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Infant Acute Lymphoblastic Leukemia without MLL Gene Rearrangement

MedGen UID:
889234
Concept ID:
C4054728
Neoplastic Process
Synonym: Infant Acute Lymphoblastic Leukemia without KMT2A Gene Rearrangement

Definition

An acute lymphoblastic leukemia without rearrangement of the MLL (KMT2A) gene that occurs in infancy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfant Acute Lymphoblastic Leukemia without MLL Gene Rearrangement

Professional guidelines

PubMed

Tomizawa D
Pediatr Int 2015 Oct;57(5):811-9. doi: 10.1111/ped.12758. PMID: 26215843
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298
Pui CH, Kane JR, Crist WM
Leukemia 1995 May;9(5):762-9. PMID: 7769837

Recent clinical studies

Etiology

Tomizawa D, Miyamura T, Koh K, Ishii E
Pediatr Int 2022 Jan;64(1):e14935. doi: 10.1111/ped.14935. PMID: 34324764
El Chaer F, Keng M, Ballen KK
Curr Hematol Malig Rep 2020 Apr;15(2):83-89. doi: 10.1007/s11899-020-00582-5. PMID: 32350732
Pieters R, De Lorenzo P, Ancliffe P, Aversa LA, Brethon B, Biondi A, Campbell M, Escherich G, Ferster A, Gardner RA, Kotecha RS, Lausen B, Li CK, Locatelli F, Attarbaschi A, Peters C, Rubnitz JE, Silverman LB, Stary J, Szczepanski T, Vora A, Schrappe M, Valsecchi MG
J Clin Oncol 2019 Sep 1;37(25):2246-2256. Epub 2019 Jul 8 doi: 10.1200/JCO.19.00261. PMID: 31283407
Meyer C, Burmeister T, Gröger D, Tsaur G, Fechina L, Renneville A, Sutton R, Venn NC, Emerenciano M, Pombo-de-Oliveira MS, Barbieri Blunck C, Almeida Lopes B, Zuna J, Trka J, Ballerini P, Lapillonne H, De Braekeleer M, Cazzaniga G, Corral Abascal L, van der Velden VHJ, Delabesse E, Park TS, Oh SH, Silva MLM, Lund-Aho T, Juvonen V, Moore AS, Heidenreich O, Vormoor J, Zerkalenkova E, Olshanskaya Y, Bueno C, Menendez P, Teigler-Schlegel A, Zur Stadt U, Lentes J, Göhring G, Kustanovich A, Aleinikova O, Schäfer BW, Kubetzko S, Madsen HO, Gruhn B, Duarte X, Gameiro P, Lippert E, Bidet A, Cayuela JM, Clappier E, Alonso CN, Zwaan CM, van den Heuvel-Eibrink MM, Izraeli S, Trakhtenbrot L, Archer P, Hancock J, Möricke A, Alten J, Schrappe M, Stanulla M, Strehl S, Attarbaschi A, Dworzak M, Haas OA, Panzer-Grümayer R, Sedék L, Szczepański T, Caye A, Suarez L, Cavé H, Marschalek R
Leukemia 2018 Feb;32(2):273-284. Epub 2017 Jul 13 doi: 10.1038/leu.2017.213. PMID: 28701730Free PMC Article
Tomizawa D
Pediatr Int 2015 Oct;57(5):811-9. doi: 10.1111/ped.12758. PMID: 26215843

Diagnosis

Candelli T, Schneider P, Garrido Castro P, Jones LA, Bodewes E, Rockx-Brouwer D, Pieters R, Holstege FCP, Margaritis T, Stam RW
Leukemia 2022 Jan;36(1):58-67. Epub 2021 Jul 24 doi: 10.1038/s41375-021-01341-y. PMID: 34304246Free PMC Article
El Chaer F, Keng M, Ballen KK
Curr Hematol Malig Rep 2020 Apr;15(2):83-89. doi: 10.1007/s11899-020-00582-5. PMID: 32350732
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298
Chowdhury T, Brady HJ
Blood Cells Mol Dis 2008 Mar-Apr;40(2):192-9. Epub 2007 Oct 1 doi: 10.1016/j.bcmd.2007.07.005. PMID: 17905612
Silverman LB
Pediatr Blood Cancer 2007 Dec;49(7 Suppl):1070-3. doi: 10.1002/pbc.21352. PMID: 17943956

