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Carcinoma ex pleomorphic adenoma

MedGen UID:
87486
•Concept ID:
C0344460
•
Neoplastic Process
Synonyms: Carcinoma ex Pleomorphic Adenoma; carcinoma ex pleomorphic adenoma; carcinoma ex pleomorphic adenoma (morphologic abnormality); Carcinoma in pleomorphic adenoma; Carcinoma in Pleomorphic Adenoma; carcinoma in pleomorphic adenoma
SNOMED CT: Carcinoma in pleomorphic adenoma (17264009); Carcinoma ex pleomorphic adenoma (17264009)
 
Monarch Initiative: MONDO:0002472

Definition

A carcinoma arising in a pre-existing pleomorphic adenoma. It most often occurs in the parotid gland and less often in the submandibular gland and minor salivary gland. Patients usually present with a history of a long-standing mass which recently had undergone rapid growth. The prognosis depends on the invasiveness of the malignant component. Patients with non-invasive or minimally invasive tumors usually have a good prognosis following surgical resection. Invasive tumors are usually aggressive and are associated with recurrences and metastases. [from NCI]

Professional guidelines

PubMed

Selinexor for the treatment of recurrent or metastatic salivary gland tumors: Results from the GEMS-001 clinical trial.
Hernando-Calvo A, Malone E, Day D, Prawira A, Weinreb I, Yang SYC, Wong H, Rodriguez A, Jennings S, Eliason A, Wang L, Spreafico A, Siu LL, Hansen AR
Cancer Med 2023 Oct;12(20):20299-20310. Epub 2023 Oct 11 doi: 10.1002/cam4.6589. PMID: 37818869Free PMC Article
Management of malignant submandibular gland tumors: A 30-year experience from a single center.
Luksic I, Mamic M, Suton P
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Sep;134(3):302-309. Epub 2022 Feb 4 doi: 10.1016/j.oooo.2022.01.023. PMID: 35428601
Clinical outcomes of bulky parotid gland cancers: need for self-examination and screening program for early diagnosis of parotid tumors.
Choi SY, Lee E, Kim E, Chung MK, Son YI, Baek CH, Jeong HS
BMC Cancer 2021 Feb 18;21(1):178. doi: 10.1186/s12885-021-07902-9. PMID: 33602169Free PMC Article

Recent clinical studies

Etiology

Molecular Factors in Carcinoma Ex Pleomorphic Adenoma: Systematic Review and Meta-Analysis.
Key S, Chia C, Hasan Z, Sundaresan P, Riffat F, Dwivedi RC
Laryngoscope 2024 Mar;134(3):1042-1053. Epub 2023 Aug 23 doi: 10.1002/lary.30993. PMID: 37610148
Carcinoma Ex Pleomorphic Adenomas: An Institutional Experience and Literature Review.
Tondi-Resta I, Hobday SB, Gubbiotti MA, Jalaly JB, Rassekh CH, Montone KT, Baloch ZW
Am J Clin Pathol 2023 May 2;159(5):502-515. doi: 10.1093/ajcp/aqac181. PMID: 36921078
Systematic review of prognostic factors in carcinoma ex pleomorphic adenoma.
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Carcinoma ex pleomorphic adenoma of major salivary glands: CT and MR imaging findings.
Wang C, Yu Q, Li S, Sun J, Zhu L, Wang P
Dentomaxillofac Radiol 2021 Oct 1;50(7):20200485. Epub 2021 Jun 23 doi: 10.1259/dmfr.20200485. PMID: 34161740Free PMC Article
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400

Diagnosis

Carcinoma ex pleomorphic adenoma of the parotid gland.
Park KS, Kim JH, Lee DH, Lee JK, Lim SC
Am J Otolaryngol 2022 Mar-Apr;43(2):103389. Epub 2022 Feb 3 doi: 10.1016/j.amjoto.2022.103389. PMID: 35149345
Myoepithelial Carcinoma.
Xu B, Katabi N
Surg Pathol Clin 2021 Mar;14(1):67-73. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.008. PMID: 33526224Free PMC Article
Carcinoma Ex-Pleomorphic Adenoma Diagnosis During Global Health Engagement Operations.
Haltiner CC, Betz S, Smith J, Nelson B, Ambrosio AA
Mil Med 2021 Jan 25;186(Suppl 1):828-832. doi: 10.1093/milmed/usaa448. PMID: 33499534
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Pleomorphic adenoma: the great mimicker of malignancy.
Hernandez-Prera JC, Skálová A, Franchi A, Rinaldo A, Vander Poorten V, Zbären P, Ferlito A, Wenig BM
Histopathology 2021 Sep;79(3):279-290. Epub 2021 Apr 22 doi: 10.1111/his.14322. PMID: 33368685

