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Abnormal metaphysis morphology

MedGen UID:: 871326
•Concept ID:: C4025814
•: Anatomical Abnormality

Synonym:	Abnormality of the metaphysis

HPO:	HP:0000944

Definition

An abnormality of one or more metaphysis, i.e., of the somewhat wider portion of a long bone that is adjacent to the epiphyseal growth plate and grows during childhood. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal metaphysis morphology

Phenotypic abnormality
- Abnormality of the musculoskeletal system
  - Abnormality of the skeletal system
    - Abnormal skeletal morphology
      - Abnormal appendicular skeleton morphology
        Abnormal long bone morphology
        Abnormal metaphysis morphology
        Abnormal metaphyseal trabeculation
        Absent primary metaphyseal spongiosa
        Abnormal metaphyseal vascular invasion
        Alternating radiolucent and radiodense metaphyseal lines
        Corner fracture of metaphysis
        Dense metaphyseal bands
        Dumbbell-shaped metaphyses
        Enlarged metaphyses
        Metaphyseal cupping
        Metaphyseal cupping of metacarpals
        Metaphyseal cupping of proximal phalanges
        Metaphyseal enchondromatosis
        Metaphyseal chondromatosis of femur
        Metaphyseal chondromatosis of humerus
        Metaphyseal chondromatosis of radius
        Metaphyseal chondromatosis of tibia
        Metaphyseal chondromatosis of ulna
        Metaphyseal irregularity
        Irregular, rachitic-like metaphyses
        Lower-limb metaphyseal irregularity
        Distal femoral metaphyseal irregularity
        Fibular metaphyseal irregularity
        Proximal femoral metaphyseal irregularity
        Tibial metaphyseal irregularity
        Metaphyseal rarefaction
        Metaphyseal sclerosis
        Metaphyseal dappling
        Streaky metaphyseal sclerosis
        Metaphyseal spurs
        Metaphyseal striations
        Growth arrest lines
        Osteopathia striata
        Metaphyseal widening
        Dumbbell-shaped long bone
        Dumbbell-shaped humerus
        Flared metaphysis
        Flared lower limb metaphysis
        Widened proximal tibial metaphyses

Recent clinical studies

Etiology

Does the Clinical Presentation of Secondary Osteosarcoma in Patients Who Survive Retinoblastoma Differ From That of Conventional Osteosarcoma and How Do We Detect Them?

Kim Y, Park JW, Cho HS, Jang WY, Han I, Kim HS
Clin Orthop Relat Res 2023 Nov 1;481(11):2154-2163. Epub 2023 May 5 doi: 10.1097/CORR.0000000000002667. PMID: 37145140 Free PMC Article

Imaging of Pediatric Growth Plate Disturbances.

Nguyen JC, Markhardt BK, Merrow AC, Dwek JR
Radiographics 2017 Oct;37(6):1791-1812. doi: 10.1148/rg.2017170029. PMID: 29019753

Shwachman-Diamond syndrome.

Dall'oca C, Bondi M, Merlini M, Cipolli M, Lavini F, Bartolozzi P
Musculoskelet Surg 2012 Aug;96(2):81-8. Epub 2011 Dec 27 doi: 10.1007/s12306-011-0174-z. PMID: 22201042

Longitudinal microvascularity in Achilles tendinopathy (power Doppler ultrasound, magnetic resonance imaging time-intensity curves and the Victorian Institute of Sport Assessment-Achilles questionnaire): a pilot study.

Richards PJ, McCall IW, Day C, Belcher J, Maffulli N
Skeletal Radiol 2010 Jun;39(6):509-21. Epub 2009 Aug 27 doi: 10.1007/s00256-009-0772-0. PMID: 19711073

The Erlenmeyer flask bone deformity in the skeletal dysplasias.

Faden MA, Krakow D, Ezgu F, Rimoin DL, Lachman RS
Am J Med Genet A 2009 Jun;149A(6):1334-45. doi: 10.1002/ajmg.a.32253. PMID: 19444897 Free PMC Article

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Diagnosis

Does the Clinical Presentation of Secondary Osteosarcoma in Patients Who Survive Retinoblastoma Differ From That of Conventional Osteosarcoma and How Do We Detect Them?

Kim Y, Park JW, Cho HS, Jang WY, Han I, Kim HS
Clin Orthop Relat Res 2023 Nov 1;481(11):2154-2163. Epub 2023 May 5 doi: 10.1097/CORR.0000000000002667. PMID: 37145140 Free PMC Article

Primary lymphoma of the tibia in children: Two case reports.

Suo H, Fu L, Wang Z, Liang H, Xu Z, Feng W
Medicine (Baltimore) 2020 Jan;99(4):e18807. doi: 10.1097/MD.0000000000018807. PMID: 31977874 Free PMC Article

Chronic recurrent multifocal osteomyelitis: typical patterns of bone involvement in whole-body bone scintigraphy.

Acikgoz G, Averill LW
Nucl Med Commun 2014 Aug;35(8):797-807. doi: 10.1097/MNM.0000000000000126. PMID: 24736329

Lesser metatarsalgia evaluation and treatment.

