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Abnormal endometrium morphology

MedGen UID:
868228
•Concept ID:
C4022620
•
Anatomical Abnormality
Synonym: Abnormality of the endometrium
 
HPO: HP:0030126

Definition

An anomaly of the inner mucous membrane of the uterus. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal endometrium morphology

Professional guidelines

PubMed

Endometrial biopsy: Indications, techniques and recommendations. An evidence-based guideline for clinical practice.
Vitale SG, Buzzaccarini G, Riemma G, Pacheco LA, Di Spiezio Sardo A, Carugno J, Chiantera V, Török P, Noventa M, Haimovich S, De Franciscis P, Perez-Medina T, Angioni S, Laganà AS
J Gynecol Obstet Hum Reprod 2023 Jun;52(6):102588. Epub 2023 Apr 13 doi: 10.1016/j.jogoh.2023.102588. PMID: 37061093
Endometrial stromal tumors of the uterus: Epidemiology, pathological and biological features, treatment options and clinical outcomes.
Gadducci A, Multinu F, De Vitis LA, Cosio S, Carinelli S, Aletti GD
Gynecol Oncol 2023 Apr;171:95-105. Epub 2023 Feb 24 doi: 10.1016/j.ygyno.2023.02.009. PMID: 36842409
Management of pre-, peri-, and post-menopausal abnormal uterine bleeding: When to perform endometrial sampling?
Papakonstantinou E, Adonakis G
Int J Gynaecol Obstet 2022 Aug;158(2):252-259. Epub 2021 Oct 31 doi: 10.1002/ijgo.13988. PMID: 34669187

Recent clinical studies

Etiology

Endometrial polyps.
Berceanu C, Cernea N, Căpitănescu RG, Comănescu AC, Paitici Ş, Rotar IC, Bohîlţea RE, Olinca MV
Rom J Morphol Embryol 2022 Apr-Jun;63(2):323-334. doi: 10.47162/RJME.63.2.04. PMID: 36374138Free PMC Article
Management of pre-, peri-, and post-menopausal abnormal uterine bleeding: When to perform endometrial sampling?
Papakonstantinou E, Adonakis G
Int J Gynaecol Obstet 2022 Aug;158(2):252-259. Epub 2021 Oct 31 doi: 10.1002/ijgo.13988. PMID: 34669187
Risk Factors Associated with Endometrial Pathology in Premenopausal Breast Cancer Patients Treated with Tamoxifen.
Lee M, Piao J, Jeon MJ
Yonsei Med J 2020 Apr;61(4):317-322. doi: 10.3349/ymj.2020.61.4.317. PMID: 32233174Free PMC Article
Diagnosing adenomyosis: an integrated clinical and imaging approach.
Chapron C, Vannuccini S, Santulli P, Abrão MS, Carmona F, Fraser IS, Gordts S, Guo SW, Just PA, Noël JC, Pistofidis G, Van den Bosch T, Petraglia F
Hum Reprod Update 2020 Apr 15;26(3):392-411. doi: 10.1093/humupd/dmz049. PMID: 32097456
Pathogenesis of endometriosis: the genetic/epigenetic theory.
Koninckx PR, Ussia A, Adamyan L, Wattiez A, Gomel V, Martin DC
Fertil Steril 2019 Feb;111(2):327-340. Epub 2018 Dec 7 doi: 10.1016/j.fertnstert.2018.10.013. PMID: 30527836

Diagnosis

Contemporary evaluation of women and girls with abnormal uterine bleeding: FIGO Systems 1 and 2.
Jain V, Munro MG, Critchley HOD
Int J Gynaecol Obstet 2023 Aug;162 Suppl 2(Suppl 2):29-42. doi: 10.1002/ijgo.14946. PMID: 37538019Free PMC Article
Endometrial polyps.
Berceanu C, Cernea N, Căpitănescu RG, Comănescu AC, Paitici Ş, Rotar IC, Bohîlţea RE, Olinca MV
Rom J Morphol Embryol 2022 Apr-Jun;63(2):323-334. doi: 10.47162/RJME.63.2.04. PMID: 36374138Free PMC Article
Management of pre-, peri-, and post-menopausal abnormal uterine bleeding: When to perform endometrial sampling?
Papakonstantinou E, Adonakis G
Int J Gynaecol Obstet 2022 Aug;158(2):252-259. Epub 2021 Oct 31 doi: 10.1002/ijgo.13988. PMID: 34669187
Adenomyosis pathogenesis: insights from next-generation sequencing.
Bulun SE, Yildiz S, Adli M, Wei JJ
Hum Reprod Update 2021 Oct 18;27(6):1086-1097. doi: 10.1093/humupd/dmab017. PMID: 34131719Free PMC Article
Diagnosing adenomyosis: an integrated clinical and imaging approach.
Chapron C, Vannuccini S, Santulli P, Abrão MS, Carmona F, Fraser IS, Gordts S, Guo SW, Just PA, Noël JC, Pistofidis G, Van den Bosch T, Petraglia F
Hum Reprod Update 2020 Apr 15;26(3):392-411. doi: 10.1093/humupd/dmz049. PMID: 32097456

