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BCLC Stage C Hepatocellular Carcinoma

MedGen UID:
859571
•Concept ID:
C3899977
•
Neoplastic Process
Synonym: Barcelona Clinic Liver Cancer Stage C Hepatocellular Carcinoma

Definition

Advanced hepatocellular carcinoma. Patients may receive new agents in the setting of randomized controlled trials. (HPB (Oxford) 2005; 7(1):35-41) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBCLC Stage C Hepatocellular Carcinoma

Professional guidelines

PubMed

A novel treatment strategy using indocyanine green for transarterial chemoembolization in BCLC stage C hepatocellular carcinoma.
Mei J, Li SH, Wang QX, Zhong XP, Lu LH, Kan A, Wei W, Guo RP
Cancer Med 2020 Jan;9(1):62-76. Epub 2019 Nov 8 doi: 10.1002/cam4.2671. PMID: 31701652Free PMC Article
Comparison of the efficacy and safety of Transarterial chemoembolization with and without Apatinib for the treatment of BCLC stage C hepatocellular carcinoma.
Chen S, Yu W, Zhang K, Liu W
BMC Cancer 2018 Nov 19;18(1):1131. doi: 10.1186/s12885-018-5081-3. PMID: 30453925Free PMC Article
(18)F-fluorodeoxyglucose uptake of hepatocellular carcinoma as a prognostic predictor in patients with sorafenib treatment.
Sung PS, Park HL, Yang K, Hwang S, Song MJ, Jang JW, Choi JY, Yoon SK, Yoo IR, Bae SH
Eur J Nucl Med Mol Imaging 2018 Mar;45(3):384-391. Epub 2017 Nov 10 doi: 10.1007/s00259-017-3871-5. PMID: 29124280

Recent clinical studies

Etiology

Role of radiotherapy in Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma treated with sorafenib.
Chang WI, Kim BH, Kim YJ, Yoon JH, Jung YJ, Chie EK
J Gastroenterol Hepatol 2022 Feb;37(2):387-394. Epub 2021 Nov 5 doi: 10.1111/jgh.15722. PMID: 34693560
Transarterial Chemoembolization Combined with Sorafenib in Patients with BCLC Stage C Hepatocellular Carcinoma.
Liu KC, Hao YH, Lv WF, Jia WD, Ji CS, Zhou CZ, Cheng DL, Xu SB, Gao ZG, Su MX, Shi CS
Drug Des Devel Ther 2020;14:3461-3468. Epub 2020 Aug 25 doi: 10.2147/DDDT.S248850. PMID: 32904650Free PMC Article
Challenges of BCLC stage C hepatocellular carcinoma: Results of a single-institutional experience on stereotactic body radiation therapy.
Que J, Lin CH, Lin LC, Ho CH
Medicine (Baltimore) 2020 Aug 7;99(32):e21561. doi: 10.1097/MD.0000000000021561. PMID: 32769898Free PMC Article
Yttrium-90 Radioembolization for BCLC Stage C Hepatocellular Carcinoma Comparing Child-Pugh A Versus B7 Patients: Are the Outcomes Equivalent?
Zu Q, Schenning RC, Jahangiri Y, Tomozawa Y, Kolbeck KJ, Kaufman JA, Al-Hakim R, Naugler WE, Nabavizadeh N, Kardosh A, Billingsley KG, Mayo SC, Orloff SL, Enestvedt KK, Maynard E, Ahn J, Lhewa D, Farsad K
Cardiovasc Intervent Radiol 2020 May;43(5):721-731. Epub 2020 Mar 5 doi: 10.1007/s00270-020-02434-4. PMID: 32140840
Surgical resection versus transarterial chemoembolization for BCLC stage C hepatocellular carcinoma.
Liu PH, Hsia CY, Lee YH, Hsu CY, Huang YH, Su CW, Lee RC, Lin HC, Huo TI
J Surg Oncol 2015 Mar 15;111(4):404-9. Epub 2015 Feb 2 doi: 10.1002/jso.23854. PMID: 25643842

