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Infant Acute Lymphoblastic Leukemia

MedGen UID:
889772
•Concept ID:
C4054727
•
Neoplastic Process

Definition

An acute lymphoblastic leukemia that occurs in infancy. [from NCI]

Professional guidelines

PubMed

Combination of chemotherapy and all-trans retinoic acid for the treatment KMT2A-rearranged infant acute lymphoblastic leukemia. Results of the MLL-Baby trial.
Fechina L, Popov A, Tsaur G, Henze G, Shorikov E, Makarova O, Khlebnikova O, Zhukova Y, Arakaev O, Streneva O, Verzhbitskaya T, Riger T, Solodovnikov A, Lapotentova E, Aleinikova O, Myakova N, Boichenko E, Kondratchik K, Nikonova O, Shapochnik A, Goroshkova M, Ponomareva N, Novichkova G, Karachunskiy A, Roumiantsev A
Leukemia 2023 Nov;37(11):2276-2281. Epub 2023 Sep 23 doi: 10.1038/s41375-023-02034-4. PMID: 37741948
Recent progress in the treatment of infant acute lymphoblastic leukemia.
Tomizawa D
Pediatr Int 2015 Oct;57(5):811-9. doi: 10.1111/ped.12758. PMID: 26215843
Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia.
Stumpel DJ, Schneider P, Seslija L, Osaki H, Williams O, Pieters R, Stam RW
Leukemia 2012 Apr;26(4):682-92. Epub 2011 Oct 21 doi: 10.1038/leu.2011.278. PMID: 22015773

Recent clinical studies

Etiology

Infant Acute Lymphoblastic Leukemia-New Therapeutic Opportunities.
Kulczycka M, Derlatka K, Tasior J, Sygacz M, Lejman M, Zawitkowska J
Int J Mol Sci 2024 Mar 27;25(7) doi: 10.3390/ijms25073721. PMID: 38612531Free PMC Article
Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.
Isobe T, Takagi M, Sato-Otsubo A, Nishimura A, Nagae G, Yamagishi C, Tamura M, Tanaka Y, Asada S, Takeda R, Tsuchiya A, Wang X, Yoshida K, Nannya Y, Ueno H, Akazawa R, Kato I, Mikami T, Watanabe K, Sekiguchi M, Seki M, Kimura S, Hiwatari M, Kato M, Fukuda S, Tatsuno K, Tsutsumi S, Kanai A, Inaba T, Shiozawa Y, Shiraishi Y, Chiba K, Tanaka H, Kotecha RS, Cruickshank MN, Ishikawa F, Morio T, Eguchi M, Deguchi T, Kiyokawa N, Arakawa Y, Koh K, Aoki Y, Ishihara T, Tomizawa D, Miyamura T, Ishii E, Mizutani S, Wilson NK, Göttgens B, Miyano S, Kitamura T, Goyama S, Yokoyama A, Aburatani H, Ogawa S, Takita J
Nat Commun 2022 Aug 30;13(1):4501. doi: 10.1038/s41467-022-32266-4. PMID: 36042201Free PMC Article
Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia.
Chen C, Yu W, Alikarami F, Qiu Q, Chen CH, Flournoy J, Gao P, Uzun Y, Fang L, Davenport JW, Hu Y, Zhu Q, Wang K, Libbrecht C, Felmeister A, Rozich I, Ding YY, Hunger SP, Felix CA, Wu H, Brown PA, Guest EM, Barrett DM, Bernt KM, Tan K
Blood 2022 Apr 7;139(14):2198-2211. doi: 10.1182/blood.2021013442. PMID: 34864916Free PMC Article
Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized Study.
Pieters R, De Lorenzo P, Ancliffe P, Aversa LA, Brethon B, Biondi A, Campbell M, Escherich G, Ferster A, Gardner RA, Kotecha RS, Lausen B, Li CK, Locatelli F, Attarbaschi A, Peters C, Rubnitz JE, Silverman LB, Stary J, Szczepanski T, Vora A, Schrappe M, Valsecchi MG
J Clin Oncol 2019 Sep 1;37(25):2246-2256. Epub 2019 Jul 8 doi: 10.1200/JCO.19.00261. PMID: 31283407
Updates in the biology and therapy for infant acute lymphoblastic leukemia.
Guest EM, Stam RW
Curr Opin Pediatr 2017 Feb;29(1):20-26. doi: 10.1097/MOP.0000000000000437. PMID: 27841777

