JJ, Benns MV, Nash NA, Miller KR
Curr Gastroenterol Rep 2016 Apr;18(4):18. doi: 10.1007/s11894-016-0492-2. PMID: 26951231
Kim MP, Hofstetter WL
Thorac Surg Clin 2009 Nov;19(4):521-9. doi: 10.1016/j.thorsurg.2009.08.007. PMID: 20112635
Laigle-Donadey F, Taillibert S, Mokhtari K, Hildebrand J, Delattre JY
J Neurooncol 2005 Oct;75(1):57-61. doi: 10.1007/s11060-004-8098-1. PMID: 16215816

Therapy

Yu AJ, Espinosa M, Adappa ND, Douglas JE
Otolaryngol Clin North Am 2024 Dec;57(6):1019-1030. Epub 2024 Jul 23 doi: 10.1016/j.otc.2024.06.003. PMID: 39048507
Jiménez-Pérez JC, Yoon MK
Semin Ophthalmol 2017;32(1):116-124. Epub 2016 Oct 14 doi: 10.1080/08820538.2016.1228405. PMID: 27740876
McKinney TJ, Patel JJ, Benns MV, Nash NA, Miller KR
Curr Gastroenterol Rep 2016 Apr;18(4):18. doi: 10.1007/s11894-016-0492-2. PMID: 26951231
Hoenigl M, Krause R
Curr Pharm Des 2013;19(20):3648-68. doi: 10.2174/13816128113199990342. PMID: 23278539
Hanauer SB
Neth J Med 1989 Jun;35 Suppl 1:S11-20. PMID: 2702307

Prognosis

Jiménez-Pérez JC, Yoon MK
Semin Ophthalmol 2017;32(1):116-124. Epub 2016 Oct 14 doi: 10.1080/08820538.2016.1228405. PMID: 27740876
McKinney TJ, Patel JJ, Benns MV, Nash NA, Miller KR
Curr Gastroenterol Rep 2016 Apr;18(4):18. doi: 10.1007/s11894-016-0492-2. PMID: 26951231
Cracchiolo JR, Shaha AR
Otolaryngol Clin North Am 2016 Apr;49(2):415-24. Epub 2016 Feb 17 doi: 10.1016/j.otc.2015.10.007. PMID: 26895698Free PMC Article
Kim MP, Hofstetter WL
Thorac Surg Clin 2009 Nov;19(4):521-9. doi: 10.1016/j.thorsurg.2009.08.007. PMID: 20112635
Laigle-Donadey F, Taillibert S, Mokhtari K, Hildebrand J, Delattre JY
J Neurooncol 2005 Oct;75(1):57-61. doi: 10.1007/s11060-004-8098-1. PMID: 16215816

Clinical prediction guides

Mustak H, Lo C, Cohen LM, Tran A, Almanzor R, McCannel TA, Goldberg RA, Rootman DB
Eye (Lond) 2023 Feb;37(2):249-255. Epub 2022 Jan 5 doi: 10.1038/s41433-021-01861-y. PMID: 34987200Free PMC Article
Juniat V, Lee J, Sia P, Curragh D, Hardy TG, Selva D
Orbit 2021 Dec;40(6):505-508. Epub 2020 Sep 7 doi: 10.1080/01676830.2020.1817101. PMID: 32893697
Li SX, Polacco MA, Gosselin BJ, Harrington LX, Titus AJ, Paydarfar JA
J Laryngol Otol 2017 Aug;131(8):740-744. Epub 2017 Jun 8 doi: 10.1017/S0022215117001244. PMID: 28592347Free PMC Article
Cracchiolo JR, Shaha AR
Otolaryngol Clin North Am 2016 Apr;49(2):415-24. Epub 2016 Feb 17 doi: 10.1016/j.otc.2015.10.007. PMID: 26895698Free PMC Article
Rosenthal DI
Cancer 1997 Oct 15;80(8 Suppl):1595-607. doi: 10.1002/(sici)1097-0142(19971015)80:8+<1595::aid-cncr10>3.3.co;2-z. PMID: 9362427

Recent systematic reviews

Tosh JM, Navriya SC, Kumar S, Singh S, Ramachandra D, Khandari A
Pol Przegl Chir 2022 Mar 1;94(4):37-44. doi: 10.5604/01.3001.0015.7678. PMID: 36047362
Akman C, Kantarci F, Cetinkaya S
Clin Radiol 2004 Jul;59(7):573-85. doi: 10.1016/j.crad.2003.12.001. PMID: 15208062

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...