Diagnosis

Comparison of the efficacy and safety of Transarterial chemoembolization with and without Apatinib for the treatment of BCLC stage C hepatocellular carcinoma.
Chen S, Yu W, Zhang K, Liu W
BMC Cancer 2018 Nov 19;18(1):1131. doi: 10.1186/s12885-018-5081-3. PMID: 30453925Free PMC Article
Vascular Invasion and Metastasis is Predictive of Outcome in Barcelona Clinic Liver Cancer Stage C Hepatocellular Carcinoma.
Mokdad AA, Singal AG, Marrero JA, Zhu H, Yopp AC
J Natl Compr Canc Netw 2017 Feb;15(2):197-204. doi: 10.6004/jnccn.2017.0020. PMID: 28188189
(18)F-FDG PET/CT Can Predict Survival of Advanced Hepatocellular Carcinoma Patients: A Multicenter Retrospective Cohort Study.
Na SJ, Oh JK, Hyun SH, Lee JW, Hong IK, Song BI, Kim TS, Eo JS, Lee SW, Yoo IR, Chung YA, Yun M
J Nucl Med 2017 May;58(5):730-736. Epub 2016 Oct 27 doi: 10.2967/jnumed.116.182022. PMID: 27789714

Therapy

Efficacy and Prognostic Factors of Regorafenib in the Treatment of BCLC Stage C Hepatocellular Carcinoma After Failure of the First-Line Therapy.
Xu B, Lu D, Liu K, Lv W, Xiao J, Zhang X, Zhang Z, Chai J, Wang L
Drug Des Devel Ther 2023;17:507-518. Epub 2023 Feb 16 doi: 10.2147/DDDT.S400533. PMID: 36814894Free PMC Article
Role of radiotherapy in Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma treated with sorafenib.
Chang WI, Kim BH, Kim YJ, Yoon JH, Jung YJ, Chie EK
J Gastroenterol Hepatol 2022 Feb;37(2):387-394. Epub 2021 Nov 5 doi: 10.1111/jgh.15722. PMID: 34693560
Transarterial Chemoembolization Combined with Sorafenib in Patients with BCLC Stage C Hepatocellular Carcinoma.
Liu KC, Hao YH, Lv WF, Jia WD, Ji CS, Zhou CZ, Cheng DL, Xu SB, Gao ZG, Su MX, Shi CS
Drug Des Devel Ther 2020;14:3461-3468. Epub 2020 Aug 25 doi: 10.2147/DDDT.S248850. PMID: 32904650Free PMC Article
Yttrium-90 Radioembolization for BCLC Stage C Hepatocellular Carcinoma Comparing Child-Pugh A Versus B7 Patients: Are the Outcomes Equivalent?
Zu Q, Schenning RC, Jahangiri Y, Tomozawa Y, Kolbeck KJ, Kaufman JA, Al-Hakim R, Naugler WE, Nabavizadeh N, Kardosh A, Billingsley KG, Mayo SC, Orloff SL, Enestvedt KK, Maynard E, Ahn J, Lhewa D, Farsad K
Cardiovasc Intervent Radiol 2020 May;43(5):721-731. Epub 2020 Mar 5 doi: 10.1007/s00270-020-02434-4. PMID: 32140840
Surgical resection versus transarterial chemoembolization for BCLC stage C hepatocellular carcinoma.
Liu PH, Hsia CY, Lee YH, Hsu CY, Huang YH, Su CW, Lee RC, Lin HC, Huo TI
J Surg Oncol 2015 Mar 15;111(4):404-9. Epub 2015 Feb 2 doi: 10.1002/jso.23854. PMID: 25643842

