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Abnormal blood sodium concentration

MedGen UID:
869221
•Concept ID:
C4023644
•
Finding
Synonym: Abnormality of sodium homeostasis
 
HPO: HP:0010931

Definition

An abnormal concentration of sodium. [from HPO]

Conditions with this feature

Congenital secretory sodium diarrhea 8
MedGen UID:
1783137
•Concept ID:
C5441928
•
Disease or Syndrome
Any secretory diarrhea in which the cause of the disease is a mutation in the SLC9A3 gene.
See: Condition Record
Congenital secretory sodium diarrhea 8

Professional guidelines

PubMed

Clinical Management of Hyperkalemia.
Palmer BF, Carrero JJ, Clegg DJ, Colbert GB, Emmett M, Fishbane S, Hain DJ, Lerma E, Onuigbo M, Rastogi A, Roger SD, Spinowitz BS, Weir MR
Mayo Clin Proc 2021 Mar;96(3):744-762. Epub 2020 Nov 5 doi: 10.1016/j.mayocp.2020.06.014. PMID: 33160639
Diagnosis and Management of Disorders of Body Tonicity-Hyponatremia and Hypernatremia: Core Curriculum 2020.
Seay NW, Lehrich RW, Greenberg A
Am J Kidney Dis 2020 Feb;75(2):272-286. Epub 2019 Oct 10 doi: 10.1053/j.ajkd.2019.07.014. PMID: 31606238
▼Patiromer for the management of hyperkalaemia.
Drug Ther Bull 2018 Jan;56(1):6-9. doi: 10.1136/dtb.2018.1.0575. PMID: 29326277

Recent clinical studies

Therapy

Exercise and hyperuricemia: an opinion article.
Zhang T, Liu W, Gao S
Ann Med 2024 Dec;56(1):2396075. Epub 2024 Aug 26 doi: 10.1080/07853890.2024.2396075. PMID: 39183708Free PMC Article
Effect of Dialysate and Plasma Sodium on Mortality in a Global Historical Hemodialysis Cohort.
Pinter J, Smyth B, Stuard S, Jardine M, Wanner C, Rossignol P, Wheeler DC, Marshall MR, Canaud B, Genser B
J Am Soc Nephrol 2024 Feb 1;35(2):167-176. Epub 2023 Nov 15 doi: 10.1681/ASN.0000000000000262. PMID: 37967469Free PMC Article
Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults.
López-Briz E, Ruiz Garcia V, Cabello JB, Bort-Martí S, Carbonell Sanchis R
Cochrane Database Syst Rev 2022 Jul 18;7(7):CD008462. doi: 10.1002/14651858.CD008462.pub4. PMID: 35849083Free PMC Article
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Clinical Management of Hyperkalemia.
Palmer BF, Carrero JJ, Clegg DJ, Colbert GB, Emmett M, Fishbane S, Hain DJ, Lerma E, Onuigbo M, Rastogi A, Roger SD, Spinowitz BS, Weir MR
Mayo Clin Proc 2021 Mar;96(3):744-762. Epub 2020 Nov 5 doi: 10.1016/j.mayocp.2020.06.014. PMID: 33160639

Prognosis

Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Trimethylamine oxide: a potential target for heart failure therapy.
Lv S, Wang Y, Zhang W, Shang H
Heart 2022 May 25;108(12):917-922. doi: 10.1136/heartjnl-2021-320054. PMID: 34611047
Relationship and interaction between serum sodium concentration and portal hemodynamics in patients with cirrhosis.
Maruyama H, Kondo T, Kiyono S, Sekimoto T, Takahashi M, Okugawa H, Yokosuka O
J Gastroenterol Hepatol 2015 Nov;30(11):1635-42. doi: 10.1111/jgh.13006. PMID: 25968445
Vasopressin receptor antagonists.
Greenberg A, Verbalis JG
Kidney Int 2006 Jun;69(12):2124-30. Epub 2006 May 3 doi: 10.1038/sj.ki.5000432. PMID: 16672911
A prediction rule to identify low-risk patients with community-acquired pneumonia.
Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, Coley CM, Marrie TJ, Kapoor WN
N Engl J Med 1997 Jan 23;336(4):243-50. doi: 10.1056/NEJM199701233360402. PMID: 8995086