Therapy

Selinexor for the treatment of recurrent or metastatic salivary gland tumors: Results from the GEMS-001 clinical trial.
Hernando-Calvo A, Malone E, Day D, Prawira A, Weinreb I, Yang SYC, Wong H, Rodriguez A, Jennings S, Eliason A, Wang L, Spreafico A, Siu LL, Hansen AR
Cancer Med 2023 Oct;12(20):20299-20310. Epub 2023 Oct 11 doi: 10.1002/cam4.6589. PMID: 37818869Free PMC Article
Mixed response and mechanisms of resistance to larotrectinib in metastatic carcinoma ex pleomorphic adenoma of the parotid harboring an NTRK2 fusion: A case report.
Pircher M, Briner HR, Bonomo M, Horcic M, Petrausch U, Helbling D, Winder T
Medicine (Baltimore) 2021 Jan 29;100(4):e24463. doi: 10.1097/MD.0000000000024463. PMID: 33530256Free PMC Article
RANK and RANK Ligand Expression in Parotid Gland Carcinomas.
Franchi A, Taverna C, Simoni A, Pepi M, Mannelli G, Fasolati M, Gallo O
Appl Immunohistochem Mol Morphol 2018 Aug;26(7):478-482. doi: 10.1097/PAI.0000000000000465. PMID: 29494398
Small cell carcinoma ex-pleomorphic adenoma of the parotid gland.
Cimino-Mathews A, Lin BM, Chang SS, Boahene KD, Bishop JA
Head Neck Pathol 2012 Dec;6(4):502-6. Epub 2012 Jun 27 doi: 10.1007/s12105-012-0376-1. PMID: 22736150Free PMC Article
Sustained response of carcinoma ex pleomorphic adenoma treated with trastuzumab and capecitabine.
Sharon E, Kelly RJ, Szabo E
Head Neck Oncol 2010 May 26;2:12. doi: 10.1186/1758-3284-2-12. PMID: 20504363Free PMC Article

Prognosis

Molecular Factors in Carcinoma Ex Pleomorphic Adenoma: Systematic Review and Meta-Analysis.
Key S, Chia C, Hasan Z, Sundaresan P, Riffat F, Dwivedi RC
Laryngoscope 2024 Mar;134(3):1042-1053. Epub 2023 Aug 23 doi: 10.1002/lary.30993. PMID: 37610148
Systematic review of prognostic factors in carcinoma ex pleomorphic adenoma.
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Myoepithelial Carcinoma.
Xu B, Katabi N
Surg Pathol Clin 2021 Mar;14(1):67-73. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.008. PMID: 33526224Free PMC Article
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Carcinoma ex pleomorphic adenoma: a comprehensive review of clinical, pathological and molecular data.
Antony J, Gopalan V, Smith RA, Lam AK
Head Neck Pathol 2012 Mar;6(1):1-9. Epub 2011 Jul 9 doi: 10.1007/s12105-011-0281-z. PMID: 21744105Free PMC Article

Clinical prediction guides

Molecular Factors in Carcinoma Ex Pleomorphic Adenoma: Systematic Review and Meta-Analysis.
Key S, Chia C, Hasan Z, Sundaresan P, Riffat F, Dwivedi RC
Laryngoscope 2024 Mar;134(3):1042-1053. Epub 2023 Aug 23 doi: 10.1002/lary.30993. PMID: 37610148
Metabolic alterations in carcinoma ex pleomorphic adenoma development of lacrimal glands.
de Lima-Souza RA, Rodrigues NM, Scarini JF, Silva MFS, Tincani AJ, Egal ESA, Altemani A, Mariano FV
Int Ophthalmol 2022 Apr;42(4):1101-1109. Epub 2021 Nov 10 doi: 10.1007/s10792-021-02096-2. PMID: 34757565
Carcinoma ex pleomorphic adenoma of major salivary glands: CT and MR imaging findings.
Wang C, Yu Q, Li S, Sun J, Zhu L, Wang P
Dentomaxillofac Radiol 2021 Oct 1;50(7):20200485. Epub 2021 Jun 23 doi: 10.1259/dmfr.20200485. PMID: 34161740Free PMC Article
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Carcinoma ex pleomorphic adenoma: A review of incidence, demographics, risk factors, and survival.
Gupta A, Koochakzadeh S, Neskey DM, Nguyen SA, Lentsch EJ
Am J Otolaryngol 2019 Nov-Dec;40(6):102279. Epub 2019 Aug 21 doi: 10.1016/j.amjoto.2019.102279. PMID: 31471126

Recent systematic reviews

Molecular Factors in Carcinoma Ex Pleomorphic Adenoma: Systematic Review and Meta-Analysis.
Key S, Chia C, Hasan Z, Sundaresan P, Riffat F, Dwivedi RC
Laryngoscope 2024 Mar;134(3):1042-1053. Epub 2023 Aug 23 doi: 10.1002/lary.30993. PMID: 37610148
Systematic review of prognostic factors in carcinoma ex pleomorphic adenoma.
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Evaluation of HER2/neu expression in different types of salivary gland tumors: a systematic review and meta-analysis.
Javaheripour A, Saatloo MV, Vahed N, Gavgani LF, Kouhsoltani M
J Med Life 2022 May;15(5):595-600. doi: 10.25122/jml-2021-0394. PMID: 35815077Free PMC Article
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Extracapsular invasion: A potential prognostic marker for Carcinoma ex-pleomorphic adenoma of the salivary glands? A Systematic Review.
de Morais EF, Pinheiro JC, Sena DAC, Galvão HC, de Souza LB, de Almeida Freitas R
J Oral Pathol Med 2019 Jul;48(6):433-440. Epub 2019 Feb 28 doi: 10.1111/jop.12841. PMID: 30756461

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