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Endometrial mixed adenocarcinoma

MedGen UID:
1670192
Concept ID:
C4745252
Neoplastic Process
Synonyms: endometrial mixed adenocarcinoma; Endometrial Mixed Carcinoma; Endometrial Mixed Cell Adenocarcinoma
 
Monarch Initiative: MONDO:0004321

Definition

An adenocarcinoma that arises from the endometrium and is characterized by the presence of both type I and type II endometrial adenocarcinoma components. The minor component constitutes at least 5% of the entire tumor. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Chu C, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Holmes J, Howitt BE, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian NR, Aggarwal S
J Natl Compr Canc Netw 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006. PMID: 36791750
Orellana TJ, Garrett AA, Soong TR, Rives T, Courtney-Brooks M, Taylor SE, Lesnock J, Berger J, Boisen M, Coffman L, Buckanovich R, Mahdi H, Comerci JC, Beriwal S, Sukumvanich P, Edwards RP, Bhargava R, Olawaiye AB
Gynecol Oncol 2023 Mar;170:77-83. Epub 2023 Jan 13 doi: 10.1016/j.ygyno.2022.12.024. PMID: 36641903Free PMC Article
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231

Recent clinical studies

Etiology

Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
J Gynecol Oncol 2023 Sep;34(5):e85. Epub 2023 Aug 8 doi: 10.3802/jgo.2023.34.e85. PMID: 37593813Free PMC Article
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
Int J Gynaecol Obstet 2023 Aug;162(2):383-394. Epub 2023 Jun 20 doi: 10.1002/ijgo.14923. PMID: 37337978
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Chu C, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Holmes J, Howitt BE, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian NR, Aggarwal S
J Natl Compr Canc Netw 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006. PMID: 36791750
Arciuolo D, Travaglino A, Raffone A, Raimondo D, Santoro A, Russo D, Varricchio S, Casadio P, Inzani F, Seracchioli R, Mollo A, Mascolo M, Zannoni GF
Int J Mol Sci 2022 Oct 2;23(19) doi: 10.3390/ijms231911684. PMID: 36232987Free PMC Article
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231

Diagnosis

Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Chu C, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Holmes J, Howitt BE, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian NR, Aggarwal S
J Natl Compr Canc Netw 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006. PMID: 36791750
Arciuolo D, Travaglino A, Raffone A, Raimondo D, Santoro A, Russo D, Varricchio S, Casadio P, Inzani F, Seracchioli R, Mollo A, Mascolo M, Zannoni GF
Int J Mol Sci 2022 Oct 2;23(19) doi: 10.3390/ijms231911684. PMID: 36232987Free PMC Article
Zhou L, Yao L, Dai L, Zhu H, Ye X, Wang S, Cheng H, Ma R, Liu H, Cui H, Chang X
J Ovarian Res 2021 May 4;14(1):63. doi: 10.1186/s13048-021-00804-1. PMID: 33941230Free PMC Article
Bartosch C, Manuel Lopes J, Oliva E
Adv Anat Pathol 2011 Nov;18(6):415-37. doi: 10.1097/PAP.0b013e318234ab18. PMID: 21993268

Therapy

Heinzelmann-Schwarz V, Kind AB, Vetter M, Russell K, Omar S, Schoetzau A, Hoeck K, Fink D, Friedlander ML, Hacker NF
J Cancer Res Clin Oncol 2020 Mar;146(3):695-704. Epub 2020 Jan 28 doi: 10.1007/s00432-019-03091-y. PMID: 31993743Free PMC Article
De Milliano I, Van Hattum D, Ket JCF, Huirne JAF, Hehenkamp WJK
Eur J Obstet Gynecol Reprod Biol 2017 Jul;214:56-64. Epub 2017 Apr 28 doi: 10.1016/j.ejogrb.2017.04.042. PMID: 28482329
Jang KS, Lee WM, Kim YJ, Cho SH
J Korean Med Sci 2012 Jan;27(1):89-92. Epub 2011 Dec 19 doi: 10.3346/jkms.2012.27.1.89. PMID: 22219620Free PMC Article
Cho JH, Hur M, Moon HW, Yun YM, Ko YS, Kim WS, Lee MH
Hum Pathol 2012 Apr;43(4):605-9. Epub 2011 Oct 28 doi: 10.1016/j.humpath.2011.07.010. PMID: 22036054
Silverberg SG
Clin Obstet Gynaecol 1984 Apr;11(1):189-208. PMID: 6370532

