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Abnormality of vitamin B12 metabolism

MedGen UID:
867295
•Concept ID:
C4021658
•
Finding
Synonym: Abnormality of the vitamin B12 metabolism
 
HPO: HP:0004341

Professional guidelines

PubMed

Oral lichen planus - Differential diagnoses, serum autoantibodies, hematinic deficiencies, and management.
Chiang CP, Yu-Fong Chang J, Wang YP, Wu YH, Lu SY, Sun A
J Formos Med Assoc 2018 Sep;117(9):756-765. Epub 2018 Feb 19 doi: 10.1016/j.jfma.2018.01.021. PMID: 29472048
The Role of Nutrients in Protecting Mitochondrial Function and Neurotransmitter Signaling: Implications for the Treatment of Depression, PTSD, and Suicidal Behaviors.
Du J, Zhu M, Bao H, Li B, Dong Y, Xiao C, Zhang GY, Henter I, Rudorfer M, Vitiello B
Crit Rev Food Sci Nutr 2016 Nov 17;56(15):2560-2578. doi: 10.1080/10408398.2013.876960. PMID: 25365455Free PMC Article
Recognition and Differential Diagnosis of Psychosis in Primary Care.
Griswold KS, Del Regno PA, Berger RC
Am Fam Physician 2015 Jun 15;91(12):856-63. PMID: 26131945

Recent clinical studies

Etiology

Folic acid versus 5- methyl tetrahydrofolate supplementation in pregnancy.
Ferrazzi E, Tiso G, Di Martino D
Eur J Obstet Gynecol Reprod Biol 2020 Oct;253:312-319. Epub 2020 Jun 13 doi: 10.1016/j.ejogrb.2020.06.012. PMID: 32868164
Folic acid and primary prevention of neural tube defects: A review.
van Gool JD, Hirche H, Lax H, De Schaepdrijver L
Reprod Toxicol 2018 Sep;80:73-84. Epub 2018 May 16 doi: 10.1016/j.reprotox.2018.05.004. PMID: 29777755
Vitamin B(12) deficiency.
Green R, Allen LH, Bjørke-Monsen AL, Brito A, Guéant JL, Miller JW, Molloy AM, Nexo E, Stabler S, Toh BH, Ueland PM, Yajnik C
Nat Rev Dis Primers 2017 Jun 29;3:17040. doi: 10.1038/nrdp.2017.40. PMID: 28660890
Vitamin B12 in health and disease.
O'Leary F, Samman S
Nutrients 2010 Mar;2(3):299-316. Epub 2010 Mar 5 doi: 10.3390/nu2030299. PMID: 22254022Free PMC Article
Evaluation of macrocytosis.
Kaferle J, Strzoda CE
Am Fam Physician 2009 Feb 1;79(3):203-8. PMID: 19202968

Diagnosis

Vitamin B12 deficiency: case report and review of literature.
Hasbaoui BE, Mebrouk N, Saghir S, Yajouri AE, Abilkassem R, Agadr A
Pan Afr Med J 2021;38:237. Epub 2021 Mar 4 doi: 10.11604/pamj.2021.38.237.20967. PMID: 34046142Free PMC Article
Vitamin B(12) deficiency.
Green R, Allen LH, Bjørke-Monsen AL, Brito A, Guéant JL, Miller JW, Molloy AM, Nexo E, Stabler S, Toh BH, Ueland PM, Yajnik C
Nat Rev Dis Primers 2017 Jun 29;3:17040. doi: 10.1038/nrdp.2017.40. PMID: 28660890
Vitamin B12 deficiency - A 21st century perspective .
Shipton MJ, Thachil J
Clin Med (Lond) 2015 Apr;15(2):145-50. doi: 10.7861/clinmedicine.15-2-145. PMID: 25824066Free PMC Article
The pathophysiology of elevated vitamin B12 in clinical practice.
Andrès E, Serraj K, Zhu J, Vermorken AJ
QJM 2013 Jun;106(6):505-15. Epub 2013 Feb 27 doi: 10.1093/qjmed/hct051. PMID: 23447660
Evaluation of macrocytosis.
Kaferle J, Strzoda CE
Am Fam Physician 2009 Feb 1;79(3):203-8. PMID: 19202968

Therapy

Vitamin B12 deficiency: case report and review of literature.
Hasbaoui BE, Mebrouk N, Saghir S, Yajouri AE, Abilkassem R, Agadr A
Pan Afr Med J 2021;38:237. Epub 2021 Mar 4 doi: 10.11604/pamj.2021.38.237.20967. PMID: 34046142Free PMC Article
Folic acid and primary prevention of neural tube defects: A review.
van Gool JD, Hirche H, Lax H, De Schaepdrijver L
Reprod Toxicol 2018 Sep;80:73-84. Epub 2018 May 16 doi: 10.1016/j.reprotox.2018.05.004. PMID: 29777755
Vitamin B12 deficiency - A 21st century perspective .
Shipton MJ, Thachil J
Clin Med (Lond) 2015 Apr;15(2):145-50. doi: 10.7861/clinmedicine.15-2-145. PMID: 25824066Free PMC Article
Vitamins and type 2 diabetes mellitus.
Valdés-Ramos R, Guadarrama-López AL, Martínez-Carrillo BE, Benítez-Arciniega AD
Endocr Metab Immune Disord Drug Targets 2015;15(1):54-63. doi: 10.2174/1871530314666141111103217. PMID: 25388747Free PMC Article
Evaluation of macrocytosis.
Kaferle J, Strzoda CE
Am Fam Physician 2009 Feb 1;79(3):203-8. PMID: 19202968

