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Hypocellular Myelodysplastic Syndrome

MedGen UID:
888822
•Concept ID:
C4054752
•
Neoplastic Process

Definition

Myelodysplastic syndrome characterized by decreased cellularity in the bone marrow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHypocellular Myelodysplastic Syndrome

Professional guidelines

PubMed

Anti Thymocyte Globulin-Based Treatment for Acquired Bone Marrow Failure in Adults.
Tjon JM, Langemeijer SMC, Halkes CJM
Cells 2021 Oct 27;10(11) doi: 10.3390/cells10112905. PMID: 34831130Free PMC Article
Management of the refractory aplastic anemia patient: what are the options?
Marsh JC, Kulasekararaj AG
Hematology Am Soc Hematol Educ Program 2013;2013:87-94. doi: 10.1182/asheducation-2013.1.87. PMID: 24319168
Management of the refractory aplastic anemia patient: what are the options?
Marsh JC, Kulasekararaj AG
Blood 2013 Nov 21;122(22):3561-7. Epub 2013 Sep 19 doi: 10.1182/blood-2013-05-498279. PMID: 24052548

Recent clinical studies

Etiology

Anti Thymocyte Globulin-Based Treatment for Acquired Bone Marrow Failure in Adults.
Tjon JM, Langemeijer SMC, Halkes CJM
Cells 2021 Oct 27;10(11) doi: 10.3390/cells10112905. PMID: 34831130Free PMC Article
Idiopathic aplastic anemia vs hypocellular myelodysplastic syndrome.
Durrani J, Maciejewski JP
Hematology Am Soc Hematol Educ Program 2019 Dec 6;2019(1):97-104. doi: 10.1182/hematology.2019000019. PMID: 31808900Free PMC Article
Predicting survival of patients with hypocellular myelodysplastic syndrome: development of a disease-specific prognostic score system.
Tong WG, Quintás-Cardama A, Kadia T, Borthakur G, Jabbour E, Ravandi F, Faderl S, Wierda W, Pierce S, Shan J, Bueso-Ramos C, Kantarjian H, Garcia-Manero G
Cancer 2012 Sep 15;118(18):4462-70. Epub 2012 Jan 17 doi: 10.1002/cncr.27420. PMID: 22252728Free PMC Article
Hypocellularity in myelodysplastic syndrome is an independent factor which predicts a favorable outcome.
Yue G, Hao S, Fadare O, Baker S, Pozdnyakova O, Galili N, Woda BA, Raza A, Wang SA
Leuk Res 2008 Apr;32(4):553-8. Epub 2007 Sep 20 doi: 10.1016/j.leukres.2007.08.006. PMID: 17888511
Aplastic anaemia and the hypocellular myelodysplastic syndrome: histomorphological, diagnostic, and prognostic features.
Fohlmeister I, Fischer R, Mödder B, Rister M, Schaefer HE
J Clin Pathol 1985 Nov;38(11):1218-24. doi: 10.1136/jcp.38.11.1218. PMID: 4066981Free PMC Article

Diagnosis

Plasma lipidome acts as diagnostic marker and predictor for cyclosporin response in patients with aplastic anemia.
Ruan J, Yang C, Du Y, Chen M, Han B
Clin Exp Med 2023 Jul;23(3):767-776. Epub 2022 Apr 21 doi: 10.1007/s10238-022-00826-z. PMID: 35445952
The clinical and laboratory evaluation of patients with suspected hypocellular marrow failure.
Keel S, Geddis A
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):134-142. doi: 10.1182/hematology.2021000244. PMID: 34889426Free PMC Article
Idiopathic aplastic anemia vs hypocellular myelodysplastic syndrome.
Durrani J, Maciejewski JP
Hematology Am Soc Hematol Educ Program 2019 Dec 6;2019(1):97-104. doi: 10.1182/hematology.2019000019. PMID: 31808900Free PMC Article
CD34 and p53 immunohistochemical stains differentiate hypocellular myelodysplastic syndrome (hMDS) from aplastic anemia and a CD34 immunohistochemical stain provides useful survival information for hMDS.
Cha CH, Park CJ, Chi HS, Seo EJ, Jang S, Cho YU, Lee KH, Lee JH, Lee JH, Im HJ, Seo JJ
Ann Lab Med 2014 Nov;34(6):426-32. Epub 2014 Oct 28 doi: 10.3343/alm.2014.34.6.426. PMID: 25368817Free PMC Article
Aplastic anaemia and the hypocellular myelodysplastic syndrome: histomorphological, diagnostic, and prognostic features.
Fohlmeister I, Fischer R, Mödder B, Rister M, Schaefer HE
J Clin Pathol 1985 Nov;38(11):1218-24. doi: 10.1136/jcp.38.11.1218. PMID: 4066981Free PMC Article