Therapy

Endometrial biopsy: Indications, techniques and recommendations. An evidence-based guideline for clinical practice.
Vitale SG, Buzzaccarini G, Riemma G, Pacheco LA, Di Spiezio Sardo A, Carugno J, Chiantera V, Török P, Noventa M, Haimovich S, De Franciscis P, Perez-Medina T, Angioni S, Laganà AS
J Gynecol Obstet Hum Reprod 2023 Jun;52(6):102588. Epub 2023 Apr 13 doi: 10.1016/j.jogoh.2023.102588. PMID: 37061093
Risk Factors Associated with Endometrial Pathology in Premenopausal Breast Cancer Patients Treated with Tamoxifen.
Lee M, Piao J, Jeon MJ
Yonsei Med J 2020 Apr;61(4):317-322. doi: 10.3349/ymj.2020.61.4.317. PMID: 32233174Free PMC Article
Scaffold-Free Endometrial Organoids Respond to Excess Androgens Associated With Polycystic Ovarian Syndrome.
Wiwatpanit T, Murphy AR, Lu Z, Urbanek M, Burdette JE, Woodruff TK, Kim JJ
J Clin Endocrinol Metab 2020 Mar 1;105(3):769-80. doi: 10.1210/clinem/dgz100. PMID: 31614364Free PMC Article
Surgery in adenomyosis.
Oliveira MAP, Crispi CP Jr, Brollo LC, Crispi CP, De Wilde RL
Arch Gynecol Obstet 2018 Mar;297(3):581-589. Epub 2017 Dec 2 doi: 10.1007/s00404-017-4603-6. PMID: 29197987
Defective endometrial receptivity.
Revel A
Fertil Steril 2012 May;97(5):1028-32. doi: 10.1016/j.fertnstert.2012.03.039. PMID: 22542142

Prognosis

Endometrial stromal tumors of the uterus: Epidemiology, pathological and biological features, treatment options and clinical outcomes.
Gadducci A, Multinu F, De Vitis LA, Cosio S, Carinelli S, Aletti GD
Gynecol Oncol 2023 Apr;171:95-105. Epub 2023 Feb 24 doi: 10.1016/j.ygyno.2023.02.009. PMID: 36842409
Clear cell carcinoma of the endometrium.
Bogani G, Ray-Coquard I, Concin N, Ngoi NYL, Morice P, Enomoto T, Takehara K, Denys H, Lorusso D, Coleman R, Vaughan MM, Takano M, Provencher D, Sagae S, Wimberger P, Póka R, Segev Y, Kim SI, Kim JW, Candido Dos Reis FJ, Mariani A, Leitao MM Jr, Makker V, Rustum NA, Vergote I, Zannoni GF, Tan DSP, McCormack M, Bini M, Lopez S, Raspagliesi F, Panici PB, di Donato V, Muzii L, Colombo N, Scambia G, Pignata S, Monk BJ
Gynecol Oncol 2022 Mar;164(3):658-666. Epub 2022 Jan 19 doi: 10.1016/j.ygyno.2022.01.012. PMID: 35063279
Endometrial carcinoma: molecular subtypes, precursors and the role of pathology in early diagnosis.
Huvila J, Pors J, Thompson EF, Gilks CB
J Pathol 2021 Apr;253(4):355-365. Epub 2021 Feb 6 doi: 10.1002/path.5608. PMID: 33368243
Endometrial Calcifications.
AbdullGaffar B, AlMulla A
Int J Surg Pathol 2020 Sep;28(6):590-599. Epub 2020 Mar 1 doi: 10.1177/1066896920909425. PMID: 32114859
Pathogenesis of endometriosis: the genetic/epigenetic theory.
Koninckx PR, Ussia A, Adamyan L, Wattiez A, Gomel V, Martin DC
Fertil Steril 2019 Feb;111(2):327-340. Epub 2018 Dec 7 doi: 10.1016/j.fertnstert.2018.10.013. PMID: 30527836

