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Carcinoma ex pleomorphic adenoma

MedGen UID:
87486
Concept ID:
C0344460
Neoplastic Process
Synonyms: Carcinoma ex Pleomorphic Adenoma; carcinoma ex pleomorphic adenoma; carcinoma ex pleomorphic adenoma (morphologic abnormality); Carcinoma in pleomorphic adenoma; Carcinoma in Pleomorphic Adenoma; carcinoma in pleomorphic adenoma
SNOMED CT: Carcinoma in pleomorphic adenoma (17264009); Carcinoma ex pleomorphic adenoma (17264009)
 
Monarch Initiative: MONDO:0002472

Definition

A carcinoma arising in a pre-existing pleomorphic adenoma. It most often occurs in the parotid gland and less often in the submandibular gland and minor salivary gland. Patients usually present with a history of a long-standing mass which recently had undergone rapid growth. The prognosis depends on the invasiveness of the malignant component. Patients with non-invasive or minimally invasive tumors usually have a good prognosis following surgical resection. Invasive tumors are usually aggressive and are associated with recurrences and metastases. [from NCI]

Professional guidelines

PubMed

Hernando-Calvo A, Malone E, Day D, Prawira A, Weinreb I, Yang SYC, Wong H, Rodriguez A, Jennings S, Eliason A, Wang L, Spreafico A, Siu LL, Hansen AR
Cancer Med 2023 Oct;12(20):20299-20310. Epub 2023 Oct 11 doi: 10.1002/cam4.6589. PMID: 37818869Free PMC Article
Luksic I, Mamic M, Suton P
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Sep;134(3):302-309. Epub 2022 Feb 4 doi: 10.1016/j.oooo.2022.01.023. PMID: 35428601
Choi SY, Lee E, Kim E, Chung MK, Son YI, Baek CH, Jeong HS
BMC Cancer 2021 Feb 18;21(1):178. doi: 10.1186/s12885-021-07902-9. PMID: 33602169Free PMC Article

Recent clinical studies

Etiology

Key S, Chia C, Hasan Z, Sundaresan P, Riffat F, Dwivedi RC
Laryngoscope 2024 Mar;134(3):1042-1053. Epub 2023 Aug 23 doi: 10.1002/lary.30993. PMID: 37610148
Levyn H, Subramanian T, Eagan A, Katabi N, Lin O, Badillo ND, Martinez G, Scholfield DW, Wong RJ, Shah JP, Givi B, Morris LGT, Ganly I, Patel SG
JAMA Otolaryngol Head Neck Surg 2023 Nov 1;149(11):1034-1041. doi: 10.1001/jamaoto.2023.3212. PMID: 37824134Free PMC Article
Tondi-Resta I, Hobday SB, Gubbiotti MA, Jalaly JB, Rassekh CH, Montone KT, Baloch ZW
Am J Clin Pathol 2023 May 2;159(5):502-515. doi: 10.1093/ajcp/aqac181. PMID: 36921078
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400

Diagnosis

Tondi-Resta I, Hobday SB, Gubbiotti MA, Jalaly JB, Rassekh CH, Montone KT, Baloch ZW
Am J Clin Pathol 2023 May 2;159(5):502-515. doi: 10.1093/ajcp/aqac181. PMID: 36921078
Xu B, Katabi N
Surg Pathol Clin 2021 Mar;14(1):67-73. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.008. PMID: 33526224Free PMC Article
Haltiner CC, Betz S, Smith J, Nelson B, Ambrosio AA
Mil Med 2021 Jan 25;186(Suppl 1):828-832. doi: 10.1093/milmed/usaa448. PMID: 33499534
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Hernandez-Prera JC, Skálová A, Franchi A, Rinaldo A, Vander Poorten V, Zbären P, Ferlito A, Wenig BM
Histopathology 2021 Sep;79(3):279-290. Epub 2021 Apr 22 doi: 10.1111/his.14322. PMID: 33368685