Therapy

Plasma lipidome acts as diagnostic marker and predictor for cyclosporin response in patients with aplastic anemia.
Ruan J, Yang C, Du Y, Chen M, Han B
Clin Exp Med 2023 Jul;23(3):767-776. Epub 2022 Apr 21 doi: 10.1007/s10238-022-00826-z. PMID: 35445952
Anti Thymocyte Globulin-Based Treatment for Acquired Bone Marrow Failure in Adults.
Tjon JM, Langemeijer SMC, Halkes CJM
Cells 2021 Oct 27;10(11) doi: 10.3390/cells10112905. PMID: 34831130Free PMC Article
Pyoderma gangrenosum: a presenting sign of myelodysplastic syndrome in undiagnosed Fanconi anemia.
Kandula P, Shah KM, Wolverton JE, Le C, Wolverton SE
Dermatol Online J 2019 Jan 15;25(1) PMID: 30710899
Management of the refractory aplastic anemia patient: what are the options?
Marsh JC, Kulasekararaj AG
Hematology Am Soc Hematol Educ Program 2013;2013:87-94. doi: 10.1182/asheducation-2013.1.87. PMID: 24319168
Management of the refractory aplastic anemia patient: what are the options?
Marsh JC, Kulasekararaj AG
Blood 2013 Nov 21;122(22):3561-7. Epub 2013 Sep 19 doi: 10.1182/blood-2013-05-498279. PMID: 24052548

Prognosis

Plasma lipidome acts as diagnostic marker and predictor for cyclosporin response in patients with aplastic anemia.
Ruan J, Yang C, Du Y, Chen M, Han B
Clin Exp Med 2023 Jul;23(3):767-776. Epub 2022 Apr 21 doi: 10.1007/s10238-022-00826-z. PMID: 35445952
Idiopathic aplastic anemia vs hypocellular myelodysplastic syndrome.
Durrani J, Maciejewski JP
Hematology Am Soc Hematol Educ Program 2019 Dec 6;2019(1):97-104. doi: 10.1182/hematology.2019000019. PMID: 31808900Free PMC Article
Management of the refractory aplastic anemia patient: what are the options?
Marsh JC, Kulasekararaj AG
Hematology Am Soc Hematol Educ Program 2013;2013:87-94. doi: 10.1182/asheducation-2013.1.87. PMID: 24319168
Management of the refractory aplastic anemia patient: what are the options?
Marsh JC, Kulasekararaj AG
Blood 2013 Nov 21;122(22):3561-7. Epub 2013 Sep 19 doi: 10.1182/blood-2013-05-498279. PMID: 24052548
Aplastic anaemia and the hypocellular myelodysplastic syndrome: histomorphological, diagnostic, and prognostic features.
Fohlmeister I, Fischer R, Mödder B, Rister M, Schaefer HE
J Clin Pathol 1985 Nov;38(11):1218-24. doi: 10.1136/jcp.38.11.1218. PMID: 4066981Free PMC Article

Clinical prediction guides

Plasma lipidome acts as diagnostic marker and predictor for cyclosporin response in patients with aplastic anemia.
Ruan J, Yang C, Du Y, Chen M, Han B
Clin Exp Med 2023 Jul;23(3):767-776. Epub 2022 Apr 21 doi: 10.1007/s10238-022-00826-z. PMID: 35445952
Idiopathic aplastic anemia vs hypocellular myelodysplastic syndrome.
Durrani J, Maciejewski JP
Hematology Am Soc Hematol Educ Program 2019 Dec 6;2019(1):97-104. doi: 10.1182/hematology.2019000019. PMID: 31808900Free PMC Article
Predicting survival of patients with hypocellular myelodysplastic syndrome: development of a disease-specific prognostic score system.
Tong WG, Quintás-Cardama A, Kadia T, Borthakur G, Jabbour E, Ravandi F, Faderl S, Wierda W, Pierce S, Shan J, Bueso-Ramos C, Kantarjian H, Garcia-Manero G
Cancer 2012 Sep 15;118(18):4462-70. Epub 2012 Jan 17 doi: 10.1002/cncr.27420. PMID: 22252728Free PMC Article
Hypocellularity in myelodysplastic syndrome is an independent factor which predicts a favorable outcome.
Yue G, Hao S, Fadare O, Baker S, Pozdnyakova O, Galili N, Woda BA, Raza A, Wang SA
Leuk Res 2008 Apr;32(4):553-8. Epub 2007 Sep 20 doi: 10.1016/j.leukres.2007.08.006. PMID: 17888511
Aplastic anaemia and the hypocellular myelodysplastic syndrome: histomorphological, diagnostic, and prognostic features.
Fohlmeister I, Fischer R, Mödder B, Rister M, Schaefer HE
J Clin Pathol 1985 Nov;38(11):1218-24. doi: 10.1136/jcp.38.11.1218. PMID: 4066981Free PMC Article

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