Prognosis

Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
J Gynecol Oncol 2023 Sep;34(5):e85. Epub 2023 Aug 8 doi: 10.3802/jgo.2023.34.e85. PMID: 37593813Free PMC Article
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
Int J Gynaecol Obstet 2023 Aug;162(2):383-394. Epub 2023 Jun 20 doi: 10.1002/ijgo.14923. PMID: 37337978
Arciuolo D, Travaglino A, Raffone A, Raimondo D, Santoro A, Russo D, Varricchio S, Casadio P, Inzani F, Seracchioli R, Mollo A, Mascolo M, Zannoni GF
Int J Mol Sci 2022 Oct 2;23(19) doi: 10.3390/ijms231911684. PMID: 36232987Free PMC Article
Thomakos N, Dimopoulou S, Sotiropoulou M, Machairiotis N, Pandraklakis A, Haidopoulos D, Liontos M, Bamias A, Rodolakis A
Horm Mol Biol Clin Investig 2020 Dec 18;42(1):105-111. doi: 10.1515/hmbci-2020-0042. PMID: 33781006
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231

Clinical prediction guides

Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Mirkovic J, Olkhov-Mitsel E, Amemiya Y, Al-Hussaini M, Nofech-Mozes S, Djordjevic B, Kupets R, Seth A, McCluggage WG
Histopathology 2023 Jun;82(7):978-990. Epub 2023 Mar 31 doi: 10.1111/his.14892. PMID: 36860193
Travaglino A, Raffone A, Gencarelli A, Raimondo D, Moretta P, Pignatiello S, Granata M, Seracchioli R, Zullo F, Insabato L
Pathol Res Pract 2021 Jan;217:153307. Epub 2020 Nov 30 doi: 10.1016/j.prp.2020.153307. PMID: 33316539
Kakimoto S, Miyamoto M, Einama T, Matsuura H, Iwahashi H, Ishibashi H, Sakamoto T, Hada T, Takano M
Pathol Oncol Res 2020 Oct;26(4):2299-2306. Epub 2020 May 28 doi: 10.1007/s12253-020-00823-1. PMID: 32468249
Lopez-Garcia MA, Palacios J
Semin Diagn Pathol 2010 Nov;27(4):274-86. doi: 10.1053/j.semdp.2010.09.005. PMID: 21309261

Recent systematic reviews

Travaglino A, Raffone A, Santoro A, Raimondo D, Angelico G, Valente M, Arciuolo D, Scaglione G, D'alessandris N, Casadio P, Inzani F, Mollo A, Seracchioli R, Zannoni GF
Gynecol Oncol 2021 Sep;162(3):804-808. Epub 2021 Jul 12 doi: 10.1016/j.ygyno.2021.07.007. PMID: 34266691
Marchocki Z, Cusimano MC, Clarfield L, Kim SR, Fazelzad R, Espin-Garcia O, Bouchard-Fortier G, Rossi EC, Stewart KI, Soliman PT, How JA, Gotlieb WH, Holloway RW, Ianieri MM, Cabrera S, Lim YK, Ferguson SE
Am J Obstet Gynecol 2021 Oct;225(4):367.e1-367.e39. Epub 2021 May 29 doi: 10.1016/j.ajog.2021.05.034. PMID: 34058168
De Milliano I, Van Hattum D, Ket JCF, Huirne JAF, Hehenkamp WJK
Eur J Obstet Gynecol Reprod Biol 2017 Jul;214:56-64. Epub 2017 Apr 28 doi: 10.1016/j.ejogrb.2017.04.042. PMID: 28482329

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