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Thyroid macrofollicular adenoma

MedGen UID:
868789
•Concept ID:
C4023194
•
Neoplastic Process
HPO: HP:0011775

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid macrofollicular adenoma

Professional guidelines

PubMed

New attempt of preoperative differential diagnosis of thyroid neoplasms by telomerase activity measurement.
Suzuki S, Fukushima T, Ami H, Onogi H, Nakamura I, Takenoshita S
Oncol Rep 2002 May-Jun;9(3):539-44. PMID: 11956624

Recent clinical studies

Etiology

Clinicopathological profile of papillary carcinoma of thyroid: A 10-year experience in a tertiary care institute in North Karnataka, India.
Rao R, Giriyan SS, Rangappa PK
Indian J Cancer 2017 Jul-Sep;54(3):514-518. doi: 10.4103/ijc.IJC_337_17. PMID: 29798949
The role of thyroid fine-needle aspiration cytology in the pediatric population: an institutional experience.
Rossi ED, Straccia P, Martini M, Revelli L, Lombardi CP, Pontecorvi A, Fadda G
Cancer Cytopathol 2014 May;122(5):359-67. Epub 2014 Jan 28 doi: 10.1002/cncy.21400. PMID: 24474727
Ultrasound-guided fine-needle aspiration biopsy of the thyroid.
Tambouret R, Szyfelbein WM, Pitman MB
Cancer 1999 Oct 25;87(5):299-305. doi: 10.1002/(sici)1097-0142(19991025)87:5<299::aid-cncr10>3.0.co;2-m. PMID: 10536356
MUC1 mucin gene, transcripts, and protein in adenomas and papillary carcinomas of the thyroid.
Bièche I, Ruffet E, Zweibaum A, Vildé F, Lidereau R, Franc B
Thyroid 1997 Oct;7(5):725-31. doi: 10.1089/thy.1997.7.725. PMID: 9349575
Efficacy of sonographically guided biopsy of thyroid masses and cervical lymph nodes.
Boland GW, Lee MJ, Mueller PR, Mayo-Smith W, Dawson SL, Simeone JF
AJR Am J Roentgenol 1993 Nov;161(5):1053-6. doi: 10.2214/ajr.161.5.8273609. PMID: 8273609

Diagnosis

Macrofollicular variant follicular thyroid tumors are DICER1 mutated and exhibit distinct histological features.
Juhlin CC, Stenman A, Zedenius J
Histopathology 2021 Oct;79(4):661-666. Epub 2021 Aug 3 doi: 10.1111/his.14416. PMID: 34008223
Preoperative diagnostic categories of fine needle aspiration cytology for histologically proven thyroid follicular adenoma and carcinoma, and Hurthle cell adenoma and carcinoma: Analysis of cause of under- or misdiagnoses.
Na HY, Moon JH, Choi JY, Yu HW, Jeong WJ, Kim YK, Choe JY, Park SY
PLoS One 2020;15(11):e0241597. Epub 2020 Nov 4 doi: 10.1371/journal.pone.0241597. PMID: 33147258Free PMC Article
Macrofollicular Variant of Follicular Thyroid Carcinoma: A Rare Underappreciated Pitfall in the Diagnosis of Thyroid Carcinoma.
Bongiovanni M, Sykiotis GP, La Rosa S, Bisig B, Trimech M, Missiaglia E, Gremaud M, Salvatori Chappuis V, De Vito C, Sciarra A, Foulkes WD, Pusztaszeri M
Thyroid 2020 Jan;30(1):72-80. Epub 2019 Dec 30 doi: 10.1089/thy.2018.0607. PMID: 31701808
The many faces and mimics of papillary thyroid carcinoma.
Albores-Saavedra J, Wu J
Endocr Pathol 2006 Spring;17(1):1-18. doi: 10.1385/ep:17:1:1. PMID: 16760576
Macrofollicular variant of papillary carcinoma of the thyroid: a histologic, cytologic, and immunohistochemical study of 3 cases and review of the literature.
Lugli A, Terracciano LM, Oberholzer M, Bubendorf L, Tornillo L
Arch Pathol Lab Med 2004 Jan;128(1):54-8. doi: 10.5858/2004-128-54-MVOPCO. PMID: 14692811