Diagnosis

Infant Acute Lymphoblastic Leukemia-New Therapeutic Opportunities.
Kulczycka M, Derlatka K, Tasior J, Sygacz M, Lejman M, Zawitkowska J
Int J Mol Sci 2024 Mar 27;25(7) doi: 10.3390/ijms25073721. PMID: 38612531Free PMC Article
Updates in infant acute lymphoblastic leukemia and the potential for targeted therapy.
Kotecha RS
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):611-617. doi: 10.1182/hematology.2022000359. PMID: 36485124Free PMC Article
Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia.
Chen C, Yu W, Alikarami F, Qiu Q, Chen CH, Flournoy J, Gao P, Uzun Y, Fang L, Davenport JW, Hu Y, Zhu Q, Wang K, Libbrecht C, Felmeister A, Rozich I, Ding YY, Hunger SP, Felix CA, Wu H, Brown PA, Guest EM, Barrett DM, Bernt KM, Tan K
Blood 2022 Apr 7;139(14):2198-2211. doi: 10.1182/blood.2021013442. PMID: 34864916Free PMC Article
Infant lymphoblastic leukemia: a single centers 10 year experience.
Yaman-Bajin İ, Aytaç S, Kuşkonmaz B, Uçkan-Çetinkaya D, Ünal Ş, Gümrük F, Çetin M
Turk J Pediatr 2019;61(3):325-329. doi: 10.24953/turkjped.2019.03.002. PMID: 31916708
Updates in the biology and therapy for infant acute lymphoblastic leukemia.
Guest EM, Stam RW
Curr Opin Pediatr 2017 Feb;29(1):20-26. doi: 10.1097/MOP.0000000000000437. PMID: 27841777

Therapy

Updates in infant acute lymphoblastic leukemia and the potential for targeted therapy.
Kotecha RS
Hematology Am Soc Hematol Educ Program 2022 Dec 9;2022(1):611-617. doi: 10.1182/hematology.2022000359. PMID: 36485124Free PMC Article
Real-world use of tisagenlecleucel in infant acute lymphoblastic leukemia.
Moskop A, Pommert L, Baggott C, Prabhu S, Pacenta HL, Phillips CL, Rossoff J, Stefanski HE, Talano JA, Margossian SP, Verneris MR, Myers GD, Karras NA, Brown PA, Qayed M, Hermiston ML, Satwani P, Krupski C, Keating AK, Wilcox R, Rabik CA, Fabrizio VA, Chinnabhandar V, Goksenin AY, Curran KJ, Mackall CL, Laetsch TW, Guest EM, Breese EH, Schultz LM
Blood Adv 2022 Jul 26;6(14):4251-4255. doi: 10.1182/bloodadvances.2021006393. PMID: 35580324Free PMC Article
Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia.
Chen C, Yu W, Alikarami F, Qiu Q, Chen CH, Flournoy J, Gao P, Uzun Y, Fang L, Davenport JW, Hu Y, Zhu Q, Wang K, Libbrecht C, Felmeister A, Rozich I, Ding YY, Hunger SP, Felix CA, Wu H, Brown PA, Guest EM, Barrett DM, Bernt KM, Tan K
Blood 2022 Apr 7;139(14):2198-2211. doi: 10.1182/blood.2021013442. PMID: 34864916Free PMC Article
Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized Study.
Pieters R, De Lorenzo P, Ancliffe P, Aversa LA, Brethon B, Biondi A, Campbell M, Escherich G, Ferster A, Gardner RA, Kotecha RS, Lausen B, Li CK, Locatelli F, Attarbaschi A, Peters C, Rubnitz JE, Silverman LB, Stary J, Szczepanski T, Vora A, Schrappe M, Valsecchi MG
J Clin Oncol 2019 Sep 1;37(25):2246-2256. Epub 2019 Jul 8 doi: 10.1200/JCO.19.00261. PMID: 31283407
Updates in the biology and therapy for infant acute lymphoblastic leukemia.
Guest EM, Stam RW
Curr Opin Pediatr 2017 Feb;29(1):20-26. doi: 10.1097/MOP.0000000000000437. PMID: 27841777

