U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Metastatic Malignant Neoplasm in the Testis

MedGen UID:
87567
•Concept ID:
C0347003
•
Neoplastic Process
Synonyms: Metastasis to testis; Metastatic malignant neoplasm of testis; Metastatic malignant neoplasm to testis; Metastatic Malignant Neoplasm to the Testis; Metastatic Neoplasm to the Testis; Metastatic tumor to testis; Metastatic Tumor to the Testis; Secondary malignant neoplasm of testis
SNOMED CT: Metastatic tumor to testis (94623007); Metastasis to testis (94623007); Secondary malignant neoplasm of testis (94623007); Metastatic malignant neoplasm to testis (94623007); Metastatic malignant neoplasm of testis (94623007)

Definition

A malignant neoplasm that has spread to the testis from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Testis

Professional guidelines

PubMed

Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Testicular Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Gilligan T, Lin DW, Aggarwal R, Chism D, Cost N, Derweesh IH, Emamekhoo H, Feldman DR, Geynisman DM, Hancock SL, LaGrange C, Levine EG, Longo T, Lowrance W, McGregor B, Monk P, Picus J, Pierorazio P, Rais-Bahrami S, Saylor P, Sircar K, Smith DC, Tzou K, Vaena D, Vaughn D, Yamoah K, Yamzon J, Johnson-Chilla A, Keller J, Pluchino LA
J Natl Compr Canc Netw 2019 Dec;17(12):1529-1554. doi: 10.6004/jnccn.2019.0058. PMID: 31805523
Testicular Cancer: Diagnosis and Treatment.
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528

Recent clinical studies

Etiology

Synchronous Seminoma of Testis and Renal Cell Carcinoma: A Rare Case Report.
Auskalnis S, Janciauskiene R, Rimsaite U, Alksnyte A, Ugenskiene R
Medicina (Kaunas) 2024 Sep 23;60(9) doi: 10.3390/medicina60091553. PMID: 39336594Free PMC Article

Diagnosis

Synchronous Seminoma of Testis and Renal Cell Carcinoma: A Rare Case Report.
Auskalnis S, Janciauskiene R, Rimsaite U, Alksnyte A, Ugenskiene R
Medicina (Kaunas) 2024 Sep 23;60(9) doi: 10.3390/medicina60091553. PMID: 39336594Free PMC Article

Therapy

mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer.
Cafri G, Gartner JJ, Zaks T, Hopson K, Levin N, Paria BC, Parkhurst MR, Yossef R, Lowery FJ, Jafferji MS, Prickett TD, Goff SL, McGowan CT, Seitter S, Shindorf ML, Parikh A, Chatani PD, Robbins PF, Rosenberg SA
J Clin Invest 2020 Nov 2;130(11):5976-5988. doi: 10.1172/JCI134915. PMID: 33016924Free PMC Article
Glyoxalases in Urological Malignancies.
Antognelli C, Talesa VN
Int J Mol Sci 2018 Jan 31;19(2) doi: 10.3390/ijms19020415. PMID: 29385039Free PMC Article
Male hypogonadism.
Basaria S
Lancet 2014 Apr 5;383(9924):1250-63. Epub 2013 Oct 10 doi: 10.1016/S0140-6736(13)61126-5. PMID: 24119423
First-line treatment for primary testicular diffuse large B-cell lymphoma with rituximab-CHOP, CNS prophylaxis, and contralateral testis irradiation: final results of an international phase II trial.
Vitolo U, Chiappella A, Ferreri AJ, Martelli M, Baldi I, Balzarotti M, Bottelli C, Conconi A, Gomez H, Lopez-Guillermo A, Martinelli G, Merli F, Novero D, Orsucci L, Pavone V, Ricardi U, Storti S, Gospodarowicz MK, Cavalli F, Sarris AH, Zucca E
J Clin Oncol 2011 Jul 10;29(20):2766-72. Epub 2011 Jun 6 doi: 10.1200/JCO.2010.31.4187. PMID: 21646602
Combination of paclitaxel, ifosfamide, and cisplatin is an effective second-line therapy for patients with relapsed testicular germ cell tumors.
Kondagunta GV, Bacik J, Donadio A, Bajorin D, Marion S, Sheinfeld J, Bosl GJ, Motzer RJ
J Clin Oncol 2005 Sep 20;23(27):6549-55. doi: 10.1200/JCO.2005.19.638. PMID: 16170162