Jimenez AL, Martin DE, Phillips AJ
Clin Podiatr Med Surg 1990 Oct;7(4):597-618. PMID: 2253167

Infantile coxa vara.

Pavlov H, Goldman AB, Freiberger RH
Radiology 1980 Jun;135(3):631-40. doi: 10.1148/radiology.135.3.7384448. PMID: 7384448

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Therapy

Does the Capital Femoral Physis Bony MorphologyDiffer in Children with Symptomatic Cam-type Femoroacetabular Impingement.

Hosseinzadeh S, Novais EN, Emami A, Portilla G, Maranho DA, Kim YJ, Kiapour AM
Clin Orthop Relat Res 2021 May 1;479(5):922-931. doi: 10.1097/CORR.0000000000001602. PMID: 33337602 Free PMC Article

Siglec-15-targeting therapy protects against glucocorticoid-induced osteoporosis of growing skeleton in juvenile rats.

Sato D, Takahata M, Ota M, Fukuda C, Hasegawa T, Yamamoto T, Amizuka N, Tsuda E, Okada A, Hiruma Y, Fujita R, Iwasaki N
Bone 2020 Jun;135:115331. Epub 2020 Mar 23 doi: 10.1016/j.bone.2020.115331. PMID: 32217159

Primary lymphoma of the tibia in children: Two case reports.

Suo H, Fu L, Wang Z, Liang H, Xu Z, Feng W
Medicine (Baltimore) 2020 Jan;99(4):e18807. doi: 10.1097/MD.0000000000018807. PMID: 31977874 Free PMC Article

Shwachman-Diamond syndrome.

Dall'oca C, Bondi M, Merlini M, Cipolli M, Lavini F, Bartolozzi P
Musculoskelet Surg 2012 Aug;96(2):81-8. Epub 2011 Dec 27 doi: 10.1007/s12306-011-0174-z. PMID: 22201042

Richards PJ, McCall IW, Day C, Belcher J, Maffulli N
Skeletal Radiol 2010 Jun;39(6):509-21. Epub 2009 Aug 27 doi: 10.1007/s00256-009-0772-0. PMID: 19711073

See all (16)

Prognosis

Imaging Review of Normal and Abnormal Skeletal Maturation.

Augusto ACL, Goes PCK, Flores DV, Costa MAF, Takahashi MS, Rodrigues ACO, Padula LC, Gasparetto TD, Nogueira-Barbosa MH, Aihara AY
Radiographics 2022 May-Jun;42(3):861-879. Epub 2022 Feb 25 doi: 10.1148/rg.210088. PMID: 35213260

Does the Capital Femoral Physis Bony MorphologyDiffer in Children with Symptomatic Cam-type Femoroacetabular Impingement.

Hosseinzadeh S, Novais EN, Emami A, Portilla G, Maranho DA, Kim YJ, Kiapour AM
Clin Orthop Relat Res 2021 May 1;479(5):922-931. doi: 10.1097/CORR.0000000000001602. PMID: 33337602 Free PMC Article

Primary lymphoma of the tibia in children: Two case reports.

Suo H, Fu L, Wang Z, Liang H, Xu Z, Feng W
Medicine (Baltimore) 2020 Jan;99(4):e18807. doi: 10.1097/MD.0000000000018807. PMID: 31977874 Free PMC Article

Chronic recurrent multifocal osteomyelitis: typical patterns of bone involvement in whole-body bone scintigraphy.

Acikgoz G, Averill LW
Nucl Med Commun 2014 Aug;35(8):797-807. doi: 10.1097/MNM.0000000000000126. PMID: 24736329

Mobility in Hurler syndrome.

Taylor C, Brady P, O'Meara A, Moore D, Dowling F, Fogarty E
J Pediatr Orthop 2008 Mar;28(2):163-8. doi: 10.1097/BPO.0b013e3181649e25. PMID: 18388709

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Clinical prediction guides

Does the Clinical Presentation of Secondary Osteosarcoma in Patients Who Survive Retinoblastoma Differ From That of Conventional Osteosarcoma and How Do We Detect Them?

Kim Y, Park JW, Cho HS, Jang WY, Han I, Kim HS
Clin Orthop Relat Res 2023 Nov 1;481(11):2154-2163. Epub 2023 May 5 doi: 10.1097/CORR.0000000000002667. PMID: 37145140 Free PMC Article

Imaging Review of Normal and Abnormal Skeletal Maturation.

Morphogenesis of the femur at different stages of normal human development.

Suzuki Y, Matsubayashi J, Ji X, Yamada S, Yoneyama A, Imai H, Matsuda T, Aoyama T, Takakuwa T
PLoS One 2019;14(8):e0221569. Epub 2019 Aug 23 doi: 10.1371/journal.pone.0221569. PMID: 31442281 Free PMC Article

Mobility in Hurler syndrome.

Taylor C, Brady P, O'Meara A, Moore D, Dowling F, Fogarty E
J Pediatr Orthop 2008 Mar;28(2):163-8. doi: 10.1097/BPO.0b013e3181649e25. PMID: 18388709

Coxa magna.

Powers JA, Bach PJ
South Med J 1977 Nov;70(11):1297-9. doi: 10.1097/00007611-197711000-00014. PMID: 918696

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Abnormal metaphysis morphology

Definition

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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