Prognosis

Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.
Isobe T, Takagi M, Sato-Otsubo A, Nishimura A, Nagae G, Yamagishi C, Tamura M, Tanaka Y, Asada S, Takeda R, Tsuchiya A, Wang X, Yoshida K, Nannya Y, Ueno H, Akazawa R, Kato I, Mikami T, Watanabe K, Sekiguchi M, Seki M, Kimura S, Hiwatari M, Kato M, Fukuda S, Tatsuno K, Tsutsumi S, Kanai A, Inaba T, Shiozawa Y, Shiraishi Y, Chiba K, Tanaka H, Kotecha RS, Cruickshank MN, Ishikawa F, Morio T, Eguchi M, Deguchi T, Kiyokawa N, Arakawa Y, Koh K, Aoki Y, Ishihara T, Tomizawa D, Miyamura T, Ishii E, Mizutani S, Wilson NK, Göttgens B, Miyano S, Kitamura T, Goyama S, Yokoyama A, Aburatani H, Ogawa S, Takita J
Nat Commun 2022 Aug 30;13(1):4501. doi: 10.1038/s41467-022-32266-4. PMID: 36042201Free PMC Article
Infant lymphoblastic leukemia: a single centers 10 year experience.
Yaman-Bajin İ, Aytaç S, Kuşkonmaz B, Uçkan-Çetinkaya D, Ünal Ş, Gümrük F, Çetin M
Turk J Pediatr 2019;61(3):325-329. doi: 10.24953/turkjped.2019.03.002. PMID: 31916708
Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized Study.
Pieters R, De Lorenzo P, Ancliffe P, Aversa LA, Brethon B, Biondi A, Campbell M, Escherich G, Ferster A, Gardner RA, Kotecha RS, Lausen B, Li CK, Locatelli F, Attarbaschi A, Peters C, Rubnitz JE, Silverman LB, Stary J, Szczepanski T, Vora A, Schrappe M, Valsecchi MG
J Clin Oncol 2019 Sep 1;37(25):2246-2256. Epub 2019 Jul 8 doi: 10.1200/JCO.19.00261. PMID: 31283407
Updates in the biology and therapy for infant acute lymphoblastic leukemia.
Guest EM, Stam RW
Curr Opin Pediatr 2017 Feb;29(1):20-26. doi: 10.1097/MOP.0000000000000437. PMID: 27841777
Infant acute lymphoblastic leukemia: Lessons learned and future directions.
Pieters R
Curr Hematol Malig Rep 2009 Jul;4(3):167-74. doi: 10.1007/s11899-009-0023-4. PMID: 20425430

Clinical prediction guides

Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia.
Isobe T, Takagi M, Sato-Otsubo A, Nishimura A, Nagae G, Yamagishi C, Tamura M, Tanaka Y, Asada S, Takeda R, Tsuchiya A, Wang X, Yoshida K, Nannya Y, Ueno H, Akazawa R, Kato I, Mikami T, Watanabe K, Sekiguchi M, Seki M, Kimura S, Hiwatari M, Kato M, Fukuda S, Tatsuno K, Tsutsumi S, Kanai A, Inaba T, Shiozawa Y, Shiraishi Y, Chiba K, Tanaka H, Kotecha RS, Cruickshank MN, Ishikawa F, Morio T, Eguchi M, Deguchi T, Kiyokawa N, Arakawa Y, Koh K, Aoki Y, Ishihara T, Tomizawa D, Miyamura T, Ishii E, Mizutani S, Wilson NK, Göttgens B, Miyano S, Kitamura T, Goyama S, Yokoyama A, Aburatani H, Ogawa S, Takita J
Nat Commun 2022 Aug 30;13(1):4501. doi: 10.1038/s41467-022-32266-4. PMID: 36042201Free PMC Article
Single-cell multiomics reveals increased plasticity, resistant populations, and stem-cell-like blasts in KMT2A-rearranged leukemia.
Chen C, Yu W, Alikarami F, Qiu Q, Chen CH, Flournoy J, Gao P, Uzun Y, Fang L, Davenport JW, Hu Y, Zhu Q, Wang K, Libbrecht C, Felmeister A, Rozich I, Ding YY, Hunger SP, Felix CA, Wu H, Brown PA, Guest EM, Barrett DM, Bernt KM, Tan K
Blood 2022 Apr 7;139(14):2198-2211. doi: 10.1182/blood.2021013442. PMID: 34864916Free PMC Article
Combinatorial efficacy of entospletinib and chemotherapy in patient-derived xenograft models of infant acute lymphoblastic leukemia.
Loftus JP, Yahiaoui A, Brown PA, Niswander LM, Bagashev A, Wang M, Schauf A, Tannheimer S, Tasian SK
Haematologica 2021 Apr 1;106(4):1067-1078. doi: 10.3324/haematol.2019.241729. PMID: 32414848Free PMC Article
Infant lymphoblastic leukemia: a single centers 10 year experience.
Yaman-Bajin İ, Aytaç S, Kuşkonmaz B, Uçkan-Çetinkaya D, Ünal Ş, Gümrük F, Çetin M
Turk J Pediatr 2019;61(3):325-329. doi: 10.24953/turkjped.2019.03.002. PMID: 31916708
Updates in the biology and therapy for infant acute lymphoblastic leukemia.
Guest EM, Stam RW
Curr Opin Pediatr 2017 Feb;29(1):20-26. doi: 10.1097/MOP.0000000000000437. PMID: 27841777

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