Prognosis

Epidemiology of liver metastases.
Horn SR, Stoltzfus KC, Lehrer EJ, Dawson LA, Tchelebi L, Gusani NJ, Sharma NK, Chen H, Trifiletti DM, Zaorsky NG
Cancer Epidemiol 2020 Aug;67:101760. Epub 2020 Jun 17 doi: 10.1016/j.canep.2020.101760. PMID: 32562887
Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Advanced testis cancer.
Droz JP, Rivoire M
Curr Treat Options Oncol 2001 Oct;2(5):421-9. doi: 10.1007/s11864-001-0047-z. PMID: 12057105
Early-stage testis cancer.
Foster RS
Curr Treat Options Oncol 2001 Oct;2(5):413-9. doi: 10.1007/s11864-001-0046-0. PMID: 12057104
Testicular lymphoma.
Shahab N, Doll DC
Semin Oncol 1999 Jun;26(3):259-69. PMID: 10375083

Clinical prediction guides

Metastasis and recurrence patterns in the molecular subtypes of urothelial bladder cancer.
Sjödahl G, Eriksson P, Holmsten K, Abrahamsson J, Höglund M, Bernardo C, Ullén A, Liedberg F
Int J Cancer 2024 Jan 1;154(1):180-190. Epub 2023 Sep 6 doi: 10.1002/ijc.34715. PMID: 37671617
The role of the NY-ESO-1 in the prognosis of gastric cancer.
Misir Z, Glavčić G, Janković S, Kruljac I, Čugura Filipović J, Čimić K, Ulamec M
Biomol Biomed 2023 Dec 28;24(4):813-820. doi: 10.17305/bb.2023.9937. PMID: 38153439Free PMC Article
mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer.
Cafri G, Gartner JJ, Zaks T, Hopson K, Levin N, Paria BC, Parkhurst MR, Yossef R, Lowery FJ, Jafferji MS, Prickett TD, Goff SL, McGowan CT, Seitter S, Shindorf ML, Parikh A, Chatani PD, Robbins PF, Rosenberg SA
J Clin Invest 2020 Nov 2;130(11):5976-5988. doi: 10.1172/JCI134915. PMID: 33016924Free PMC Article
Risk Factors and Treatment Outcomes of 1,375 Patients with Testicular Leydig Cell Tumors: Analysis of Published Case Series Data.
Fankhauser CD, Grogg JB, Hayoz S, Wettstein MS, Dieckmann KP, Sulser T, Bode PK, Clarke NW, Beyer J, Hermanns T
J Urol 2020 May;203(5):949-956. Epub 2019 Dec 17 doi: 10.1097/JU.0000000000000705. PMID: 31845841
Testicular cancer.
Oliver RT
Curr Opin Oncol 2001 May;13(3):191-8. doi: 10.1097/00001622-200105000-00011. PMID: 11307064

Recent systematic reviews

Significance of PD-L1 in Metastatic Urothelial Carcinoma Treated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis.
Maiorano BA, Di Maio M, Cerbone L, Maiello E, Procopio G, Roviello G; MeetURO Group
JAMA Netw Open 2024 Mar 4;7(3):e241215. doi: 10.1001/jamanetworkopen.2024.1215. PMID: 38446479Free PMC Article
Preferentially Expressed Antigen in Melanoma (PRAME) and Human Malignant Melanoma: A Retrospective Study.
Cazzato G, Mangialardi K, Falcicchio G, Colagrande A, Ingravallo G, Arezzo F, Giliberti G, Trilli I, Loizzi V, Lettini T, Scarcella S, Annese T, Parente P, Lupo C, Casatta N, Maiorano E, Cormio G, Resta L, Ribatti D
Genes (Basel) 2022 Mar 19;13(3) doi: 10.3390/genes13030545. PMID: 35328098Free PMC Article
Expression of cancer/testis antigens in cutaneous melanoma: a systematic review.
Tio D, Kasiem FR, Willemsen M, van Doorn R, van der Werf N, Hoekzema R, Luiten RM, Bekkenk MW
Melanoma Res 2019 Aug;29(4):349-357. doi: 10.1097/CMR.0000000000000569. PMID: 30615012
The contemporary role of chemotherapy for advanced testis cancer: a systematic review of the literature.
Calabrò F, Albers P, Bokemeyer C, Martin C, Einhorn LH, Horwich A, Krege S, Schmoll HJ, Sternberg CN, Daugaard G
Eur Urol 2012 Jun;61(6):1212-21. Epub 2012 Mar 24 doi: 10.1016/j.eururo.2012.03.038. PMID: 22464311
Screening for testicular cancer.
Ilic D, Misso ML
Cochrane Database Syst Rev 2011 Feb 16;(2):CD007853. doi: 10.1002/14651858.CD007853.pub2. PMID: 21328302

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...