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Metastatic Malignant Neoplasm in the Testis

MedGen UID:
87567
•Concept ID:
C0347003
•
Neoplastic Process
Synonyms: Metastasis to testis; Metastatic malignant neoplasm of testis; Metastatic malignant neoplasm to testis; Metastatic Malignant Neoplasm to the Testis; Metastatic Neoplasm to the Testis; Metastatic tumor to testis; Metastatic Tumor to the Testis; Secondary malignant neoplasm of testis
SNOMED CT: Metastatic tumor to testis (94623007); Metastasis to testis (94623007); Secondary malignant neoplasm of testis (94623007); Metastatic malignant neoplasm to testis (94623007); Metastatic malignant neoplasm of testis (94623007)

Definition

A malignant neoplasm that has spread to the testis from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Testis

Professional guidelines

PubMed

Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Testicular Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Gilligan T, Lin DW, Aggarwal R, Chism D, Cost N, Derweesh IH, Emamekhoo H, Feldman DR, Geynisman DM, Hancock SL, LaGrange C, Levine EG, Longo T, Lowrance W, McGregor B, Monk P, Picus J, Pierorazio P, Rais-Bahrami S, Saylor P, Sircar K, Smith DC, Tzou K, Vaena D, Vaughn D, Yamoah K, Yamzon J, Johnson-Chilla A, Keller J, Pluchino LA
J Natl Compr Canc Netw 2019 Dec;17(12):1529-1554. doi: 10.6004/jnccn.2019.0058. PMID: 31805523
Testicular Cancer: Diagnosis and Treatment.
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528

Recent clinical studies

Etiology

European Association of Urology Guidelines on Testicular Cancer: 2023 Update.
Patrikidou A, Cazzaniga W, Berney D, Boormans J, de Angst I, Di Nardo D, Fankhauser C, Fischer S, Gravina C, Gremmels H, Heidenreich A, Janisch F, Leão R, Nicolai N, Oing C, Oldenburg J, Shepherd R, Tandstad T, Nicol D
Eur Urol 2023 Sep;84(3):289-301. Epub 2023 May 12 doi: 10.1016/j.eururo.2023.04.010. PMID: 37183161
The 2022 revision of the World Health Organization classification of tumors of the urinary system and male genital organs: advances and challenges.
Mohanty SK, Lobo A, Cheng L
Hum Pathol 2023 Jun;136:123-143. Epub 2022 Sep 6 doi: 10.1016/j.humpath.2022.08.006. PMID: 36084769
Testicular Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Gilligan T, Lin DW, Aggarwal R, Chism D, Cost N, Derweesh IH, Emamekhoo H, Feldman DR, Geynisman DM, Hancock SL, LaGrange C, Levine EG, Longo T, Lowrance W, McGregor B, Monk P, Picus J, Pierorazio P, Rais-Bahrami S, Saylor P, Sircar K, Smith DC, Tzou K, Vaena D, Vaughn D, Yamoah K, Yamzon J, Johnson-Chilla A, Keller J, Pluchino LA
J Natl Compr Canc Netw 2019 Dec;17(12):1529-1554. doi: 10.6004/jnccn.2019.0058. PMID: 31805523
Testicular Cancer: Diagnosis and Treatment.
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528
Testicular cancer update.
Adra N, Einhorn LH
Clin Adv Hematol Oncol 2017 May;15(5):386-396. PMID: 28591093

Diagnosis

Testicular Tumors.
Krege S, Oing C, Bokemeyer C
Dtsch Arztebl Int 2023 Dec 8;120(49):843-854. doi: 10.3238/arztebl.m2023.0143. PMID: 37378600Free PMC Article
PRAME Expression in Cancer. A Systematic Immunohistochemical Study of >5800 Epithelial and Nonepithelial Tumors.
Kaczorowski M, Chłopek M, Kruczak A, Ryś J, Lasota J, Miettinen M
Am J Surg Pathol 2022 Nov 1;46(11):1467-1476. Epub 2022 Aug 16 doi: 10.1097/PAS.0000000000001944. PMID: 35973038Free PMC Article
Testicular Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Gilligan T, Lin DW, Aggarwal R, Chism D, Cost N, Derweesh IH, Emamekhoo H, Feldman DR, Geynisman DM, Hancock SL, LaGrange C, Levine EG, Longo T, Lowrance W, McGregor B, Monk P, Picus J, Pierorazio P, Rais-Bahrami S, Saylor P, Sircar K, Smith DC, Tzou K, Vaena D, Vaughn D, Yamoah K, Yamzon J, Johnson-Chilla A, Keller J, Pluchino LA
J Natl Compr Canc Netw 2019 Dec;17(12):1529-1554. doi: 10.6004/jnccn.2019.0058. PMID: 31805523
Testicular Cancer: Diagnosis and Treatment.
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528
Male hypogonadism.
Basaria S
Lancet 2014 Apr 5;383(9924):1250-63. Epub 2013 Oct 10 doi: 10.1016/S0140-6736(13)61126-5. PMID: 24119423