Therapy

Tomizawa D, Miyamura T, Koh K, Ishii E
Pediatr Int 2022 Jan;64(1):e14935. doi: 10.1111/ped.14935. PMID: 34324764
El Chaer F, Keng M, Ballen KK
Curr Hematol Malig Rep 2020 Apr;15(2):83-89. doi: 10.1007/s11899-020-00582-5. PMID: 32350732
Pieters R, De Lorenzo P, Ancliffe P, Aversa LA, Brethon B, Biondi A, Campbell M, Escherich G, Ferster A, Gardner RA, Kotecha RS, Lausen B, Li CK, Locatelli F, Attarbaschi A, Peters C, Rubnitz JE, Silverman LB, Stary J, Szczepanski T, Vora A, Schrappe M, Valsecchi MG
J Clin Oncol 2019 Sep 1;37(25):2246-2256. Epub 2019 Jul 8 doi: 10.1200/JCO.19.00261. PMID: 31283407
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298
Pieters R
Curr Hematol Malig Rep 2009 Jul;4(3):167-74. doi: 10.1007/s11899-009-0023-4. PMID: 20425430

Prognosis

El Chaer F, Keng M, Ballen KK
Curr Hematol Malig Rep 2020 Apr;15(2):83-89. doi: 10.1007/s11899-020-00582-5. PMID: 32350732
Pieters R, De Lorenzo P, Ancliffe P, Aversa LA, Brethon B, Biondi A, Campbell M, Escherich G, Ferster A, Gardner RA, Kotecha RS, Lausen B, Li CK, Locatelli F, Attarbaschi A, Peters C, Rubnitz JE, Silverman LB, Stary J, Szczepanski T, Vora A, Schrappe M, Valsecchi MG
J Clin Oncol 2019 Sep 1;37(25):2246-2256. Epub 2019 Jul 8 doi: 10.1200/JCO.19.00261. PMID: 31283407
Yang L, Ding L, Liang J, Chen J, Tang Y, Xue H, Gu L, Shen S, Li B, Chen J
Pediatr Blood Cancer 2018 Oct;65(10):e27266. Epub 2018 Jun 26 doi: 10.1002/pbc.27266. PMID: 29943896
Pieters R
Curr Hematol Malig Rep 2009 Jul;4(3):167-74. doi: 10.1007/s11899-009-0023-4. PMID: 20425430
Silverman LB
Pediatr Blood Cancer 2007 Dec;49(7 Suppl):1070-3. doi: 10.1002/pbc.21352. PMID: 17943956

Clinical prediction guides

Candelli T, Schneider P, Garrido Castro P, Jones LA, Bodewes E, Rockx-Brouwer D, Pieters R, Holstege FCP, Margaritis T, Stam RW
Leukemia 2022 Jan;36(1):58-67. Epub 2021 Jul 24 doi: 10.1038/s41375-021-01341-y. PMID: 34304246Free PMC Article
Meyer C, Burmeister T, Gröger D, Tsaur G, Fechina L, Renneville A, Sutton R, Venn NC, Emerenciano M, Pombo-de-Oliveira MS, Barbieri Blunck C, Almeida Lopes B, Zuna J, Trka J, Ballerini P, Lapillonne H, De Braekeleer M, Cazzaniga G, Corral Abascal L, van der Velden VHJ, Delabesse E, Park TS, Oh SH, Silva MLM, Lund-Aho T, Juvonen V, Moore AS, Heidenreich O, Vormoor J, Zerkalenkova E, Olshanskaya Y, Bueno C, Menendez P, Teigler-Schlegel A, Zur Stadt U, Lentes J, Göhring G, Kustanovich A, Aleinikova O, Schäfer BW, Kubetzko S, Madsen HO, Gruhn B, Duarte X, Gameiro P, Lippert E, Bidet A, Cayuela JM, Clappier E, Alonso CN, Zwaan CM, van den Heuvel-Eibrink MM, Izraeli S, Trakhtenbrot L, Archer P, Hancock J, Möricke A, Alten J, Schrappe M, Stanulla M, Strehl S, Attarbaschi A, Dworzak M, Haas OA, Panzer-Grümayer R, Sedék L, Szczepański T, Caye A, Suarez L, Cavé H, Marschalek R
Leukemia 2018 Feb;32(2):273-284. Epub 2017 Jul 13 doi: 10.1038/leu.2017.213. PMID: 28701730Free PMC Article
Mansur MB, Ford AM, Emerenciano M
Biochim Biophys Acta Rev Cancer 2017 Dec;1868(2):521-526. Epub 2017 Oct 19 doi: 10.1016/j.bbcan.2017.10.005. PMID: 29056538
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298
Silverman LB
Pediatr Blood Cancer 2007 Dec;49(7 Suppl):1070-3. doi: 10.1002/pbc.21352. PMID: 17943956

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