Clinical prediction guides

Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics.
Chen T, Xu Y, Xu X, Wang J, Qiu Z, Yu Y, Jiang X, Shao W, Bai D, Wang M, Mei S, Cheng T, Wu L, Gao S, Che X
Protein Cell 2024 Jul 1;15(7):530-546. doi: 10.1093/procel/pwae012. PMID: 38486356Free PMC Article
Adenomyosis pathogenesis: insights from next-generation sequencing.
Bulun SE, Yildiz S, Adli M, Wei JJ
Hum Reprod Update 2021 Oct 18;27(6):1086-1097. doi: 10.1093/humupd/dmab017. PMID: 34131719Free PMC Article
ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation.
Wilson MR, Reske JJ, Holladay J, Neupane S, Ngo J, Cuthrell N, Wegener M, Rhodes M, Adams M, Sheridan R, Hostetter G, Alotaibi FT, Yong PJ, Anglesio MS, Lessey BA, Leach RE, Teixeira JM, Missmer SA, Fazleabas AT, Chandler RL
Cell Rep 2020 Nov 10;33(6):108366. doi: 10.1016/j.celrep.2020.108366. PMID: 33176148Free PMC Article
Diagnosing adenomyosis: an integrated clinical and imaging approach.
Chapron C, Vannuccini S, Santulli P, Abrão MS, Carmona F, Fraser IS, Gordts S, Guo SW, Just PA, Noël JC, Pistofidis G, Van den Bosch T, Petraglia F
Hum Reprod Update 2020 Apr 15;26(3):392-411. doi: 10.1093/humupd/dmz049. PMID: 32097456
Pathogenesis of endometriosis: the genetic/epigenetic theory.
Koninckx PR, Ussia A, Adamyan L, Wattiez A, Gomel V, Martin DC
Fertil Steril 2019 Feb;111(2):327-340. Epub 2018 Dec 7 doi: 10.1016/j.fertnstert.2018.10.013. PMID: 30527836

Recent systematic reviews

Endometrial Angiogenesis of Abnormal Uterine Bleeding and Infertility in Patients with Uterine Fibroids-A Systematic Review.
Don EE, Middelkoop MA, Hehenkamp WJK, Mijatovic V, Griffioen AW, Huirne JAF
Int J Mol Sci 2023 Apr 10;24(8) doi: 10.3390/ijms24087011. PMID: 37108180Free PMC Article
Comparison of 3D ultrasound, 2D ultrasound and 3D Doppler in the diagnosis of endometrial carcinoma in patients with uterine bleeding: A systematic review and meta-analysis.
Xydias EM, Kalantzi S, Tsakos E, Ntanika A, Beis N, Prior M, Daponte A, Ziogas AC
Eur J Obstet Gynecol Reprod Biol 2022 Oct;277:42-52. Epub 2022 Aug 10 doi: 10.1016/j.ejogrb.2022.08.005. PMID: 35988462
Hysteroscopy for treating subfertility associated with suspected major uterine cavity abnormalities.
Bosteels J, van Wessel S, Weyers S, Broekmans FJ, D'Hooghe TM, Bongers MY, Mol BWJ
Cochrane Database Syst Rev 2018 Dec 5;12(12):CD009461. doi: 10.1002/14651858.CD009461.pub4. PMID: 30521679Free PMC Article
Current strategies in the diagnosis of endometrial cancer.
Tzur T, Kessous R, Weintraub AY
Arch Gynecol Obstet 2017 Jul;296(1):5-14. Epub 2017 May 15 doi: 10.1007/s00404-017-4391-z. PMID: 28508342
What is the influence of cyclooxygenase-2 on postmenopausal endometrial polyps?
Pereira AK, Garcia MT, Pinheiro W, Ejzenberg D, Soares JM Jr, Baracat EC
Climacteric 2015;18(4):498-502. Epub 2014 Nov 19 doi: 10.3109/13697137.2014.966240. PMID: 25242379

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