Therapy

Management of testicular germ cell tumors.
Wee CE, Gilligan TD
Clin Adv Hematol Oncol 2023 Apr;21(4):179-188. PMID: 37039725
mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer.
Cafri G, Gartner JJ, Zaks T, Hopson K, Levin N, Paria BC, Parkhurst MR, Yossef R, Lowery FJ, Jafferji MS, Prickett TD, Goff SL, McGowan CT, Seitter S, Shindorf ML, Parikh A, Chatani PD, Robbins PF, Rosenberg SA
J Clin Invest 2020 Nov 2;130(11):5976-5988. doi: 10.1172/JCI134915. PMID: 33016924Free PMC Article
Glyoxalases in Urological Malignancies.
Antognelli C, Talesa VN
Int J Mol Sci 2018 Jan 31;19(2) doi: 10.3390/ijms19020415. PMID: 29385039Free PMC Article
Male hypogonadism.
Basaria S
Lancet 2014 Apr 5;383(9924):1250-63. Epub 2013 Oct 10 doi: 10.1016/S0140-6736(13)61126-5. PMID: 24119423
Combination of paclitaxel, ifosfamide, and cisplatin is an effective second-line therapy for patients with relapsed testicular germ cell tumors.
Kondagunta GV, Bacik J, Donadio A, Bajorin D, Marion S, Sheinfeld J, Bosl GJ, Motzer RJ
J Clin Oncol 2005 Sep 20;23(27):6549-55. doi: 10.1200/JCO.2005.19.638. PMID: 16170162

Prognosis

Epidemiology of liver metastases.
Horn SR, Stoltzfus KC, Lehrer EJ, Dawson LA, Tchelebi L, Gusani NJ, Sharma NK, Chen H, Trifiletti DM, Zaorsky NG
Cancer Epidemiol 2020 Aug;67:101760. Epub 2020 Jun 17 doi: 10.1016/j.canep.2020.101760. PMID: 32562887
Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Neoplastic metastases to the endocrine glands.
Angelousi A, Alexandraki KI, Kyriakopoulos G, Tsoli M, Thomas D, Kaltsas G, Grossman A
Endocr Relat Cancer 2020 Jan;27(1):R1-R20. doi: 10.1530/ERC-19-0263. PMID: 31645015
Testicular Cancer: Diagnosis and Treatment.
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528
Testicular lymphoma.
Shahab N, Doll DC
Semin Oncol 1999 Jun;26(3):259-69. PMID: 10375083

Clinical prediction guides

Cutaneous Melanoma and Hormones: Focus on Sex Differences and the Testis.
Cosci I, Grande G, Di Nisio A, Rocca MS, Del Fiore P, Benna C, Mocellin S, Ferlin A
Int J Mol Sci 2022 Dec 29;24(1) doi: 10.3390/ijms24010599. PMID: 36614041Free PMC Article
Treatment and follow-up of rare testis tumours.
Fankhauser CD, Grogg JB, Rothermundt C, Clarke NW
J Cancer Res Clin Oncol 2022 Mar;148(3):667-671. Epub 2022 Jan 20 doi: 10.1007/s00432-021-03890-2. PMID: 35048196
mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer.
Cafri G, Gartner JJ, Zaks T, Hopson K, Levin N, Paria BC, Parkhurst MR, Yossef R, Lowery FJ, Jafferji MS, Prickett TD, Goff SL, McGowan CT, Seitter S, Shindorf ML, Parikh A, Chatani PD, Robbins PF, Rosenberg SA
J Clin Invest 2020 Nov 2;130(11):5976-5988. doi: 10.1172/JCI134915. PMID: 33016924Free PMC Article
Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Testicular cancer.
Oliver RT
Curr Opin Oncol 2001 May;13(3):191-8. doi: 10.1097/00001622-200105000-00011. PMID: 11307064

Recent systematic reviews

Preferentially Expressed Antigen in Melanoma (PRAME) and Human Malignant Melanoma: A Retrospective Study.
Cazzato G, Mangialardi K, Falcicchio G, Colagrande A, Ingravallo G, Arezzo F, Giliberti G, Trilli I, Loizzi V, Lettini T, Scarcella S, Annese T, Parente P, Lupo C, Casatta N, Maiorano E, Cormio G, Resta L, Ribatti D
Genes (Basel) 2022 Mar 19;13(3) doi: 10.3390/genes13030545. PMID: 35328098Free PMC Article
Cryptorchidism, gonocyte development, and the risks of germ cell malignancy and infertility: A systematic review.
Loebenstein M, Thorup J, Cortes D, Clasen-Linde E, Hutson JM, Li R
J Pediatr Surg 2020 Jul;55(7):1201-1210. Epub 2019 Jul 5 doi: 10.1016/j.jpedsurg.2019.06.023. PMID: 31327540
Expression of cancer/testis antigens in cutaneous melanoma: a systematic review.
Tio D, Kasiem FR, Willemsen M, van Doorn R, van der Werf N, Hoekzema R, Luiten RM, Bekkenk MW
Melanoma Res 2019 Aug;29(4):349-357. doi: 10.1097/CMR.0000000000000569. PMID: 30615012
The contemporary role of chemotherapy for advanced testis cancer: a systematic review of the literature.
Calabrò F, Albers P, Bokemeyer C, Martin C, Einhorn LH, Horwich A, Krege S, Schmoll HJ, Sternberg CN, Daugaard G
Eur Urol 2012 Jun;61(6):1212-21. Epub 2012 Mar 24 doi: 10.1016/j.eururo.2012.03.038. PMID: 22464311
Screening for testicular cancer.
Ilic D, Misso ML
Cochrane Database Syst Rev 2011 Feb 16;(2):CD007853. doi: 10.1002/14651858.CD007853.pub2. PMID: 21328302

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