Prognosis

Role of radiotherapy in Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma treated with sorafenib.
Chang WI, Kim BH, Kim YJ, Yoon JH, Jung YJ, Chie EK
J Gastroenterol Hepatol 2022 Feb;37(2):387-394. Epub 2021 Nov 5 doi: 10.1111/jgh.15722. PMID: 34693560
Challenges of BCLC stage C hepatocellular carcinoma: Results of a single-institutional experience on stereotactic body radiation therapy.
Que J, Lin CH, Lin LC, Ho CH
Medicine (Baltimore) 2020 Aug 7;99(32):e21561. doi: 10.1097/MD.0000000000021561. PMID: 32769898Free PMC Article
Yttrium-90 Radioembolization for BCLC Stage C Hepatocellular Carcinoma Comparing Child-Pugh A Versus B7 Patients: Are the Outcomes Equivalent?
Zu Q, Schenning RC, Jahangiri Y, Tomozawa Y, Kolbeck KJ, Kaufman JA, Al-Hakim R, Naugler WE, Nabavizadeh N, Kardosh A, Billingsley KG, Mayo SC, Orloff SL, Enestvedt KK, Maynard E, Ahn J, Lhewa D, Farsad K
Cardiovasc Intervent Radiol 2020 May;43(5):721-731. Epub 2020 Mar 5 doi: 10.1007/s00270-020-02434-4. PMID: 32140840
Comparison of the efficacy and safety of Transarterial chemoembolization with and without Apatinib for the treatment of BCLC stage C hepatocellular carcinoma.
Chen S, Yu W, Zhang K, Liu W
BMC Cancer 2018 Nov 19;18(1):1131. doi: 10.1186/s12885-018-5081-3. PMID: 30453925Free PMC Article
Surgical resection versus transarterial chemoembolization for BCLC stage C hepatocellular carcinoma.
Liu PH, Hsia CY, Lee YH, Hsu CY, Huang YH, Su CW, Lee RC, Lin HC, Huo TI
J Surg Oncol 2015 Mar 15;111(4):404-9. Epub 2015 Feb 2 doi: 10.1002/jso.23854. PMID: 25643842

Clinical prediction guides

Role of radiotherapy in Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma treated with sorafenib.
Chang WI, Kim BH, Kim YJ, Yoon JH, Jung YJ, Chie EK
J Gastroenterol Hepatol 2022 Feb;37(2):387-394. Epub 2021 Nov 5 doi: 10.1111/jgh.15722. PMID: 34693560
Transarterial Chemoembolization Combined with Sorafenib in Patients with BCLC Stage C Hepatocellular Carcinoma.
Liu KC, Hao YH, Lv WF, Jia WD, Ji CS, Zhou CZ, Cheng DL, Xu SB, Gao ZG, Su MX, Shi CS
Drug Des Devel Ther 2020;14:3461-3468. Epub 2020 Aug 25 doi: 10.2147/DDDT.S248850. PMID: 32904650Free PMC Article
Challenges of BCLC stage C hepatocellular carcinoma: Results of a single-institutional experience on stereotactic body radiation therapy.
Que J, Lin CH, Lin LC, Ho CH
Medicine (Baltimore) 2020 Aug 7;99(32):e21561. doi: 10.1097/MD.0000000000021561. PMID: 32769898Free PMC Article
Yttrium-90 Radioembolization for BCLC Stage C Hepatocellular Carcinoma Comparing Child-Pugh A Versus B7 Patients: Are the Outcomes Equivalent?
Zu Q, Schenning RC, Jahangiri Y, Tomozawa Y, Kolbeck KJ, Kaufman JA, Al-Hakim R, Naugler WE, Nabavizadeh N, Kardosh A, Billingsley KG, Mayo SC, Orloff SL, Enestvedt KK, Maynard E, Ahn J, Lhewa D, Farsad K
Cardiovasc Intervent Radiol 2020 May;43(5):721-731. Epub 2020 Mar 5 doi: 10.1007/s00270-020-02434-4. PMID: 32140840
Surgical resection versus transarterial chemoembolization for BCLC stage C hepatocellular carcinoma.
Liu PH, Hsia CY, Lee YH, Hsu CY, Huang YH, Su CW, Lee RC, Lin HC, Huo TI
J Surg Oncol 2015 Mar 15;111(4):404-9. Epub 2015 Feb 2 doi: 10.1002/jso.23854. PMID: 25643842

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