Clinical prediction guides

Effect of Dialysate and Plasma Sodium on Mortality in a Global Historical Hemodialysis Cohort.
Pinter J, Smyth B, Stuard S, Jardine M, Wanner C, Rossignol P, Wheeler DC, Marshall MR, Canaud B, Genser B
J Am Soc Nephrol 2024 Feb 1;35(2):167-176. Epub 2023 Nov 15 doi: 10.1681/ASN.0000000000000262. PMID: 37967469Free PMC Article
Stress Cardiac Biomarkers, Cardiovascular and Renal Outcomes, and Response to Canagliflozin.
Vaduganathan M, Sattar N, Xu J, Butler J, Mahaffey KW, Neal B, Shaw W, Rosenthal N, Pfeifer M, Hansen MK, Januzzi JL Jr
J Am Coll Cardiol 2022 Feb 8;79(5):432-444. doi: 10.1016/j.jacc.2021.11.027. PMID: 35115099Free PMC Article
Exercise-Associated Hyponatremia.
Hew-Butler T
Front Horm Res 2019;52:178-189. Epub 2019 Jan 15 doi: 10.1159/000493247. PMID: 32097926
Diabetes and branched-chain amino acids: What is the link?
Bloomgarden Z
J Diabetes 2018 May;10(5):350-352. Epub 2018 Feb 13 doi: 10.1111/1753-0407.12645. PMID: 29369529
A prediction rule to identify low-risk patients with community-acquired pneumonia.
Fine MJ, Auble TE, Yealy DM, Hanusa BH, Weissfeld LA, Singer DE, Coley CM, Marrie TJ, Kapoor WN
N Engl J Med 1997 Jan 23;336(4):243-50. doi: 10.1056/NEJM199701233360402. PMID: 8995086

Recent systematic reviews

Effect of SGLT2 Inhibitors on Improving Glucolipid Metabolism and Reproductive Hormone Status in Overweight/Obese Women with PCOS: A Systematic Review and Meta-Analysis.
Zhang L, Wang Z, Kong L, Liu H, Ma Z, Xu M, Yushanjiang S, Yuan D, Yu L
Reprod Sci 2024 May;31(5):1190-1203. Epub 2023 Dec 6 doi: 10.1007/s43032-023-01415-5. PMID: 38057530
Micronutrient status in children and adolescents with Down syndrome: systematic review and meta-analysis.
Barišić A, Ravančić ME, Majstorivić D, Vraneković J
J Intellect Disabil Res 2023 Aug;67(8):701-719. Epub 2023 May 22 doi: 10.1111/jir.13042. PMID: 37218392
Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults.
López-Briz E, Ruiz Garcia V, Cabello JB, Bort-Martí S, Carbonell Sanchis R
Cochrane Database Syst Rev 2022 Jul 18;7(7):CD008462. doi: 10.1002/14651858.CD008462.pub4. PMID: 35849083Free PMC Article
Development of diagnostic criteria and severity scale for polydipsia: A systematic literature review and well-experienced clinicians' consensus.
Sakuma M, Misawa F, Maeda M, Fujii Y, Uchida H, Mimura M, Takeuchi H
Psychiatry Res 2021 Mar;297:113708. Epub 2021 Jan 4 doi: 10.1016/j.psychres.2021.113708. PMID: 33461119
Interventions for chronic non-hypovolaemic hypotonic hyponatraemia.
Nagler EV, Haller MC, Van Biesen W, Vanholder R, Craig JC, Webster AC
Cochrane Database Syst Rev 2018 Jun 28;6(6):CD010965. doi: 10.1002/14651858.CD010965.pub2. PMID: 29953167Free PMC Article

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