Therapy

Remarkable response to radioiodine therapy in a case of metastatic macrofollicular variant of papillary thyroid carcinoma.
Marques P, Leite V, Bugalho MJ
Clin Nucl Med 2014 Feb;39(2):219-21. doi: 10.1097/RLU.0000000000000322. PMID: 24368535
Ultrasound-guided fine-needle aspiration biopsy of the thyroid.
Tambouret R, Szyfelbein WM, Pitman MB
Cancer 1999 Oct 25;87(5):299-305. doi: 10.1002/(sici)1097-0142(19991025)87:5<299::aid-cncr10>3.0.co;2-m. PMID: 10536356
Thyroperoxidase immunodetection for the diagnosis of malignancy on fine-needle aspiration of thyroid nodules.
Henry JF, Denizot A, Porcelli A, Villafane M, Zoro P, Garcia S, De Micco C
World J Surg 1994 Jul-Aug;18(4):529-34. doi: 10.1007/BF00353756. PMID: 7725740

Prognosis

The role of thyroid fine-needle aspiration cytology in the pediatric population: an institutional experience.
Rossi ED, Straccia P, Martini M, Revelli L, Lombardi CP, Pontecorvi A, Fadda G
Cancer Cytopathol 2014 May;122(5):359-67. Epub 2014 Jan 28 doi: 10.1002/cncy.21400. PMID: 24474727
The many faces and mimics of papillary thyroid carcinoma.
Albores-Saavedra J, Wu J
Endocr Pathol 2006 Spring;17(1):1-18. doi: 10.1385/ep:17:1:1. PMID: 16760576
Macrofollicular variant of papillary carcinoma of the thyroid: a histologic, cytologic, and immunohistochemical study of 3 cases and review of the literature.
Lugli A, Terracciano LM, Oberholzer M, Bubendorf L, Tornillo L
Arch Pathol Lab Med 2004 Jan;128(1):54-8. doi: 10.5858/2004-128-54-MVOPCO. PMID: 14692811
Fine-needle aspiration of the macrofollicular and microfollicular subtypes of the follicular variant of papillary carcinoma of the thyroid.
Mesonero CE, Jugle JE, Wilbur DC, Nayar R
Cancer 1998 Aug 25;84(4):235-44. PMID: 9723599
MUC1 mucin gene, transcripts, and protein in adenomas and papillary carcinomas of the thyroid.
Bièche I, Ruffet E, Zweibaum A, Vildé F, Lidereau R, Franc B
Thyroid 1997 Oct;7(5):725-31. doi: 10.1089/thy.1997.7.725. PMID: 9349575

Clinical prediction guides

Macrofollicular variant follicular thyroid tumors are DICER1 mutated and exhibit distinct histological features.
Juhlin CC, Stenman A, Zedenius J
Histopathology 2021 Oct;79(4):661-666. Epub 2021 Aug 3 doi: 10.1111/his.14416. PMID: 34008223
Macrofollicular Variant of Follicular Thyroid Carcinoma: A Rare Underappreciated Pitfall in the Diagnosis of Thyroid Carcinoma.
Bongiovanni M, Sykiotis GP, La Rosa S, Bisig B, Trimech M, Missiaglia E, Gremaud M, Salvatori Chappuis V, De Vito C, Sciarra A, Foulkes WD, Pusztaszeri M
Thyroid 2020 Jan;30(1):72-80. Epub 2019 Dec 30 doi: 10.1089/thy.2018.0607. PMID: 31701808
Improving the diagnostic accuracy of thyroid follicular neoplasms: cytological features in fine-needle aspiration cytology.
Maruta J, Hashimoto H, Suehisa Y, Yamashita H, Noguchi S, Aratake Y, Ohno E, Kobayashi TK
Diagn Cytopathol 2011 Jan;39(1):28-34. doi: 10.1002/dc.21321. PMID: 20091899
Fine-needle aspiration of the macrofollicular and microfollicular subtypes of the follicular variant of papillary carcinoma of the thyroid.
Mesonero CE, Jugle JE, Wilbur DC, Nayar R
Cancer 1998 Aug 25;84(4):235-44. PMID: 9723599
MUC1 mucin gene, transcripts, and protein in adenomas and papillary carcinomas of the thyroid.
Bièche I, Ruffet E, Zweibaum A, Vildé F, Lidereau R, Franc B
Thyroid 1997 Oct;7(5):725-31. doi: 10.1089/thy.1997.7.725. PMID: 9349575

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