Prognosis

Vitamin B12 deficiency: case report and review of literature.
Hasbaoui BE, Mebrouk N, Saghir S, Yajouri AE, Abilkassem R, Agadr A
Pan Afr Med J 2021;38:237. Epub 2021 Mar 4 doi: 10.11604/pamj.2021.38.237.20967. PMID: 34046142Free PMC Article
A rare mutation c.1663G > A (p.A555T) in the MMUT gene associated with mild clinical and biochemical phenotypes of methylmalonic acidemia in 30 Chinese patients.
Liang L, Shuai R, Yu Y, Qiu W, Shen L, Wu S, Wei H, Chen Y, Yang C, Xu P, Chen X, Zou H, Feng J, Niu T, Hu H, Ye J, Zhang H, Lu D, Gong Z, Zhan X, Ji W, Yu Y, Gu X, Han L
Orphanet J Rare Dis 2021 Jan 7;16(1):22. doi: 10.1186/s13023-020-01632-0. PMID: 33413471Free PMC Article
Recognition and Differential Diagnosis of Psychosis in Primary Care.
Griswold KS, Del Regno PA, Berger RC
Am Fam Physician 2015 Jun 15;91(12):856-63. PMID: 26131945
The pathophysiology of elevated vitamin B12 in clinical practice.
Andrès E, Serraj K, Zhu J, Vermorken AJ
QJM 2013 Jun;106(6):505-15. Epub 2013 Feb 27 doi: 10.1093/qjmed/hct051. PMID: 23447660
Evaluation of macrocytosis.
Kaferle J, Strzoda CE
Am Fam Physician 2009 Feb 1;79(3):203-8. PMID: 19202968

Clinical prediction guides

Clinical Pathobiochemistry of Vitamin B(12) Deficiency: Improving Our Understanding by Exploring Novel Mechanisms with a Focus on Diabetic Neuropathy.
Schleicher E, Didangelos T, Kotzakioulafi E, Cegan A, Peter A, Kantartzis K
Nutrients 2023 Jun 1;15(11) doi: 10.3390/nu15112597. PMID: 37299560Free PMC Article
Vitamin B12 deficiency and metabolism-mediated thrombotic microangiopathy (MM-TMA).
Sabry W, Elemary M, Burnouf T, Seghatchian J, Goubran H
Transfus Apher Sci 2020 Feb;59(1):102717. Epub 2019 Dec 31 doi: 10.1016/j.transci.2019.102717. PMID: 31902683
Water Soluble Vitamins and their Role in Diabetes and its Complications.
Deshmukh SV, Prabhakar B, Kulkarni YA
Curr Diabetes Rev 2020;16(7):649-656. doi: 10.2174/1573399815666190916114040. PMID: 31526351
Pearls: myelopathy.
Kumar N
Semin Neurol 2010 Feb;30(1):38-43. Epub 2010 Feb 1 doi: 10.1055/s-0029-1244993. PMID: 20127580
Evaluation of macrocytosis.
Kaferle J, Strzoda CE
Am Fam Physician 2009 Feb 1;79(3):203-8. PMID: 19202968

Recent systematic reviews

Association between abnormal maternal serum levels of vitamin B12 and preeclampsia: a systematic review and meta-analysis.
Mardali F, Fatahi S, Alinaghizadeh M, Kord Varkaneh H, Sohouli MH, Shidfar F, Găman MA
Nutr Rev 2021 Apr 7;79(5):518-528. doi: 10.1093/nutrit/nuaa096. PMID: 33001182
Vitamin B12 deficiency in inflammatory bowel disease: prevalence, risk factors, evaluation, and management.
Battat R, Kopylov U, Szilagyi A, Saxena A, Rosenblatt DS, Warner M, Bessissow T, Seidman E, Bitton A
Inflamm Bowel Dis 2014 Jun;20(6):1120-8. doi: 10.1097/MIB.0000000000000024. PMID: 24739632
Micronutrient deficiencies after bariatric surgery.
Shankar P, Boylan M, Sriram K
Nutrition 2010 Nov-Dec;26(11-12):1031-7. Epub 2010 Apr 3 doi: 10.1016/j.nut.2009.12.003. PMID: 20363593
Vitamin B12 insufficiency and the risk of fetal neural tube defects.
Ray JG, Blom HJ
QJM 2003 Apr;96(4):289-95. doi: 10.1093/qjmed/hcg043. PMID: 12651973
Blood folic acid and vitamin B12 in relation to neural tube defects.
Wald NJ, Hackshaw AD, Stone R, Sourial NA
Br J Obstet Gynaecol 1996 Apr;103(4):319-24. doi: 10.1111/j.1471-0528.1996.tb09735.x. PMID: 8605127

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