Therapy

Hernando-Calvo A, Malone E, Day D, Prawira A, Weinreb I, Yang SYC, Wong H, Rodriguez A, Jennings S, Eliason A, Wang L, Spreafico A, Siu LL, Hansen AR
Cancer Med 2023 Oct;12(20):20299-20310. Epub 2023 Oct 11 doi: 10.1002/cam4.6589. PMID: 37818869Free PMC Article
Pircher M, Briner HR, Bonomo M, Horcic M, Petrausch U, Helbling D, Winder T
Medicine (Baltimore) 2021 Jan 29;100(4):e24463. doi: 10.1097/MD.0000000000024463. PMID: 33530256Free PMC Article
Franchi A, Taverna C, Simoni A, Pepi M, Mannelli G, Fasolati M, Gallo O
Appl Immunohistochem Mol Morphol 2018 Aug;26(7):478-482. doi: 10.1097/PAI.0000000000000465. PMID: 29494398
Cimino-Mathews A, Lin BM, Chang SS, Boahene KD, Bishop JA
Head Neck Pathol 2012 Dec;6(4):502-6. Epub 2012 Jun 27 doi: 10.1007/s12105-012-0376-1. PMID: 22736150Free PMC Article
Sharon E, Kelly RJ, Szabo E
Head Neck Oncol 2010 May 26;2:12. doi: 10.1186/1758-3284-2-12. PMID: 20504363Free PMC Article

Prognosis

Key S, Chia C, Hasan Z, Sundaresan P, Riffat F, Dwivedi RC
Laryngoscope 2024 Mar;134(3):1042-1053. Epub 2023 Aug 23 doi: 10.1002/lary.30993. PMID: 37610148
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Xu B, Katabi N
Surg Pathol Clin 2021 Mar;14(1):67-73. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.008. PMID: 33526224Free PMC Article
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Antony J, Gopalan V, Smith RA, Lam AK
Head Neck Pathol 2012 Mar;6(1):1-9. Epub 2011 Jul 9 doi: 10.1007/s12105-011-0281-z. PMID: 21744105Free PMC Article

Clinical prediction guides

Key S, Chia C, Hasan Z, Sundaresan P, Riffat F, Dwivedi RC
Laryngoscope 2024 Mar;134(3):1042-1053. Epub 2023 Aug 23 doi: 10.1002/lary.30993. PMID: 37610148
Levyn H, Subramanian T, Eagan A, Katabi N, Lin O, Badillo ND, Martinez G, Scholfield DW, Wong RJ, Shah JP, Givi B, Morris LGT, Ganly I, Patel SG
JAMA Otolaryngol Head Neck Surg 2023 Nov 1;149(11):1034-1041. doi: 10.1001/jamaoto.2023.3212. PMID: 37824134Free PMC Article
Liu S, Lu H, Liu L, Wu Y, Zhu Y, Xu W, Yang W, Zhang C
Oral Dis 2023 May;29(4):1602-1612. Epub 2022 Mar 7 doi: 10.1111/odi.14168. PMID: 35199423
de Lima-Souza RA, Rodrigues NM, Scarini JF, Silva MFS, Tincani AJ, Egal ESA, Altemani A, Mariano FV
Int Ophthalmol 2022 Apr;42(4):1101-1109. Epub 2021 Nov 10 doi: 10.1007/s10792-021-02096-2. PMID: 34757565
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400

Recent systematic reviews

Key S, Chia C, Hasan Z, Sundaresan P, Riffat F, Dwivedi RC
Laryngoscope 2024 Mar;134(3):1042-1053. Epub 2023 Aug 23 doi: 10.1002/lary.30993. PMID: 37610148
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Javaheripour A, Saatloo MV, Vahed N, Gavgani LF, Kouhsoltani M
J Med Life 2022 May;15(5):595-600. doi: 10.25122/jml-2021-0394. PMID: 35815077Free PMC Article
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
de Morais EF, Pinheiro JC, Sena DAC, Galvão HC, de Souza LB, de Almeida Freitas R
J Oral Pathol Med 2019 Jul;48(6):433-440. Epub 2019 Feb 28 doi: 10.1111/jop.12841. PMID: 30756461

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